View More View Less
  • 1 SUNY College at Old Westbury, Neuroscience Research Institute (NRI) Old Westbury, NY 11568, USA
  • | 2 SUNY College at Old Westbury, Neuroscience Research Institute (NRI) Old Westbury, NY 11568, USA
  • | 3 SUNY College at Old Westbury, Neuroscience Research Institute (NRI) Old Westbury, NY 11568, USA
  • | 4 SUNY College at Old Westbury, Neuroscience Research Institute (NRI) Old Westbury, NY 11568, USA
Restricted access

Cross Mark

The vertebrate system of steroid hormones appears to have been conserved widely throughout the animal kingdom. The sex hormone estrogen, 17-ß-estradiol (E2), long considered to be exclusively a vertebrate hormone, is found also in invertebrates related to reproductive and developmental processes such as spawning, vitellogenesis and molting. These processes are affected by estrogen induced changes at the genomic level and take place at a large time scale. The discovery of surface membrane receptors for E2 has opened new possibilities for the involvement of estrogen in biological functions other than reproductive. These processes take place within a few seconds to minutes and involve sudden cytosolic calcium transients, activation of adenylate cyclase or activation of phospholipase C (PLC). E2 can modulate the production of nitric oxide (NO) in endotheliar and other cells. A similar mechanism linking estrogen to cNOS catalized nitric oxide (NO) release is reported herein for the first time in several tissues of the giant cockroach Blaberus craniifer. This process has been identified in the brain, nerve cord, vasculature and ovaries. This effect is concentration dependent and is inhibited by tamoxifen an estrogen receptor blocker.

  • Prevot, V., Croix, D., Rialas, C. M., Poulain, P., Fricchione, G. L., Stefano, G. B., Beauvillain, J. C. (1999) Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor. Endocrinology 140, 652-659.

    'Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor ' () 140 Endocrinology : 31 -659.

    • Search Google Scholar
  • Stefano, G. B., Cadet, P., Mantione, K., Cho, J. J., Jones, D., Zhu, W. (2003) Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system. Endocrinology 144, 1234-1240.

    'Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system ' () 144 Endocrinology : 31 -1240.

    • Search Google Scholar
  • Stefano, G. B., Cadet, P., Breton, C., Goumon, Y., Prevot, V., Dessaint, J. P., Beauvillain, J. C., Roumier, A. S., Welters, I., Salzet, M. (2000) Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor. Blood 95, 3951-3958.

    'Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor ' () 95 Blood : 31 -3958.

    • Search Google Scholar
  • Stefano, G. B., Goumon, Y., Bilfinger, T. V., Welters, I. D., Cadet, P. (2000) Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor. Prog. Neurobiol. 60, 513-530.

    'Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor ' () 60 Prog. Neurobiol. : 31 -530.

    • Search Google Scholar
  • Stefano, G. B., Salzet, B., Rialas, C. M., Pope, M., Kustka, A., Neenan, K., Pryor, S., Salzet, M. (1997) Morphine-and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release. Brain Res. 763, 63-68.

    'Morphine-and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release ' () 763 Brain Res. : 31 -68.

    • Search Google Scholar
  • Swevers, L., Lambert, J. G., De Loof, A. (1991) Synthesis and metabolism of vertebrate-type steroids by tissues of insects: a critical evaluation. Experientia 47, 687-698.

    'Synthesis and metabolism of vertebrate-type steroids by tissues of insects: a critical evaluation ' () 47 Experientia : 31 -698.

    • Search Google Scholar
  • Stefano, G. B., Prevot, V., Beauvillain, J. C., Cadet, P., Fimiani, C., Welters, I., Fricchione, G. L., Breton, C., Lassalle, P., Salzet, M., Bilfinger, T. V. (2000) Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation 101, 1594-1597.

    'Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia ' () 101 Circulation : 31 -1597.

    • Search Google Scholar
  • Tarrant, A. M., Atkinson, S., Atkinson, M. J. (1999) Estrone and estradiol-17 beta concentration in tissue of the scleractinian coral, Montipora verrucosa. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 122, 85-92.

