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  • 1 Selcuk University Department of Physiology, Meram Medical School Konya 42080 Turkey
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The present study was conducted to determine the effects of basal, isotonic as well as hypertonic and hypovolemic treatments on fluid-electrolyte balance and plasma AVP levels in rats supplemented with L-thyroxine and pinealectomized L-thyroxine. The animals were initially separated into 4 groups: control (n = 24), L-thyroxine treated (n = 24); L-thyroxine + sham-pinealectomy (n = 24) treated and 4-Lthyroxine + pinealectomy (n = 24) treated. L-thyroxine was given for 4 weeks. At the end of the 4-week experimental period, the sub-groups were formed before decapitation, which were classified as unstimulated (n = 6), isotonic (n = 6), hypertonic (n = 6) and hypovolemic (n = 6) stimulation. Plasma AVP, total triiodothyronine (TT 3 ) and total thyroxine (TT 4 ) levels were examined in plasma by RIA. Hematocrit and osmolality levels were also determined. It was found that the TT 3 and TT 4 levels showed significant increases in L-thyroxine treated groups (P < 0.001). Also, plasma AVP levels increased in the group subjected to L-thyroxine treatment. However, this increase was depicted to be significantly more prominent in L-thyroxine + pinealectomy treated group (P < 0.001). The results of the present study indicate that Lthyroxine treatment increases the basal and stimulated AVP release, which became more significant in the pinealectomy plus L-thyroxine treatment group. Moreover, the results indicate that AVP response to hypertonic and hypovolemic stimulations does not undergo any change due to supplementation by L-thyroxine treatment and/or pinealectomy plus L-thyroxine.

  • Ali, M., Guillon, G., Cantau, B., Balestre, M. N., Chicot, D., Clos, J. (1987) A comparative study of plasma vasopressin levels and V1 and V2 vasopressin receptor properties in congenital hypothyroid rat under thyroxine or vasopressin therapy. Horm. Metab. Res. 19 , 624–628.

    Clos J. , 'A comparative study of plasma vasopressin levels and V1 and V2 vasopressin receptor properties in congenital hypothyroid rat under thyroxine or vasopressin therapy ' (1987 ) 19 Horm. Metab. Res. : 624 -628.

    • Search Google Scholar
  • Baltaci, A. K., Mogulkoc, R., Bediz, C. S., Kul, A., Ugur, A. (2003) Pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats. Endocr. Res. 29 , 473–481.

    Ugur A. , 'Pinealectomy and zinc deficiency have opposite effects on thyroid hormones in rats ' (2003 ) 29 Endocr. Res. : 473 -481.

    • Search Google Scholar
  • Baltaci, A. K., Mogulkoc, R., Bediz, C. S., Kul, A., Ugur, A. (2004) Opposite effects of zinc and melatonin on thyroid hormones in rats. Toxicology 195 , 69–75.

    Ugur A. , 'Opposite effects of zinc and melatonin on thyroid hormones in rats ' (2004 ) 195 Toxicology : 69 -75.

    • Search Google Scholar
  • Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Maffei, M. L., Coiro, V. (1998) Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men. Neuropeptide 32 , 125–129.

    Coiro V. , 'Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men ' (1998 ) 32 Neuropeptide : 125 -129.

    • Search Google Scholar
  • Ciosek, J. (2002) Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats. J. Physiol. Pharmacol. 53 , 423–437.

    Ciosek J. , 'Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats ' (2002 ) 53 J. Physiol. Pharmacol. : 423 -437.

    • Search Google Scholar
  • Ciosek, J., Drobnik, J. (2004) Vasopressin and oxytocin release and the thyroid function. J. Physiol. Pharmacol. 55 , 423–441.

    Drobnik J. , 'Vasopressin and oxytocin release and the thyroid function ' (2004 ) 55 J. Physiol. Pharmacol. : 423 -441.

    • Search Google Scholar
  • Coiro, V., Volpi, R., Caffarri, G., Capretti, L., Marchesi, C., Giacalone, G., Chiodera, P. (1997) Effect of melatonin on hypoglycemia and metoclopramide-stimulated arginine vasopressin secretion in normal men. Neuropeptides 31 , 323–326.

    Chiodera P. , 'Effect of melatonin on hypoglycemia and metoclopramide-stimulated arginine vasopressin secretion in normal men ' (1997 ) 31 Neuropeptides : 323 -326.

    • Search Google Scholar
  • Cowley, A. W. Jr, Skelton, M. M., Merrill, D. C. (1984) Long-term influence of vasopressin on the control of arterial blood pressure independent of volume changes. J. Hypertens. Suppl. 2 , 337–339.

    Merrill D. C. , 'Long-term influence of vasopressin on the control of arterial blood pressure independent of volume changes ' (1984 ) 2 J. Hypertens. Suppl. : 337 -339.

    • Search Google Scholar
  • Dakine, N., Olier, C., Grio, M. (2000) Thyroxine modulates corticotropin-releasing factor but not arginine vasopressin gene expression in the hypothalamic paraventricular nucleus of the developing Rat. J. Neuroendocrinol. 12 , 774–783.

