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  • 1 University of Szeged Department of Public Health Szeged Hungary
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3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.

  • Alexi, T., Borlongan, C. V., Faull, R. L. M., Williams, C. E., Clark, R. G., Gluckmann, P. D., Hughes, P. E. (2000) Neuroprotective strategies for basal ganglia degeneration: Parkinson’s and Huntington’s diseases. Prog. Neurobiol. 60 , 409–470.

    Hughes P. E. , 'Neuroprotective strategies for basal ganglia degeneration: Parkinson’s and Huntington’s diseases ' (2000 ) 60 Prog. Neurobiol. : 409 -470.

    • Search Google Scholar
  • Authier, N., Dupuis, E., Kwasiborski, A., Eschalier, A., Coudoré, F. (2002) Behavioural assessment of dimethylsulfoxide neurotoxicity in rats. Toxicol. Lett. 132 , 117–121.

    Coudoré F. , 'Behavioural assessment of dimethylsulfoxide neurotoxicity in rats ' (2002 ) 132 Toxicol. Lett. : 117 -121.

    • Search Google Scholar
  • Bast, T., da Silva, B. M., Morris, R. G. (2005) Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory. J. Neurosci. 25 , 5845–5856.

    Morris R. G. , 'Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory ' (2005 ) 25 J. Neurosci. : 5845 -5856.

    • Search Google Scholar
  • Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J. M., Storey, E., Srivastava, R., Rosen, B. R., Hyman, B. T. (1993) Neurochemical and histological characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitroproprionic acid. J. Neurosci. 13 , 4181–4192.

    Hyman B. T. , 'Neurochemical and histological characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitroproprionic acid ' (1993 ) 13 J. Neurosci. : 4181 -4192.

    • Search Google Scholar
  • Borlongan, C. V., Koutouzis, T. K., Randall, T. S., Freeman, B., Cahill, D. W., Sanberg, P. R. (1995) Systemic 3-nitropropionic acid: behavioural deficits and striatal damage in adult rats. Brain Res. Bull. 36 , 549–556.

    Sanberg P. R. , 'Systemic 3-nitropropionic acid: behavioural deficits and striatal damage in adult rats ' (1995 ) 36 Brain Res. Bull. : 549 -556.

    • Search Google Scholar
  • Borlongan, C. V., Koutouzis, T. K., Sanberg, P. R. (1997) 3-nitropropionic acid animal model and Huntington’s Disease. Neurosci. Biobehav. Res. 21 , 289–293.

    Sanberg P. R. , '3-nitropropionic acid animal model and Huntington’s Disease ' (1997 ) 21 Neurosci. Biobehav. Res. : 289 -293.

    • Search Google Scholar
  • Brouillet, E., Jenkins, B. G., Hyman, B. T., Ferrante, R. J., Kowall, N. W., Srivastava, R., Roy, D. S., Rosen, B. R., Beal, M. F. (1993) Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid. J. Neurochem. 60 , 356–359.

    Beal M. F. , 'Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid ' (1993 ) 60 J. Neurochem. : 356 -359.

    • Search Google Scholar
  • Gao, X., Xu, X., Pang, J., Zhang, C., Ding, J. M., Peng, X., Liu, Y., Cao, J. M. (2007) NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytes. Physiol. Res. 56 , 559–569.

    Cao J. M. , 'NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytes ' (2007 ) 56 Physiol. Res. : 559 -569.

    • Search Google Scholar
  • Garcia, M., Vanhoutte, P., Pages, C., Besson, M. J., Brouillet, E., Caboche, J. (2002) The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module. J. Neurosci. 22 , 2174–2184.

    Caboche J. , 'The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module ' (2002 ) 22 J. Neurosci. : 2174 -2184.

    • Search Google Scholar
  • Hersch, S. M., Ciliax, B. J., Gutekunst, C-A., Rees, H. D., Heilman, C. J., Yung, K. K. L., Bolam, J. P., Ince, E., Yi, H., Levey, A. I. (1995) Electron microscopic analysis of D 1 and D 2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J. Neurosci. 15 , 5222–5237.

    Levey A. I. , 'Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents ' (1995 ) 15 J. Neurosci. : 5222 -5237.

