Acta Biologica Hungarica
Volume/Issue:
Volume 63: Issue 4
In vitro interactions of amantadine hydrochloride, R-(-)-deprenyl hydrochloride and valproic acid sodium salt with antifungal agents against filamentous fungal species causing central nervous system infection
Authors:
L. Galgóczy University of Szeged Department of Microbiology, Faculty of Science and Informatics Szeged Hungary

Search for other papers by L. Galgóczy in
Current site
Google Scholar
PubMed Close
,
Liliána Tóth University of Szeged Department of Microbiology, Faculty of Science and Informatics Szeged Hungary

Search for other papers by Liliána Tóth in
Current site
Google Scholar
PubMed Close
,
M. Virágh University of Szeged Department of Microbiology, Faculty of Science and Informatics Szeged Hungary

Search for other papers by M. Virágh in
Current site
Google Scholar
PubMed Close
,
T. Papp University of Szeged Department of Microbiology, Faculty of Science and Informatics Szeged Hungary

Search for other papers by T. Papp in
Current site
Google Scholar
PubMed Close
, and
Cs. Vágvölgyi University of Szeged Department of Microbiology, Faculty of Science and Informatics Szeged Hungary

Search for other papers by Cs. Vágvölgyi in
Current site
Google Scholar
PubMed Close
Pages:
490–500
Online Publication Date:
07 Nov 2012
Publication Date:
01 Dec 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.63.2012.4.8
Keywords:
Zygomycetes; Aspergillus spp.; central nervous fungal infection; non-antifungal drugs; antifungal agents; drug interaction
Restricted access

The mortality rates of fungal infections that affect the central nervous system are high in consequence of the absence of effective antifungal drugs with good penetration across the blood-brain barrier and the blood-cerebrospinal fluid barrier. In the present work in vitro antifungal activities of three good penetrating non-antifungal drugs (amantadine hydrochloride, R-(-)-deprenyl hydrochloride, valproic acid sodium salt) and their combinations with three antifungal agents (amphotericin B, itraconazole, terbinafine) were tested with broth microdilution method against eight fungal isolates belonging to Zygomycetes (Lichtheimia corymbifera, Rhizomucor miehei, Rhizopus microsporus var. rhizopodiformis, Saksenaeavasiformis) and Aspergillus genus (A. flavus, A. fumigatus, A. nidulans, A. terreus). These are known to be possible agents of central nervous fungal infections (CNFI). When used alone, the investigated nonantifungal drugs exerted slight antifungal effects. In their combinations with antifungal agents they acted antagonistically, additively and synergistically against zygomyceteous isolates. Primarily antagonistic interactions were revealed between the investigated drugs in case of Aspergilli, but additive and synergistic interactions were also observed. The additive and synergistic combinations allowed the usage of reduced concentrations of antifungal agents to inhibit the fungal growth in our study. These combinations would be a basis of an effective, less toxic therapy for treatment of CNFI.

  • Abraham, O. C., Manavathu, E. K., Cutright, J. L., Chandrasekar, P. H. (1999) In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B. Diagn. Microbiol. Infect. Dis. 33, 7–11.

    Chandrasekar P. H. , 'In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B ' (1999 ) 33 Diagn. Microbiol. Infect. Dis. : 7 -11 .

    • Search Google Scholar

  • Afeltra, J., Verweij, P. E. (2003) Antifungal activity of nonantifungal drugs. Eur. J. Clin. Microbiol. Infect. Dis. 22, 397–407.

    Verweij P. E. , 'Antifungal activity of nonantifungal drugs ' (2003 ) 22 Eur. J. Clin. Microbiol. Infect. Dis. : 397 -407 .

    • Search Google Scholar

  • Azzaro, A. J., Ziemniak, J., Kemper, E., Campbell, B. J., Van Den Berg, C. (2007) Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J. Clin. Pharmacol. 47, 1256–1267.

