Acta Biologica Hungarica
Volume/Issue:
Volume 58: Issue 3
Subchronic heavy metal and alcohol treatment in rats: Changes in the somatosensory evoked cortical activity
Authors:
Anita Lukács University of Szeged Department of Public Health, Faculty of Medicine Dóm tér 10 H-6720 Szeged Hungary

Search for other papers by Anita Lukács in
Current site
Google Scholar
PubMed Close
,
Zsuzsanna Lengyel University of Szeged Department of Public Health, Faculty of Medicine Dóm tér 10 H-6720 Szeged Hungary

Search for other papers by Zsuzsanna Lengyel in
Current site
Google Scholar
PubMed Close
,
L. Institóris University of Szeged Department of Public Health, Faculty of Medicine Dóm tér 10 H-6720 Szeged Hungary

Search for other papers by L. Institóris in
Current site
Google Scholar
PubMed Close
, and
Andrea Szabó University of Szeged Department of Public Health, Faculty of Medicine Dóm tér 10 H-6720 Szeged Hungary

Search for other papers by Andrea Szabó in
Current site
Google Scholar
PubMed Close
Pages:
259–267
Online Publication Date:
18 Jul 2007
Publication Date:
01 Sep 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.58.2007.3.2
Keywords:
Lead; mercury; alcohol; neurotoxicity; combination; rat
Restricted access

Young adult male Wistar rats were treated, by gavage, with 80 or 320 mg/kg Pb 2+ (lead acetate), 0.4 or 1.6 mg/kg Hg 2+ (mercuric chloride) or both by combining the lower doses. For combination with alcohol, ethanol was added to the rats’ drinking water in 5 v/v %. After 12 weeks of treatment, electrophysiological recording was made from the somatosensory cortex in urethane anaesthesia. Evoked potentials obtained by stimulation of the whiskers were recorded. Both metals, and alcohol alone, increased significantly the latency of the evoked response. Alcohol seemed to abolish the effect of Pb, but not of Hg. Fatigue, calculated form the response amplitude, was increased by Pb and Hg treatment and this effect of Hg was reduced by ethanol. Evoked activity and its dynamic characteristics were sensitive to the complex neurotoxic effect induced in the rats and can provide a basis for developing functional markers.

  • Araki, S., Sato, H., Yokoyama, K., Murata, K. (2000) Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers. Am. J. Ind. Med. 37 , 193–204.

    Murata K. , 'Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers ' (2000 ) 37 Am. J. Ind. Med. : 193 -204 .

    • Search Google Scholar

  • Braga, M. F. M., Pereira, E. F. R., Albuquerque, E. X. (1999) Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res. 826 , 22–34.

    Albuquerque E. X. , 'Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons ' (1999 ) 826 Brain Res. : 22 -34 .

    • Search Google Scholar

  • Brookes, N. (1992) In vivo evidence for the role of glutamate in the CNS toxicity of mercury. Toxicology 76 , 245–256.

    Brookes N. , 'In vivo evidence for the role of glutamate in the CNS toxicity of mercury ' (1992 ) 76 Toxicology : 245 -256 .

    • Search Google Scholar

  • Büsselberg, D. (1995) Calcium channels as target sites of heavy metals. Toxicol. Lett. 82 , 255–261.

    Büsselberg D. , 'Calcium channels as target sites of heavy metals ' (1995 ) 82 Toxicol. Lett. : 255 -261 .

    • Search Google Scholar

  • Dally, S., Girre, C., Hispand, E., Tomoas, G., Fournier, I. (1989) High blood lead levels in alcoholics, wine vs. beer. Drug. Alcohol Depend. 23 , 45–48.

    Fournier I. , 'High blood lead levels in alcoholics, wine vs. beer ' (1989 ) 23 Drug. Alcohol Depend. : 45 -48 .

    • Search Google Scholar

  • Dieter, M. P., Boorman, G. A., Jameson, C. W. (1992) Development of renal toxicity in F344 rats gavaged with mercuric chloride for 2 weeks, or 2, 4, 6, 15, and 24 months. J. Toxicol. Environ. Health 36 , 319–340.

    Jameson C. W. , 'Development of renal toxicity in F344 rats gavaged with mercuric chloride for 2 weeks, or 2, 4, 6, 15, and 24 months ' (1992 ) 36 J. Toxicol. Environ. Health : 319 -340 .

    • Search Google Scholar

  • Discalzi, G., Fabbro, D., Meliga, F., Mocellini, A., Capellaro, F. (1993) Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials. J. Psychophysiol. 14 , 21–25.

    Capellaro F. , 'Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials ' (1993 ) 14 J. Psychophysiol. : 21 -25 .

    • Search Google Scholar

  • Gulati, A., Chandishwar, N., Schanker, K., Srimal, R. C., Dhawan, K. N., Bhargava, K. P. (1985) Effect of alcohols on the permeability of blood-brain barrier. Pharmacol. Res. Commun. 17 , 85–93.

    Bhargava K. P. , 'Effect of alcohols on the permeability of blood-brain barrier ' (1985 ) 17 Pharmacol. Res. Commun. : 85 -93 .

    • Search Google Scholar

  • Lille, F., Hazemann, P., Garnier, R., Dally, S. (1988) Effects of lead and mercury intoxications on evoked potentials. J. Toxicol. Clin. Toxicol. 26 , 103–116.

    Dally S. , 'Effects of lead and mercury intoxications on evoked potentials ' (1988 ) 26 J. Toxicol. Clin. Toxicol. : 103 -116 .

