Acta Biologica Hungarica
Volume/Issue:
Volume 57: Issue 3
Evaluation of ketamine systemic absorption from topical preparations Short communication
Authors: G. Zapantis 1 , G. Zapantis 2 , Ildikó Csóka 3 , E. Csányi 4 , E. Csányi 5 , G. Horváth 6 , G. Horváth 7 , I. Erős 8 , and I. Erős 9
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  • 1 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 2 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 3 Department of Drug Regulatory Affairs, Faculty of Pharmacy University of Szeged, Hungary
  • 4 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 5 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 6 Department of Physiology, Faculty of Medicine Department of Physiotherapy, Faculty of Health Sciences University of Szeged, Hungary University of Szeged, Hungary
  • 7 Department of Physiology, Faculty of Medicine Department of Physiotherapy, Faculty of Health Sciences University of Szeged, Hungary University of Szeged, Hungary
  • 8 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 9 Department of Pharmaceutical Technology University of Szeged, Hungary
DOI:
https://doi.org/10.1556/abiol.57.2006.3.12
Page Count:
387–389
Publication Date:
01 Sep 2006
Online Publication Date:
14 Oct 2006
Article Category:
Research Article
Restricted access

The aim of this study was to evaluate the systemic absorption of the topically administered ketamine using different vehicles and additives, in order to develop a transdermal therapeutic system (TTS) of this drug. After the application of different ketamine preparations (1% in hydrogel, o/w cream, or organogel) the ketamine appeared in the blood. The lowest level could be observed with o/w cream, while the highest concentration was achieved by means of the hydrogel system, however this difference was not significant. Further studies are going to be performed with higher drug concentrations for the characterization of the differences in the pharmacodynamics of the drug with different vehicles and to evaluate the correlation between the in vitro and in vivo absorption.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X
Keywords:
transdermal drug delivery - topical - ketamine - gel-cream

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