    • Search Google Scholar
  • Horváth, Zs. C., Czopf, J., Buzsáki, Gy. (1997) MK-801 induced neuronal damage in rats. Brain Res. 753 , 181–195.

    Buzsáki Gy. , 'MK-801 induced neuronal damage in rats ' (1997 ) 753 Brain Res. : 181 -195.

  • Kodsi, M. H., Swerdlow, N. R. (1997) Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington’s disease. Neurosci. Lett. 231 , 103–107.

    Swerdlow N. R. , 'Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington’s disease ' (1997 ) 231 Neurosci. Lett. : 103 -107.

    • Search Google Scholar
  • Koyuncuoglu, H., Kara, I., Günel, M. A., Nurten, A., Yamantürk, P. (1998) N -Methyl- D -aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission. Pharmacol. Res. 37 , 485–491.

    Yamantürk P. , 'N-Methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission ' (1998 ) 37 Pharmacol. Res. : 485 -491.

    • Search Google Scholar
  • Lee, W. T., Shen, Y. Z., Chang, C. (2000) Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neuroscience 95 , 89–95.

    Chang C. , 'Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy ' (2000 ) 95 Neuroscience : 89 -95.

    • Search Google Scholar
  • Lee, W. T., Yin, H. S., Shen, Y. Z. (2002) The mechanism of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N -methyl- D -aspartate glutamate receptors and mitochondrial calcium overload. Neuroscience 112 , 707–716.

    Shen Y. Z. , 'The mechanism of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N-methyl-D-aspartate glutamate receptors and mitochondrial calcium overload ' (2002 ) 112 Neuroscience : 707 -716.

    • Search Google Scholar
  • Ludolph, A. C., He, F., Spencer, P. S., Hammerstad, J., Sabri, M. (1991) 3-Nitropropionic acidexogenous animal neurotoxin and possible human striatal toxin. Can. J. Neurol. Sci. 18 , 492–498.

    Sabri M. , '3-Nitropropionic acidexogenous animal neurotoxin and possible human striatal toxin ' (1991 ) 18 Can. J. Neurol. Sci. : 492 -498.

    • Search Google Scholar
  • Lukács, A., Szabó, A., Nagymajtényi, L. (2005) Changes in neurobehavioural parameters and spontaneous cortical activity in rats after acute single and combined exposure by 3-nitropropionic acid and MK-801. Homeostasis 43 , 169–172.

    Nagymajtényi L. , 'Changes in neurobehavioural parameters and spontaneous cortical activity in rats after acute single and combined exposure by 3-nitropropionic acid and MK-801 ' (2005 ) 43 Homeostasis : 169 -172.

    • Search Google Scholar
  • Lukács, A., Szabó, A., Vezér, T., Papp, A. (2006) The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats. Acta Neurobiol. Exp. 66 , 227–233.

    Papp A. , 'The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats ' (2006 ) 66 Acta Neurobiol. Exp. : 227 -233.

    • Search Google Scholar
  • Lukács, A., Szabó, A., Vezér, T., Papp, A. (2007) Immediate and acute neurobehavioural effects of a glutamate agonist and antagonist in rats. Clin. Neurosci. 60 , 42.

    Papp A. , 'Immediate and acute neurobehavioural effects of a glutamate agonist and antagonist in rats ' (2007 ) 60 Clin. Neurosci. : 42 -.

    • Search Google Scholar
  • Miller, A. D., Forster, G. L., Metcalf, K. M., Blaha, C. D. (2002) Excitotoxic lesions of the pedunculopontine differentially mediate morphine- and d -amphetamine-evoked striatal dopamine efflux and behaviors. Neuroscience 111 , 351–362.

    Blaha C. D. , 'Excitotoxic lesions of the pedunculopontine differentially mediate morphine- and d-amphetamine-evoked striatal dopamine efflux and behaviors ' (2002 ) 111 Neuroscience : 351 -362.

    • Search Google Scholar
  • Nishino, H., Kumazaki, M., Fukuda, A., Fujimoto, I., Shimano, Y., Hida, H., Sakurai, T., Deshpande, S. B., Shimizu, H., Morikawa, S., Inubushi, T. (1997) Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity. Neurosci. Res. 27 , 343–355.