    Berg C. , 'Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules ' (2007 ) 47 J. Clin. Pharmacol. : 1256 -1267 .

    • Search Google Scholar

  • Baddley, J. W., Salzman, D., Pappas, P. G. (2002) Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features. Clin. Transplant. 16, 419–424.

    Pappas P. G. , 'Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features ' (2002 ) 16 Clin. Transplant. : 419 -424 .

    • Search Google Scholar

  • Bazinet, R. P., Weis, M. T., Rapoport, S. I., Rosenberger, T. A. (2006) Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. Psychopharmacology (Berl.) 184, 122–129.

    Rosenberger T. A. , 'Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder ' (2006 ) 184 Psychopharmacology (Berl.) : 122 -129 .

    • Search Google Scholar

  • Blum, G., Perkhofer, S., Haas, H., Schrettl, M., Würzner, R., Dierich, M. P., Lass-Flörl, C. (2008) Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob. Agents. Chemother. 52, 1553–1555.

    Lass-Flörl C. , 'Potential basis for amphotericin B resistance in Aspergillus terreus ' (2008 ) 52 Antimicrob. Agents. Chemother. : 1553 -1555 .

    • Search Google Scholar

  • Chakrabarti, A., Marak, R. S. K., Singhi, S., Gupta, S., Hurst, S. F., Padhye, A. A. (2005) Brain abscess due to Aspergillus nidulans. J. Mycol. Med. 16, 100–104.

    Padhye A. A. , 'Brain abscess due to Aspergillus nidulans ' (2005 ) 16 J. Mycol. Med. : 100 -104 .

    • Search Google Scholar

  • Cohen, R. A., Fisher, M. (1989) Amantadine treatment of fatigue associated with multiple sclerosis. Arch. Neurol. 46, 676–680.

    Fisher M. , 'Amantadine treatment of fatigue associated with multiple sclerosis ' (1989 ) 46 Arch. Neurol. : 676 -680 .

    • Search Google Scholar

  • Crosby, N., Deane, K. H., Clarke, C. E. (2003) Amantadine in Parkinson’s disease. Cochrane Database Syst. Rev. 1, CD003468.

    Clarke C. E. , 'Amantadine in Parkinson’s disease ' (2003 ) 1 Cochrane Database Syst. Rev. : CD003468 -.

    • Search Google Scholar

  • Dannaoui, E., Persat, F., Monier, M. F., Borel, E., Piens, M. A., Picot, S. (1999) In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole. J. Antimicrob. Chemother. 44, 553–555.

    Picot S. , 'In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole ' (1999 ) 44 J. Antimicrob. Chemother. : 553 -555 .

    • Search Google Scholar

  • Dannaoui, E., Meletiadis, J., Mouton, J. W., Meis, J. F., Verweij, P. E., Eurofung Network (2003) In vitro susceptibilities of zygomycetes to conventional and new antifungals. J. Antimicrob. Chemother. 51, 45–52.

    Verweij P. E. , 'In vitro susceptibilities of zygomycetes to conventional and new antifungals ' (2003 ) 51 J. Antimicrob. Chemother. : 45 -52 .

    • Search Google Scholar

  • Deyde, V. M., Xu, X., Bright, R. A., Shaw, M., Smith, C. B., Zhang, Y., Shu, Y., Gubareva, L. V., Cox, N. J., Klimov, A. I. (2007) Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J. Infect. Dis. 196, 249–257.

    Klimov A. I. , 'Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide ' (2007 ) 196 J. Infect. Dis. : 249 -257 .

    • Search Google Scholar

  • Dotis, J., Roilides, E. (2007) Immunopathogenesis of central nervous system fungal infections. Neurol. India 55, 216–220.

    Roilides E. , 'Immunopathogenesis of central nervous system fungal infections ' (2007 ) 55 Neurol. India : 216 -220 .

