View More View Less
  • 1 Universidade do Estado do Rio de Janeiro Departamento de Farmacologia e Psicobiologia Avenida 28 de Setembro, 87, Fundos Rio de Janeiro Brasil 20551-030
  • | 2 Universidade do Estado do Rio de Janeiro Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes Avenida 28 de Setembro, 87, Fundos Rio de Janeiro Brasil 20551-030
Restricted access

The aim of this work was to evaluate, by comet assay, the possible inducing of DNA lesions in peripheral blood mononuclear cells of rats subjected to acute or chronic food deprivation. Wistar male rats were subjected to 72 h of partial (50%), or total acute food deprivation, and then allowed to recover for different time periods (24, 48 and 72 h). In other experiments, comet scores were determined in peripheral blood mononuclear cells of rats subjected to chronic food deprivation (25% and 50%) for 50 days. Blood aliquots were obtained before, during and after food deprivation. Comet assay was carried out, the comet units photographed and scored (class 0 up to 3). Acute and chronic food-deprived rats presented peripheral blood mononuclear cells with DNA lesions (comet classes 1, 2 and 3) and a significant increase ( p < 0.05) in the number of comet units compared with its basal level. The increase was proportional to acute food deprivation time, but after being taken off, it progressively returned to basal level after 48 h (partial group) or 72 h (total group). Chronic food-deprived rats presented a progressive increase of comet score up to 5 days, and a decrease thereafter to reach a basal level. Possible mechanisms of DNA lesions are discussed.

  • Anson, R. M., Guo, Z., de Cabo, R., Iyun, T., Rios, M., Hagepanos, A., Ingram, D. K., Lane, M. A., Mattson, M. P. (2003) Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc. Nat. Acad. Sci. USA 100 , 6216–6220.

    Mattson M. P. , 'Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake ' (2003 ) 100 Proc. Nat. Acad. Sci. USA : 6216 -6220.

    • Search Google Scholar
  • Aravich, P. F., Rieg, T. S., Lauterio, T. J., Doerries, L. E. (1993) β-Endorphin and dynorphin abnormalities rats subjected to exercise and restricted feeding: relationship to anorexia nervosa? Brain Res. 622 , 1–8.

    Doerries L. E. , 'β-Endorphin and dynorphin abnormalities rats subjected to exercise and restricted feeding: relationship to anorexia nervosa? ' (1993 ) 622 Brain Res. : 1 -8.

    • Search Google Scholar
  • Armeni, T., Tomasetti, M., Svegliati Baroni, S., Saccucci, F., Marra, M., Pieri, C., Littarru, G. P., Principato, G., Battino, M. (1997) Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing. Mol. Aspects Med. 18 , S247–250.

    Battino M. , 'Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing ' (1997 ) 18 Mol. Aspects Med. : S247 -250.

    • Search Google Scholar
  • Barja, G. (2002) Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Ageing Res. Rev. 1 , 397–411.

    Barja G. , 'Endogenous oxidative stress: relationship to aging, longevity and caloric restriction ' (2002 ) 1 Ageing Res. Rev. : 397 -411.

    • Search Google Scholar
  • Barja, G. (2004) Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism? Biol. Rev. Camb. Philos. Soc. 79 , 235–251.

    Barja G. , 'Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism? ' (2004 ) 79 Biol. Rev. Camb. Philos. Soc. : 235 -251.

    • Search Google Scholar
  • Birt, D. F., Yaktine, A., Duysen, E. (1999) Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis. J. Nutr. 129 , 571S–574S.

    Duysen E. , 'Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis ' (1999 ) 129 J. Nutr. : 571S -574S.

    • Search Google Scholar
  • Bodiga, V. L., Boindala, S., Putcha, U., Subramaniam, K., Manchala, R. (2005) Chronic low intake of protein or vitamins increases the intestinal epithelial cell apoptosis in Wistar / NIN rats. Nutrition 21 , 949–960.

    Manchala R. , 'Chronic low intake of protein or vitamins increases the intestinal epithelial cell apoptosis in Wistar / NIN rats ' (2005 ) 21 Nutrition : 949 -960.

    • Search Google Scholar
  • Boer, D. P., Epling, W. F., Pierce, W. D., Russel, J. C. (1990) Suppression of food deprivation-induced high-rate wheel running in rats. Physiol. Behav. 48 , 339–342.

    Russel J. C. , 'Suppression of food deprivation-induced high-rate wheel running in rats ' (1990 ) 48 Physiol. Behav. : 339 -342.

