Acta Biologica Hungarica
Volume/Issue:
Volume 56: Issue 3-4
Stimulus frequency dependence of the central and peripheral somatosensory evoked activity in rats treated with various pesticides
Authors:
Andrea Szabó Department of Public Health, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary

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A. Papp Department of Public Health, Faculy of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary

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L. Nagymajtényi Department of Public Health, Faculy of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary

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Pages:
205–214
Online Publication Date:
09 Sep 2005
Publication Date:
01 Aug 2005
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.56.2005.3-4.4
Keywords:
rat; rat; rat; Insecticides; somatosensory system; cortical activity; peripheral activity; fatigue
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Rats were treated with a combination of insecticide agents in different timing schemes. In acute administration, 1/5 LD50 of the three insecticides: dimethoate, propoxur and cypermethrin, or their combination, was given once by gavage. In the developmental model, female rats received oral doses of 1/25 LD50 of the above insecticides in combination in three timing schemes including pregnancy and lactation. Responses in the somatosensory cortex and in the tail nerve, evoked by peripheral electric stimulation, were recorded in acute preparation under urethane anesthesia. It was tested whether the parameters of the cortical and peripheral evoked response are dependent on the frequency and whether this dependence is different in control and treated animals. The latency increase of the cortical responses with increasing stimulation frequency was significantly stronger in rats treated acutely with cypermethrin and the combination, and in rats receiving the combination during both intra- and extrauterine development. On the duration, the effects were less clear. Frequency dependent increase of the tail nerve action potential latency was significantly intensified by cypermethrin, and the amplitude decrease, by cypermethrin and dimethoate. Fatigue of this response during a stimulation series was also altered by the insecticides. Frequency dependence and fatigue possibly reflect the actual state of the nervous system and may have the potency to be developed to functional biomarkers.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

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Editor(s)-in-Chief: Elekes, Károly

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    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
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    1. Hideg, Éva (Szeged)
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    1. Kavanaugh, Michael P. (Missoula)
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    1. Kovács, János (Budapest)
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    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
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