Acta Biologica Hungarica
Volume/Issue:
Volume 65: Issue 4
The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion
A review
Authors:
Eszter László PTE-MTA PACAP “Lendület” Research Team Department of Anatomy Pécs Hungary

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,
P. Kiss PTE-MTA PACAP “Lendület” Research Team Department of Anatomy Pécs Hungary

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Gabriella Horváth PTE-MTA PACAP “Lendület” Research Team Department of Anatomy Pécs Hungary

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,
P. Szakály University of Pécs Department of Surgery Pécs Hungary

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Andrea Tamás PTE-MTA PACAP “Lendület” Research Team Department of Anatomy Pécs Hungary

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, and
Dóra Reglődi PTE-MTA PACAP “Lendület” Research Team Department of Anatomy Pécs Hungary

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Pages:
369–378
Online Publication Date:
04 Dec 2014
Publication Date:
01 Dec 2014
Article Category:
Research Article
DOI:
https://doi.org/10.1556/abiol.65.2014.4.1
Keywords:
Kidney; ischemia/reperfusion; PACAP; renoprotection
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Pituitary adenylate cyclase activating polypeptide (PACAP ) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycin- and cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.

  • Arimura, A., Somogyvári-Vigh, A., Miyata, A., Mizuno, K., Coy, D. H., Kitada, C. (1991) Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology 129, 2787–2789.

    Kitada C. , 'Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes ' (1991 ) 129 Endocrinology : 2787 -2789 .

    • Search Google Scholar

  • Arimura, A., Li, M., Batuman, V. (2006) Potential protective action of pituitary adenylate cyclase activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury. Blood 107, 661–668.

    Batuman V. , 'Potential protective action of pituitary adenylate cyclase activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury ' (2006 ) 107 Blood : 661 -668 .

    • Search Google Scholar

  • Arimura, A., Li, M., Batuman, V. (2006) Treatment of renal failure associated with multiple myeloma and other diseases by PACAP-38. Ann. NY Acad. Sci. 1070, 14.

    Batuman V. , 'Treatment of renal failure associated with multiple myeloma and other diseases by PACAP-38 ' (2006 ) 1070 Ann. NY Acad. Sci. : 14 -.

    • Search Google Scholar

  • Atlasz, T., Babai, N., Kiss, P., Reglodi, D., Tamas, A., Szabadfi, K., Toth, G., Hegyi, O., Lubics, A., Gabriel, R. (2007) Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats. Gen. Comp. 153, 108–114.

    Gabriel R. , 'Pituitary adenylate cyclase activating polypeptide is protective in bilateral carotid occlusion-induced retinal lesion in rats ' (2007 ) 153 Gen. Comp. : 108 -114 .

    • Search Google Scholar

  • Bánki, E., Degrell, P., Kiss, P., Kovacs, K., Kemeny, A., Csanaky, K., Duh, A., Nagy, D., Toth, G., Tamas, A., Reglodi, D. (2013) Effect of PACAP treatment on kidney morphology and cytokine expression in rat diabetic nephropathy. Peptides 42, 125–130.

    Reglodi D. , 'Effect of PACAP treatment on kidney morphology and cytokine expression in rat diabetic nephropathy ' (2013 ) 42 Peptides : 125 -130 .

    • Search Google Scholar

  • Basile, D. P., Martin, D. R., Hammerman, M. R. (1998) Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-beta in repair. Am. J. Physiol. 275, 894–903.

    Hammerman M. R. , 'Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-beta in repair ' (1998 ) 275 Am. J. Physiol. : 894 -903 .

    • Search Google Scholar

  • Brubel, R., Horvath, G., Reglodi, D., Lubics, A., Tamas, A., Kiss, P., Laszlo, E., Nemeth, J., Mark, L., Szakaly, P. (2011) Presence of pituitary adenylate cyclase activating polypeptide and its type I receptor in the rat kidney. Transplant. Proc. 43, 1297–1299.

    Szakaly P. , 'Presence of pituitary adenylate cyclase activating polypeptide and its type I receptor in the rat kidney ' (2011 ) 43 Transplant. Proc. : 1297 -1299 .

