View More View Less
  • 1 Department of Zoology, Banaras Hindu University Varanasi-221 005, India
  • | 2 Department of Zoology, Banaras Hindu University Varanasi-221 005, India
Restricted access

The aim of the present study was to evaluate the relationship between corticosterone, body weight, insulin and androstenedione in order to understand the role of adrenal in contributing hyperandrogenism during delayed ovulation in S. heathi. The circulating corticosterone concentration in female S. heathi showed significant seasonal variation. The peak corticosterone concentration observed during August-September coincides with increased feeding activities in S. heathi. The present study noted a seasonal variation in relationship of corticosterone with insulin and androstenedione in S. heathi. An inverse relationship of corticosterone with insulin and androstenedione was found during August to December, but not during January to May. A seasonal variation in the effect of adrenocorticotropic hormone (ACTH) on adrenal corticosterone production invitro was observed during reproductive cycle. Corticosterone production in vitro by adrenal declined significantly as compared to the control during quiescence in September. The finding suggests that adrenal attained the peak responsiveness to ACTH during September. ACTH significantly enhanced the androstenedione production by the adrenal in vitro during December, when the circulating androstenedione was also high in S. heathi. This suggests that the adrenal may also contribute to hyperandrogenism during the period of delayed ovulation in S. heathi. Further studies are required to reveal the unique pattern of seasonal relationship between corticosterone, insulin and androstenedione in S. heathi.

  • Green, P. K., Wilkinson, C. W., Woods, S. C. (1992) Intraventricular corticosterone increases the body weight gain in underweight adrenalectomised rats. Endocrinol. 130, 269-275.

    'Intraventricular corticosterone increases the body weight gain in underweight adrenalectomised rats ' () 130 Endocrinol. : 269 -275.

    • Search Google Scholar
  • Gustafson, A. W., Belt, W. D. (1981) The adrenal cortex during activity and hibernation in the male little brown rat, Myotis lucifugus lucifugus: Annual rhythms of plasma cortisol levels. Gen. Comp. Endocrinol. 44, 269-278.

    'The adrenal cortex during activity and hibernation in the male little brown rat, Myotis lucifugus lucifugus: Annual rhythms of plasma cortisol levels. ' () 44 Gen. Comp. Endocrinol. : 269 -278.

    • Search Google Scholar
  • Hautanen, A., Aldercreutz, H. (1993) Altered adrenocorticotrophin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J. Intern. Med. 124, 461-469.

    'Altered adrenocorticotrophin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome ' () 124 J. Intern. Med. : 461 -469.

    • Search Google Scholar
  • King, B. M. (1988) Glucocorticoids and hypothalamic obesity. Neurosci. Biobehav. Rev. 12, 29-37.

    'Glucocorticoids and hypothalamic obesity ' () 12 Neurosci. Biobehav. Rev. : 29 -37.

  • Krishna, A., Singh, U. P. (1992) Morphometric changes in the ovaries of Indian vespertilionid bat, Scotophilus heathi with reference to delayed ovulation. Eur. Arch. Biol. 103, 257-264.

    'Morphometric changes in the ovaries of Indian vespertilionid bat, Scotophilus heathi with reference to delayed ovulation. ' () 103 Eur. Arch. Biol. : 257 -264.

    • Search Google Scholar
  • Krishna, A., Singh, K., Doval, J., Chanda, D. (1998) Changes in circulating insulin and corticosterone concentrations during different reproductive phases and their relationships to body weight and androstenedione concentration of male Scotophilus heathi. J. Exp. Zool. 281, 201-206.

    'Changes in circulating insulin and corticosterone concentrations during different reproductive phases and their relationships to body weight and androstenedione concentration of male Scotophilus heathi. ' () 281 J. Exp. Zool. : 201 -206.

    • Search Google Scholar
  • Lanzone, A., Fulghesu, A. M., Guido, M., Fortini, A., Caruso, A., Mancuso, S. (1992) Differential androgen response to adrenocorticotrophic hormone stimulation in polycystic ovarian syndrome: relationship with insulin secretion. Fertil. Steril. 58 (2), 296-301.

