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  • 1 Oncology Institute of Vilnius University LT 2007, Vilnius, Lithuania
  • 2 Oncology Institute of Vilnius University LT 2007, Vilnius, Lithuania
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The effects of ethyl alcohol and synthetic β-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose -100 mg/mouse), subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse). β-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that β-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurrence. In our studies chronic ethanol intake did not show significant influence on this delay.

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