    • Search Google Scholar

  • Ferencz, A., Racz, B,. Tamas, A., Reglodi, D., Lubics, A., Nemeth, J., Nedvig, K., Kalmar-Nagy, K., Horvath, O. P., Weber, G., Roth, E. (2009) Influence of PACAP on oxidative stress and tissue injury following small bowel autotransplantation. J. Mol. Neurosci. 37, 168–176.

    Roth E. , 'Influence of PACAP on oxidative stress and tissue injury following small bowel autotransplantation ' (2009 ) 37 J. Mol. Neurosci. : 168 -176 .

    • Search Google Scholar

  • Ferencz, A., Kiss, P., Weber, Gy., Helyes, Z., Shintani, N., Baba, A., Reglodi, D. (2010) Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice. J. Mol. Neurosci. 42, 435–442.

    Reglodi D. , 'Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice ' (2010 ) 42 J. Mol. Neurosci. : 435 -442 .

    • Search Google Scholar

  • Ferencz, A., Weber, Gy., Helyes, Z., Hashimoto, H., Baba, A., Reglodi, D. (2010) Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury. J. Mol. Neurosci. 42, 428–434.

    Reglodi D. , 'Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury ' (2010 ) 42 J. Mol. Neurosci. : 428 -434 .

    • Search Google Scholar

  • Gardiner, S. M., Rakhit, T., Kemp, P. A., March, J. E., Bennett, T. (1994) Regional haemodynamic responses to pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in conscious rats. Br. J. Pharmacol. 111, 589–597.

    Bennett T. , 'Regional haemodynamic responses to pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in conscious rats ' (1994 ) 111 Br. J. Pharmacol. : 589 -597 .

    • Search Google Scholar

  • Harmar, A. J., Sheward, W. J., Morrison, C. F., Waser, B., Gugger, M., Reubi, J. C. (2004) Distribution of the VPAC 2 receptor in peripheral tissues of the mouse. Endocrinology 145, 1203–1210.

    Reubi J. C. , 'Distribution of the VPAC 2 receptor in peripheral tissues of the mouse ' (2004 ) 145 Endocrinology : 1203 -1210 .

    • Search Google Scholar

  • Hautmann, M., Friis, U. G., Desch, M., Todorov, V., Castrop, H., Segerer, F., Otto, C., Schutz, G., Schweda, F. (2007) Pituitary adenylate cyclase activating polypeptide stimulates renin secretion via activation of PAC 1 receptors. J. Am. Soc. Nephrol. 18, 1150–1156.

    Schweda F. , 'Pituitary adenylate cyclase activating polypeptide stimulates renin secretion via activation of PAC 1 receptors ' (2007 ) 18 J. Am. Soc. Nephrol. : 1150 -1156 .

    • Search Google Scholar

  • Horvath, G., Mark, L., Brubel, R., Szakaly, P., Racz, B., Kiss, P., Tamas, A., Helyes, Z., Lubics, A., Hashimoto, H., Baba, A., Shintani, S., Furjes, G., Nemeth, J., Reglodi, D. (2010) Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro. Neurosci. Lett. 469, 70–74.

    Reglodi D. , 'Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro ' (2010 ) 469 Neurosci. Lett. : 70 -74 .

    • Search Google Scholar

  • Horvath, G., Racz, B., Reglodi, D., Kovacs, K., Kiss, P., Gallyas Jr., F., Bognar, Z., Szabo, A., Magyarlaki, T., Laszlo, E., Lubics, A., Tamas, A., Toth, G., Szakaly, P. (2010) Effects of PACAP on mitochondrial apoptotic pathways and cytokine expression in rats subjected to renal ischemia/reperfusion. J. Mol. Neurosci. 42, 411–418.

    Szakaly P. , 'Effects of PACAP on mitochondrial apoptotic pathways and cytokine expression in rats subjected to renal ischemia/reperfusion ' (2010 ) 42 J. Mol. Neurosci. : 411 -418 .

    • Search Google Scholar

  • Horvath, G., Racz, B., Szakaly, P., Kiss, P., Laszlo, E., Hau, L., Tamas, A., Helyes, Z., Lubics, A., Hashimoto, H., Baba, A., Reglodi, D. (2010) Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia. Transplant. Proc. 42, 2293–2295.

