The influence of estradiol and progesterone and melatonin supplementation on TNF- a levels in ovariectomized and pinealectomized rats

Esma Oztekin; R. Mogulkoc; A. K. Baltaci; A. M. Tiftik

doi:10.1556/abiol.57.2006.3.1

Acta Biologica Hungarica

Volume/Issue:: Volume 57: Issue 3

The influence of estradiol and progesterone and melatonin supplementation on TNF- a levels in ovariectomized and pinealectomized rats

Authors:

Esma Oztekin

Esma Oztekin Department of Biochemistry Meram Medical School, Selcuk University 42080 Konya, Turkey

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R. Mogulkoc

R. Mogulkoc Department of Physiology Meram Medical School, Selcuk University 42080 Konya, Turkey

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A. K. Baltaci

A. K. Baltaci Department of Physiology Meram Medical School, Selcuk University 42080 Konya, Turkey

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, and

A. M. Tiftik

A. M. Tiftik Department of Biochemistry Meram Medical School, Selcuk University 42080 Konya, Turkey

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Pages:: 275–281

Online Publication Date:: 14 Oct 2006

Publication Date:: 01 Sep 2006

Article Category:: Research Article

DOI:: https://doi.org/10.1556/abiol.57.2006.3.1

Keywords:: Ovariectomy - pinealectomy - estradiol and progesterone application - TNF-a rat

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The aim of this study was to investigate the effect of estradiol and progesterone and melatonin supplementation on TNF-a levels in ovariectomized and pinealectomized rats. The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams. The rats were divided into 6 groups, each group contained 7 rats. Group 1: Sham-ovariectomized (Sham-Ovx), Group 2: Ovariectomized (Ovx), Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) group, Group 4: Ovx+E-P+Melatonin (M) supplemented group, Group 5: Ovx - Pinealectomized (Pnx) group, Group 6: Ovx - Pnx+E-P supplemented group. Serum TNF-a levels were determined after 4 weeks application period. Group 6 (Ovx-Pnx+E-P) has the highest serum TNF-a compared with other groups while group 2 (ovariectomized), has the lowest levels (P<0.001). Group 5 was higher than groups 1, 2, 3 and 4 (P<0.001). The results of the study show that ovariectomy reduces the serum level of TNF-a, but estradiol and progesterone application prevents this reduction in ovariectomized rats. However, pinealectomy intensifies the increases in TNF- a levels in ovariectomized and estradiol and progesterone supplemented rats, whereas melatonin reduces TNF- a levels in ovariectomized rats.

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Acta Biologica Hungarica

Print ISSN:: 0236-5383

Online ISSN:: 1588-256X

Editorial Board

1. Csányi, Vilmos (Göd)
1. Dudits, Dénes (Szeged)
1. Falus, András (Budapest)
1. Fischer, Ernő (Pécs)
1. Gábriel, Róbert (Pécs)
1. Gulya, Károly (Szeged)
1. Gulyás, Balázs (Stockholm)
1. Hajós, Ferenc (Budapest)
1. Hámori, József (Budapest)
1. Heszky, László (Gödöllő)
1. Hideg, Éva (Szeged)
1. E. Ito (Sanuki)
1. Janda, Tibor (Martonvásár)
1. Kavanaugh, Michael P. (Missoula)
1. Kása, Péter (Szeged)
1. Klein, Éva (Stockholm)
1. Kovács, János (Budapest)
1. Brigitte Mauch-Mani (Neuchâtel)
1. Nässel, Dick R. (Stockholm)
1. Nemcsók, János (Szeged)
1. Péczely, Péter (Gödöllő)
1. Roberts, D. F. (Newcastle-upon-Tyne)
1. Sakharov, Dimitri A. (Moscow)
1. Singh, Meharvan (Fort Worth)
1. Sipiczky, Mátyás (Debrecen)
1. Szeberényi, József (Pécs)
1. Székely, György (Debrecen)
1. Tari, Irma (Szeged)
1. Vágvölgyi, Csaba (Szeged),
1. L. Zaborszky (Newark)

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Acta Biologica Hungarica
Language	English
Size
Year of Foundation	1950
Publication Programme	changed title
Volumes per Year
Issues per Year
Founder	Magyar Tudományos Akadémia
Founder's Address	H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher	Akadémiai Kiadó
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5383 (Print)
ISSN	1588-256X (Online)