    • Search Google Scholar

  • Eliopoulos, G. M., Moellering, R. C. (1996) Antimicrobial combinations. In: Lorian, V. (ed.) Antibiotics in Laboratory Medicine, 4th edn. Williams and Wilkins, Baltimore MD, USA, pp. 330–396.

    Moellering R. C. , '', in Antibiotics in Laboratory Medicine, 4th edn , (1996 ) -.

  • Eltoukhy, N. S., Crank, C. W. (2010) Antifungal distribution into cerebrospinal fluid, vitreous humor, bone, and other difficult sites. Curr. Fungal. Infect. Rep. 4, 111–119.

    Crank C. W. , 'Antifungal distribution into cerebrospinal fluid, vitreous humor, bone, and other difficult sites ' (2010 ) 4 Curr. Fungal. Infect. Rep. : 111 -119 .

    • Search Google Scholar

  • Gallagher, C. G., Ashley, E. S. D., Drew, R. H., Perfect, J. R. (2003) Antifungal pharmacotherapy for invasive mould infections. Expert Opin. Pharm. 4, 147–164.

    Perfect J. R. , 'Antifungal pharmacotherapy for invasive mould infections ' (2003 ) 4 Expert Opin. Pharm. : 147 -164 .

    • Search Google Scholar

  • Garcia-Effron, G., Gomez-Lopez, A., Mellado, E., Monzon, A., Rodriguez-Tudela, J. L., Cuenca-Estrella, M. (2004) In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi. J. Antimicrob. Chemother. 53, 1086–1089.

    Cuenca-Estrella M. , 'In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi ' (2004 ) 53 J. Antimicrob. Chemother : 1086 -1089 .

    • Search Google Scholar

  • Gómez-López, A., Cuenca-Estrella, M., Mellado, E., Rodríguez-Tudela, J. L. (2003) In vitro evaluation of combination of terbinafine with itraconazole or amphotericin B against Zygomycota. Diagn. Microbiol. Infect. Dis. 45, 199–202.

    Rodríguez-Tudela J. L. , 'In vitro evaluation of combination of terbinafine with itraconazole or amphotericin B against Zygomycota ' (2003 ) 45 Diagn. Microbiol. Infect. Dis. : 199 -202 .

    • Search Google Scholar

  • Groll, A. H., Giri, N., Petraitis, V., Petraitiene, R., Candelario, M., Bacher, J. S., Piscitelli, S. C., Walsh, T. J. (2000) Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system. J. Infect. Dis. 182, 274–282.

    Walsh T. J. , 'Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system ' (2000 ) 182 J. Infect. Dis. : 274 -282 .

    • Search Google Scholar

  • Hosseini-Yeganeh, M., McLachlan, A. J. (2001) Tissue distribution of terbinafine in rats. J. Pharm. Sci. 90, 1817–1828.

    McLachlan A. J. , 'Tissue distribution of terbinafine in rats ' (2001 ) 90 J. Pharm. Sci. : 1817 -1828 .

    • Search Google Scholar

  • Hosseini-Yeganeh, M., McLachlan, A. J. (2002) Physiologically based pharmacokinetic model for terbinafine in rats and humans. Antimicrob. Agents. Chemother. 46, 2219–2228.

    McLachlan A. J. , 'Physiologically based pharmacokinetic model for terbinafine in rats and humans ' (2002 ) 46 Antimicrob. Agents. Chemother. : 2219 -2228 .

    • Search Google Scholar

  • Imbert, F., Jardin, M., Fernandez, C., Gantier, J. C., Dromer, F., Baron, G., Mentre, F., Van Beijsterveldt, L., Singlas, E., Gimenez, F. (2003) Effect of efflux inhibition on brain uptake of itraconazole in mice infected with Cryptococcus neoformans. Drug Metab. Dispos. 31, 319–325.

    Gimenez F. , 'Effect of efflux inhibition on brain uptake of itraconazole in mice infected with Cryptococcus neoformans ' (2003 ) 31 Drug Metab. Dispos. : 319 -325 .