    Reglodi D. , 'Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia ' (2010 ) 42 Transplant. Proc. : 2293 -2295 .

    • Search Google Scholar

  • Horvath, G., Brubel, R., Kovacs, K., Reglodi, D., Opper, B., Ferencz, A., Szakaly, P., Laszlo, E., Hau, L., Kiss, P., Tamas, A., Racz, B. (2011) Effects of PACAP on oxidative stress-induced cell death in primary rat kidney and human hepatocyte cell cultures. J. Mol. Neurosci. 43, 67–75.

    Racz B. , 'Effects of PACAP on oxidative stress-induced cell death in primary rat kidney and human hepatocyte cell cultures ' (2011 ) 43 J. Mol. Neurosci. : 67 -75 .

    • Search Google Scholar

  • Jain, S., Bicknell, G. R., Nicholson, M. L. (2000) Molecular changes in extracellular matrix turnover after renal ischemia-reperfusion injury. Br. J. Surg. 87, 1188–1192.

    Nicholson M. L. , 'Molecular changes in extracellular matrix turnover after renal ischemia-reperfusion injury ' (2000 ) 87 Br. J. Surg. : 1188 -1192 .

    • Search Google Scholar

  • Jang, H. R., Gandolfo, M. T., Ko, G. J., Satpute, S. R., Racusen, L., Rabb, H. (2010) B cells limit repair after ischemic acute kindey injury. J. Am. Soc. Nephrol. 21, 654–665.

    Rabb H. , 'B cells limit repair after ischemic acute kindey injury ' (2010 ) 21 J. Am. Soc. Nephrol. : 654 -665 .

    • Search Google Scholar

  • Ji, H., Zhang, Y., Shen, X. D., Gao, F., Huang, C. Y., Abad, C., Busuttil, R. W., Waschek, J. A., Kupiec-Weglinski, J. W. (2013) Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. Hepatology 57, 1225–1237.

    Kupiec-Weglinski J. W. , 'Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway ' (2013 ) 57 Hepatology : 1225 -1237 .

    • Search Google Scholar

  • Khan, A. M., Li, M., Brant, E., Maderdrut, J. L., Majid, D. S. A., Simon, E. E., Batuman, V. (2011) Renoprotection with pituitary adenylate cyclase activating polypeptide in cyclosporin A-induced nephrotoxicity. J. Invest. Med. 59, 793–802.

    Batuman V. , 'Renoprotection with pituitary adenylate cyclase activating polypeptide in cyclosporin A-induced nephrotoxicity ' (2011 ) 59 J. Invest. Med. : 793 -802 .

    • Search Google Scholar

  • Khan, A. M., Li, M., Abdulnour-Nakhoul, S., Maderdrut, J. L., Simon, E. E., Batuman, V. (2012) Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors. Peptides 38, 395–403.

    Batuman V. , 'Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors ' (2012 ) 38 Peptides : 395 -403 .

    • Search Google Scholar

  • Laburthe, M., Couvineau, A., Tan, V. (2007) Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology. Peptides 28, 1631–1639.

    Tan V. , 'Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology ' (2007 ) 28 Peptides : 1631 -1639 .

    • Search Google Scholar

  • Lam, H. C., Takahashi, K., Ghatei, M. A., Kanse, S. M., Polak, J. M., Bloom, S. R. (1990) Binding sites of a novel neuropeptide pituitary adenylate cyclase activating polypeptide in the rat brain and lung. Eur. J. Biochem. 193, 725–729.

    Bloom S. R. , 'Binding sites of a novel neuropeptide pituitary adenylate cyclase activating polypeptide in the rat brain and lung ' (1990 ) 193 Eur. J. Biochem. : 725 -729 .

    • Search Google Scholar

  • Li, M., Cortez, S., Nakamachi, T., Batuman, V., Arimura, A. (2006) Pituitary adenylate cyclase activating polypeptide is a potent inhibitor of the growth of light chain-secreting human multiple myeloma cells. Cancer Res. 66, 8796–8803.

    Arimura A. , 'Pituitary adenylate cyclase activating polypeptide is a potent inhibitor of the growth of light chain-secreting human multiple myeloma cells ' (2006 ) 66 Cancer Res. : 8796 -8803 .

