View More View Less
  • 1 Institute of Developmental Biology RAS Department of Comparative Physiology Moscow Russia
Restricted access

We investigated involvement of different 5-HT receptors in regulation of ciliary rotation, gliding locomotion and heartbeat of Helisoma embryo at pre- and post-metamorphic stages. Pharmacological analysis suggested that activation of 5-HT1 receptor enhance ciliary rotation but do not affect gliding locomotion. Activation of 5-HT4 receptor depresses both types of locomotion. Before metamorphosis heart contraction is depressed by activation of 5-HT4 and enhanced by activation of 5-HT7 receptor. However, the heart became insensitive to all agonists by hatching. We hypothesized that alterations in affinity or expression of particular 5-HT receptors can underlie the well-coordinated character of serotonin-dependent larval behavior.

  • Goldberg, J. I., Koehncke, N. K., Christopher, K. J., Neumann, C., Diefenbach, T. J. (1994) Pharmacological characterization of a serotonin receptor involved in an early embryonic behavior of Helisoma trivolvis. J. Neurobiol. 25, 1545–1557.

    Diefenbach T. J. , 'Pharmacological characterization of a serotonin receptor involved in an early embryonic behavior of Helisoma trivolvis ' (1994 ) 25 J. Neurobiol. : 1545 -1557.

    • Search Google Scholar
  • Mapara, S., Parries, S., Quarrington, C., Ahn, K.-Ch., Gallin, W. J., Goldberg, J. I. (2008) Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis. J. of Experimental Biology 211, 900–910.

    Goldberg J. I. , 'Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis ' (2008 ) 211 J. of Experimental Biology : 900 -910.

    • Search Google Scholar
  • Mescheriakov, V. N. (1990) The common pond snail Lymnaea stagnalis L. In: Dettlaff, D. A., Vassetzky, S. G. (eds) Animal species for developmental studies. Plenum Press, New York, pp. 69–132.

    Mescheriakov V. N. , '', in Animal species for developmental studies , (1990 ) -.

  • Voronezhskaya, E. E., Khabarova, M. Yu., Nezlin, L. P. (2004) Apical sensory neurons mediate developmental retardation induced by conspecific environmental stimuli in freshwater pulmonate snails. Development 131, 3671–3680.

    Nezlin L. P. , 'Apical sensory neurons mediate developmental retardation induced by conspecific environmental stimuli in freshwater pulmonate snails ' (2004 ) 131 Development : 3671 -3680.

    • Search Google Scholar
  • Voronezhskaya, E. E., Khabarova, M. Yu., Chaban, N. K., Nezlin, L. P. (2007) Role of chemical signalling in release of motor programs during embryogenesis of freshwater snails Lymnaea stagnalis and Helisoma trivolvis. Russ. J. Dev. Biol. 38, 66–75.

    Nezlin L. P. , 'Role of chemical signalling in release of motor programs during embryogenesis of freshwater snails Lymnaea stagnalis and Helisoma trivolvis ' (2007 ) 38 Russ. J. Dev. Biol. : 66 -75.

    • Search Google Scholar