    Inubushi T. , 'Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity ' (1997 ) 27 Neurosci. Res. : 343 -355.

    • Search Google Scholar
  • Pang, Z., Geddes, J. W. (1997) Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J. Neurosci. 17 , 3064–3073.

    Geddes J. W. , 'Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis ' (1997 ) 17 J. Neurosci. : 3064 -3073.

    • Search Google Scholar
  • Park, C. K., Nehls, D. G., Graham, D. I., Teasdale, G. M., McCulloch, J. (1988) The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol. 24 , 543–551.

    McCulloch J. , 'The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat ' (1988 ) 24 Ann. Neurol. : 543 -551.

    • Search Google Scholar
  • Schulz, J. B., Matthews, R. T., Henshaw, D. R., Beal, M. F. (1996) Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience 71 , 1043–1048.

    Beal M. F. , 'Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases ' (1996 ) 71 Neuroscience : 1043 -1048.

    • Search Google Scholar
  • Seaman, R. L. (2000) Effects of acute systemic 3-nitropropionic acid administration on rat activity and acoustic startle. Neurosci. Lett. 280 , 183–186.

    Seaman R. L. , 'Effects of acute systemic 3-nitropropionic acid administration on rat activity and acoustic startle ' (2000 ) 280 Neurosci. Lett. : 183 -186.

    • Search Google Scholar
  • Sedelis, M., Schwarting, R. K., Huston, J. P. (2001) Behavioral phenotyping of the MPTP mouse model of Parkinson’s disease. Behav. Brain Res. 125 , 109–125.

    Huston J. P. , 'Behavioral phenotyping of the MPTP mouse model of Parkinson’s disease ' (2001 ) 125 Behav. Brain Res. : 109 -125.

    • Search Google Scholar
  • Swerdlow, N. R., Paulsen, J., Braff, D. L., Butters, N., Geyer, M. A., Swenson, M. R. (1995) Impaired prepulse inhibition of acoustic and tactile startle in patients with Huntington’s disease. J. Neurol. Neurosurg. Psychiatry 58 , 192–200.

    Swenson M. R. , 'Impaired prepulse inhibition of acoustic and tactile startle in patients with Huntington’s disease ' (1995 ) 58 J. Neurol. Neurosurg. Psychiatry : 192 -200.

    • Search Google Scholar
  • Szabó, A., Papp, A. (2003) Instantaneous and subacute functional neurotoxic effects elicited in rats by 3-nitropropionic acid. Clin. Neurosci. 56 , 84.

    Papp A. , 'Instantaneous and subacute functional neurotoxic effects elicited in rats by 3-nitropropionic acid ' (2003 ) 56 Clin. Neurosci. : 84 -.

    • Search Google Scholar

Editorial Board

      Csányi, Vilmos (Göd)
      Dudits, Dénes (Szeged)
      Falus, András (Budapest)
      Fischer, Ernő (Pécs)
      Gábriel, Róbert (Pécs)
      Gulya, Károly (Szeged)
      Gulyás, Balázs (Stockholm)
      Hajós, Ferenc (Budapest)
      Hámori, József (Budapest)
      Heszky, László (Gödöllő)
      Hideg, Éva (Szeged)
      E. Ito (Sanuki)
      Janda, Tibor (Martonvásár)
      Kavanaugh, Michael P. (Missoula)
      Kása, Péter (Szeged)
      Klein, Éva (Stockholm)
      Kovács, János (Budapest)
      Brigitte Mauch-Mani (Neuchâtel)
      Nässel, Dick R. (Stockholm)
      Nemcsók, János (Szeged)
      Péczely, Péter (Gödöllő)
      Roberts, D. F. (Newcastle-upon-Tyne)
      Sakharov, Dimitri A. (Moscow)
      Singh, Meharvan (Fort Worth)
      Sipiczky, Mátyás (Debrecen)
      Szeberényi, József (Pécs)
      Székely, György (Debrecen)
      Tari, Irma (Szeged)
      Vágvölgyi, Csaba (Szeged),
      L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
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per Year
 
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per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)