    Grio M. , 'Thyroxine modulates corticotropin-releasing factor but not arginine vasopressin gene expression in the hypothalamic paraventricular nucleus of the developing Rat ' (2000 ) 12 J. Neuroendocrinol. : 774 -783.

    • Search Google Scholar
  • Forsling, M. L., Stoughton, R., Kelestimur, H., Koistoglou-Athanassiou, I., Demaine, C. (1996) Release of vasopressin in response to altered plasma volume and sodium concentrations following pinealectomy in the rat. J. Pineal Res. 20 , 211–216.

    Demaine C. , 'Release of vasopressin in response to altered plasma volume and sodium concentrations following pinealectomy in the rat ' (1996 ) 20 J. Pineal Res. : 211 -216.

    • Search Google Scholar
  • Forsling, M. L., Stoughton, R. P., Zhou, Y., Kelestimur, H., Demaine, C. (1993) The role of the pineal in the control of the daily patterns of neurohypophyseal hormone secretion. J. Pineal Res. 14 , 45–51.

    Demaine C. , 'The role of the pineal in the control of the daily patterns of neurohypophyseal hormone secretion ' (1993 ) 14 J. Pineal Res. : 45 -51.

    • Search Google Scholar
  • Hoffman, R. A., Reiter, R. J. (1965) Rapid pinealectomy in hamsters and other small rodents. Anat. Rec. 153 , 19–21.

    Reiter R. J. , 'Rapid pinealectomy in hamsters and other small rodents ' (1965 ) 153 Anat. Rec. : 19 -21.

    • Search Google Scholar
  • Isobe, Y., Torii, T., Nishino, H. (2001) Melatonin inhibits Arg-vasopressin release via MT( 2 ) receptor in the suprachiasmatic nucleus-slice culture of rats. Brain Res. 889 , 214–219.

    Nishino H. , 'Melatonin inhibits Arg-vasopressin release via MT(2) receptor in the suprachiasmatic nucleus-slice culture of rats ' (2001 ) 889 Brain Res. : 214 -219.

    • Search Google Scholar
  • Isobe, Y., Fujioi, J., Nishino, H. (2001) Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release. Brain Res. 918 , 67–73.

    Nishino H. , 'Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release ' (2001 ) 918 Brain Res. : 67 -73.

    • Search Google Scholar
  • Juszczak, M., Bojanowska, E., Dabroswki, R. (2000) Melatonin and the synthesis of vasopressin in pinealectomized rats. Proc. Soc. Exp. Biol. Med. 225 , 207–210.

    Dabroswki R. , 'Melatonin and the synthesis of vasopressin in pinealectomized rats ' (2000 ) 225 Proc. Soc. Exp. Biol. Med. : 207 -210.

    • Search Google Scholar
  • Juszczak, M., Kopotowska, A., Stempniak, B., Guzek, J. W. (1993) Hypothalamic and neurohypophyseal vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats. Pathol. Pol. 44 , 55–59.

    Guzek J. W. , 'Hypothalamic and neurohypophyseal vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats ' (1993 ) 44 Pathol. Pol. : 55 -59.

    • Search Google Scholar
  • Juszczak, M., Stempniak, B., Guzek, J. W. (1992) Melatonin, pinealectomy, and release of neurohypophyseal hormones: in vitro studies. J. Pineal Res. 12 , 1–6.

    Guzek J. W. , 'Melatonin, pinealectomy, and release of neurohypophyseal hormones: in vitro studies ' (1992 ) 12 J. Pineal Res. : 1 -6.

    • Search Google Scholar
  • Konakchieva, R., Mitev, Y., Almeida, O. F., Patchev, V. K. (1997) Chronic melatonin treatment and the hypothalamo-pituitary-adrenal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release. Biol. Cell. 89 , 587–596.

    Patchev V. K. , 'Chronic melatonin treatment and the hypothalamo-pituitary-adrenal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release ' (1997 ) 89 Biol. Cell. : 587 -596.

    • Search Google Scholar
  • Marcisz, C., Jonderko, G., Kucharz, E. J. (2001) Changes of plasma arginine-vasopressin level in patients with hyperthyroidism during treatment. Med. Sic. Monit. 7 , 409–414.

    Kucharz E. J. , 'Changes of plasma arginine-vasopressin level in patients with hyperthyroidism during treatment ' (2001 ) 7 Med. Sic. Monit. : 409 -414.

    • Search Google Scholar
  • Mogulkoc, R., Baltaci, A. K., Yilmaz, B., Kelestimur, H. (1999) Influence of hypovolemic and hypertonic treatments on plasma vasopressin levels and fluid balance in the propylthiouracil-induced hypothyroid rat. Neuro Endocrinol. Lett. 20 , 311–314.

    Kelestimur H. , 'Influence of hypovolemic and hypertonic treatments on plasma vasopressin levels and fluid balance in the propylthiouracil-induced hypothyroid rat ' (1999 ) 20 Neuro Endocrinol. Lett. : 311 -314.