    'Estrone and estradiol-17 beta concentration in tissue of the scleractinian coral ' () 122 Montipora verrucosa. Comp. Biochem. Physiol. A Mol. Integr. Physiol. : 31 -92.

    • Search Google Scholar
  • Warrier, S. R., Tirumalai, R., Subramoniam, T. (2001) Occurrence of vertebrate steroids, estradiol 17beta and progesterone in the reproducing females of the mud crab Scylla serrata. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 130, 283-294.

    'Occurrence of vertebrate steroids, estradiol 17beta and progesterone in the reproducing females of the mud crab Scylla serrata ' () 130 Comp. Biochem. Physiol. A Mol. Integr. Physiol. : 31 -294.

    • Search Google Scholar
  • You, H. J., Kim, J. Y., Jeong, H. G. (2003) 17 beta-estradiol increases inducible nitric oxide synthase expression in macrophages. Biochem. Biophys. Res. Commun. 303, 1129-1134.

    '17 beta-estradiol increases inducible nitric oxide synthase expression in macrophages ' () 303 Biochem. Biophys. Res. Commun. : 31 -1134.

    • Search Google Scholar
  • Pedram, A., Razandi, M., Aitkenhead, M., Hughes, C. C., Levin, E. R. (2002) Integration of the nongenomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J. Biol. Chem. 277, 50768-50775.

    'Integration of the nongenomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology ' () 277 J. Biol. Chem. : 31 -50775.

    • Search Google Scholar
  • Prevot, V., Bouret, S., Stefano, G. B., Beauvillain, J. (2000) Median eminence nitric oxide signaling. Brain. Res. Rev. 34, 27-41.

    'Median eminence nitric oxide signaling ' () 34 Brain. Res. Rev. : 31 -41.

  • Goetz, R. M., Thatte, H. S., Prabhakar, P., Cho, M. R., Michel, T., Golan, D. E. (1999) Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 96, 2788-2793.

    'Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase ' () 96 Proc. Natl. Acad. Sci. USA : 31 -2793.

    • Search Google Scholar
  • Gonzales, R. J., Kanagy N. L. (1999) Endothelium-independent relaxation of vascular smooth muscle by 17beta-estradiol. J. Cardiovasc. Pharmacol. Ther. 4, 227-234.

    'Endothelium-independent relaxation of vascular smooth muscle by 17beta-estradiol ' () 4 J. Cardiovasc. Pharmacol. Ther. : 31 -234.

    • Search Google Scholar
  • Gonzales, R. J., Walker, B. R., Kanagy, N. L. (2001) 17beta-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta. Am. J. Physiol. Lung Cell Mol. Physiol. 280, 555-564.

    '17beta-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta ' () 280 Am. J. Physiol. Lung Cell Mol. Physiol. : 31 -564.

    • Search Google Scholar
  • Kelly, M. J., Levin, E. R. (2001) Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol. Metab. 12, 152-156.

    'Rapid actions of plasma membrane estrogen receptors ' () 12 Trends Endocrinol. Metab. : 31 -156.

    • Search Google Scholar
  • Keshan, B., Ray, A. K. (2000) Estradiol-17beta in Bombyx mori: possible significance and its effect on silk production. J. Insect. Physiol. 46, 1061-1068.

    'Estradiol-17beta in Bombyx mori: possible significance and its effect on silk production ' () 46 J. Insect. Physiol. : 31 -1068.

    • Search Google Scholar
  • Keshan, B., Ray, A. K. (2001) Effect of estradiol-17beta on cell area, lumen area and trehalase activity of posterior silk gland of Bombyx mori L. Indian J. Exp. Biol. 39, 1096-1102.

    'Effect of estradiol-17beta on cell area, lumen area and trehalase activity of posterior silk gland of Bombyx mori L ' () 39 Indian J. Exp. Biol. : 31 -1102.