    • Search Google Scholar

  • Maranelli, G., Apostoli, P., Ferrari, P. (1990) Influence of smoking, alcohol and dietary habits on blood Pb and Cd levels. Bull. Environ. Contam. Toxicol. 45 , 804–810.

    Ferrari P. , 'Influence of smoking, alcohol and dietary habits on blood Pb and Cd levels ' (1990 ) 45 Bull. Environ. Contam. Toxicol. : 804 -810 .

    • Search Google Scholar

  • Nagymajtényi, L., Dési, I., Papp, A., Vezér, T. (2000) Experimentally induced functional changes of the nervous system caused by subchronic combined administration of heavy metals and an organophosphate pesticide. Centr. Eur. J. Public Health 8 , 64–65.

    Vezér T. , 'Experimentally induced functional changes of the nervous system caused by subchronic combined administration of heavy metals and an organophosphate pesticide ' (2000 ) 8 Centr. Eur. J. Public Health : 64 -65 .

    • Search Google Scholar

  • Olsen, R. W., Avoli, M. (1997) GABA and epileptogenesis. Epilepsia 38 , 399–407.

    Avoli M. , 'GABA and epileptogenesis ' (1997 ) 38 Epilepsia : 399 -407 .

  • Papp, A., Baydar, T., Vezér, T., Nagymajtényi, L. (2000) Changes in certain dynamic features of sensory evoked potentials of rats on exposure to metal xenobiotics. Centr. Eur. J. Occup. Envir. Med. 6 , 202–208.

    Nagymajtényi L. , 'Changes in certain dynamic features of sensory evoked potentials of rats on exposure to metal xenobiotics ' (2000 ) 6 Centr. Eur. J. Occup. Envir. Med. : 202 -208 .

    • Search Google Scholar

  • Papp, A., Nagymajtényi, L., Vezér, T. (2005) Subchronic mercury treatment of rats in different phases of ontogenesis: functional effects on the central and peripheral nervous system. Food Chem. Toxicol. 43 , 77–85.

    Vezér T. , 'Subchronic mercury treatment of rats in different phases of ontogenesis: functional effects on the central and peripheral nervous system ' (2005 ) 43 Food Chem. Toxicol. : 77 -85 .

    • Search Google Scholar

  • Papp, A., Pecze, L., Vezér, T. (2004) Dynamics of central and peripheral evoked electrical activity in the nervous system of rats exposed to xenobiotics. Centr. Eur. J. Occup. Envir. Med. 10 , 52–59.

    Vezér T. , 'Dynamics of central and peripheral evoked electrical activity in the nervous system of rats exposed to xenobiotics ' (2004 ) 10 Centr. Eur. J. Occup. Envir. Med. : 52 -59 .

    • Search Google Scholar

  • Pecze, L., Papp, A., Nagymajtényi, L. (2003) Acute effects of lead and mercury on the central and peripheral nervous system in rats pretreated with alcohol. Centr. Eur. J. Occup. Envir. Med. 9 , 253–262.

    Nagymajtényi L. , 'Acute effects of lead and mercury on the central and peripheral nervous system in rats pretreated with alcohol ' (2003 ) 9 Centr. Eur. J. Occup. Envir. Med. : 253 -262 .

    • Search Google Scholar

  • Piikivi, L., Tolonen, U. (1989) EEG findings in chloralkali workers subjected to low long term exposure to mercury vapour. Br. J. Ind. Med. 46 , 370–375.

    Tolonen U. , 'EEG findings in chloralkali workers subjected to low long term exposure to mercury vapour ' (1989 ) 46 Br. J. Ind. Med. : 370 -375 .

    • Search Google Scholar

  • Strubelt, O. (1984) Alcohol potentiation of liver injury. Fundam. Appl. Toxicol. 4 , 144–151.

    Strubelt O. , 'Alcohol potentiation of liver injury ' (1984 ) 4 Fundam. Appl. Toxicol. : 144 -151 .

    • Search Google Scholar

  • Vezér, T., Papp, A., Kurunczi, A., Párducz, Á., Náray, M., Nagymajtényi, L. (2005) Behavioral and neurotoxic effects seen during and after subchronic exposure of rats to organic mercury. Env. Toxicol. Pharmacol. 19 , 785–796.

    Nagymajtényi L. , 'Behavioral and neurotoxic effects seen during and after subchronic exposure of rats to organic mercury ' (2005 ) 19 Env. Toxicol. Pharmacol. : 785 -796 .

    • Search Google Scholar

  • Vezér, T., Schulz, H., Nagymajtényi, L. (2000) Memory effect of neurotoxic lead compounds in subacute animal experiments. Centr. Eur. J. Occup. Environ. Med. 6 , 209–216.

    Nagymajtényi L. , 'Memory effect of neurotoxic lead compounds in subacute animal experiments ' (2000 ) 6 Centr. Eur. J. Occup. Environ. Med. : 209 -216 .

    • Search Google Scholar

  • Yokoyama, K., Araki, S. (1992) Assessment of axonal transport in lead-exposed rats. Environ. Res. 59 , 4440–4446.

    Araki S. , 'Assessment of axonal transport in lead-exposed rats ' (1992 ) 59 Environ. Res. : 4440 -4446 .

    • Search Google Scholar
  • Collapse
  • Expand
Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

Senior editors

Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 38 0 0
Sep 2024 15 0 0
Oct 2024 106 0 0
Nov 2024 55 0 0
Dec 2024 34 0 0
Jan 2025 11 0 0
Feb 2025 0 0 0