Acta Biologica Hungarica
Volume/Issue:
Volume 63: Issue 4
Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles
Authors: Sz. Takács 1 , Andrea Szabó 1 , G. Oszlánczi 1 , P. Pusztai 2 , A. Sápi 2 , Z. Kónya 2 , and A. Papp 1
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  • 1 University of Szeged, Faculty of Medicine Department of Public Health Szeged Hungary
  • 2 University of Szeged, Faculty of Science and Informatics Department of Applied and Environmental Chemistry Szeged Hungary
DOI:
https://doi.org/10.1556/abiol.63.2012.4.2
Page Count:
426–440
Publication Date:
01 Dec 2012
Online Publication Date:
07 Nov 2012
Article Category:
Research Article
Restricted access

Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats’ cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4–5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats’ internal Mn exposure determined from brain samples. The results confirmed the non-linear dose- and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.

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Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X
Keywords:
Manganese; rat; cortical electrical activity; open field motility; chronic recording

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