    • Search Google Scholar

  • Karaarslan, A., Arikan, S., Ozcan, M., Ozcan, K. M. (2004) In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis. Mycoses. 47, 284–287.

    Ozcan K. M. , 'In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis ' (2004 ) 47 Mycoses. : 284 -287 .

    • Search Google Scholar

  • Kontoyiannis, D. P., Lewis, R. E., May, G. S., Osherov, N., Rinaldi, M. G. (2002) Aspergillus nidulans is frequently resistant to amphotericin B. Mycoses. 45, 406–407.

    Rinaldi M. G. , 'Aspergillus nidulans is frequently resistant to amphotericin B ' (2002 ) 45 Mycoses. : 406 -407 .

    • Search Google Scholar

  • Kornhuber, J., Quack, G., Danysz, W., Jellinger, K., Danielczyk, W., Gsell, W., Riederer, P. (1995) Therapeutic brain concentration of the NMDA receptor antagonist amantadine. Neuropharmacology. 34, 713–721.

    Riederer P. , 'Therapeutic brain concentration of the NMDA receptor antagonist amantadine ' (1995 ) 34 Neuropharmacology. : 713 -721 .

    • Search Google Scholar

  • Kurita, M., Nishino, S., Ohtomo, K., Rai, M., Shirakawa, H., Mashiko, H., Niwa, S., Nakahata, N. (2007) Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. Prog. Neuropsychopharmacol. Biol. Psychiatry 31, 600–604.

    Nakahata N. , 'Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells ' (2007 ) 31 Prog. Neuropsychopharmacol. Biol. Psychiatry : 600 -604 .

    • Search Google Scholar

  • Mahmood, I. (1997) Clinical pharmacokinetics and pharmacodynamics of selegiline. An update. Clin. Pharmacokinet. 33, 91–102.

    Mahmood I. , 'Clinical pharmacokinetics and pharmacodynamics of selegiline. An update ' (1997 ) 33 Clin. Pharmacokinet. : 91 -102 .

    • Search Google Scholar

  • Meletiadis, J., te Dorsthorst, D. T. A., Verweij, P. E. (2006) The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions. Int. J. Antimicrob. Agents. 28, 439–449.

    Verweij P. E. , 'The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions ' (2006 ) 28 Int. J. Antimicrob. Agents. : 439 -449 .

    • Search Google Scholar

  • Minassian, B., Huczko, E., Washo, T., Bonner, T., Fung-Tomc, J. (2003) In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates. Clin. Microbiol. Infect. 9, 1250–1252.

    Fung-Tomc J. , 'In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates ' (2003 ) 9 Clin. Microbiol. Infect. : 1250 -1252 .

    • Search Google Scholar

  • Misra, R., Malik, A., Singhal, S. (2011) Comparison of the activities of amphotericin B, itraconazole, and voriconazole against clinical and environmental isolates of Aspergillus species. Indian. J. Pathol. Microbiol. 54, 112–116.

    Singhal S. , 'Comparison of the activities of amphotericin B, itraconazole, and voriconazole against clinical and environmental isolates of Aspergillus species ' (2011 ) 54 Indian. J. Pathol. Microbiol. : 112 -116 .

    • Search Google Scholar

  • Moosa, M. Y., Alangaden, G. J., Manavathu, E., Chandrasekar, P. H. (2002) Resistance to amphotericin B does not emerge during treatment for invasive aspergillosis. J. Antimicrob. Chemother. 49, 209–213.

    Chandrasekar P. H. , 'Resistance to amphotericin B does not emerge during treatment for invasive aspergillosis ' (2002 ) 49 J. Antimicrob. Chemother. : 209 -213 .

    • Search Google Scholar

  • Moreno, A. B., del Pozo, A. M., Borja, M., San Segudo, B. (2003) Activity of the antifungal protein from Aspergillus giganteus against Botrytis cinerea. Phytopathology 93, 1344–1353.

