Acta Biologica Hungarica
Volume/Issue:
Volume 57: Issue 2
A study on the antioxidant activities of some new benzazole derivatives
Authors:
O. Temiz-Arpaci Department of Pharmaceutical Chemistry, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by O. Temiz-Arpaci in
Current site
Google Scholar
PubMed Close
,
T. Coban Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by T. Coban in
Current site
Google Scholar
PubMed Close
,
B. Tekiner-Gulbas Department of Pharmaceutical Chemistry, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by B. Tekiner-Gulbas in
Current site
Google Scholar
PubMed Close
,
B. Can-Eke Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by B. Can-Eke in
Current site
Google Scholar
PubMed Close
,
I. Yildiz Department of Pharmaceutical Chemistry, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by I. Yildiz in
Current site
Google Scholar
PubMed Close
,
E. Aki-Sener Department of Pharmaceutical Chemistry, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by E. Aki-Sener in
Current site
Google Scholar
PubMed Close
,
I. Yalcin Department of Pharmaceutical Chemistry, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by I. Yalcin in
Current site
Google Scholar
PubMed Close
, and
M. Iscan Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ankara University TR-06100 Tandogan, Ankara, Turkey

Search for other papers by M. Iscan in
Current site
Google Scholar
PubMed Close
Pages:
201–209
Online Publication Date:
08 Jun 2006
Publication Date:
01 Jun 2006
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.57.2006.2.7
Restricted access

The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10-3 M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10-3 M concentration.

  • Y1ld1z, İ., Yalçm, Ϊot;., Ak1-Şener, E., Uçartürk, N. (2004) Synthesis and structure-activity relationships of new antimicrobial active multisubstituted benzazole derivatives. Eur. J. Med. Chem.39, 291-295.

    'Synthesis and structure-activity relationships of new antimicrobial active multisubstituted benzazole derivatives ' () 39 Eur. J. Med. Chem. : 291 -295 .

    • Search Google Scholar

  • McCord, J., Fridowich, I. (1969) An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem.243, 6049-6055.

    'An enzymic function for erythrocuprein (hemocuprein) ' () 243 J. Biol. Chem. : 6049 -6055 .

    • Search Google Scholar

  • Blois, M. S. (1958) Antioxidant determinations by the use of a stable free radical. Nature181, 1199-1200.

    'Antioxidant determinations by the use of a stable free radical ' () 181 Nature : 1199 -1200 .

    • Search Google Scholar

  • İşcan, M., Arinç, E., Vural, N., İşcan, M. Y. (1984) Mixed function oxidase system of guinea-pig: a comparative study. Comp. Biochem. Physiol.77C, 177-190.

    'Mixed function oxidase system of guinea-pig: a comparative study ' () 77C Comp. Biochem. Physiol. : 177 -190 .

    • Search Google Scholar

  • Wills, E. D. (1966) Mechanism of lipid peroxide formation in animal tissues. Biochem. J.99, 667-676.

    'Mechanism of lipid peroxide formation in animal tissues ' () 99 Biochem. J. : 667 -676 .

    • Search Google Scholar

  • Wills, E. D. (1969) Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation. Biochem. J.113, 333-341.

    'Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation ' () 113 Biochem. J. : 333 -341 .

    • Search Google Scholar

  • Bishayee, S., Balasubramanian, A. S. (1971) Lipid peroxide formation in rat brain. Neurochem.18, 909-920.

    'Lipid peroxide formation in rat brain ' () 18 Neurochem. : 909 -920 .

  • Gewirtz, D. A. (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol.57, 727-741.

    'A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin ' () 57 Biochem. Pharmacol. : 727 -741 .

    • Search Google Scholar

  • Al-Assadi, H. M., Rodgers, E. H., Grant, M. H. (1992) Antioxidant prevent nickel chloride inhibition of cytochrome P450 dependent mixed function oxidation in guinea-pig lung microsomes. Biochem. Soc. Trans.21, 68S.

    'Antioxidant prevent nickel chloride inhibition of cytochrome P450 dependent mixed function oxidation in guinea-pig lung microsomes ' () 21 Biochem. Soc. Trans. : 68S .

    • Search Google Scholar

  • Oshugi, M., Fan, W., Hase, K., Xiong, Q., Tezuka, Y., Komatsu, K., Namba, T., Saitoh, T., Tazawa, K., Kadota, S. (1999) Active-oxygen scavenging activity of tradional nourishing-tonic herbal medicines and active constituents of Rhadolia sacra. J. Ethnopharmacol.67, 111-119.

    'Active-oxygen scavenging activity of tradional nourishing-tonic herbal medicines and active constituents of Rhadolia sacra ' () 67 J. Ethnopharmacol. : 111 -119 .

    • Search Google Scholar

  • Kombrust, D. J., Mavis, R. D. (1980) Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride. Mol. Pharmacol.17, 408-414.

    'Microsomal lipid peroxidation. II. Stimulation by carbon tetrachloride ' () 17 Mol. Pharmacol. : 408 -414 .