    • Search Google Scholar

  • Li, M., Maderdrut, J. L., Lertora, J. J. L., Batuman, V. (2007) Intravenous infusion of pituitary adenylate cyclase activating polypeptide (PACAP ) in a patient with multiple myeloma and myeloma kidney: a case study. Peptides 28, 1891–1895.

    Batuman V. , 'Intravenous infusion of pituitary adenylate cyclase activating polypeptide (PACAP ) in a patient with multiple myeloma and myeloma kidney: a case study ' (2007 ) 28 Peptides : 1891 -1895 .

    • Search Google Scholar

  • Li, M., Maderdrut, J. L., Lertora, J. J. L., Arimura, A., Batuman, V. (2008) Renoprotection by pituitary adenylate cyclase activating polypeptide in multiple myeloma and other kidney diseases. Regul. Pept. 145, 24–32.

    Batuman V. , 'Renoprotection by pituitary adenylate cyclase activating polypeptide in multiple myeloma and other kidney diseases ' (2008 ) 145 Regul. Pept. : 24 -32 .

    • Search Google Scholar

  • Li, M., Balamuthusamy, S., Khan, A. M., Maderdrut, J. L., Simon, E. E., Batuman, V. (2010) Pituitary adenylate cyclase activating polypeptide ameliorates cisplatin-induced acute kidney injury. Peptides 31, 592–602.

    Batuman V. , 'Pituitary adenylate cyclase activating polypeptide ameliorates cisplatin-induced acute kidney injury ' (2010 ) 31 Peptides : 592 -602 .

    • Search Google Scholar

  • Li, M., Khan, A. M., Maderdrut, J. L., Simon, E. E., Batuman, V. (2010) The effect of PACAP 38 on MyD88-mediated signal transduction in ischemia/hypoxia-induced acute kidney injury. Am. J. Nephrol. 32, 522–532.

    Batuman V. , 'The effect of PACAP 38 on MyD88-mediated signal transduction in ischemia/hypoxia-induced acute kidney injury ' (2010 ) 32 Am. J. Nephrol. : 522 -532 .

    • Search Google Scholar

  • Li, M., Balamuthusamy, S., Khan, A. M., Maderdrut, J. L., Simon, E. E., Batuman, V. (2011) Pituitary adenylate cyclase activating polypeptide prevents cisplatin-induced renal failure. J. Mol. Neurosci. 43, 58–66.

    Batuman V. , 'Pituitary adenylate cyclase activating polypeptide prevents cisplatin-induced renal failure ' (2011 ) 43 J. Mol. Neurosci. : 58 -66 .

    • Search Google Scholar

  • Menger, M. D., Vollmar, B. (2007) Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds? Transplant. Proc. 39, 485–488.

    Vollmar B. , 'Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds ' (2007 ) 39 Transplant. Proc. : 485 -488 .

    • Search Google Scholar

  • Reglodi, D., Somogyvari-Vigh, A., Vigh, S., Kozicz, T., Arimura, A. (2000) Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke 31, 1411–1417.

    Arimura A. , 'Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat ' (2000 ) 31 Stroke : 1411 -1417 .

    • Search Google Scholar

  • Reglodi, D., Kiss, P., Lubics, A., Tamas, A. (2011) Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo. Curr. Pharm. Des. 17, 962–972.

    Tamas A. , 'Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo ' (2011 ) 17 Curr. Pharm. Des. : 962 -972 .

    • Search Google Scholar

  • Reglodi, D., Kiss, P., Horvath, G, Lubics, A., Laszlo, E., Tamas, A., Racz, B., Szakaly, P. (2012) Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney. Neuropeptides 46, 61–70.

    Szakaly P. , 'Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney ' (2012 ) 46 Neuropeptides : 61 -70 .

    • Search Google Scholar

  • Reglodi, D., Kiss, P., Szabadfi, K., Atlasz, T., Gabriel, R., Horvath, G., Szakaly, P., Sandor, B., Lubics, A., Laszlo, E., Farkas, J., Matkovits, A., Brubel, R., Hashimoto, H., Ferencz, A., Vincze, A., Helyes, Z., Welke, L., Lakatos, A., Tamas, A. (2012) PACAP is an endogenous protective factor-insights from PACAP-deficient mice. J. Mol. Neurosci. 48, 482–492.

