Acta Biologica Hungarica
Volume/Issue:
Volume 57: Issue 1
A novel aspect of NADPH production in ageing Penicilliumchrysogenum
Authors:
Z. Varecza Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen Department of Environmental Sciences, Faculty of Science, College of Nyíregyháza Debrecen, Hungary Nyíregyháza, Hungary

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T. Emri Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen Debrecen, Hungary

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Tünde Pusztahelyi Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen Debrecen, Hungary

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I. Pócsi Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen Debrecen, Hungary

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Pages:
115–121
Online Publication Date:
28 Feb 2006
Publication Date:
01 Mar 2006
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.57.2006.1.11
Restricted access

NADPH is involved in many basically important anabolic processes. For a long time, pentose phosphate pathway (PPS) was regarded as the most important source of NADPH in fungi. Here we present evidence of a metabolic switch to an alternative NADPH-producing pathway in ageing Penicillium chrysogenumcultures, which involves NADP+-specific isocitrate dehydrogenase (NADP+-ID) rather than PPS enzymes. Considering the main biochemical functions of NADPH, we propose that NADP+-ID could have deep impact on many physiological processes switched on glucose deprivation including proteinase production or penicillin biosynthesis. We also demonstrate that although the alternative pathway was inferior to PPS when the fungus was grown on well-utilisable carbon sources yet it could have an important role in fatty acid biosynthesis as well as in the maintenance of high intracellular NADPH/NADP+ratios.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

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Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
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per Year		  
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per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

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