    • Search Google Scholar
  • Cavallini, G., Donati, A., Gori, Z., Pollera, M., Bergamini, E. (2001) The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction. Exp. Gerontol. 36 , 497–506.

    Bergamini E. , 'The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction ' (2001 ) 36 Exp. Gerontol. : 497 -506.

    • Search Google Scholar
  • Courter, L. A., Musafia-Jeknic, T., Fischer, K., Bildfell, R., Giovanini, J., Pereira, C., Baird, W. M. (2007) Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Toxicol. Sci. 95 , 63–73.

    Baird W. M. , 'Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1 ' (2007 ) 95 Toxicol. Sci. : 63 -73.

    • Search Google Scholar
  • Dallman, M. F. (1993) Stress update: adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress. Trends Endocrinol. Metab. 4 , 62–69.

    Dallman M. F. , 'Stress update: adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress ' (1993 ) 4 Trends Endocrinol. Metab. : 62 -69.

    • Search Google Scholar
  • Dantas, F. J., de Mattos, J. C., Moraes, M. O., Viana, M. E., Lage, C. A., Cabral-Neto, J. B., Leitão, A. C., Bernardo-Filho, M., Bezerra, R. J., Carvalho, J. J., Caldeira-de-Araujo, A. (2002) Genotoxic effects of stannous chloride (SnCl2) in K562 cell line. Food Chem. Toxicol. 40 , 1493–1498.

    Caldeira-de-Araujo A. , 'Genotoxic effects of stannous chloride (SnCl2) in K562 cell line ' (2002 ) 40 Food Chem. Toxicol. : 1493 -1498.

    • Search Google Scholar
  • Di Simplicio, P., Rossi R., Falcinelli, S., Ceserani, R., Formento, M. L. (1997) Antioxidant status of various tissues of the mouse after fasting and swimming stress. Eur. J. Appl. Occupation Physiol. 76 , 302–307.

    Formento M. L. , 'Antioxidant status of various tissues of the mouse after fasting and swimming stress ' (1997 ) 76 Eur. J. Appl. Occupation Physiol. : 302 -307.

    • Search Google Scholar
  • Domenicali, M., Caraceni, P., Vendemiale, G., Grattagliano, I., Nardo, B., Dallágata, M., Santoni, B., Trevisani, F., Cavallari, A., Altomare, E., Bernardi, M. (2001) Food deprivation exacerbates mitochondrial oxidative stress in rat liver exposed to ischemia-reperfusion injury. J. Nutr. 131 , 105–110.

    Bernardi M. , 'Food deprivation exacerbates mitochondrial oxidative stress in rat liver exposed to ischemia-reperfusion injury ' (2001 ) 131 J. Nutr. : 105 -110.

    • Search Google Scholar
  • Endou, M., Yanai, K., Sakurai, E., Fukudo, S., Hongo, M., Watanabe, T. (2001) Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats. Brain Res. 891 , 32–41.

    Watanabe T. , 'Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats ' (2001 ) 891 Brain Res. : 32 -41.

    • Search Google Scholar
  • Frame, L. T., Hart, R. W., Leakey, J. E. (1998) Caloric restriction as mechanism mediating resistance to environmental disease. Environ. Health Perspect. 106 (Suppl 1), 313–324.

    Leakey J. E. , 'Caloric restriction as mechanism mediating resistance to environmental disease ' (1998 ) 106 Environ. Health Perspect. : 313 -324.

    • Search Google Scholar
  • Gedik, C. M., Grant, G., Morrice, P. C., Wood, S. G., Collins, A. R. (2005) Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats. Eur. J. Nutr. 44 , 263–272.

    Collins A. R. , 'Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats ' (2005 ) 44 Eur. J. Nutr. : 263 -272.

    • Search Google Scholar
  • Guo, Z., Yang, H., Hamilton, M. L., VanRemmen, H., Richardson, A. (2001) Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta. Mech. Ageing Dev. 122 , 1771–1786.

    Richardson A. , 'Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta ' (2001 ) 122 Mech. Ageing Dev. : 1771 -1786.

    • Search Google Scholar
  • Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., Richardson, A. (2001) Does oxidative damage to DNA increase with age? Proc. Natl. Acad. Sci. USA 98 , 10469–10474.

    Richardson A. , 'Does oxidative damage to DNA increase with age? ' (2001 ) 98 Proc. Natl. Acad. Sci. USA : 10469 -10474.

    • Search Google Scholar
  • Holtenius, K., Dahlborn, K. (1990) Water and sodium movements across the ruminal epithelium in fed and food-deprived sheep. Exp. Physiol. 75 , 57–67.