    'Differential androgen response to adrenocorticotrophic hormone stimulation in polycystic ovarian syndrome: relationship with insulin secretion ' () 58 Fertil. Steril. : 296 -301.

    • Search Google Scholar
  • McKenna, T. J. (1988) Pathogenesis and treatment of polycystic ovary syndrome. New Eng. J. Med. 318, 558-562.

    'Pathogenesis and treatment of polycystic ovary syndrome ' () 318 New Eng. J. Med. : 558 -562.

    • Search Google Scholar
  • Nosadini, R., Del Prato, S., Tiengo, A., Valerio, A., Muggeo, M., Opocher, G., Mantero, F., Duner, E., Marescotti, C., Mollo, F., Belloni, F. (1983) Insulin resistance in Cushing's syndrome. New Eng. J. Med. 335, 617-623.

    'Insulin resistance in Cushing's syndrome ' () 335 New Eng. J. Med. : 617 -623.

  • Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., Porte, D. Jr. (1992) Insulin in the brain: A hormonal regulator of energy balance. Endocrin. Rev. 13, 387-414.

    'Insulin in the brain: A hormonal regulator of energy balance ' () 13 Endocrin. Rev. : 387 -414.

    • Search Google Scholar
  • Singh, K., Krishna, A. (1996) Seasonal changes in circulating serum concentration and in vitro testicular secretion of testosterone and androstenedione in the male vespertilionid bat (Scotophilus heathi). J. Exp. Zool. 276, 43-52.

    'Seasonal changes in circulating serum concentration and in vitro testicular secretion of testosterone and androstenedione in the male vespertilionid bat (Scotophilus heathi). ' () 276 J. Exp. Zool. : 43 -52.

    • Search Google Scholar
  • Weinstein, S. P., Paquin, T., Pritsker, A., Haber, R. S. (1995) Glucocorticoid induced insulin resistance: Dexamethasone inhibits the activation of glucose transport in the rat skeletal muscle by both insulin and non-insulin-related stimuli. Diabetes 44, 441-445.

    'Glucocorticoid induced insulin resistance: Dexamethasone inhibits the activation of glucose transport in the rat skeletal muscle by both insulin and non-insulin-related stimuli ' () 44 Diabetes : 441 -445.

    • Search Google Scholar
  • Abhilasha, Krishna, A. (1996) High androstenedione production by ovarian thecal-interstitial cells: A mechanism for delayed ovulation in an Indian vespertilionid bat, Scotophilus heathi. J. Reprod. Fertil. 106, 207-211.

    'High androstenedione production by ovarian thecal-interstitial cells: A mechanism for delayed ovulation in an Indian vespertilionid bat, Scotophilus heathi ' () 106 J. Reprod. Fertil. : 207 -211.

    • Search Google Scholar
  • Abhilasha, Krishna, A. (1997) Adiposity and androstenedione production in relation to delayed ovulation in the Indian bat, Scotophilus heathi. Comp. Biochem. Physiol. 116c, 97-101.

    'Adiposity and androstenedione production in relation to delayed ovulation in the Indian bat, Scotophilus heathi ' () 116c Comp. Biochem. Physiol. : 97 -101.

    • Search Google Scholar
  • Azziz, R. (1996) Hyperandrogenism: The adrenal connection. In: Reproductive Endocrinology, Surgery and Technology, E. Y. Adashi, J. A. Rock, Z. Rosenwaks (eds) Lippincott-Raven Publishers, Philadelphia, pp. 1161-1180.

    1161 1180

  • Widmaier, E. P., Kunz, T. H. (1993) Basal, diurnal and stress induced levels of glucose and glucocorticoids in captive bats. J. Exp. Zool. 265, 533-540.

    'Basal, diurnal and stress induced levels of glucose and glucocorticoids in captive bats ' () 265 J. Exp. Zool. : 533 -540.

    • Search Google Scholar
  • Widmaier, E. P., Harmer, T. L., Sulak, A. M., Kunz, T. H. (1994) Further characterization of the pituitary-adrenocortical responses to high stress in chiroptera. J. Exp. Zool. 269, 442-449.

    'Further characterization of the pituitary-adrenocortical responses to high stress in chiroptera ' () 269 J. Exp. Zool. : 442 -449.

