Authors:
N. Hájos Department of Functional Neuroanatomy, Institute of Experimental Medicine, Hungarian Academy of Sciences Departments of Neurology and Physiology, UCLA School of Medicine H-1450 Budapest, Hungary Los Angeles, California 90095-1769, USA

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T. F. Freund Department of Functional Neuroanatomy, Institute of Experimental Medicine, Hungarian Academy of Sciences H-1450 Budapest, Hungary

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I. Mody Departments of Neurology and Physiology, UCLA School of Medicine Los Angeles, California 90095-1769, USA

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NMDA receptors participate in the glutamatergic excitation of both principal cells and GABAergic interneurons. The features of NMDA channels on specific interneurons, however, are not known. Therefore, we obtained direct measurements of single NMDA receptor channels on anatomically identified oriens/alveus interneurons projecting to stratum lacunosum-moleculare (O-LM cells) and compared them to those found on hippocampal principal cells using cell-attached recordings in in vitro slice preparations. The recorded channels could be blocked by ketamine, a membrane-permeable NMDA channel inhibitor. In the absence of Mg2+, all O-LM cells had NMDA channels with a comparable slope conductance (~60pS) to those measured on CA1 pyramidal cells or dentate granule cells. In addition, NMDA channels with smaller conductance (43-45 pS) were also found on two O-LM cells but not on principal cells. These results suggest that at least two types of NMDA channels are expressed on O-LM cells likely reflecting distinct subunit composition.

  • Kirson, E. D., Schirra, C., Konnerth, A., Yaari, Y. (1999) Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J. Physiol. 521, 99-111.

    'Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells ' () 521 J. Physiol. : 99 -111 .

    • Search Google Scholar
  • Maccaferri, G., McBain, C. J. (1995) Passive propagation of LTD to stratum oriens-alveus inhibitory neurons modulates the temporoammonic input to the hippocampal CA1 region. Neuron 15, 137-145.

    'Passive propagation of LTD to stratum oriens-alveus inhibitory neurons modulates the temporoammonic input to the hippocampal CA1 region ' () 15 Neuron : 137 -145 .

    • Search Google Scholar
  • McBain, C. J., DiChiara, T. J., Kauer, J. A. (1994) Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission. J. Neurosci. 14, 4433-4445.

    'Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission ' () 14 J. Neurosci. : 4433 -4445 .

    • Search Google Scholar
  • Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., Seeburg, P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.

    'Developmental and regional expression in the rat brain and functional properties of four NMDA receptors ' () 12 Neuron : 529 -540 .

    • Search Google Scholar
  • Köhr, G., De Koninck, Y., Mody, I. (1993) Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats. J. Neurosci. 13, 3612-3627.

    'Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats ' () 13 J. Neurosci. : 3612 -3627 .

    • Search Google Scholar
  • Krupp, J. J., Vissel, B., Heinemann, S. F., Westbrook, G. L. (1996) Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific. Mol. Pharmacol. 50, 1680-1688.

    'Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific ' () 50 Mol. Pharmacol. : 1680 -1688 .

    • Search Google Scholar
  • Lau, L. F., Huganir, R. L. (1995) Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 270, 20036-20041.

    'Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits ' () 270 J. Biol. Chem. : 20036 -20041 .

    • Search Google Scholar
  • Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., Prochiantz, A. (1984) Magnesium gates gluta-mate-activated channels in mouse central neurones. Nature 307, 462-465.

    'Magnesium gates gluta-mate-activated channels in mouse central neurones ' () 307 Nature : 462 -465 .

    • Search Google Scholar
  • Gibb, A. J., Colquhoun, D. (1992) Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus. J. Physiol. 456, 143-179.

    'Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus ' () 456 J. Physiol. : 143 -179 .

    • Search Google Scholar
  • Hájos, N., Mody, I. (1997]) Synaptic communication among hippocampal interneurons: properties of spontaneous IPSCs in morphologically identified cells. J. Neurosci. 17, 8427-8442.

