The responses of the inner retinal neurons of turtle to light spots of sizes were studied in an attempt to reveal characteristics that may reflect possible interactions of the neural circuits underlying the center and surround responses. For the ON-OFF cells, the responses were also analyzed to observe whether interference or augmentation of these responses occur. The intracellular recordings revealed several such interactions, observed either in the form of altered spike activity or as changes in the transiency of the light responses. The ON-responding amacrine cell presented in this study became more sustained, while for the ON-OFF amacrine cells larger light spots tended to make the responses more transient and both the ON and OFF components became more pronounced. The spiking activity of the OFF-type ganglion cell shifted in relation to the light stimulus and the number of spikes observed upon presentation of larger spots increased. We suggest that the surround circuits activated by increasing light spots may substantially influence and reorganize not only the overall center-surround balance, but also the center response of the cells. Although it cannot be excluded that intrinsic membrane properties also influence these processes to some extent, it is more likely that lateral inhibition and disinhibitory mechanisms play the leading role in this process.
Ammermüller, J., Kolb, H. (1995) The organization of the turtle inner retina. I. ON- and OFF-center pathways. J. Comp. Neurol. 358, 553-563.
'The organization of the turtle inner retina. I. ON- and OFF-center pathways ' () 358 J. Comp. Neurol. : 31 -563 .
Watanabe, S.-I., Satoh, H., Koizumi, A., Takayanagi, T., Kaneko, A. (2000) Tetrodotoxin-sensitive persistent current boots the depolarization of retinal amacrine cells in goldfish. Neurosci. Lett. 278, 97-100.
'Tetrodotoxin-sensitive persistent current boots the depolarization of retinal amacrine cells in goldfish ' () 278 Neurosci. Lett. : 31 -100 .
Akopian, A., Witkovsky, P. (2001) Intracellular calcium reduces light-induced excitatory postsynaptic responses in salamander retinal ganglion cells. J. Physiol. 532, 43-53.
'Intracellular calcium reduces light-induced excitatory postsynaptic responses in salamander retinal ganglion cells ' () 532 J. Physiol. : 31 -53 .
Burkhardt, D. A., Fahey, P. K., Sikora, M. (1998) Responses of ganglion cells to contrast steps in the light-adapted retina of the tiger salamander. Visual Neurosci. 15, 219-229.
'Responses of ganglion cells to contrast steps in the light-adapted retina of the tiger salamander ' () 15 Visual Neurosci. : 31 -229 .
Cook, P. B., McReynolds, J. (1998) Lateral inhibition in the inner retina is important for spatial tuning of ganglion cells. Nature Neurosci. 1, 714-719.
'Lateral inhibition in the inner retina is important for spatial tuning of ganglion cells ' () 1 Nature Neurosci. : 31 -719 .
Dowling, J. E. (1987) The Retina. An Approachable Part of the Brain. Belknap Press of Harvard University Press, Cambridge.
The Retina. An Approachable Part of the Brain. , ().
Thoreson, W. B., Witkovsky, P. (1999) Glutamate circuits and receptors in the retina. Prog. Retinal Res. 18, 765-810.
'Glutamate circuits and receptors in the retina ' () 18 Prog. Retinal Res. : 31 -810 .
Vidnyánszky, Z., Hámori, J. (1994) Quantitative electron microscopic analysis of synaptic input from cortical areas 17 and 18 to the lateral geniculate nucleus in cat. J. Comp. Neurol. 349, 259-268.
'Quantitative electron microscopic analysis of synaptic input from cortical areas 17 and 18 to the lateral geniculate nucleus in cat ' () 349 J. Comp. Neurol. : 31 -268 .
Vigh, J., Bánvölgyi, T., Wilhelm, M. (2000) Amacrine cells of the anuran retina: morphology, chemical neuroanatomy and physiology. Microsc. Res. Techn. 50, 373-383.
'Amacrine cells of the anuran retina: morphology, chemical neuroanatomy and physiology ' () 50 Microsc. Res. Techn. : 31 -383 .
Eldred, W. D., Cheung, K. (1989) Immunocytochemical localization of glycine in the retina of the turtle (Pseudemys scripta elegans). Visual Neurosci. 2, 331-338.
'Immunocytochemical localization of glycine in the retina of the turtle (Pseudemys scripta elegans) ' () 2 Visual Neurosci. : 331 -338 .
Gabbott, P. L. A., Somogyi, J., Stewart, M. G., Hámori, J. (1985) GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus: light microscopical observations. Brain Res. 346, 171-175.
'GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus: light microscopical observations ' () 346 Brain Res. : 31 -175 .
Watt, C.-B., Yang, J. H., Jones, B. W., Marc, R. E. (2001) Nested feed-back and concatenated inhibition in the rabbit inner plexiform layer. Invest. Ophthalmol. Vis. Sci. 42, S373.
'Nested feed-back and concatenated inhibition in the rabbit inner plexiform layer ' () 42 Invest. Ophthalmol. Vis. Sci. : S373 .
Yang, C. Y., Lukasiewicz, P., Maguire, G., Werblin, F., Yazulla, S. (1991) Amacrine cells in the tiger salamander retina: morphology, physiology, and neurotransmitter identification. J. Comp. Neurol. 312, 19-32.
