View More View Less
  • 1 University of Szeged, Faculty of Medicine Department of Public Health Szeged Hungary
  • 2 University of Szeged, Faculty of Science and Informatics Department of Applied and Environmental Chemistry Szeged Hungary
Restricted access

Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats’ cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4–5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats’ internal Mn exposure determined from brain samples. The results confirmed the non-linear dose- and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.

  • Antonini, J. M., Lewis, A. B., Roberts, J. R., Whaley, D. A. (2003) Pulmonary effects of welding fumes: review of worker and experimental animal studies. Am. J. Ind. Med. 43, 350–360.

    Whaley D. A. , 'Pulmonary effects of welding fumes: review of worker and experimental animal studies ' (2003 ) 43 Am. J. Ind. Med. : 350 -360.

    • Search Google Scholar
  • Bader, M., Dietz, M. C., Ihring, A., Triebig, G. (1999) Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries. Int. Arch. Occup. Environ. Health 72, 521–527.

    Triebig G. , 'Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries ' (1999 ) 72 Int. Arch. Occup. Environ. Health : 521 -527.

    • Search Google Scholar
  • Bowler, R., Koller, W., Schultz, P. E. (2006) Parkinsonism due to manganism in a welder: Neurological and neuropsychological sequelae. Neurotoxicology 27, 327–332.

    Schultz P. E. , 'Parkinsonism due to manganism in a welder: Neurological and neuropsychological sequelae ' (2006 ) 27 Neurotoxicology : 327 -332.

    • Search Google Scholar
  • Calderon-Garciduenas, L., Azzarelli, B., Acuna, H. Garcia, R., Gambling, T. M., Osnaya, N., Monroy, S., Tizapantzi M. D. R., Carson, J. L., Villarreal-Calderon, A., Rewcastle, B. (2002) Air pollution and brain damage. Toxicol. Pathol. 3, 373–389.

    Rewcastle B. , 'Air pollution and brain damage ' (2002 ) 3 Toxicol. Pathol. : 373 -389.

  • Calne, D. B., Chu, N. S., Huang, C. C., Lu, C. S., Olanow, W. (1994) Manganism and idiopathic Parkinsonism: Similarities and differences. Neurology 44, 1583–1586.

    Olanow W. , 'Manganism and idiopathic Parkinsonism: Similarities and differences ' (1994 ) 44 Neurology : 1583 -1586.

    • Search Google Scholar
  • Couper, J. (1837) On the effects of black oxide of manganese when inhaled into the lungs. Br. Ann. Med. Pharm. Vit. Stat. Gen. Sci. 1, 41–42.

    Couper J. , 'On the effects of black oxide of manganese when inhaled into the lungs ' (1837 ) 1 Br. Ann. Med. Pharm. Vit. Stat. Gen. Sci. : 41 -42.

    • Search Google Scholar
  • Erikson, K. M., Aschner, M. (2003) Manganese neurotoxicity and glutamate-GABA interaction. Neurochem. Int. 43, 475–480.

    Aschner M. , 'Manganese neurotoxicity and glutamate-GABA interaction ' (2003 ) 43 Neurochem. Int. : 475 -480.

    • Search Google Scholar
  • Gwiazda, R., Lucchini, R., Smith, D. (2007) Adequacy and consistency of animal studies to evaluate the neurotoxicology of chronic low-level manganese exposure in humans. J. Toxicol. Environ. Health 70, 594–605.

    Smith D. , 'Adequacy and consistency of animal studies to evaluate the neurotoxicology of chronic low-level manganese exposure in humans ' (2007 ) 70 J. Toxicol. Environ. Health : 594 -605.

    • Search Google Scholar
  • Halatek, T., Sinczuk-Walczak, H., Szymcsak, M., Rydzynski, K. (2005) Neurological and respiratory symptoms in shipyard welders exposed to manganase. Int. J. Occup. Med. Environ. Health 18, 265–274.

    Rydzynski K. , 'Neurological and respiratory symptoms in shipyard welders exposed to manganase ' (2005 ) 18 Int. J. Occup. Med. Environ. Health : 265 -274.

    • Search Google Scholar
  • He, S. C., Niu, Q. (2004) Subclinical neurophysiological effects of manganese in welding workers. Int. J. Immunopathol. Pharmacol. 17, 11–16.

    Niu Q. , 'Subclinical neurophysiological effects of manganese in welding workers ' (2004 ) 17 Int. J. Immunopathol. Pharmacol. : 11 -16.

    • Search Google Scholar
  • ICRP (1994) Human respiratory tract model for radiological protection. A report of a task group of the ICRP. Annals of the International Commission on Radiation Protection, ICRP Publication 66, Pergamon Press, Oxford

    '', in Annals of the International Commission on Radiation Protection, ICRP Publication 66 , (1994 ) -.

  • Máté, Zs., Szabó, A., Oszlánczi, G., Papp, A. (2011) Modelling per os Mn exposure and examining its functional nervous system effects in rats. Egészségtudomány 55, 71–81 (in Hungarian).

    Papp A. , 'Modelling per os Mn exposure and examining its functional nervous system effects in rats ' (2011 ) 55 Egészségtudomány : 71 -81.

    • Search Google Scholar
  • Mena, I., Marin, O., Fuenzalida, S., Cotzias, G. C. (1967) Chronic manganese poisoning: clinical picture and manganese turnover. Neurology 17, 128–136.

    Cotzias G. C. , 'Chronic manganese poisoning: clinical picture and manganese turnover ' (1967 ) 17 Neurology : 128 -136.