    'Synaptic communication among hippocampal interneurons: properties of spontaneous IPSCs in morphologically identified cells ' () 17 J. Neurosci. : 8427 -8442 .

    • Search Google Scholar
  • Katona, I., Acsády, L., Freund, T. F. (1998) Postsynaptic targets os somatostatin-immunoreactive interneurons in the rat hippocampus. Neuroscience 88, 37-55.

    'Postsynaptic targets os somatostatin-immunoreactive interneurons in the rat hippocampus ' () 88 Neuroscience : 37 -55 .

    • Search Google Scholar
  • Cossart, R., Dinocourt, C., Hirsch, J. C., Merchan-Perez, A., De Felipe, J., Ben-Ari, Y., Esclapez, M., Bernard, C. (2001) Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy. Nat. Neurosci. 4, 52-62.

    'Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy ' () 4 Nat. Neurosci. : 52 -62 .

    • Search Google Scholar
  • Cull-Candy, S., Brickley, S., Farrant, M. (2001) NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11, 327-335.

    'NMDA receptor subunits: diversity, development and disease ' () 11 Curr. Opin. Neurobiol. : 327 -335 .

    • Search Google Scholar
  • Freund, T. F., Buzsáki, G. (1996) Interneurons of the hippocampus. Hippocampus 6, 345-470.

    'Interneurons of the hippocampus ' () 6 Hippocampus : 345 -470 .

  • Orser, B. A., Pennefather, P. S., MacDonald, J. F. (1997) Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 86, 903-917.

    'Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors ' () 86 Anesthesiology : 903 -917 .

    • Search Google Scholar
  • Schiller, J., Schiller, Y., Clapham, D. E. (1998) NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation [see comments]. Nat. Neurosci. 1, 114-118.

    'NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation [see comments] ' () 1 Nat. Neurosci. : 114 -118 .

    • Search Google Scholar
  • Sik, A., Hájos, N., Gulácsi, A., Mody, I., Freund, T. F. (1998) The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. Proc. Natl. Acad. Sci. USA 95, 3245-3250.

    'The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. ' () 95 Proc. Natl. Acad. Sci. USA : 3245 -3250 .

    • Search Google Scholar
  • Smart, T. G. (1997) Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr. Opin. Neurobiol. 7, 358-367.

    'Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation ' () 7 Curr. Opin. Neurobiol. : 358 -367 .

    • Search Google Scholar
  • Cauli, B., Porter, J. T., Tsuzuki, K., Lambolez, B., Rossier, J., Quenet, B., Audinat, E. (2000) Classification of fusiform neocortical interneurons based on unsupervised clustering. Proc. Natl. Acad. Sci. USA, 97, 6144-6149.

    'Classification of fusiform neocortical interneurons based on unsupervised clustering ' () 97 Proc. Natl. Acad. Sci. USA : 6144 -6149 .

    • Search Google Scholar
  • Clark, B. A., Farrant, M., Cull-Candy, S. G. (1997) A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors. J. Neurosci. 17, 107-116.

    'A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors ' () 17 J. Neurosci. : 107 -116 .

    • Search Google Scholar
  • Standaert, D. G., Landwehrmeyer, G. B., Kerner, J. A., Penney, J. B., Jr., Young, A. B. (1996) Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. Brain Res. Mol. Brain Res. 42, 89-102.

    'Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus ' () 42 Brain Res. Mol. Brain Res. : 89 -102 .

    • Search Google Scholar
  • Woodson, W., Nitecka, L., Ben-Ari, Y. (1989) Organization of the GABAergic system in the rat hippocampal formation: a quantitative immunocytochemical study. J. Comp. Neurol. 280, 254-271.

    'Organization of the GABAergic system in the rat hippocampal formation: a quantitative immunocytochemical study ' () 280 J. Comp. Neurol. : 254 -271 .

    • Search Google Scholar
  • Lieberman, D. N., Mody, I. (1994) Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 369, 235-239.

    'Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. ' () 369 Nature : 235 -239 .

    • Search Google Scholar
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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)