Acta Biologica Hungarica
Volume/Issue:
Volume 61: Issue 2
Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure
Authors:
N. Li Zhengzhou University College of Public Health Zhengzhou 450001 China

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Z. Yu Zhengzhou University College of Public Health Zhengzhou 450001 China

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L. Wang Zhengzhou University College of Public Health Zhengzhou 450001 China

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Y. Zheng Zhengzhou University College of Public Health Zhengzhou 450001 China

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J. Jia Zhengzhou University College of Public Health Zhengzhou 450001 China

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Q. Wang Zhengzhou University College of Public Health Zhengzhou 450001 China

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M. Zhu Zhengzhou University College of Public Health Zhengzhou 450001 China

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X. Liu Zhengzhou University College of Public Health Zhengzhou 450001 China

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X. Xia Zhengzhou University College of Public Health Zhengzhou 450001 China

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W. Li Zhengzhou University College of Public Health Zhengzhou 450001 China

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Pages:
123–134
Online Publication Date:
01 Jun 2010
Publication Date:
01 Jun 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.61.2010.2.1
Keywords:
Lead (Pb); tau phosphorylation; beta amyloid; neurotoxicity; learning and memory
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The aim of this study was to investigate the effects of maternal lead exposure on the learning and memory ability and expression of tau protein phosphorylation (P-tau) and beta amyloid protein (Aβ) in hippocampus of mice offspring. Pb exposure initiated from beginning of gestation to weaning. Pb acetate administered in drinking solutions was dissolved in distilled deionized water at the concentrations of 0.1%, 0.5% and 1% groups. On the 21 th of postnatal day, the learning and memory ability of the mouse pups was tested by Water Maze test and the Pb levels in blood and hippocampus of the offspring were also determined. The expression of P-tau and Aβ in hippocampus was measured by immunohistochemistry and Western blotting. The Pb levels in blood and hippocampus of all exposure groups were significantly higher than that of the control group ( P < 0.05). In Water Maze test, the performances of 0.5% and 1% groups were worse than that of the control group ( P < 0.05). The expression of P-tau and Aβ was increased in Pb exposed groups than that of the control group ( P < 0.05). Tau hyper-phosphorylation and Aβ increase in the hippocampus of pups may contribute to the impairment of learning and memory associated with maternal Pb exposure.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
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1588-256X

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Editor(s)-in-Chief: Elekes, Károly

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Acta Biologica Hungarica
Language English
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Foundation		 1950
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Founder Magyar Tudományos Akadémia
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