    • Search Google Scholar
  • Normandin, L., Beaupré, L. A., Salehi, F., St-Pierre, A., Kennedy, G., Mergler, D., Butterworth, R. F., Philippe, S., Zayed, J. (2004) Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology 25, 411–433.

    Zayed J. , 'Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese ' (2004 ) 25 Neurotoxicology : 411 -433.

    • Search Google Scholar
  • Oberdörster, G., Oberdörster, E., Oberdörster, J. (2005) Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Persp. 7, 823–839.

    Oberdörster J. , 'Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles ' (2005 ) 7 Environ. Health Persp. : 823 -839.

    • Search Google Scholar
  • Oszlánczi, G., Vezér, T., Sárközi, L., Horváth, E., Kónya, Z., Papp, A. (2010) Functional neurotoxicity of Mn-containing nanoparticles in rats. Ecotoxicol. Environ. Saf. 73, 2004–2009.

    Papp A. , 'Functional neurotoxicity of Mn-containing nanoparticles in rats ' (2010 ) 73 Ecotoxicol. Environ. Saf. : 2004 -2009.

    • Search Google Scholar
  • Santamaria, A. B., Cushing, C. A., Antonini, J. M., Finley, B. L., Mowat, F. S. (2007) State-of-thescience review: Does manganese exposure during welding pose a neurological risk? J. Toxicol. Environ. Health, Part B 10, 417–465.

    Mowat F. S. , 'State-of-thescience review: Does manganese exposure during welding pose a neurological risk? ' (2007 ) 10 J. Toxicol. Environ. Health, Part B : 417 -465.

    • Search Google Scholar
  • Saric, M., Markicevic, A., Hrustic, O. (1977) Occupational exposure to manganese. Br. J. Ind. Med. 34, 114–118.

    Hrustic O. , 'Occupational exposure to manganese ' (1977 ) 34 Br. J. Ind. Med. : 114 -118.

  • Sinczuk-Walczak, H., Jakubowski, M., Matczak, W. (2001) Neurological and neurophysiological examinations of workers occupationally exposed to manganese. Int. J. Occup. Med. Environ. Health 14, 329–337.

    Matczak W. , 'Neurological and neurophysiological examinations of workers occupationally exposed to manganese ' (2001 ) 14 Int. J. Occup. Med. Environ. Health : 329 -337.

    • Search Google Scholar
  • Sjögren, B., Iregren, A., Frech, W., Hagman, M., Johansson, L., Tesarz, M., Wennberg, A. (1996) Effects of the nervous system among welders exposed to aluminium and manganese. Occup. Environ. Med. 53, 32–40.

    Wennberg A. , 'Effects of the nervous system among welders exposed to aluminium and manganese ' (1996 ) 53 Occup. Environ. Med. : 32 -40.

    • Search Google Scholar
  • Takács, Sz., Papp, A. (2010) Effects of antiepileptics and an anesthetic on basal cortical activity and spontaneous motility in an epilepsy-prone rat strain. Acta Physiol. Hung. 97, 480–481.

    Papp A. , 'Effects of antiepileptics and an anesthetic on basal cortical activity and spontaneous motility in an epilepsy-prone rat strain ' (2010 ) 97 Acta Physiol. Hung. : 480 -481.

    • Search Google Scholar
  • Takeda, A., Sawashita, J., Okada, S. (1995) Biological half-lives of zinc and manganese in rat brain. Brain Res. 695, 53–58.

    Okada S. , 'Biological half-lives of zinc and manganese in rat brain ' (1995 ) 695 Brain Res. : 53 -58.

    • Search Google Scholar
  • Tapin, D., Kennedy, G., Lambert, J., Zayed, J. (2006) Bioaccumulation and locomotor effects of manganese sulphate in Sprague-Dawley rats following subchronic (90 days) inhalation exposure. Toxicol. Appl. Pharmacol. 211, 166–174.

    Zayed J. , 'Bioaccumulation and locomotor effects of manganese sulphate in Sprague-Dawley rats following subchronic (90 days) inhalation exposure ' (2006 ) 211 Toxicol. Appl. Pharmacol. : 166 -174.

    • Search Google Scholar
  • Vezér, T., Kurunczi, Á., Náray, M, Papp, A., Nagymajtényi, L. (2007) Behavioral effects of subchronic inorganic manganese exposure in rats. Amer. J. Ind. Med. 50, 841–852.

    Nagymajtényi L. , 'Behavioral effects of subchronic inorganic manganese exposure in rats ' (2007 ) 50 Amer. J. Ind. Med. : 841 -852.

    • Search Google Scholar
  • Vezér, T., Papp, A., Hoyk, Z., Varga, C., Náray, M., Nagymajtényi, L. (2005) Behavioral and neurotoxicological effects of subchronic manganese exposure in rats. Env. Toxicol. Pharmacol. 19, 797–810.

    Nagymajtényi L. , 'Behavioral and neurotoxicological effects of subchronic manganese exposure in rats ' (2005 ) 19 Env. Toxicol. Pharmacol. : 797 -810.

    • Search Google Scholar
  • Young, T., Myers, J. E., Thompson, M. L. (2005) The nervous system effects of occupational exposure to manganese — measured as respirable dust — in a South African manganese smelter. Neurotoxicology 26, 993–1000.

    Thompson M. L. , 'The nervous system effects of occupational exposure to manganese — measured as respirable dust — in a South African manganese smelter ' (2005 ) 26 Neurotoxicology : 993 -1000.

    • Search Google Scholar