Authors:
P. Massányi Slovak Agricultural University Department of Animal Physiology, Faculty of Biotechnology and Food Sciences Nitra Slovak Republic

Search for other papers by P. Massányi in
Current site
Google Scholar
PubMed
Close
,
N. Lukáč Slovak Agricultural University Department of Animal Physiology, Faculty of Biotechnology and Food Sciences Nitra Slovak Republic

Search for other papers by N. Lukáč in
Current site
Google Scholar
PubMed
Close
,
V. Uhrín Slovak Agricultural University Department of Animal Physiology, Faculty of Biotechnology and Food Sciences Nitra Slovak Republic

Search for other papers by V. Uhrín in
Current site
Google Scholar
PubMed
Close
,
R. Toman Slovak Agricultural University Department of Veterinary Disciplines, Faculty of Agrobiology and Food Resources Nitra Slovak Republic

Search for other papers by R. Toman in
Current site
Google Scholar
PubMed
Close
,
J. Pivko

Search for other papers by J. Pivko in
Current site
Google Scholar
PubMed
Close
,
J. Rafay Slovak Centre for Agricultural Research Nitra Slovak Republic

Search for other papers by J. Rafay in
Current site
Google Scholar
PubMed
Close
,
Zs. Forgács Fodor József National Center of Public Health Budapest Hungary

Search for other papers by Zs. Forgács in
Current site
Google Scholar
PubMed
Close
, and
Z. Somosy Fodor József National Center of Public Health Budapest Hungary

Search for other papers by Z. Somosy in
Current site
Google Scholar
PubMed
Close
Restricted access

The aim of this study was to determine effects of Cd on the structure of ovary, oviduct and uterus after an experimental administration. Animals were divided into three groups. In group A rabbits received cadmium i.p. and were killed after 48 h. In group C Cd was administered p.o. for 5 month. The group K was the control. Decreased relative volume of growing follicles and increased stroma after Cd administration were detected. The number of atretic follicles was significantly higher after administration of Cd. The most frequent ultrastructural alterations observed were undulation of external nuclear membrane, dilatation of perinuclear cistern and endoplasmic reticulum. In all studied types of cells mitochondria with altered structure were found. In the oviduct the highest amount of epithelium in the group with long-term Cd administration was found. Microscopic analysis showed oedematization of the oviduct tissue, caused by disintegration of the capillary wall. An electron microscopic analysis showed dilatation of perinuclear cistern. The intercellular spaces were enlarged and junctions between cells were affected. Mainly after a long-term cadmium administration nuclear chromatin disintegration was present. In the uterus a significant change was determined in the relative volume of glandular epithelium. Increase of stroma was a sign of uterus oedamatization caused by damage in the wall of blood vessels and subsequent diapedesis. After Cd administration alteration in uterus were less expressed, in comparison with ovary and oviduct. Alteration of nuclear chromatin contain following Cd administration suggests degenerative functional changes.

  • Anke, M., Masaoka, T., Arnhold, W., Krause, U., Groppel, B., Schwarz, S. (1989) The influence of a sulfur, molybdenum or cadmium exposure on the trace-element status of cattle and pigs. Arch. Anim. Nutr. 39 , 657–666.

    Schwarz S. , 'The influence of a sulfur, molybdenum or cadmium exposure on the trace-element status of cattle and pigs ' (1989 ) 39 Arch. Anim. Nutr. : 657 -666 .

    • Search Google Scholar
  • Anke, M., Masaoka, T., Groppel, B., Zervas, G., Arnhold, W. (1989) The influence of sulfur, molybdenum and cadmium exposure on the growth of goat, cattle and pig. Arch. Anim. Nutr. 39 , 221–228.

    Arnhold W. , 'The influence of sulfur, molybdenum and cadmium exposure on the growth of goat, cattle and pig ' (1989 ) 39 Arch. Anim. Nutr. : 221 -228 .

    • Search Google Scholar
  • Blazovics, A., Abaza, M., Sípos, P., Szentmihály, K., Fehér, E., Szilágyi, M. (2002) Biochemical and morphological changes in liver and gallbladder bile of broiler chicken exposed to heavy metals. Trace Elem. Electrol. 19 , 42–47.