    San Segudo B. , 'Activity of the antifungal protein from Aspergillus giganteus against Botrytis cinerea ' (2003 ) 93 Phytopathology : 1344 -1353 .

    • Search Google Scholar

  • Murthy, J. M. (2007) Fungal infections of the central nervous system: the clinical syndromes. Neurol. India 55, 221–225.

    Murthy J. M. , 'Fungal infections of the central nervous system: the clinical syndromes ' (2007 ) 55 Neurol. India : 221 -225 .

    • Search Google Scholar

  • Nadkarni, T., Goel, A. (2005) Aspergilloma of the brain: an overview. J. Postgrad. Med. 51Suppl. uppl. 1, S37–41.

    Goel A. , 'Aspergilloma of the brain: an overview ' (2005 ) 51 J. Postgrad. Med. : S37 -41 .

    • Search Google Scholar

  • National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard (2002) NCCLS document M38-A. NCCLS, Wayne, Pennsylvania, USA.

    '', in NCCLS document M38-A , (2002 ) -.

  • Nosanchuk, J. D. (2006) Current status and future of antifungal therapy for systemic mycoses. Recent Pat. Antiinfect. Drug Discov. 1, 75–84.

    Nosanchuk J. D. , 'Current status and future of antifungal therapy for systemic mycoses ' (2006 ) 1 Recent Pat. Antiinfect. Drug Discov. : 75 -84 .

    • Search Google Scholar

  • Odds, F. C. (2003) Synergy, antagonism, and what the chequerboard puts between them. J. Antimicrob. Chemother. 52, 1.

    Odds F. C. , 'Synergy, antagonism, and what the chequerboard puts between them ' (2003 ) 52 J. Antimicrob. Chemother. : 1 -.

    • Search Google Scholar

  • Rath, P. M. (1998) Susceptibility of Aspergillus strains from culture collections to amphotericin B and itraconazole. J. Antimicrob. Chemother. 41, 567–570.

    Rath P. M. , 'Susceptibility of Aspergillus strains from culture collections to amphotericin B and itraconazole ' (1998 ) 41 J. Antimicrob. Chemother. : 567 -570 .

    • Search Google Scholar

  • Ribes, J. A., Vanhover-Sams, C. L., Baker, D. J. (2000) Zygomycetes in human disease. Clin. Microbiol. Rev. 13, 236–301.

    Baker D. J. , 'Zygomycetes in human disease ' (2000 ) 13 Clin. Microbiol. Rev. : 236 -301 .

    • Search Google Scholar

  • Sabatelli, F., Patel, R., Mann, P. A., Mendrick, C. A., Norris, C. C., Hare, R., Loebenberg, D., Black, T. A., McNicholas, P. M. (2006) In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob. Agents Chemother. 50, 2009–2015.

    McNicholas P. M. , 'In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts ' (2006 ) 50 Antimicrob. Agents Chemother. : 2009 -2015 .

    • Search Google Scholar

  • Schwartz, S., Ruhnke, M., Ribaud, P., Reed, E., Troke, P., Thiel, E. (2007) Poor efficacy of amphotericin B-based therapy in CNS aspergillosis. Mycoses. 50, 196–200.

    Thiel E. , 'Poor efficacy of amphotericin B-based therapy in CNS aspergillosis ' (2007 ) 50 Mycoses. : 196 -200 .

    • Search Google Scholar

  • Schwartz, S., Thiel, E. (2009) Cerebral aspergillosis: tissue penetration is the key. Med. Mycol. 47Suppl. uppl. 1, S387–393.

    Thiel E. , 'Cerebral aspergillosis: tissue penetration is the key ' (2009 ) 47 Med. Mycol. : S387 -393 .

    • Search Google Scholar

  • Scully, E. P., Baden, L. R., Katz, J. T. (2008) Fungal brain infections. Curr. Opin. Neurol. 21, 347–352.

    Katz J. T. , 'Fungal brain infections ' (2008 ) 21 Curr. Opin. Neurol. : 347 -352 .