    Dahlborn K. , 'Water and sodium movements across the ruminal epithelium in fed and food-deprived sheep ' (1990 ) 75 Exp. Physiol. : 57 -67.

    • Search Google Scholar
  • Kaneko, T., Tahara, S., Matsuo, M. (1997) Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2′-deoxyguanosine in organs of Fischer 344 rats during aging. Free Radic. Biol. Med. 23 , 76–81.

    Matsuo M. , 'Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2′-deoxyguanosine in organs of Fischer 344 rats during aging ' (1997 ) 23 Free Radic. Biol. Med. : 76 -81.

    • Search Google Scholar
  • Kubo, C., Gajjar, A., Johnson, B. C., Good, R. A. (1992) The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mouse. Proc. Nat. Acad. Sci. USA 89 , 3145–3149.

    Good R. A. , 'The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mouse ' (1992 ) 89 Proc. Nat. Acad. Sci. USA : 3145 -3149.

    • Search Google Scholar
  • Leal, A. M., Forsling, M. L., Moreira, A. C. (1995) Diurnal variation of the pituitary-adrenal and AVP responses to stress in rats under food restriction. Life Sci. 56 , 191–198.

    Moreira A. C. , 'Diurnal variation of the pituitary-adrenal and AVP responses to stress in rats under food restriction ' (1995 ) 56 Life Sci. : 191 -198.

    • Search Google Scholar
  • Liu, P. T., Ioannides, C., Shavila, J., Symons, A. M., Parke, D. V. (1993) Effects of ether anesthesia and fasting on various cytochromes P of rat liver and kidney. Biochem. Pharmacol. 45 , 871–877.

    Parke D. V. , 'Effects of ether anesthesia and fasting on various cytochromes P of rat liver and kidney ' (1993 ) 45 Biochem. Pharmacol. : 871 -877.

    • Search Google Scholar
  • Masoro, E. J. (1993) Dietary restriction and aging. J. Am. Geriatr. Soc. 41 , 994–999.

    Masoro E. J. , 'Dietary restriction and aging ' (1993 ) 41 J. Am. Geriatr. Soc. : 994 -999.

  • Masoro, E. J. (2000) Caloric restriciton and aging: an update. Exp. Gerontol. 35 , 299–305.

    Masoro E. J. , 'Caloric restriciton and aging: an update ' (2000 ) 35 Exp. Gerontol. : 299 -305.

    • Search Google Scholar
  • Miranda, D. D., Arcari, D. P., Ladeira, M. S., Calori-Domingues, M. A., Romero, A. C., Salvadori, D. M., Gloria, E. M., Pedrazzoli, J. Jr., Ribeiro, M. L. (2007) Analysis of DNA damage induced by aflatoxin B in Dunkin-Hartley guinea pigs. Mycopathol. 163 , 275–280.

    Ribeiro M. L. , 'Analysis of DNA damage induced by aflatoxin B in Dunkin-Hartley guinea pigs ' (2007 ) 163 Mycopathol. : 275 -280.

    • Search Google Scholar
  • Nakamura, H., Kouda, K., Tokunaga, R., Takeuchi, H. (2004) Suppressive effects on delayed type hypersensitivity by fasting and dietary restriction in ICR mice. Toxicol. Lett. 146 , 259–267.

    Takeuchi H. , 'Suppressive effects on delayed type hypersensitivity by fasting and dietary restriction in ICR mice ' (2004 ) 146 Toxicol. Lett. : 259 -267.

    • Search Google Scholar
  • Ostling, O., Johnson, J. (1984) Microelectrophoretic studies of radiation induced DNA damage in individual mammalian cells. Biochem. Biophys. Res. Commun. 123 , 291–298.

    Johnson J. , 'Microelectrophoretic studies of radiation induced DNA damage in individual mammalian cells ' (1984 ) 123 Biochem. Biophys. Res. Commun. : 291 -298.

    • Search Google Scholar
  • Pascual, P., Pedrajas, J. R., Toribio, F., López-Barea, J., Peinado, J. (2003) Effect of food deprivation on oxidative stress biomarkers in fish (Sparus aurata). Chem. Biol. Interact. 145 , 191–199.

    Peinado J. , 'Effect of food deprivation on oxidative stress biomarkers in fish (Sparus aurata) ' (2003 ) 145 Chem. Biol. Interact. : 191 -199.

    • Search Google Scholar
  • Perkins, S. N., Hursting, S. D., Phang, J. M., Haines, D. C. (1998) Calorie restriction reduces ulcerative dermatitis and infection-related mortality and wild-type mice. J. Invest. Dermatol. 111 , 292–296.