    Szilágyi M. , 'Biochemical and morphological changes in liver and gallbladder bile of broiler chicken exposed to heavy metals ' (2002 ) 19 Trace Elem. Electrol. : 42 -47 .

    • Search Google Scholar
  • Blazovics, A., Szentmihalyi, K., Rapavi, E., Feher, E., Vinkler, P. (2003) Accumulation of toxic elements in liver and bile in hyperlipidemy. Trace Elem. Electrol. 20 , 211–216.

    Vinkler P. , 'Accumulation of toxic elements in liver and bile in hyperlipidemy ' (2003 ) 20 Trace Elem. Electrol. : 211 -216 .

    • Search Google Scholar
  • Drbohlav, P., Bencko, V., Masata, J., Bendl, J., Rezacova, J., Zouhar, T., Cerny, V., Halkova, E. (1998) Detection of cadmium and zinc in the blood and follicular fluid in women in the IVF and ET program. Česká Gynekol. 6 , 292–300.

    Halkova E. , 'Detection of cadmium and zinc in the blood and follicular fluid in women in the IVF and ET program ' (1998 ) 6 Česká Gynekol. : 292 -300 .

    • Search Google Scholar
  • Henson, M. C., Chendrese, P. J. (2004) Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp. Biol. Med. 229 , 383–392.

    Chendrese P. J. , 'Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction ' (2004 ) 229 Exp. Biol. Med. : 383 -392 .

    • Search Google Scholar
  • Friberg, L., Nordberg, G. F., Vouk, V. (1986) Handbook on the Toxicology of Metals . Elsevier, Amsterdam.

    Vouk V. , '', in Handbook on the Toxicology of Metals , (1986 ) -.

  • Jancova, A., Massányi, P., Nad, P., Korenekova, B., Skalicka, M., Drabekova, J., Balaz, I. (2006) Accumulation of heavy metals in selected organs of yellow-necked mouse. Ekologia (Bratislava) 25 , 19–26.

    Balaz I. , 'Accumulation of heavy metals in selected organs of yellow-necked mouse ' (2006 ) 25 Ekologia (Bratislava) : 19 -26 .

    • Search Google Scholar
  • Henson, M. C., Chendrese, P. J. (2004) Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp. Biol. Med. 229 , 383–392.

    Chendrese P. J. , 'Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction ' (2004 ) 229 Exp. Biol. Med. : 383 -392 .

    • Search Google Scholar
  • Kaji, T. (2004) Cell biology of heavy metal toxicity in vascular tissue. Yakugaku Zasshi. 124 , 113–120.

    Kaji T. , 'Cell biology of heavy metal toxicity in vascular tissue ' (2004 ) 124 Yakugaku Zasshi. : 113 -120 .

    • Search Google Scholar
  • Kar, A. B., Das, R. P., Karkun, J. N. (1959) Ovarian changes in prepubertal rats after treatment with cadmium chloride. Acta Biol. Med. Germ. 3 , 372–399.

    Karkun J. N. , 'Ovarian changes in prepubertal rats after treatment with cadmium chloride ' (1959 ) 3 Acta Biol. Med. Germ. : 372 -399 .

    • Search Google Scholar
  • Katila, T., Kareskoski, M. (2006) Components of stallion seminal plasma and their influence on spermatozoa. Pferdeheilkunde 22 , 193–200.

    Kareskoski M. , 'Components of stallion seminal plasma and their influence on spermatozoa ' (2006 ) 22 Pferdeheilkunde : 193 -200 .

    • Search Google Scholar
  • Korenekova, B., Skalicka, M., Nad, P. (2002) Cadmium exposure of cattle after long-term emission from polluted area. Trace Elem. Electrol. 19 , 97–99.

    Nad P. , 'Cadmium exposure of cattle after long-term emission from polluted area ' (2002 ) 19 Trace Elem. Electrol. : 97 -99 .

    • Search Google Scholar
  • Kramárová, M., Massányi, P., Jancová, A., Toman, R., Slamecka, J., Tataruch, F., Kovacik, J., Gasparik, J., Nad, P., Skalicka, M., Korenekova, B., Jurcik, R., Cubon, J., Hascik, P. (2005) Concentration of cadmium in the liver and kidneys of some wild and farm animals. Bull. Vet. Inst. Pulawy 49 , 465–469.

