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G. Koricanac “Vinca” Institute of Nuclear Sciences Laboratory for Molecular Biology and Endocrinology P.O. Box 522 11001 Belgrade Serbia

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Mojca Stojiljkovic “Vinca” Institute of Nuclear Sciences Laboratory for Molecular Biology and Endocrinology P.O. Box 522 11001 Belgrade Serbia

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Snezana Radivojsa “Vinca” Institute of Nuclear Sciences Laboratory for Molecular Biology and Endocrinology P.O. Box 522 11001 Belgrade Serbia

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Zorica Zakula “Vinca” Institute of Nuclear Sciences Laboratory for Molecular Biology and Endocrinology P.O. Box 522 11001 Belgrade Serbia

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Nevena Ribarac-Stepic “Vinca” Institute of Nuclear Sciences Laboratory for Molecular Biology and Endocrinology P.O. Box 522 11001 Belgrade Serbia

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Esma Isenovic “Vinca” Institute of Nuclear Sciences Laboratory for Radiobiology and Molecular Genetics P.O. Box 522 11001 Belgrade Serbia

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The aim of this study was to examine the effects of dexamethasone (Dex) on functional properties of the rat insulin receptor (IR). Male Mill Hill hooded rats, 3, 6, 12, 18 and 21 months old, were injected with Dex (4 mg/kg) and rat liver and erythrocytes were used for experiments 18 h after Dex administration. Treatment with Dex lowered the specific binding (SB) of insulin (INS) in the liver of 3-and 18-monthold rats and concentration of INS binding sites (N 1 , N 2 ) and the dissociation constant of low-affinity binding sites (Kd 2 ) in the liver of 6-and 18-month-old rats. In addition, Dex treatment lowered the liver IR protein level in all analyzed groups, except 21-month-old rats where it remained unchanged, but raised the IR mRNA level in 18-month-old rats. In erythrocytes, treatment with Dex decreased SB and Kd 2 (in animals 3 and 6 months old) and N 1 (in ones 3 and 18 months old). Following Dex treatment, the INS plasma level increased (in rats 3, 18 and 21 months old), while glucose (Glu) concentration increased in 3 and 12 months old, but decreased in 6-and 21-month-old rats. In summary, Dex exerts the strongest effect on the erythrocyte IR of 3-and 6-month-old rats and the hepatic IR of 18-month-old rats. IR in both tissues is almost insensitive to Dex in 12-and 21-month-old rats. The pattern of age-related changes of IR induced by Dex does not correlate with changes of plasma Glu and INS.

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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
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Foundation
1950
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Founder Magyar Tudományos Akadémia
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H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)