    • Search Google Scholar
  • Keshan, B., Ray, A. K. (2001) The presence of estradiol-17beta and its specific binding sites in posterior silk gland of Bombyx mori. Gen. Comp. Endocrinol. 123, 23-30.

    'The presence of estradiol-17beta and its specific binding sites in posterior silk gland of Bombyx mori ' () 123 Gen. Comp. Endocrinol. : 31 -30.

    • Search Google Scholar
  • Kirkbride-Smith, A. E., Bell, H. A., Edwards, J. P. (2001) Effects of three vertebrate hormones on the growth, development, and reproduction of the tomato moth, Lacanobia oleracea L. (Lepidoptera: Noctuidae). Environ. Toxicol. Chem. 20, 1838-1845.

    'Effects of three vertebrate hormones on the growth, development, and reproduction of the tomato moth, Lacanobia oleracea L. (Lepidoptera: Noctuidae) ' () 20 Environ. Toxicol. Chem. : 31 -1845.

    • Search Google Scholar
  • Krukoff, T. L., Khalili, P. (1997) Stress-induced activation of nitric oxide-producing neurons in the rat brain. J. Comp. Neurol. 377, 509-519.

    'Stress-induced activation of nitric oxide-producing neurons in the rat brain ' () 377 J. Comp. Neurol. : 31 -519.

    • Search Google Scholar
  • Levin, E. R. (2001) Cell localization, physiology, and nongenomic actions of estrogen receptors. J. Appl. Physiol. 91, 1860-1867.

    'Cell localization, physiology, and nongenomic actions of estrogen receptors ' () 91 J. Appl. Physiol. : 31 -1867.

    • Search Google Scholar
  • Levin, E. R. (2002) Cellular functions of plasma membrane estrogen receptors. Steroids 67, 471-475.

    'Cellular functions of plasma membrane estrogen receptors ' () 67 Steroids : 31 -475.

  • Levin, E. R. (2003) Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Mol. Endocrinol. 17, 309-317.

    'Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor ' () 17 Mol. Endocrinol. : 31 -317.

    • Search Google Scholar
  • Ogiso, M., Ohnishi, E. (1986) Does estradiol play a role in ovarian maturation or embryonic development of the silkworm? Gen. Comp. Endocrinol. 61, 82-86.

    'Does estradiol play a role in ovarian maturation or embryonic development of the silkworm? ' () 61 Gen. Comp. Endocrinol. : 31 -86.

    • Search Google Scholar
  • Yocum, L. B., Denlinger, D. L., Katlic, N. E., Brueggemeier, R. W., Mechoulam, R. (1987) A developmental profile of estrogen and androgen radioimmunoactive substances in the flesh fly, Sarcophaga crassipalpis. Insect Biochemistry 17, 1149-1153.

    'A developmental profile of estrogen and androgen radioimmunoactive substances in the flesh fly ' () 17 Sarcophaga crassipalpis. Insect Biochemistry : 31 -1153.

    • Search Google Scholar
  • Bidmon, H. J., Stumpf, W. E. (1991) Uptake, distribution and binding of vertebrate and invertebrate steroid hormones and time-dependence of ponasterone A binding in Calliphora vicina. Comparisons among cholesterol, corticosterone, cortisol, dexamethasone, 5 alpha-dihydrotestosterone, 1,25-dihydroxyvitamin D3, ecdysone, estradiol-17 beta, ponasterone A, progesterone, and testosterone. Histochemistry 96, 419-434.

    'Uptake, distribution and binding of vertebrate and invertebrate steroid hormones and time-dependence of ponasterone A binding in Calliphora vicina. Comparisons among cholesterol, corticosterone, cortisol, dexamethasone, 5 alpha-dihydrotestosterone, 1,25-dihydroxyvitamin D3, ecdysone, estradiol-17 beta, ponasterone A, progesterone, and testosterone ' () 96 Histochemistry : 31 -434.

    • Search Google Scholar