'Amacrine cells in the tiger salamander retina: morphology, physiology, and neurotransmitter identification ' () 312 J. Comp. Neurol. : 31 -32 .
Garey, L. J., Takács, J., Revishchin, A. V., Hámori, J. (1989) Quantitative distribution of GABA-immunoreactive neurons in cetacean visual cortex is similar to that in land mammals. Brain Res. 485, 278-284.
'Quantitative distribution of GABA-immunoreactive neurons in cetacean visual cortex is similar to that in land mammals ' () 485 Brain Res. : 31 -284 .
Guiloff, G. D., Jones, J., Kolb, H. (1988) Organization of the inner plexiform layer of the turtle retina: an electron microscope study. J. Comp. Neurol. 272, 280-292.
'Organization of the inner plexiform layer of the turtle retina: an electron microscope study ' () 272 J. Comp. Neurol. : 31 -292 .
Hámori, J., Pasik, T., Pasik, P., Szentágothai, J. (1974) Triadic synaptic arrangements and their possible significance in the lateral geniculate nucleus of the monkey. Brain Res. 80, 379-393.
'Triadic synaptic arrangements and their possible significance in the lateral geniculate nucleus of the monkey ' () 80 Brain Res. : 31 -393 .
Hartline, H. K. (1938) The response of single optic fibers of the vertebrate eye to illumination of the retina. Am. J. Physiol. 121, 400-415.
'The response of single optic fibers of the vertebrate eye to illumination of the retina ' () 121 Am. J. Physiol. : 31 -415 .
Hurd, L. B., Eldred, W. D. (1989) Localization of GABA- and GAD-like immunoreactivity in the turtle retina. Visual Neurosci. 3, 9-20.
'Localization of GABA- and GAD-like immunoreactivity in the turtle retina ' () 3 Visual Neurosci. : 31 -20 .
Kolb, H. (1982) The morphology of the bipolar cells, amacrine cells and ganglion cells in the retina of the turtle, Pseudemys scripta elegans. Phil. Trans. R. Soc. Lond. B 298, 355-393.
'The morphology of the bipolar cells, amacrine cells and ganglion cells in the retina of the turtle, Pseudemys scripta elegans ' () 298 Phil. Trans. R. Soc. Lond. B : 31 -393 .
MacNeil, M. A., Masland, R. H. (1998) Extreme diversity among amacrine cells: implications for function. Neuron 20, 971-982.
'Extreme diversity among amacrine cells: implications for function ' () 20 Neuron : 31 -982 .
Pasik, P., Pasik, T., Hámori, J. (1976) Synapses between interneurones in the lateral geniculate nucleus of monkeys. Exp. Brain Res. 25, 1-13.
'Synapses between interneurones in the lateral geniculate nucleus of monkeys ' () 25 Exp. Brain Res. : 31 -13 .
Gabbott, P. L. A., Somogyi, J., Stewart, M. G., Hámori, J. (1986) GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry. Exp. Brain Res. 61, 311-322.
'GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry ' () 61 Exp. Brain Res. : 31 -322 .
Pasik, T., Pasik, P., Hámori, J., Szentágothai, J. (1973) Golgi type II interneurons in the neuronal circuit of the monkey lateral geniculate nucleus. Exp. Brain Res. 17, 18-34.
'Golgi type II interneurons in the neuronal circuit of the monkey lateral geniculate nucleus ' () 17 Exp. Brain Res. : 31 -34 .
Roska, T., Hámori, J., Lábos, E., Lotz, K., Orzó, L., Takács, J., Venetianer, P. L., Vidnyánszky, Z., Zarándy, Á. (1993) The use of CNN models in the subcortical visual pathway. IEEE Transactions 40, 182-195.
'The use of CNN models in the subcortical visual pathway ' () 40 IEEE Transactions : 31 -195 .
Szentágothai, J., Hámori, J., Tömböl, T. (1966) Degeneration and electron microscope analysis of the synaptic glomeruli in the lateral geniculate body. Exp. Brain Res. 2, 283-301.
'Degeneration and electron microscope analysis of the synaptic glomeruli in the lateral geniculate body ' () 2 Exp. Brain Res. : 31 -301 .
Takács, J., Saillour, P., Imber, M., Bogner, M., Hámori, J. (1992) Effect of dark rearing on the volume of visual cortex (areas 17 and 18) and number of visual cortical cells in young kittens. J. Neurosci. Res. 32, 449-459.
'Effect of dark rearing on the volume of visual cortex (areas 17 and 18) and number of visual cortical cells in young kittens ' () 32 J. Neurosci. Res. : 31 -459 .
Ammermüller, J., Kolb, H. (1996) Functional architecture of the turtle retina. Prog. Retinal Res. 15, 393-433.
'Functional architecture of the turtle retina ' () 15 Prog. Retinal Res. : 31 -433 .
Barlow, H. B. (1953) Summation and inhibition in the frog's retina. J. Physiol. 119, 69-88.
'Summation and inhibition in the frog's retina ' () 119 J. Physiol. : 31 -88 .
Bloomfield, S. A., Xin, D. (2000) Surround inhibition of mammalian AII amacrine cells is generated in the proximal retina. J. Physiol. 523, 771-783.
'Surround inhibition of mammalian AII amacrine cells is generated in the proximal retina ' () 523 J. Physiol. : 31 -783 .