Authors:
D. Sonetti Dipartimento di Biologia Animale, Università di Modena e Reggio Emilia Modena, Italy

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Elisa Peruzzi Dipartimento di Biologia Animale, Università di Modena e Reggio Emilia Modena, Italy

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Invertebrate microglia constitute a class of cells resident in the ganglionic nervous system which are activated after tissue injury or by the presence of pathogens. The microglia activation response includes graduated morpho-functional and biochemical changes and cell proliferation. In this study we verified in the freshwater snail Planorbariuscorneus that an activation caused by a traumatic event may induce microglia division. Cell proliferation was assessed immunocytochemically using BrdU incorporation technique and documented on both ganglionic sections and microglia cultured cells at different experimental conditions and times after activation. In addition, we studied the possibility of increasing microglia proliferation by adding to the cultured medium the Macrophage-Colony Stimulating Factor (M-CSF) that has been shown to stimulate specifically this process in vertebrates.

  • Tarui, A., Shibata, K., Takahashi, S., Kera, Y., Munegumi, T., Yamada, R. H. (2003) N-Methyl-D-glutamate and N-methyl-L-glutamate in Scapharca broughtonii (Mollusca) and other invertebrates. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 134, 79-87.

    'N-Methyl-D-glutamate and N-methyl-L-glutamate in Scapharca broughtonii (Mollusca) and other invertebrates ' () 134 Comp. Biochem. Physiol. B. Biochem. Mol. Biol. : 31 -87 .

    • Search Google Scholar
  • Tchelingerian, J. L., Le saux, F., Jacque, C. (1996) Identification and topography of neuronal cell population expressing TNF alfa and IL-1 alfa in response to hippocampal lesion. J. Neurosci. Res. 43, 99-106.

    'Identification and topography of neuronal cell population expressing TNF alfa and IL-1 alfa in response to hippocampal lesion ' () 43 J. Neurosci. Res. : 31 -106 .

    • Search Google Scholar
  • Watanabe, H., Abe, H., Takeuchi, S., Tanaka, R. (2000) Protective effect of microglial conditioning medium on neuronal damage induced by glutamate. Neurosci. Lett. 289, 53-56.

    'Protective effect of microglial conditioning medium on neuronal damage induced by glutamate ' () 289 Neurosci. Lett. : 31 -56 .

    • Search Google Scholar
  • Zietlow, R., Dunnet, S. B., Fawcett, J. W. (1999) The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective. Eur: J. Neurosci. 11, 1657-1667.

    'The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective ' () 11 Eur: J. Neurosci. : 31 -1667 .

    • Search Google Scholar
  • Walz, W., Ilshner, S., Oklemeyer, C., Banati, R., Kettenmann, H. (1993) Extracellular ATP activities and a K+ conductance in cultured microglial cells from mouse brain. J. Neurosci. 13, 4403-4411.

    'Extracellular ATP activities and a K+ conductance in cultured microglial cells from mouse brain ' () 13 J. Neurosci. : 31 -4411 .

    • Search Google Scholar
  • Wang, X., Yue, T. L., Barone, F. C., White, R. F., Gagnon, R. C., Feuerstein, G. Z. (1994) Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia. Mol. Chem. Neuropathol. 23, 103-114.

    'Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia ' () 23 Mol. Chem. Neuropathol. : 31 -114 .

    • Search Google Scholar
  • Nakajima, K., Honda, S., Tohyama, Y., Imai, Y., Kohsaka, S., Kurihara, T. (2001) Neurotrophin secretion from cultured microglia. J. Neurosci. Res. 65, 322-331.

    'Neurotrophin secretion from cultured microglia ' () 65 J. Neurosci. Res. : 31 -331 .

    • Search Google Scholar
  • Nakajima, K., Tohyama, Y., Kohsaka, S., Kurihara, T. (2001) Ability of rat microglia to uptake extracellular glutamate. Neurosci. Lett. 307, 171-174.

    'Ability of rat microglia to uptake extracellular glutamate ' () 307 Neurosci. Lett. : 31 -174 .

    • Search Google Scholar
  • Perry, V. H., Bell, M. D., Brown, H. C., Matyszak, M. K. (1995) Inflammation in the nervous system. Curr Opin. Neurobiol. 5, 636-641.

    'Inflammation in the nervous system ' () 5 Curr Opin. Neurobiol. : 31 -641 .

  • Petranyi, G. G. (2002) The complexity of immune and alloimmune response. Transpl. Immunol. 10, 91-100.

    'The complexity of immune and alloimmune response ' () 10 Transpl. Immunol. : 31 -100 .

    • Search Google Scholar
  • Shigemoto-Mogami, Y., Koizumi, S., Tsuda, M., Ohsawa, K., Kohsaka, S., Inoue, K. (2001) Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J. Neurochem. 78, 1339-1349.

    'Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5 ' () 78 J. Neurochem. : 31 -1349 .

