To detect neuroactive factors in biological fluids, we have previously elaborated a moveable biosensor, the preparation of isolated neuron penetrated with recording microelectrode [1]. Here, we report that, in the pond snail, signals emanated from a central pattern generator (CPG) for feeding and detected by such biosensor correspond to long-term changes in motor output of the CPG as recorded from buccal nerves. The results suggest that combined recording from motor nerves, neurons in situ and the neuron-based biosensors may be a useful tool in studies of the mechanisms underlying network organisation.
Chistopolsky, I. A., Sakharov, D. A. (2007) An isolated neuron-based biosensor to release of neuroactive substances. Russ. J. Physiol. 93 , 1210–1213 (in Russian).
Sakharov D. A. , 'An isolated neuron-based biosensor to release of neuroactive substances ' (2007 ) 93 Russ. J. Physiol. : 1210 -1213 .
Dyakonova, T. L. (1985) Two types of neurons which differ in plasticity: study of ionic mechanisms. Zhurn. Vyssh. Nerv. Deyat. 35 , 552–560 (in Russian).
Dyakonova T. L. , 'Two types of neurons which differ in plasticity: study of ionic mechanisms ' (1985 ) 35 Zhurn. Vyssh. Nerv. Deyat. : 552 -560 .
Rose, R. M., Benjamin, P. R. (1981) Interneuronal control of feeding in the pond snail Lymnaea stagnalis . 1. Initiation of feeding cycles by a single buccal interneurone. J. Exp. Biol. 92 , 187–201.
Benjamin P. R. , 'Interneuronal control of feeding in the pond snail Lymnaea stagnalis. 1. Initiation of feeding cycles by a single buccal interneurone ' (1981 ) 92 J. Exp. Biol. : 187 -201 .