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  • 1 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 2 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 3 Department of Drug Regulatory Affairs, Faculty of Pharmacy University of Szeged, Hungary
  • 4 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 5 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 6 Department of Physiology, Faculty of Medicine Department of Physiotherapy, Faculty of Health Sciences University of Szeged, Hungary University of Szeged, Hungary
  • 7 Department of Physiology, Faculty of Medicine Department of Physiotherapy, Faculty of Health Sciences University of Szeged, Hungary University of Szeged, Hungary
  • 8 Department of Pharmaceutical Technology University of Szeged, Hungary
  • 9 Department of Pharmaceutical Technology University of Szeged, Hungary
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The aim of this study was to evaluate the systemic absorption of the topically administered ketamine using different vehicles and additives, in order to develop a transdermal therapeutic system (TTS) of this drug. After the application of different ketamine preparations (1% in hydrogel, o/w cream, or organogel) the ketamine appeared in the blood. The lowest level could be observed with o/w cream, while the highest concentration was achieved by means of the hydrogel system, however this difference was not significant. Further studies are going to be performed with higher drug concentrations for the characterization of the differences in the pharmacodynamics of the drug with different vehicles and to evaluate the correlation between the in vitro and in vivo absorption.

  • Adams, H. A., Weber, B., Bachmann, M. B., Guerin, M., Hempelmann, G. (1992) The simultaneous determination of ketamine and midazolam using high pressure liquid chromatography and UV detection (HPLC/UV). Anaesthesist 41, 619-624.

    'The simultaneous determination of ketamine and midazolam using high pressure liquid chromatography and UV detection (HPLC/UV) ' () 41 Anaesthesist : 619 -624.

    • Search Google Scholar
  • Csóka, I., Csányi, E., Zapantis, Nagy, E., Fehér-Kiss, A., Horváth, G., Blazsò, G., Erős, I. (2005) In vitro and in vivo percutaneous absorption of topical dosage forms: case studies. Int. J. Pharm. 291, 11-19.

    'In vitro and in vivo percutaneous absorption of topical dosage forms: case studies ' () 291 Int. J. Pharm. : 11 -19.

    • Search Google Scholar
  • Enarson, M. C., Hays, H., Woodroffe, M. A. (1999) Clinical experience with oral ketamine. J. Pain Symptom Manage. 17, 384-386.

    'Clinical experience with oral ketamine ' () 17 J. Pain Symptom Manage. : 384 -386.

  • Foldvari, M. (2000) Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm. Sci. Technol. Today 3, 417-425.

    'Non-invasive administration of drugs through the skin: challenges in delivery system design ' () 3 Pharm. Sci. Technol. Today : 417 -425.

    • Search Google Scholar
  • Gross, A. S., Nicolay, A., Eschalier, A. (1999) Simultaneous analysis of ketamine and bupivacaine in plasma by high performance liquid chromatography. J. Chromatogr. B. Biomed. Sci. Appl. 728, 107-115.

    'Simultaneous analysis of ketamine and bupivacaine in plasma by high performance liquid chromatography ' () 728 J. Chromatogr. B. Biomed. Sci. Appl. : 107 -115.

    • Search Google Scholar
  • Lloyd-Thomas, A. R. (1999) Modern concepts of pediatric analgesia. Pharmacol. Ther. 83, 1-20.

    'Modern concepts of pediatric analgesia ' () 83 Pharmacol. Ther. : 1 -20.

  • Shimoyama, M., Shimoyama, N., Gorman, A. L., Elliott, K. J., Inturrisi, C. E. (1999) Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain 81, 85-93.

    'Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine ' () 81 Pain : 85 -93.

    • Search Google Scholar