    • Search Google Scholar
  • Mogulkoc, R., Dogru, O., Baltaci, A. K., Yilmaz, B., Kelestimur, H. (2000) Influence of hypovolemic and hypertonic treatments on plasma vasopressin levels and fluid balance in the thyroidectomyinduced hypothyroid rats. Neuro Endocrinol. Lett. , 21, 35–38.

    Kelestimur H. , 'Influence of hypovolemic and hypertonic treatments on plasma vasopressin levels and fluid balance in the thyroidectomyinduced hypothyroid rats ' (2000 ) 21 Neuro Endocrinol. Lett. : 35 -38.

    • Search Google Scholar
  • Mogulkoc, R., Baltaci, A. K. (2006) Influences of isotonic, hypertonic and hypovolemic treatments on vasopressin response and fluid-electrolyte balance in L-thyroxine-induced hyperthyroid rat. Life Sci. 79 , 817–821.

    Baltaci A. K. , 'Influences of isotonic, hypertonic and hypovolemic treatments on vasopressin response and fluid-electrolyte balance in L-thyroxine-induced hyperthyroid rat ' (2006 ) 79 Life Sci. : 817 -821.

    • Search Google Scholar
  • Riis, P. M., Madsen, A. (1985) Thyroxine concentrations and secretion rates in relation to pregnancy, lactation and energy balance in goats. J. Endocrinol. 107 , 421–427.

    Madsen A. , 'Thyroxine concentrations and secretion rates in relation to pregnancy, lactation and energy balance in goats ' (1985 ) 107 J. Endocrinol. : 421 -427.

    • Search Google Scholar
  • Salomez-Granier, F., Lefebvre, J., Racadot, A., Dewailly, D., Linquette, M. (1983) Antidiuretic hormone levels (arginine-vasopressin) in cases of peripheral hypothyroidism. 26 cases. Presse Med. 12 , 1001–1004.

    Linquette M. , 'Antidiuretic hormone levels (arginine-vasopressin) in cases of peripheral hypothyroidism. 26 cases ' (1983 ) 12 Presse Med. : 1001 -1004.

    • Search Google Scholar
  • Tohei, A., Watanabe, G., Taya, K. (1998) Hypersecretion of corticotropin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion. J. Endocrinol. 156 , 395–400.

    Taya K. , 'Hypersecretion of corticotropin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion ' (1998 ) 156 J. Endocrinol. : 395 -400.

    • Search Google Scholar
  • Vargas, F., Baz, M. J., Luna, J. D., Andrade, J., Jodar, E., Haro, J. M. (1991) Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin in hyper-and hypo-thyroid rats. Clin. Sci. (Lond). 81 , 471–476.

    Haro J. M. , 'Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin in hyper-and hypo-thyroid rats ' (1991 ) 81 Clin. Sci. (Lond). : 471 -476.

    • Search Google Scholar
  • Wiig, H., Reed, R. K., Tenstad, O. (2000) Interstitial fluid pressure, composition of interstitium, and interstitial exclusion of albumin in hypothyroid rats. Am. J. Physiol. Heart Circ. Physiol. 278 , H1627–1639.

    Tenstad O. , 'Interstitial fluid pressure, composition of interstitium, and interstitial exclusion of albumin in hypothyroid rats ' (2000 ) 278 Am. J. Physiol. Heart Circ. Physiol. : H1627 -1639.

    • Search Google Scholar
  • Windle, R. J., Luckman, S. M., Stoughton, R. P., Forsling, M. L. (1996) The effect of pinealectomy on osmotically stimulated vasopressin and oxytocin release and Fos protein production within the hypothalamus of the rat. J. Neuroendocrinol. 8 , 747–753.

    Forsling M. L. , 'The effect of pinealectomy on osmotically stimulated vasopressin and oxytocin release and Fos protein production within the hypothalamus of the rat ' (1996 ) 8 J. Neuroendocrinol. : 747 -753.

    • Search Google Scholar
  • Yasin, S. A., Costa, A., Besser, G. M., Hucks, D., Grossman, A., Forsling, M. L. (1993) Melatonin and its analogs inhibit the basal and stimulated release of hypothalamic vasopressin and oxytocin in vitro. Endocrinology 132 , 1329–1336.

    Forsling M. L. , 'Melatonin and its analogs inhibit the basal and stimulated release of hypothalamic vasopressin and oxytocin in vitro ' (1993 ) 132 Endocrinology : 1329 -1336.

    • Search Google Scholar
  • Zimmerman, R. S., Ryan, J., Edwards, B. S., Klee, G., Zimmerman, D., Scott, N., Burnett, J. C. Jr. (1988) Cardiorenal endocrine dynamics during volume expansion in hypothyroid dogs. Am. J. Physiol. 255 , R 61–66.

    Burnett J. C. , 'Cardiorenal endocrine dynamics during volume expansion in hypothyroid dogs ' (1988 ) 255 Am. J. Physiol. : 61 -66.

    • Search Google Scholar