Acta Biologica Hungarica
Volume/Issue:
Volume 60: Issue 4
Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: Possible glutamatergic and dopaminergic involvement
Authors:
Anita Lukács University of Szeged Department of Public Health Szeged Hungary

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Andrea Szabó University of Szeged Department of Public Health Szeged Hungary

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A. Papp University of Szeged Department of Public Health Szeged Hungary

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Tünde Vezér University of Szeged Department of Public Health Szeged Hungary

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Pages:
359–367
Online Publication Date:
16 Dec 2009
Publication Date:
01 Dec 2009
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.60.2009.4.3
Keywords:
3-nitropropionic acid; locomotor activity; open field; rat
Restricted access

3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

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Editor(s)-in-Chief: Elekes, Károly

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    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
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Foundation		 1950
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Founder Magyar Tudományos Akadémia
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