Neurotoxic and general effects of combined subchronic exposure of rats to insecticides and heavy metals

Zsuzsanna Lengyel; Anita Lukács; Andrea Szabó; L. Institóris

doi:10.1556/abiol.57.2006.4.4

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Acta Biologica Hungarica

Volume/Issue:: Volume 57: Issue 4

Neurotoxic and general effects of combined subchronic exposure of rats to insecticides and heavy metals

Authors:

Zsuzsanna Lengyel

Zsuzsanna Lengyel Department of Public Health, Faculty of Medicine, University of Szeged Szeged, Hungary

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Anita Lukács

Anita Lukács Department of Public Health, Faculty of Medicine, University of Szeged Szeged, Hungary

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Andrea Szabó

Andrea Szabó Department of Public Health, Faculty of Medicine, University of Szeged Szeged, Hungary

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L. Institóris

L. Institóris Department of Public Health, Faculty of Medicine, University of Szeged Szeged, Hungary

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Pages:: 423–432

Online Publication Date:: 14 Nov 2006

Publication Date:: 01 Dec 2006

Article Category:: Research Article

DOI:: https://doi.org/10.1556/abiol.57.2006.4.4

Keywords:: neurotoxicity; insecticide; heavy metal; rat; combination

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Three different insecticides: dimethoate, cypermethrin and amitraz were given, alone or combined with the heavy metals Pb, Hg and Cd, to male Wistar rats per os for 12 weeks from their 4th week of life. After the treatment period, the left hemisphere of the rats was exposed in urethane anaesthesia, and spontaneous and evoked cortical activity was recorded from the primary sensory areas. The effects of dimethoate on the spontaneous activity, and of dimethoate and amitraz on the evoked responses, were increased by the metal combination treatment, whereby the metals alone had no effect on the spontaneous and mild effect on the evoked activity. Finally, the animals were dissected, organ weights measured, and relative organ weights calculated. The weight gain of all treated groups was significantly retarded compared to the control. Several organ weights were also significantly reduced, mainly in groups receiving insecticide plus metal treatment. The toxic interactions observed in this work indicate that combined human exposure to environmental pesticide residues and heavy metals may have unexpectedly severe effects.

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Acta Biologica Hungarica

Print ISSN:: 0236-5383

Online ISSN:: 1588-256X

Editorial Board

1. Csányi, Vilmos (Göd)
1. Dudits, Dénes (Szeged)
1. Falus, András (Budapest)
1. Fischer, Ernő (Pécs)
1. Gábriel, Róbert (Pécs)
1. Gulya, Károly (Szeged)
1. Gulyás, Balázs (Stockholm)
1. Hajós, Ferenc (Budapest)
1. Hámori, József (Budapest)
1. Heszky, László (Gödöllő)
1. Hideg, Éva (Szeged)
1. E. Ito (Sanuki)
1. Janda, Tibor (Martonvásár)
1. Kavanaugh, Michael P. (Missoula)
1. Kása, Péter (Szeged)
1. Klein, Éva (Stockholm)
1. Kovács, János (Budapest)
1. Brigitte Mauch-Mani (Neuchâtel)
1. Nässel, Dick R. (Stockholm)
1. Nemcsók, János (Szeged)
1. Péczely, Péter (Gödöllő)
1. Roberts, D. F. (Newcastle-upon-Tyne)
1. Sakharov, Dimitri A. (Moscow)
1. Singh, Meharvan (Fort Worth)
1. Sipiczky, Mátyás (Debrecen)
1. Szeberényi, József (Pécs)
1. Székely, György (Debrecen)
1. Tari, Irma (Szeged)
1. Vágvölgyi, Csaba (Szeged),
1. L. Zaborszky (Newark)

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Acta Biologica Hungarica
Language	English
Size
Year of Foundation	1950
Publication Programme	changed title
Volumes per Year
Issues per Year
Founder	Magyar Tudományos Akadémia
Founder's Address	H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher	Akadémiai Kiadó
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5383 (Print)
ISSN	1588-256X (Online)