    • Search Google Scholar
  • Sonetti, D., Ottaviani, E., Bianchi, F., Rodriguez, M., Stefano, M. L., Scharrer, B., Stefano, G. B. (1994) Microglia in invertebrate ganglia. Proc. Natl. Acad. Sci. USA 91, 9180-9184.

    'Microglia in invertebrate ganglia ' () 91 Proc. Natl. Acad. Sci. USA : 31 -9184 .

  • Sonetti, D., Ottaviani, E., Stefano, G. B. (1997) Opiate signaling regulates microglia activities in the invertebrates nervous system. Gen. Pharmacol. 29, 39-47.

    'Opiate signaling regulates microglia activities in the invertebrates nervous system ' () 29 Gen. Pharmacol. : 31 -47 .

    • Search Google Scholar
  • Polazzi, E., Contestabile, A. (2002) Reciprocal interactions between microglia and neurons: from survival to neuropathology. Rev. Neurosci. 13, 221-242.

    'Reciprocal interactions between microglia and neurons: from survival to neuropathology ' () 13 Rev. Neurosci. : 31 -242 .

    • Search Google Scholar
  • Prewitt, C. M., Niesman, I. R., Kane, C. J., Houle, J. D. (1997) Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cord. Exp. Neurol. 48, 433-443.

    'Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cord ' () 48 Exp. Neurol. : 31 -443 .

    • Search Google Scholar
  • Sanz, J. M., Di Virgilio, F. (2000) Kinetics and mechanisms of ATP-dependent IL-1 b release from microglial cells. J. Immunol. 164, 4893-4898.

    'Kinetics and mechanisms of ATP-dependent IL-1 b release from microglial cells ' () 164 J. Immunol. : 31 -4898 .

    • Search Google Scholar
  • Dichmann, S., Idzko, M., Zimpfer, U., Hofmann, C., Ferrari, D., Luttmann, W., Virchow Jr, C., Di Virgilio, F., Norgauer, J. (2000) Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca++ mobilization and actin reorganization in human eosinophils. Blood 95, 973-978.

    'Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca++ mobilization and actin reorganization in human eosinophils ' () 95 Blood : 31 -978 .

    • Search Google Scholar
  • Fonnum, F. (1984) Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 1-11.

    'Glutamate: a neurotransmitter in mammalian brain ' () 42 J. Neurochem. : 31 -11 .

  • Fraser, J. A., Saunders, R. D., McLellan, L. I. (2002) Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form. J. Biol. Chem. 277, 1158-1165.

    'Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form ' () 277 J. Biol. Chem. : 31 -1165 .

    • Search Google Scholar
  • Granath, W. O. Jr., Connors, V. A., Tarleton, R. L. (1994) Interleukin I activity in haemolymph from strains of the snail Biomphalaria glabrata varying in susceptibility to the human blood fluke, Schistosoma mansoni: presence, differential expression, and biological function. Cytokine 6, 21-27.

    'Interleukin I activity in haemolymph from strains of the snail Biomphalaria glabrata varying in susceptibility to the human blood fluke, Schistosoma mansoni: presence, differential expression, and biological function ' () 6 Cytokine : 31 -27 .

    • Search Google Scholar
  • Heppner, F. L., Skutella, T., Hailer, N. P., Haas, D., Nitsch, R. (1998) Activated microglial cells migrate towards sites of excitotoxic neuronal injury inside a organotypic hippocampal slice cultures. Eur. J. Neurosci. 10, 3284-3290.

    'Activated microglial cells migrate towards sites of excitotoxic neuronal injury inside a organotypic hippocampal slice cultures ' () 10 Eur. J. Neurosci. : 31 -3290 .

    • Search Google Scholar
  • Hide, I., Tanaka, M., Inoue, A., Nakajima, K., Kohsaka, S., Inoue, K., Nakata, Y. (2000) Extracellular ATP trigger tumor necrosis factor-alfa release from rat microglia. J. Neurochem. 75, 965-972.

    'Extracellular ATP trigger tumor necrosis factor-alfa release from rat microglia ' () 75 J. Neurochem. : 31 -972 .

    • Search Google Scholar
  • Nods, M., Nakanishi, H., Nabekura, J., Akaike, N. (2000) AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J. Neurosci. 20, 251-258.

    'AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia ' () 20 J. Neurosci. : 31 -258 .

    • Search Google Scholar
  • Pentreath, V. W., Radoycic, T., Seal, L. H., Winstanley, E. K. (1985) The glial cells and glia-neuron relations in the buccal ganglia of Planorbis corneus (L.): cytological, qualitative and quantitative changes during growth and ageing. Phil. Trans. R. Soc. Lond. B. 307, 399-455.

    'The glial cells and glia-neuron relations in the buccal ganglia of Planorbis corneus (L.): cytological, qualitative and quantitative changes during growth and ageing ' () 307 Phil. Trans. R. Soc. Lond. B. : 31 -455 .