    Haines D. C. , 'Calorie restriction reduces ulcerative dermatitis and infection-related mortality and wild-type mice ' (1998 ) 111 J. Invest. Dermatol. : 292 -296.

    • Search Google Scholar
  • Radak, Z., Takahashi, R., Kumiyama, A., Nakamoto, H., Ohno, H., Ookawara, T., Goto, S. (2002) Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Exp. Gerontol. 37 , 1423–1430.

    Goto S. , 'Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon ' (2002 ) 37 Exp. Gerontol. : 1423 -1430.

    • Search Google Scholar
  • Ramaiah, S. K., Apte, U., Mehendale, H. M. (2001) Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats. Drug Metab. Dispos. 29 , 1088–1095.

    Mehendale H. M. , 'Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats ' (2001 ) 29 Drug Metab. Dispos. : 1088 -1095.

    • Search Google Scholar
  • Robinson, M. K., Rustum, R. R., Chambers, E. A., Rounds, J. D., Wilmore, D. W., Jacobs, D. O. (1997) Starvation enhances hepatic free radical release following endotoxemia. J. Surg. Res. 69 , 325–330.

    Jacobs D. O. , 'Starvation enhances hepatic free radical release following endotoxemia ' (1997 ) 69 J. Surg. Res. : 325 -330.

    • Search Google Scholar
  • Singh, I. (1983) Induction of reverse mutation and mitotic gene conversion by some metal compounds in Saccharomyces cerevisae. Mutat. Res. 117 , 149–152.

    Singh I. , 'Induction of reverse mutation and mitotic gene conversion by some metal compounds in Saccharomyces cerevisae ' (1983 ) 117 Mutat. Res. : 149 -152.

    • Search Google Scholar
  • Sogawa, H., Kubo, C. (2000) Influence of short-term repeated fasting on the longevity of female (NZB × NZW)F1 mice. Mech. Ageing Dev. 15 , 61–71.

    Kubo C. , 'Influence of short-term repeated fasting on the longevity of female (NZB × NZW)F1 mice ' (2000 ) 15 Mech. Ageing Dev. : 61 -71.

    • Search Google Scholar
  • Turner, D. R., Dreimanis, M., Holt, D., Firgaira, F. A., Morley, A. A. (2003) Mitotic recombination is an important mutational event following oxidative damage. Mutat. Res. 522 , 21–26.

    Morley A. A. , 'Mitotic recombination is an important mutational event following oxidative damage ' (2003 ) 522 Mutat. Res. : 21 -26.

    • Search Google Scholar
  • Underwood, D. C., Matthews, J. K., Osborn, R. R., Hay, D. W. (1998) Food restriction-mediated adrenal influences on antigen-induced bronchoconstriction and airway eosinophil influx in the guinea pig. Int. Arch. Allergy Immunol. 117 , 52–59.

    Hay D. W. , 'Food restriction-mediated adrenal influences on antigen-induced bronchoconstriction and airway eosinophil influx in the guinea pig ' (1998 ) 117 Int. Arch. Allergy Immunol. : 52 -59.

    • Search Google Scholar
  • Usuki, F., Yasutake, A., Umehara, F., Higuchi, I. (2004) Beneficial effects of mild lifelong dietary restriction on skeletal muscle: prevention of age-related mitochondrial damage, morphological changes, and vulnerability to a chemical toxin. Acta Neuropathol. (Berl). 108 , 1–9.

    Higuchi I. , 'Beneficial effects of mild lifelong dietary restriction on skeletal muscle: prevention of age-related mitochondrial damage, morphological changes, and vulnerability to a chemical toxin ' (2004 ) 108 Acta Neuropathol. (Berl). : 1 -9.

    • Search Google Scholar
  • Van Remmen, H., Hamilton, M. L., Richardson, A. (2003) Oxidative damage to DNA and aging. Exerc. Sport Sci. Rev. 31 , 149–153.

    Richardson A. , 'Oxidative damage to DNA and aging ' (2003 ) 31 Exerc. Sport Sci. Rev. : 149 -153.

    • Search Google Scholar
  • Van Remmen, H., Guo, Z., Richardson, A. (2001) The anti-ageing action of dietary restriction. Novartis Found Symp. 235 , 221–230.

    Richardson A. , 'The anti-ageing action of dietary restriction ' (2001 ) 235 Novartis Found Symp. : 221 -230.