    Hascik P. , 'Concentration of cadmium in the liver and kidneys of some wild and farm animals ' (2005 ) 49 Bull. Vet. Inst. Pulawy : 465 -469 .

    • Search Google Scholar
  • Kramárová, M., Massányi, P., Slamecka, J., Tataruch, F., Jancová, A., Gasparik, J., Fabis, M., Kovacik, J., Toman, R., Galova, J., Jurcik, R. (2005) Distribution of cadmium and lead in liver and kidneys of some wild animals in Slovakia. J. Environ. Sci. Health A40 , 593–600.

    Jurcik R. , 'Distribution of cadmium and lead in liver and kidneys of some wild animals in Slovakia ' (2005 ) A40 J. Environ. Sci. Health : 593 -600 .

    • Search Google Scholar
  • Massányi, P., Toman, R., Uhrín, V., Renon, P. (1995) Distribution of cadmium in selected organs of rabbits after an acute and chronic administration. Ital. J. Food Sci. 7 , 311–316.

    Renon P. , 'Distribution of cadmium in selected organs of rabbits after an acute and chronic administration ' (1995 ) 7 Ital. J. Food Sci. : 311 -316 .

    • Search Google Scholar
  • Massányi, P., Toman, R., Najmik, F. (1995) Concentrations of cadmium in ovary, oviductus, uterus, testis and tunica albuginea of testis in cattle. J. Environ. Sci. Health A30 , 1685–1692.

    Najmik F. , 'Concentrations of cadmium in ovary, oviductus, uterus, testis and tunica albuginea of testis in cattle ' (1995 ) A30 J. Environ. Sci. Health : 1685 -1692 .

    • Search Google Scholar
  • Massányi, P., Uhrin, V., Sirotkin, A. V., Paksy, K., Forgács, Zs., Toman, R., Kovacik, J. (2000) Effects of cadmium on ultrastructure and steroidogenesis in cultured porcine ovarian granulosa cells. Acta Vet. Brno 69 , 101–106.

    Kovacik J. , 'Effects of cadmium on ultrastructure and steroidogenesis in cultured porcine ovarian granulosa cells ' (2000 ) 69 Acta Vet. Brno : 101 -106 .

    • Search Google Scholar
  • Merian, M. (1991) Cadmium and their Compounds in the Environment . VCH, Weinheim, NY, Basel, Cambridge.

    Merian M. , '', in Cadmium and their Compounds in the Environment , (1991 ) -.

  • Mousa, S. A. (2004) Expression of adhesion molecules during cadmium hepatotoxicity. Life Sci. 75 , 93–105.

    Mousa S. A. , 'Expression of adhesion molecules during cadmium hepatotoxicity ' (2004 ) 75 Life Sci. : 93 -105 .

    • Search Google Scholar
  • Myslek, P., Kalisinska, E. (2006) Contents of selected heavy metals in the liver, kidneys and abdominal muscle of the brown hare ( Lepus europaeus Pallas, 1778) in Central Pomerania, Poland. Polish J. Vet. Sci. 9 , 31–41.

    Kalisinska E. , 'Contents of selected heavy metals in the liver, kidneys and abdominal muscle of the brown hare (Lepus europaeus Pallas, 1778) in Central Pomerania, Poland ' (2006 ) 9 Polish J. Vet. Sci. : 31 -41 .

    • Search Google Scholar
  • Paksy, K., Varga, B., Lázár, P. (1992) Cadmium interferes with steroid biosynthesis in rat granulosa and luteal cells in vitro. BioMetals 5 , 245–250.

    Lázár P. , 'Cadmium interferes with steroid biosynthesis in rat granulosa and luteal cells in vitro ' (1992 ) 5 BioMetals : 245 -250 .

    • Search Google Scholar
  • Paksy, K., Rajczy, K., Forgacs, Zs., Lázár, P., Bernard, A., Gáti, I., Kaáli, G. S. (1997) Effects of cadmium on morphology and steroidogenesis of cultured human ovarian granulosa cells. J. Appl. Toxicol. 17 , 321–327.

    Kaáli G. S. , 'Effects of cadmium on morphology and steroidogenesis of cultured human ovarian granulosa cells ' (1997 ) 17 J. Appl. Toxicol. : 321 -327 .