  • Sharma, R.R. (2010) Fungal infections of the nervous system: current perspective and controversies in management. Int. J. Surg. 8, 591–601.

    Sharma R.R. , 'Fungal infections of the nervous system: current perspective and controversies in management ' (2010 ) 8 Int. J. Surg. : 591 -601 .

    • Search Google Scholar

  • Skiada, A., Vrana, L., Polychronopoulou, H., Prodromou, P., Chantzis, A., Tofas, P., Daikos, G. L. (2009) Disseminated zygomycosis with involvement of the central nervous system. Clin. Microbiol. Infect. 15Suppl. uppl. 5, 46–49.

    Daikos G. L. , 'Disseminated zygomycosis with involvement of the central nervous system ' (2009 ) 15 Clin. Microbiol. Infect. : 46 -49 .

    • Search Google Scholar

  • Smith, J., Andes, D. R. (2006) Pharmacokinetics of antifungals: Implications for drug selections. Infect. Med. 23, 328–333.

    Andes D. R. , 'Pharmacokinetics of antifungals: Implications for drug selections ' (2006 ) 23 Infect. Med. : 328 -333 .

    • Search Google Scholar

  • Sun, Q. N., Fothergill, A. W., McCarthy, D. I., Rinaldi, M. G., Graybill, J. R. (2002) In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes. Antimicrob. Agents. Chemother. 46, 1581–1582.

    Graybill J. R. , 'In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes ' (2002 ) 46 Antimicrob. Agents. Chemother. : 1581 -1582 .

    • Search Google Scholar

  • Sutton, D. A., Sanche, S. E., Revankar, S. G., Fothergill, A. W., Rinaldi, M. G. (1999) In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole. J. Clin. Microbiol. 37, 2343–2345.

    Rinaldi M. G. , 'In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole ' (1999 ) 37 J. Clin. Microbiol. : 2343 -2345 .

    • Search Google Scholar

  • van der Linden, J. W., Jansen, R. R., Bresters, D., Visser, C. E., Geerlings, S. E., Kuijper, E. J., Melchers, W. J., Verweij, P. E. (2009) Azole-resistant central nervous system aspergillosis. Clin. Infect. Dis. 48, 1111–1113.

    Verweij P. E. , 'Azole-resistant central nervous system aspergillosis ' (2009 ) 48 Clin. Infect. Dis. : 1111 -1113 .

    • Search Google Scholar

  • Vazquez, J. A. (2007) Combination antifungal therapy: the new frontier. Future Microbiol. 2, 115–139.

    Vazquez J. A. , 'Combination antifungal therapy: the new frontier ' (2007 ) 2 Future Microbiol. : 115 -139 .

    • Search Google Scholar

  • Vyzantiadis, T. A., Kioumi, A., Papadakis, E., Braimi, M., Dermitzakis, E., Tsitouridis, I., Antoniadis, A. (2002) Rhino-cerebral zygomycosis resistant to antimycotic treatment: a case report. Mycoses. 52, 87–90.

    Antoniadis A. , 'Rhino-cerebral zygomycosis resistant to antimycotic treatment: a case report ' (2002 ) 52 Mycoses. : 87 -90 .

    • Search Google Scholar

  • Yasar, S., Justinova, Z., Lee, S. H., Stefanski, R., Goldberg, S. R., Tanda, G. (2006) Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl]. J. Pharmacol. Exp. Ther. 317, 387–394.

    Tanda G. , 'Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl] ' (2006 ) 317 J. Pharmacol. Exp. Ther. : 387 -394 .

    • Search Google Scholar
  • Collapse
  • Expand
Cover Acta Biologica Hungarica
Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

Senior editors

Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2024 34 0 0
Jan 2025 54 0 0
Feb 2025 54 0 0
Mar 2025 62 1 2
Apr 2025 46 0 0
May 2025 4 0 0
Jun 2025 0 0 0