    • Search Google Scholar
  • Vogt, B. L., Richie, J. P. (1993) Fasting-induced depletion of glutathione in the aging mouse. Biochem. Pharmacol. 46 , 257–263.

    Richie J. P. , 'Fasting-induced depletion of glutathione in the aging mouse ' (1993 ) 46 Biochem. Pharmacol. : 257 -263.

    • Search Google Scholar
  • Wan, R., Camandola, S., Mattson, M. P. (2003) Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats. J. Nutr. 133 , 1921–1929.

    Mattson M. P. , 'Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats ' (2003 ) 133 J. Nutr. : 1921 -1929.

    • Search Google Scholar
  • Ward, T. H., Butler, J., Shahbakhti, H., Richards, J. (1997) Comet assay studies on the activation of two diaziridinylbenzoquinones in K562 cells. Biochem. Pharmacol. 53 , 1115–1121.

    Richards J. , 'Comet assay studies on the activation of two diaziridinylbenzoquinones in K562 cells ' (1997 ) 53 Biochem. Pharmacol. : 1115 -1121.

    • Search Google Scholar
  • Wohaieb, S. A., Godin, D. V. (1987) Starvation-related alterations in free radical tissue defense mechanisms in rats. Diabetes 36 , 169–173.

    Godin D. V. , 'Starvation-related alterations in free radical tissue defense mechanisms in rats ' (1987 ) 36 Diabetes : 169 -173.

    • Search Google Scholar
  • Yanai, S., Okaichi, Y. Okaichi, H. (2004) Long-term dietary restriction causes negative effects on cognitive functions in rats. Neurobiol. Aging 25 , 325–332.

    Okaichi H. , 'Long-term dietary restriction causes negative effects on cognitive functions in rats ' (2004 ) 25 Neurobiol. Aging : 325 -332.

    • Search Google Scholar
  • Yaktine, A. L., Vaughn, R., Blackwood, D., Duysen, E., Birt, D. F. (1998) Dietary energy restriction in the SENCAR mouse: elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells. Mol. Carcinog. 21 , 62–69.

    Birt D. F. , 'Dietary energy restriction in the SENCAR mouse: elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells ' (1998 ) 21 Mol. Carcinog. : 62 -69.

    • Search Google Scholar
  • Yu, B. P., Masoro, E. J., McMahan, C. A. (1985) Nutritional influences on aging of Fischer 344 rats: I physical, metabolic and longevity characteristics. J. Gerontol. 40 , 657–670.

    McMahan C. A. , 'Nutritional influences on aging of Fischer 344 rats: I physical, metabolic and longevity characteristics ' (1985 ) 40 J. Gerontol. : 657 -670.

    • Search Google Scholar
  • Yu, B. P. (1996) Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 21 , 651–668.

    Yu B. P. , 'Aging and oxidative stress: modulation by dietary restriction ' (1996 ) 21 Free Radic. Biol. Med. : 651 -668.

    • Search Google Scholar
  • Yu, B. P., Chung, H. Y. (2001) Stress resistance by caloric restriction for longevity. Ann. N. Y. Acad. Sci. 928 , 39–47.

    Chung H. Y. , 'Stress resistance by caloric restriction for longevity ' (2001 ) 928 Ann. N. Y. Acad. Sci. : 39 -47.

    • Search Google Scholar

Editorial Board

      Csányi, Vilmos (Göd)
      Dudits, Dénes (Szeged)
      Falus, András (Budapest)
      Fischer, Ernő (Pécs)
      Gábriel, Róbert (Pécs)
      Gulya, Károly (Szeged)
      Gulyás, Balázs (Stockholm)
      Hajós, Ferenc (Budapest)
      Hámori, József (Budapest)
      Heszky, László (Gödöllő)
      Hideg, Éva (Szeged)
      E. Ito (Sanuki)
      Janda, Tibor (Martonvásár)
      Kavanaugh, Michael P. (Missoula)
      Kása, Péter (Szeged)
      Klein, Éva (Stockholm)
      Kovács, János (Budapest)
      Brigitte Mauch-Mani (Neuchâtel)
      Nässel, Dick R. (Stockholm)
      Nemcsók, János (Szeged)
      Péczely, Péter (Gödöllő)
      Roberts, D. F. (Newcastle-upon-Tyne)
      Sakharov, Dimitri A. (Moscow)
      Singh, Meharvan (Fort Worth)
      Sipiczky, Mátyás (Debrecen)
      Szeberényi, József (Pécs)
      Székely, György (Debrecen)
      Tari, Irma (Szeged)
      Vágvölgyi, Csaba (Szeged),
      L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)