    • Search Google Scholar
  • Peereboom-Stegeman, J. H. J. C., Jongstraspaapen, E., Leene, W., Oosting, H., Venema, H., Demoor, E., Gerrissen, W. J. (1987) The effects of long-term exposure to cadmium on the small blood-vessels in the rat uterus — a light microscopic study. Ecotoxicol. Environ. Safety 14 , 288–297.

    Gerrissen W. J. , 'The effects of long-term exposure to cadmium on the small blood-vessels in the rat uterus — a light microscopic study ' (1987 ) 14 Ecotoxicol. Environ. Safety : 288 -297 .

    • Search Google Scholar
  • Seifert, M., Anke, M. (1999) Daily intake of cadmium in Germany in 1996 determined with the duplicate portion technique. J. Trace Microprobe Techniques 17 , 101–109.

    Anke M. , 'Daily intake of cadmium in Germany in 1996 determined with the duplicate portion technique ' (1999 ) 17 J. Trace Microprobe Techniques : 101 -109 .

    • Search Google Scholar
  • Smida, A. D., Valderrama, X. P., Agostini, M. C., Furlan, M. A., Chendrese, J. (2004) Cadmium stimulates transcription of the cytochrome P450 side chain cleavage gene in genetically modified stable porcine granulosa cells. Biol. Reprod. 70 , 25–31.

    Chendrese J. , 'Cadmium stimulates transcription of the cytochrome P450 side chain cleavage gene in genetically modified stable porcine granulosa cells ' (2004 ) 70 Biol. Reprod. : 25 -31 .

    • Search Google Scholar
  • Szentmihalyi, K., Sipos, P., Blazovics, A., Vinkler, P., Szilagyi, M. (2002) Concentration of biliary metal elements and gallstone formation in humans (cholelithiasis). Trace Elem. Electrol. 19 , 160–164.

    Szilagyi M. , 'Concentration of biliary metal elements and gallstone formation in humans (cholelithiasis) ' (2002 ) 19 Trace Elem. Electrol. : 160 -164 .

    • Search Google Scholar
  • Toman, R., Massányi, P., Uhrín, V. (2002) Changes in the testis and epididymis of rabbits after an intraperitoneal and peroral administration of cadmium. Trace Elem. Electrol. 19 , 114–117.

    Uhrín V. , 'Changes in the testis and epididymis of rabbits after an intraperitoneal and peroral administration of cadmium ' (2002 ) 19 Trace Elem. Electrol. : 114 -117 .

    • Search Google Scholar
  • Van Den Heuvel, R. L., Leppens, H., Schoeters, G. E. (2001) Use of in vitro assays to assess hematotoxic effects of environmental compounds. Cell Biol. Toxicol. 17 , 107–116.

    Schoeters G. E. , 'Use of in vitro assays to assess hematotoxic effects of environmental compounds ' (2001 ) 17 Cell Biol. Toxicol. : 107 -116 .

    • Search Google Scholar
  • Vršanská, S., Nagyová, E., Mlynarčiková, A., Fickova, M., Kolena, J. (2003) Components of cigarette smoke inhibit expansion of oocyte-cumulus complexes from porcine follicles. Physiol. Res. 52 , 383–387.

    Kolena J. , 'Components of cigarette smoke inhibit expansion of oocyte-cumulus complexes from porcine follicles ' (2003 ) 52 Physiol. Res. : 383 -387 .

    • Search Google Scholar
  • Weibel, E. R., Kistler, G. S., Scherle, W. F. (1966) Practical stereological methods for morphometric cytology. J. Cell Biol. 30 , 23–28.

    Scherle W. F. , 'Practical stereological methods for morphometric cytology ' (1966 ) 30 J. Cell Biol. : 23 -28 .

    • Search Google Scholar
  • Žitný, J., Massányi, P., Trakovická, A., Rafaj, J., Toman, R. (2004) Quantification of the ovarian follicular growth in rabbits. Bull. Vet. Instit. Pulawy 48 , 37–40.

    Toman R. , 'Quantification of the ovarian follicular growth in rabbits ' (2004 ) 48 Bull. Vet. Instit. Pulawy : 37 -40 .

    • Search Google Scholar
  • Collapse
  • Expand

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)