Authors:
H. Hall Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital S-171 76 Stockholm, Sweden

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K. Varnäs Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital S-171 76 Stockholm, Sweden

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J. Sandell Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital S-171 76 Stockholm, Sweden

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C. Halldin Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital S-171 76 Stockholm, Sweden

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L. Farde Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital S-171 76 Stockholm, Sweden

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Á. Vas Gedeon Richter Ltd. H-1103 Budapest, Hungary

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E. Kárpáti Gedeon Richter Ltd. H-1103 Budapest, Hungary

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B. Gulyás Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska HospitalKarolinska Institutet, Department of Neuroscience S-171 76 Stockholm, SwedenS-171 77 Stockholm, Sweden

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The main objective of the study was to evaluate with autoradiographic technique whether or not [11C]vinpocetine, a compound widely used in the prevention and treatment of cerebrovascular diseases (Cavinton®, Gedeon Richter Ltd., Budapest), binds to specific sites in the human brain in post mortem human brain sections. Binding was assessed under four conditions: the incubation was performed using Tris-HCl buffer with or without the addition of salts (0.1% (weight/vol) ascorbic acid, 120 mM NaCl, 5 mM KCl, 2 mM CaCl2 and 1 mM MgCl2), with or without the addition of excess (10 mM) unlabelled vinpocetine. Measurements on digitized autoradiograms indicated that [11C]vinpocetine labelled all grey matter areas in the human brain to a similar extent and no significantly heterogeneous binding could be demonstrated among cortical or subcortical regions. The addition of excess unlabelled vinpocetine lowered the binding slightly in all regions. Although these results indicate that [11C]vinpocetine does not bind to human brain transmitter receptors or transporters with a high affinity (Ki < 10 nM), it cannot be ruled out that the compound binds to receptors and/or transporters with lower affinity.

  • Hall, H., Hurd, Y., Pauli, S., Halldin, C., Sedvall, G. (2001) Human brain imaging post-mortem -- whole hemisphere technologies. Int. Rev. Psych. 13, 12-17.

    'Human brain imaging post-mortem -- whole hemisphere technologies ' () 13 Int. Rev. Psych. : 31 -17 .

    • Search Google Scholar
  • Hall, H., Sedvall, G., Magnusson, O., Kopp, J., Halldin, C., Farde, L. (1994) Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacology 11, 245-256.

    'Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain ' () 11 Neuropsychopharmacology : 31 -256 .

    • Search Google Scholar
  • Hall, H., Farde, L., Sedvall, G. (1988) Human dopamine receptor subtypes -- in vitro binding analysis using 3H-SCH 23390 and 3H-raclopride. J. Neur. 73, 7-21.

    'Human dopamine receptor subtypes -- in vitro binding analysis using 3H-SCH 23390 and 3H-raclopride ' () 73 J. Neur. : 31 -21 .

    • Search Google Scholar
  • Hall, H., Halldin, C., Farde, L., Sedvall, G. (1998) Whole hemisphere autoradiography of the postmortem human brain. Nucl. Med. Biol. 25, 715-719.

    'Whole hemisphere autoradiography of the postmortem human brain ' () 25 Nucl. Med. Biol. : 31 -719 .

    • Search Google Scholar
  • Halldin, C., Farde, L., Högberg, T., Hall, H., Sedvall, G. (1990) 11C-Labelling of eticlopride in two different positions -- a selective high affinity ligand for the study of dopamine D-2 receptors using PET. Appl. Radiat. Isot. 19, 669-674.

    '11C-Labelling of eticlopride in two different positions -- a selective high affinity ligand for the study of dopamine D-2 receptors using PET ' () 19 Appl. Radiat. Isot. : 31 -674 .

    • Search Google Scholar
  • Hara, H., Ozaki, A., Yoshidomi, M. S. T. (1990) Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia. Arch. Int. Pharmacodyn. Ther. 304, 206-218.

    'Protective effect of KB-2796, a new calcium antagonist, in cerebral hypoxia and ischemia ' () 304 Arch. Int. Pharmacodyn. Ther. : 31 -218 .

    • Search Google Scholar
  • Hidaka, H. (1984) Selective inhibitors of three forms of cyclic nucleotide phosphodiesterases. Trends Pharm. Sci. 5, 1-3.

    'Selective inhibitors of three forms of cyclic nucleotide phosphodiesterases ' () 5 Trends Pharm. Sci. : 31 -3 .

    • Search Google Scholar
  • Hortobágyi, T., Harkány, T., Reisch, R., Urbanics, R., Kálmán, M., Nyakas, C., Nagy, Z. (1998) Neurotrophin-mediated neuroprotection by solid fetal telencephalic graft in middle cerebral artery occlusion: a preventive approach. Brain Res. Bull. 47, 185-191.