    • Search Google Scholar

  • Parke, D. V., Ionnides, C., Lewis, D. F. V. (1991) The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals. Can. J. Physiol. Pharmacol.69, 537-549.

    'The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals ' () 69 Can. J. Physiol. Pharmacol. : 537 -549 .

    • Search Google Scholar

  • Dix, T. A., Aikens, J. (1993) Mechanisms and biological relevance of lipid peroxidation initiation. Chem. Res. Toxicol.6, 2-18.

    'Mechanisms and biological relevance of lipid peroxidation initiation ' () 6 Chem. Res. Toxicol. : 2 -18 .

    • Search Google Scholar

  • Zhan, C. D., Sindhu, R. K., Pang, J., Ehdaie, A., Vaziri, N. D. (2004) Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet. J. Hypertens.22, 2025-2033.

    'Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet ' () 22 J. Hypertens. : 2025 -2033 .

    • Search Google Scholar

  • Lassegue, B., Griendling, K. K. (2004) Reactive oxygen species in hypertension: an update. Am. J. Hypertens.17, 852-860.

    'Reactive oxygen species in hypertension: an update ' () 17 Am. J. Hypertens. : 852 -860 .

    • Search Google Scholar

  • McIntosh, L. J., Trush, M. A., Troncoso, J. C. (1997) Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes. Free Radical Biol.23, 183-190.

    'Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes ' () 23 Free Radical Biol. : 183 -190 .

    • Search Google Scholar

  • Brikner, E., Zalejska-Fiolka, J., Antoszewski, Z. (2004) Aktywność enzymów antyoksydacyjnych i rola witamin o charakterze antyoksydacyjnym w chorobie Alzheimera. Postepy Hig. Med. Dosw.58, 264-269.

    'Aktywność enzymów antyoksydacyjnych i rola witamin o charakterze antyoksydacyjnym w chorobie Alzheimera ' () 58 Postepy Hig. Med. Dosw. : 264 -269 .

    • Search Google Scholar

  • Gupta, M., Maz, U. K., Gupta, M., Maz, U. K., Kumar, R. S., Kumar, T. S. (2004) Antitumor activity and antioxident role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice. Acta Pharmacol. Sin.25, 1070-1076.

    'Antitumor activity and antioxident role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice ' () 25 Acta Pharmacol. Sin. : 1070 -1076 .

    • Search Google Scholar

  • Festa, F., Aglitti, T., Duranti, G., Ricordi, R., Perticone, P., Cozzi, R. (2001) Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay. Anticancer Res.21, 3903-3908.

    'Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay ' () 21 Anticancer Res. : 3903 -3908 .

    • Search Google Scholar

  • Kim, Y. T., Kim, J. W., Choi, J. S., Kim, S. H., Choi, E. K., Cho, N. H. (2004) Relation between deranged antioxidant system and cervical neoplasia. Int. J. Gynecol. Cancer.14, 889-895.

    'Relation between deranged antioxidant system and cervical neoplasia ' () 14 Int. J. Gynecol. Cancer. : 889 -895 .

    • Search Google Scholar

  • Sun, Y. (1990) Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biol. Med. 8, 583-599.

    'Free radicals, antioxidant enzymes, and carcinogenesis ' () 8 Free Radical Biol. Med. : 583 -599 .

    • Search Google Scholar

  • Nordmann, R. (1993) Free radicals, oxidative stress and antioxidant vitamins. Soc. Biol. Fil.87, 277-285.

    'Free radicals, oxidative stress and antioxidant vitamins ' () 87 Soc. Biol. Fil. : 277 -285 .

    • Search Google Scholar

  • Yoo, K. M., Lee, K. W., Park, J. B., Lee, H. J., Hwang, I. K. (2004) Variation in major antioxidants and total antioxidant activity of yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. J. Agric. FoodChem.52, 5907-5913.

    'Variation in major antioxidants and total antioxidant activity of yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars ' () 52 J. Agric. FoodChem. : 5907 -5913 .

    • Search Google Scholar

  • Dundar, B., Bozdaĝ-Dündar, O., Can-Eke, B., Çoban, T., Iscan, M., Büyükbingöl, E. (2002) Synthesis and antioxidative properties of novel thiazolidinedione/imidazolidinedione compounds as retinoids. Die Pharmazie57, 438-441.

    'Synthesis and antioxidative properties of novel thiazolidinedione/imidazolidinedione compounds as retinoids ' () 57 Die Pharmazie : 438 -441 .

    • Search Google Scholar

  • Iscan, M. (1984) A comparative study of the effects of cadmium and nickel on liver microsomal drug metabolizing enzymes of guinea-pig in vitro. Comp. Biochem. Physiol.79C, 429-433.

    'A comparative study of the effects of cadmium and nickel on liver microsomal drug metabolizing enzymes of guinea-pig in vitro ' () 79C Comp. Biochem. Physiol. : 429 -433 .

    • Search Google Scholar

  • Akbay, A., Oren, I., Arpaci-Temiz, O., Ak1-Sener, E. I., Yalcm, I. (2003) Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives. Arzneim. Forsch./Drug Res.53, 266-271.

    'Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives ' () 53 Arzneim. Forsch./Drug Res. : 266 -271 .

    • Search Google Scholar

  • Pinar, A., Yurdakul, P., Y1ld1z, I., Arpaci-Temiz, O., Acan, L. N., Ak1-Sener, E., Yalcm, I. (2004) Some fused heterocyclic compounds as eukaryotic topoisomerase II inhibitors. Biochem. Biophy. Res. Comm.317, 670-674.

    'Some fused heterocyclic compounds as eukaryotic topoisomerase II inhibitors ' () 317 Biochem. Biophy. Res. Comm. : 670 -674 .

    • Search Google Scholar

  • Temiz-Arpac1, Ö., Ören, İ., Altanlar, N. (2002) Synthesis and antimicrobial activity of some novel 2-(p-substituted-phenyl)-5-substituted-carbonylamino benzoxazoles. Il Farmaco57, 175-181.

    'Synthesis and antimicrobial activity of some novel 2-(p-substituted-phenyl)-5-substituted-carbonylamino benzoxazoles ' () 57 Il Farmaco : 175 -181 .

    • Search Google Scholar

  • Y1ld1z-Ören, İ., Tekiner, B., Yalçm, İ., Temiz-Arpac1, Ö., Ak1-Şener, E., Altanlar, N. (2004) Synthesis and antimicrobial activity of new 2-p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. Archiv der Pharmazie337, 402-410.

    'Synthesis and antimicrobial activity of new 2-p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles ' () 337 Archiv der Pharmazie : 402 -410 .

    • Search Google Scholar

  • Shi, D. F., Bradshaw, T. D., Wrigley, S., McCall, C. J., Lelieveld, P., Fichtner, I., Stevens, M. F. G. (1996) Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. J. Med. Chem.39, 3375-3384.

    'Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo ' () 39 J. Med. Chem. : 3375 -3384 .

    • Search Google Scholar

  • Olsen, D. B., Carroll, S. S., Culberson, J. C., Shafer, J. A., Kuo, L. C. (1994) Effect of template secondary structure on the inhibition of HIV-1 reverse transcriptase by a pyridinone non-nucleoside inhibitor. Nucleic Acid Res.22, 437-1443.

    'Effect of template secondary structure on the inhibition of HIV-1 reverse transcriptase by a pyridinone non-nucleoside inhibitor ' () 22 Nucleic Acid Res. : 437 -1443 .

    • Search Google Scholar

  • Shih, M. H., Ke, F. Y. (2004) Synthesis and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. Bioorg. and Med. Chem.12, 4633-4643.

    'Synthesis and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives ' () 12 Bioorg. and Med. Chem. : 4633 -4643 .

    • Search Google Scholar

  • Phillip, B. Q., Graf, E. (1997) Antioxidant functions of inositol 1,2,3-trisphosphate and inositol 1,2,3,6-tetrakisphosphate. Free Radical Biol. Med.22, 939-946.

    'Antioxidant functions of inositol 1,2,3-trisphosphate and inositol 1,2,3,6-tetrakisphosphate ' () 22 Free Radical Biol. Med. : 939 -946 .

    • Search Google Scholar

  • Ölgen, S., Coban, T. (2003) Antioxidant evaluations of novel N-H and N-substituted indole esters. Biol. Pharm. Bull.26, 736-738.

    'Antioxidant evaluations of novel N-H and N-substituted indole esters ' () 26 Biol. Pharm. Bull. : 736 -738 .

    • Search Google Scholar

  • Juliano, L., Colavita, A. R., Leo, R., Pratico, D., Violi, F. (1997) Oxygen free radicals and platelet activation. Free Radical Biol. Med.22, 999-1006.

    'Oxygen free radicals and platelet activation ' () 22 Free Radical Biol. Med. : 999 -1006 .

    • Search Google Scholar

  • Kim, J. S., Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L. F., La Voie, E. J. (1996) Structure activity relationship of benzimdazoles and related heterocycles as topoisomerase I poisons. Bioorg. Med. Chem.4, 621-630.

    'Structure activity relationship of benzimdazoles and related heterocycles as topoisomerase I poisons ' () 4 Bioorg. Med. Chem. : 621 -630 .

    • Search Google Scholar

  • Ak1-Sener, E., Arpaci-Temiz, Ö., Yalcm, İ., Altanlar, N. (2000) Synthesis and microbiological activity of some novel 5-benzamido- and 5-phenylacetamido-substituted 2-phenylbenzoxazole derivatives. Il Farmaco55, 397-405.

    'Synthesis and microbiological activity of some novel 5-benzamido- and 5-phenylacetamido-substituted 2-phenylbenzoxazole derivatives ' () 55 Il Farmaco : 397 -405 .

    • Search Google Scholar
  • Collapse
  • Expand
Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

Senior editors

Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jul 2024 27 0 0
Aug 2024 29 0 0
Sep 2024 30 0 0
Oct 2024 128 0 0
Nov 2024 38 0 0
Dec 2024 24 0 0
Jan 2025 5 0 0