Acta Biologica Hungarica
Volume/Issue:
Volume 54: Issue 3-4
Antidiuretic activity of aqueous bark extract of Sri Lankan Ficus racemosa in rats
Authors:
W. D. Ratnasooriya Department of Zoology, University of Colombo Colombo-03, Sri Lanka

Search for other papers by W. D. Ratnasooriya in
Current site
Google Scholar
PubMed Close
,
J. R. A. C. Jayakody Department of Zoology, University of Colombo Colombo-03, Sri Lanka

Search for other papers by J. R. A. C. Jayakody in
Current site
Google Scholar
PubMed Close
, and
T. Nadarajah Department of Zoology, University of Colombo Colombo-03, Sri Lanka

Search for other papers by T. Nadarajah in
Current site
Google Scholar
PubMed Close
Pages:
357–364
Online Publication Date:
22 Jul 2005
Publication Date:
01 Dec 2003
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.54.2003.3-4.13
Keywords:
Ficus racemosa; Ficus racemosa; Ficus racemosa; antidiuresis; antidiuretic; traditional medicine; Sri Lanka
Restricted access

The decoction (D) of the bark of Ficus racemosa Linn (Family: Moraceae) is claimed as an antidiuretic by some Sri Lankan traditional practitioners. However, the validity of this claim has not been scientifically proven or refuted. The aim of this study was to evaluate the antidiuretic potential of D of the bark of F. racemosa (made as specified in traditional use) in rats using three doses (250, 500 or 1000 mg/kg) following oral administration. The reference drug used was ADH. The results demonstrated both the low- and high-doses of D and ADH significantly impaired the total urine output. The D-induced antidiuresis had a rapid onset (within 1 h), peaked at 3 h and lasted throughout the study period (5 h). However, antidiuretic potential of D was about 50% lower than that of ADH. The D was well tolerated even with subchronic administration. The D caused a reduction in urinary Na+ level and Na+/K+ ratio, and an increase in urinary osmolarity indicating multiple mechanisms of action. The results provide scientific support for its claimed antidiuretic action and deserve intensive scrutiny.

  • Farnsworth, N. R., Akerele, O., Bingel, A. S., Soejarto, D. D., Guo, Z. (1985) Medicinal plants in therapy. Bull. WHO 63, 965-981.

    'Medicinal plants in therapy ' () 63 Bull. WHO : 31 -981 .

  • Jayaweera, D. M. H. (1992) Medicinal Plants used in Ceylon. Part II. National Council of Sri Lanka, Colombo, Sri Lanka.

    Medicinal Plants used in Ceylon , ().

  • Laurence, D. R., Bennet, P. N. (1992) Clinical Pharmacology. Churchill Livingstone, London.

    Clinical Pharmacology , ().

  • Mahindapala, R. (2000) Sri Lanka's medicinal plants. Loris 22, 32-36.

    'Sri Lanka's medicinal plants ' () 22 Loris : 31 -36 .

  • Bowman, W. C., Rand, M. J., West, G. B. (1975) Textbook of Pharmacology. Blackwell Scientific Publications, London.

    Textbook of Pharmacology , ().

  • Corner, E. J. H. (1987) Moraceae. In: Dassanayake, M. D., Forsberg, F. R. (eds) Revised handbook to the Flora of Ceylon. Vol. III. American Publishing Co. Ltd., New Delhi, India.

    Revised handbook to the Flora of Ceylon , ().

  • Dhawan, B. N., Srimal, R. C. (1997) Laboratory manual of pharmacological evaluation of natural products. United Nations Industrial Development Organization, Austria.

    Laboratory manual of pharmacological evaluation of natural products , ().

  • Stewart, J., Bediani, A. (1993) Tolerance and sensitization to the behavioural effects of drugs. Behav. Pharmacol. 4, 289-312.

    'Tolerance and sensitization to the behavioural effects of drugs ' () 4 Behav. Pharmacol. : 31 -312 .

    • Search Google Scholar

  • Ediriweera, E. R. H. S. S., Ratnasooriya, W. D. (2002) Antidiuretic effect of Scoparia dulcis in rats. J. Trop. Med. Plants. 3, 55-58.

    'Antidiuretic effect of Scoparia dulcis in rats ' () 3 J. Trop. Med. Plants. : 31 -58 .

    • Search Google Scholar

  • Farnsworth, N. R. (1966) Biological and phytochemical screening of plants. J. Pharm. Sci. 55, 225-276.

    'Biological and phytochemical screening of plants ' () 55 J. Pharm. Sci. : 31 -276 .

  • Murrin, L. C., Gerety, M. E., Happe, H. K., Bylund, D. B. (2000) Inverse agonism at β2-adrenoceptors in native tissues. Eur. J. Pharmacol. 398, 185-191.

    'Inverse agonism at β2-adrenoceptors in native tissues ' () 398 Eur. J. Pharmacol. : 31 -191 .

    • Search Google Scholar

  • Ramanayake, L. (1994) Ficus racemosa L. In: Weragoda, P. M. (ed.) Osuturu Visituru. Part I Department of Ayurveda, Colombo, Sri Lanka. 15-18.

  • Anonymous, British National Formulary 2000. The British Medical Association and the Royal Pharmaceutical Society of Great Britain, London.

    Anonymous, British National Formulary , ().
  • Collapse
  • Expand
Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

Senior editors

Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Nov 2024 21 0 0
Dec 2024 15 0 0
Jan 2025 9 0 0
Feb 2025 12 0 0
Mar 2025 13 0 0
Apr 2025 5 0 0
May 2025 0 0 0