Acta Biologica Hungarica
Volume/Issue:
Volume 54: Issue 1
Investigation of ethyl alcohol and β-carotene effect on two models of carcinogenesis
Authors: Saule Uleckiene 1 and Vida Domkiene 2
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  • 1 Oncology Institute of Vilnius University LT 2007, Vilnius, Lithuania
  • 2 Oncology Institute of Vilnius University LT 2007, Vilnius, Lithuania
DOI:
https://doi.org/10.1556/abiol.54.2003.1.9
Page Count:
89–93
Publication Date:
01 Mar 2003
Online Publication Date:
19 Jul 2005
Article Category:
Research Article
Restricted access

The effects of ethyl alcohol and synthetic β-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose -100 mg/mouse), subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse). β-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that β-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurrence. In our studies chronic ethanol intake did not show significant influence on this delay.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

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