Acta Biologica Hungarica
Volume/Issue:
Volume 58: Issue 4
Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells
Authors:
Y. Siddique Aligarh Muslim University Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences Aligarh 202002 U.P. India

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Gulshan Ara Aligarh Muslim University Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences Aligarh 202002 U.P. India

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T. Beg Aligarh Muslim University Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences Aligarh 202002 U.P. India

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M. Afzal Aligarh Muslim University Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences Aligarh 202002 U.P. India

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Pages:
397–409
Online Publication Date:
06 Nov 2007
Publication Date:
01 Dec 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.58.2007.4.7
Keywords:
Ocimum sanctum ; cyproterone acetate; anti-genotoxicity; human lymphocytes; aqueous extract
Restricted access

The anti-genotoxic effect of Ocimum sanctum L. extract was studied against the genotoxic effect induced by a synthetic progestin cyproterone acetate, on human lymphocytes using chromosomal aberrations, mitotic index, sister chromatid exchanges and replication index as a parameters. About 30 µM of cyproterone acetate was treated with O. sanctum L. infusion, at dosages of 1.075 × 10 −4 , 2.125 × 10 −4 and 3.15 × 10 −4 g/ml of culture medium. A clear dose-dependent decrease in the genotoxic damage of cyproterone acetate was observed, suggesting a possible modulating role of the plant infusion. The results of the present study suggest that the plant infusion per se does not have genotoxic potential, but can modulate the genotoxicity of cyproterone acetate on human lymphocytes in vitro .

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Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

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Editor(s)-in-Chief: Elekes, Károly

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    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
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    1. Gulyás, Balázs (Stockholm)
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    1. Heszky, László (Gödöllő)
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    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
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    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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