    'Neurotrophin-mediated neuroprotection by solid fetal telencephalic graft in middle cerebral artery occlusion: a preventive approach ' () 47 Brain Res. Bull. : 31 -191 .

    • Search Google Scholar
  • Kaneko, S., Takahashi, H., Satoh, M. (1990) The use of Xenopus oocytes to evaluate drugs affecting brain Ca2+ channels: effects of bifemelane and several nootropic agents. Eur. J. Pharmacol. 189, 51-58.

    'The use of Xenopus oocytes to evaluate drugs affecting brain Ca2+ channels: effects of bifemelane and several nootropic agents ' () 189 Eur. J. Pharmacol. : 31 -58 .

    • Search Google Scholar
  • Kiss, B., Cai, N. S., Erdö, S. L. (1991) Vinpocetine preferentially antagonizes quisqualate/AMPA receptor responses: evidence from release and ligand binding studies. Eur. J. Pharmacol. 209, 109-112.

    'Vinpocetine preferentially antagonizes quisqualate/AMPA receptor responses: evidence from release and ligand binding studies ' () 209 Eur. J. Pharmacol. : 31 -112 .

    • Search Google Scholar
  • Lamar, J. C., Beaughard, M., Bromont, C., Pignet, H. (1986) Effects of vinpocetine in four pharmacological models of cerebral ischaemia. In: Krieglstein, J. (ed.), Pharmacology of Cerebral Ischemia. Elsevier, Amsterdam, pp. 334-339.

    Pharmacology of Cerebral Ischemia. , () 334 -339 .

  • Lim, C. C., Cook, P. J., James, I. M. (1980) The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers. Br. J. Clin. Pharmacol. 9, 100-101.

    'The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers ' () 9 Br. J. Clin. Pharmacol. : 31 -101 .

    • Search Google Scholar
  • Miyazaki, M. (1995) The effect of a cerebral vasodilator, vinpocetine, on cerebral vascular resistance evaluated by the Doppler ultrasonic technique in patients with cerebrovascular diseases. Angiology 46, 53-58.

    'The effect of a cerebral vasodilator, vinpocetine, on cerebral vascular resistance evaluated by the Doppler ultrasonic technique in patients with cerebrovascular diseases ' () 46 Angiology : 31 -58 .

    • Search Google Scholar
  • Gulyás, B., Halldin, C., Karlsson, P., Chou, Y.-H., Swahn, C.-G., Farde, L. (1999) Brain uptake and plasma metabolism of 11C-vinpocetine. A PET-study in cynomolgus monkey. J. Neuroimaging, 9, 217-222.

    'Brain uptake and plasma metabolism of 11C-vinpocetine. A PET-study in cynomolgus monkey ' () 9 J. Neuroimaging : 31 -222 .

    • Search Google Scholar
  • Nakazawa, M., Matsuno, K., Mita, S. (1998) Activation of sigmal receptor subtype leads to neuroprotection in the rat primary neuronal cultures. Neurochem. Int. 32, 337-343.

    'Activation of sigmal receptor subtype leads to neuroprotection in the rat primary neuronal cultures ' () 32 Neurochem. Int. : 31 -343 .

    • Search Google Scholar
  • Nicholson, C. D. (1990) Pharmacology of nootropics and metabolically active compunds in relation to their use in dementia. Psychopharmacology (Berlin) 101, 147-159.

    'Pharmacology of nootropics and metabolically active compunds in relation to their use in dementia ' () 101 Psychopharmacology (Berlin) : 31 -159 .

    • Search Google Scholar
  • Persson, A., d'Argy, R., Gillberg, P. G., Halldin, C., Litton, J. E., Swahn, C. G., Sedvall, G. (1991) Autoradiography with saturation experiments of 11C-Ro 15-1788 binding to human brain sections. J. Neurosci. Methods 36, 53-61.

    'Autoradiography with saturation experiments of 11C-Ro 15-1788 binding to human brain sections ' () 36 J. Neurosci. Methods : 31 -61 .

    • Search Google Scholar
  • Rischke, R., Krieglstein, J. (1990) Effects of vinpocetine on local cerebral blood flow and glucose utilization seven days after forebrain ischemia in the rat. Pharmacology 41, 153-160.

    'Effects of vinpocetine on local cerebral blood flow and glucose utilization seven days after forebrain ischemia in the rat ' () 41 Pharmacology : 31 -160 .