    • Search Google Scholar
  • Hsu, S., Raine, L. (1981) Protein A. avidin and biotin in immunohistochemistry. J. Histochem. Cytochem. 29, 1349-1353.

    'Protein A. avidin and biotin in immunohistochemistry ' () 29 J. Histochem. Cytochem. : 31 -1353 .

    • Search Google Scholar
  • Kreutzberg, G. W. (1996) Microglia: a sensor for pathological events in the CNS. Glia 19, 312-318.

    'Microglia: a sensor for pathological events in the CNS ' () 19 Glia : 31 -318 .

  • Legac, E., Vaugier, G. L., Bousquet, F., Bajelan, M., Leclerc, M. (1996) Primitive cytokines and cytokine receptors in invertebrates: the sea star Asterias rubens as a model of study. Scand. J. Immunol. 44, 375-380.

    'Primitive cytokines and cytokine receptors in invertebrates: the sea star Asterias rubens as a model of study ' () 44 Scand. J. Immunol. : 31 -380 .

    • Search Google Scholar
  • Leibovitz, A. (1963) The growth and maintenance of tissue-cell cultures in free gas exchange with the atmosphere. Am. J. Hyg. 78, 173-180.

    'The growth and maintenance of tissue-cell cultures in free gas exchange with the atmosphere ' () 78 Am. J. Hyg. : 31 -180 .

    • Search Google Scholar
  • Li, P., Slimko, E. M., Lester, H. A. (2002) Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. FEBS Lett. 528, 77-82.

    'Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel ' () 528 FEBS Lett. : 31 -82 .

    • Search Google Scholar
  • Liu, Y., Clark, R. K., McDonnell, P. C., Young, P. R., White, R. F., Barone, F. C., Feuerstein, G. Z. (1994) Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 25, 1481-1488.

    'Tumor necrosis factor-alpha expression in ischemic neurons ' () 25 Stroke : 31 -1488 .

    • Search Google Scholar
  • Marcus, J. S., Karackattu, S. L., Fleegal, M. A., Sumners, C. (2003) Cytokine-stimulated inducible nitric oxide synnthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kB. Glia 41, 152-160.

    'Cytokine-stimulated inducible nitric oxide synnthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kB ' () 41 Glia : 31 -160 .

    • Search Google Scholar
  • Möller, T., Kann, O., VerKhatsky, A., Kettenmann, H. (2000) Activation of mouse microglial cells affects P2 receptor signaling. Brain Res. 853, 49-59.

    'Activation of mouse microglial cells affects P2 receptor signaling ' () 853 Brain Res. : 31 -59 .

    • Search Google Scholar
  • Cattaert, D., Le Bon, M., Le Ray, D. (2002) Efferent controls in crustacean mechanoreceptors. Microsc. Res. Tech. 58, 312-324.

    'Efferent controls in crustacean mechanoreceptors ' () 58 Microsc. Res. Tech. : 31 -324 .

    • Search Google Scholar
  • Chang, R. C., Hudson, P. M., Wilson, B. C., Liu, B., Abel, H., Hong, J. S. (2000) High concentrations of extracellular potassium enhance bacterial endotoxin lipopolysaccaride-induced neurotoxicity in glia-neuron mixed cultures. Neuroscience 97, 757-764.

    'High concentrations of extracellular potassium enhance bacterial endotoxin lipopolysaccaride-induced neurotoxicity in glia-neuron mixed cultures ' () 97 Neuroscience : 31 -764 .

    • Search Google Scholar
  • Aldskogius, H. (2001) Microglia in neurodegeneration. Microsc. Res. Technique 54, 40-46.

    'Microglia in neurodegeneration ' () 54 Microsc. Res. Technique : 31 -46 .

  • Arruda, J. L., Colburn, R. W., Rickman, A. J., Rutkowsky, M. D., De Leo, J. A. (1998) Increase of interleukine-6 mRNA in the spinal cordfollowing peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain. Mol. Brain Res. 62, 228-235.

    'Increase of interleukine-6 mRNA in the spinal cordfollowing peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain ' () 62 Mol. Brain Res. : 31 -235 .

    • Search Google Scholar
  • Banati, R. B., Gehrmann, J., Schubert, P., Kreutzberg G. W. (1993) Cytotoxicity of microglia. Glia 7, 111-118.

    'Cytotoxicity of microglia ' () 7 Glia : 31 -118 .

  • Spranger, M., Fontana, A. (1996) Activation of microglia: a dangerous interlude in immune function in the brain. Neuroscience 2, 293-299.

    'Activation of microglia: a dangerous interlude in immune function in the brain ' () 2 Neuroscience : 31 -299 .

    • Search Google Scholar
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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
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Foundation
1950
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changed title
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Founder Magyar Tudományos Akadémia
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H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)