    • Search Google Scholar
  • Azziz, R, Boots, L. R., Bradley, El, jr. (1992) Adrenal androgen in hyperinsulinemic hyperandrogenic women. Endocrin. Soc. p. 844.

    844

  • Berdanier, C. D. (1989) Role of glucocorticoids in the regulation of lipogenesis. FASEB J. 3, 2179-2183.

    'Role of glucocorticoids in the regulation of lipogenesis ' () 3 FASEB J. : 2179 -2183.

  • Boswell, T., Woods, S. C., Kenagy, G. J. (1994) Seasonal changes in body mass, insulin, and glucocorticoids of free-living golden-mantled ground squirrels. Gen. Comp. Endocrinol. 96, 339-346.

    'Seasonal changes in body mass, insulin, and glucocorticoids of free-living golden-mantled ground squirrels ' () 96 Gen. Comp. Endocrinol. : 339 -346.

    • Search Google Scholar
  • Brilon, D. J., Zheng, B., Campbell, R. G., Matthews, D. E. (1995) Effect of cortisol on energy expenditure and amino acid metabolism in humans. Am. J. Physiol. 268, E501-E513.

    'Effect of cortisol on energy expenditure and amino acid metabolism in humans ' () 268 Am. J. Physiol. : E501 -E513.

    • Search Google Scholar
  • Brindly, D. N. (1995) Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome. Int. J. Obes. 19 (suppl.): S69-S75.

    'Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome ' () 19 Int. J. Obes. : S69 -S75.

    • Search Google Scholar
  • Bjorntorp, P., Brodoff, B. N. (eds) (1992) Obesity. J. B. Lippincott Co., Philadelphia.

  • Doval, J., Krishna, A. (1998) Ovarian androstenedione production is enhanced by insulin during the period of delayed ovulation in a vespertilionid bat, Scotophilus heathi. J. Reprod. Fert. 114, 63-68.

    'Ovarian androstenedione production is enhanced by insulin during the period of delayed ovulation in a vespertilionid bat, Scotophilus heathi. ' () 114 J. Reprod. Fert. : 63 -68.

    • Search Google Scholar
  • Dunaif, A., Segal, K. R., Futterweit, W., Dobrojansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.

    'Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome ' () 38 Diabetes : 1165 -1174.

    • Search Google Scholar
  • Gao, H., Shan, L., Monder, C., Hardy, M. P. (1996) Suppression of endogenous corticosterone levels in vivo increases the steroidogenesis capacity of purified rat Leydig cells in vitro. Endocrinol. 137 (5), 1714-1718.

    'Suppression of endogenous corticosterone levels in vivo increases the steroidogenesis capacity of purified rat Leydig cells in vitro ' () 137 Endocrinol. : 1714 -1718.

    • Search Google Scholar
  • Wingfield, J. C., Vleck, C. M., Moore, M. C. (1992) Seasonal changes of the adrenocortical response to stress in birds of the Sonoran desert. J. Exp. Zool. 264, 419-428.

    'Seasonal changes of the adrenocortical response to stress in birds of the Sonoran desert ' () 264 J. Exp. Zool. : 419 -428.

    • Search Google Scholar
  • Woods, S. C., Figlewicz-Lattemann, D. P., Schwartz, M. W., Porte, D. Jr. (1990) A reassessment of the regulation of adiposity and appetite by the brain insulin system. Int. J. Obesity 14 (suppl. 3), 69-76.

    'A reassessment of the regulation of adiposity and appetite by the brain insulin system. ' () 14 Int. J. Obesity : 69 -76.

    • Search Google Scholar
  • Conway, G. S., Jacobs, H. S. (1993) Clinical implications of hyperinsulinemia in women. Clin. Endocrinol. 39, 623-632.

    'Clinical implications of hyperinsulinemia in women ' () 39 Clin. Endocrinol. : 623 -632.

  • Rosenfield, R. L. (1999) Ovarian and adrenal function in polycystic ovary syndrome. Endocrinol. Metab. Clin. N. Am. 28, 265-294.

    'Ovarian and adrenal function in polycystic ovary syndrome ' () 28 Endocrinol. Metab. Clin. N. Am. : 265 -294.

    • Search Google Scholar