Acta Biologica Hungarica
Volume/Issue:
Volume 59: Issue 2
The effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxine
Authors: R. Mogulkoc 1 and A. Baltaci 1
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  • 1 Selcuk University Department of Physiology, Meram Medical School Konya 42080 Turkey
DOI:
https://doi.org/10.1556/abiol.59.2008.2.3
Page Count:
163–172
Publication Date:
01 Jun 2008
Online Publication Date:
31 May 2008
Article Category:
Research Article
Restricted access

The present study was conducted to determine the effects of basal, isotonic as well as hypertonic and hypovolemic treatments on fluid-electrolyte balance and plasma AVP levels in rats supplemented with L-thyroxine and pinealectomized L-thyroxine. The animals were initially separated into 4 groups: control (n = 24), L-thyroxine treated (n = 24); L-thyroxine + sham-pinealectomy (n = 24) treated and 4-Lthyroxine + pinealectomy (n = 24) treated. L-thyroxine was given for 4 weeks. At the end of the 4-week experimental period, the sub-groups were formed before decapitation, which were classified as unstimulated (n = 6), isotonic (n = 6), hypertonic (n = 6) and hypovolemic (n = 6) stimulation. Plasma AVP, total triiodothyronine (TT 3 ) and total thyroxine (TT 4 ) levels were examined in plasma by RIA. Hematocrit and osmolality levels were also determined. It was found that the TT 3 and TT 4 levels showed significant increases in L-thyroxine treated groups (P < 0.001). Also, plasma AVP levels increased in the group subjected to L-thyroxine treatment. However, this increase was depicted to be significantly more prominent in L-thyroxine + pinealectomy treated group (P < 0.001). The results of the present study indicate that Lthyroxine treatment increases the basal and stimulated AVP release, which became more significant in the pinealectomy plus L-thyroxine treatment group. Moreover, the results indicate that AVP response to hypertonic and hypovolemic stimulations does not undergo any change due to supplementation by L-thyroxine treatment and/or pinealectomy plus L-thyroxine.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X
Keywords:
AVP; L-thyroxine treatment; pinealectomy; hypertonic and hypovolemic stimulation; osmolality; rat

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