    • Search Google Scholar
  • Salamon, G. (1971) Atlas de la Vascularisation Arterielle du Cerveau chez l'Homme. Sandoz, Paris, p. 189.

    Atlas de la Vascularisation Arterielle du Cerveau chez l'Homme. , () 189 .

  • Culmsee, C., Semkova, I., Krieglstein, J. (1999) NGF mediates the neuroprotective effect of the beta2-adrenoceptor agonist clenbuterol in vitro and in vivo: evidence from an NGF-antisense study. Neurochem. Int. 35, 47-57.

    'NGF mediates the neuroprotective effect of the beta2-adrenoceptor agonist clenbuterol in vitro and in vivo: evidence from an NGF-antisense study ' () 35 Neurochem. Int. : 31 -57 .

    • Search Google Scholar
  • Gulyás, B., Csiba, L., Kerényi, L., Trón, L. (1998) The effect of a single-dose intravenous vinpocetine on chronic stroke patients. A PET study. In: B. Gulyás and H. W. Müller-Gärtner (eds), Positron Emission Tomography: A Critical Assessment of Recent Trends. Kluwer Academic Publishers, Dordrecht, pp. 291-306.

    Positron Emission Tomography: A Critical Assessment of Recent Trends. , () 291 -306 .

    • Search Google Scholar
  • Santos, M. S., Duarte, A. I., Moreira, P. I., Oliveira, C. R. (2000) Synaptosomal response to oxidative stress: effect of vinpocetine. Free Radic. Res. 32, 57-66.

    'Synaptosomal response to oxidative stress: effect of vinpocetine ' () 32 Free Radic. Res. : 31 -66 .

    • Search Google Scholar
  • Sauer, D., Rischke, R., Beck, T., Rossberg, C., Mennel, H. D., Bielenberg, G. W., Krieglstein, J. (1988) Vinpocetine prevents ischemic cell damage in rat hippocampus. Life Sci. 43, 1733-1739.

    'Vinpocetine prevents ischemic cell damage in rat hippocampus ' () 43 Life Sci. : 31 -1739 .

    • Search Google Scholar
  • Stolc, S. (1999) Indole derivatives as neuroprotectants. Life Sci. 65, 1943-1950.

    'Indole derivatives as neuroprotectants ' () 65 Life Sci. : 31 -1950 .

  • Tretter, L., Ádám-Vizi, V. (1998) The neuroprotective drug vinpocetine prevents veratridine-induced [Na+]i and [Ca2+]i rise in synaptosomes. Neuroreport 9, 1849-1853.

    'The neuroprotective drug vinpocetine prevents veratridine-induced [Na+]i and [Ca2+]i rise in synaptosomes ' () 9 Neuroreport : 31 -1853 .

    • Search Google Scholar
  • Urenjak, J., Obrenovitch, T. P. (1996) Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol. Rev. 48, 21-67.

    'Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage ' () 48 Pharmacol. Rev. : 31 -67 .

    • Search Google Scholar
  • Yamaguchi, K., Yamada, S., Yoshida, M., Kyuki, K., Okuyama, S. (1993) Anti-anoxic effects of VA-045. J. Pharmacol. 61 (Suppl. 1), 184.

    'Anti-anoxic effects of VA-045 ' () 61 J. Pharmacol. : 184 .

  • Beavo, J. A. (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75, 725-748.

    'Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms ' () 75 Physiol. Rev. : 31 -748 .

    • Search Google Scholar
  • Bönöczk, P., Gulyás, B., Ádám-Vizi, V., Nemes, A., Kárpáti, E., Kiss, B., Kapás, M., Szántay, C., Koncz, I., Zelles, T., Vas, Á. (2000) Role of sodium channel inhibition in neuroprotection: effect of vinpocetine. Brain Res. Bull. 53, 245-254.

    'Role of sodium channel inhibition in neuroprotection: effect of vinpocetine ' () 53 Brain Res. Bull. : 31 -254 .

    • Search Google Scholar
  • Szakáll, S., Boros, I., Balkay, L. Emri, M., Fekete, I., Kerényi, L., Lehel, S., Márián, T., Molnár, T., Varga, J., Galuska, L., Trón, L., Bereczki, D., Csiba, L., Gulyás, B. (1998) The cerebral effects of a single dose intravenous vinpocetine in chronic stroke patients: A PET study. J. Neuroimaging, 8, 197-294.

    'The cerebral effects of a single dose intravenous vinpocetine in chronic stroke patients: A PET study ' () 8 J. Neuroimaging : 31 -294 .

    • Search Google Scholar
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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
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Phone: (36 87) 448 244 ext. 103
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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)