    Tamas A. , 'PACAP is an endogenous protective factor-insights from PACAP-deficient mice ' (2012 ) 48 J. Mol. Neurosci. : 482 -492 .

    • Search Google Scholar

  • Reubi, J. C. (2000) In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications. Ann. NY Acad. Sci. 921, 1–25.

    Reubi J. C. , 'In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications ' (2000 ) 921 Ann. NY Acad. Sci. : 1 -25 .

    • Search Google Scholar

  • Reubi, J. C., Laderach, U., Waser, B., Gebbers, J. O., Robberecht, P., Laissue, J. A. (2000) Vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor subtypes in human tumors and their tissues of origin. Cancer Res. 60, 3105–3112.

    Laissue J. A. , 'Vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor subtypes in human tumors and their tissues of origin ' (2000 ) 60 Cancer Res. : 3105 -3112 .

    • Search Google Scholar

  • Riera, M., Torras, J., Cruzado, J. M., Lloberas, N., Liron, J., Herrero, I., Navarro, M. A., Grinyo, J. M. (2001) The enhancement of endogenous cAMP with pituitary adenylate cyclase activating polypeptide protects rat kidney against ischemia through the modulation of inflammatory response. Transplantation 72, 1217–1223.

    Grinyo J. M. , 'The enhancement of endogenous cAMP with pituitary adenylate cyclase activating polypeptide protects rat kidney against ischemia through the modulation of inflammatory response ' (2001 ) 72 Transplantation : 1217 -1223 .

    • Search Google Scholar

  • Roth, E., Weber, G., Kiss, P., Horvath, G., Toth, G., Gasz, B., Ferencz, A., Gallyas, F. Jr., Reglodi, D., Racz, B. (2009) Effects of PACAP and preconditioning against ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro. Ann. NY Acad. Sci. 1163, 512–516.

    Racz B. , 'Effects of PACAP and preconditioning against ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro ' (2009 ) 1163 Ann. NY Acad. Sci. : 512 -516 .

    • Search Google Scholar

  • Saikumar, P., Venkatachalam, M. A. (2003) Role of apoptosis in hypoxic/ischemic damage in the kidney. Semin Nephrol. 23, 511–521.

    Venkatachalam M. A. , 'Role of apoptosis in hypoxic/ischemic damage in the kidney ' (2003 ) 23 Semin Nephrol. : 511 -521 .

    • Search Google Scholar

  • Seaborn, T., Masmoudi-Kouli, O., Fournier, A., Vaudry, H., Vaudry, D. (2011) Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP ) against apoptosis. Curr. Pharm. Des. 17, 204–214.

    Vaudry D. , 'Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP ) against apoptosis ' (2011 ) 17 Curr. Pharm. Des. : 204 -214 .

    • Search Google Scholar

  • Somogyvari-Vigh, A., Reglodi, D. (2004) Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide. Curr. Pharm. Des. 10, 2861–2889.

    Reglodi D. , 'Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide ' (2004 ) 10 Curr. Pharm. Des. : 2861 -2889 .

    • Search Google Scholar

  • Szabadfi, K., Atlasz, T., Kiss, P., Danyadi, B., Tamas, A., Helyes, Z., Hashimoto, H., Shintani, N., Baba, A., Toth, G., Gabriel, R., Reglodi, D. (2012) Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo. Neurotox. Res. 21, 41–48.

    Reglodi D. , 'Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo ' (2012 ) 21 Neurotox. Res. : 41 -48 .

    • Search Google Scholar

  • Szakaly, P., Kiss, P., Lubics, A., Magyarlaki, T., Tamas, A., Racz, B., Lengvari, I., Toth, G., Reglodi, D. (2008) Effects of PACAP on survival and renal morphology in rats subjected to renal ischemia-reperfusion. J. Mol. Neurosci. 36, 89–96.

    Reglodi D. , 'Effects of PACAP on survival and renal morphology in rats subjected to renal ischemia-reperfusion ' (2008 ) 36 J. Mol. Neurosci. : 89 -96 .

    • Search Google Scholar

  • Szakaly, P., Horvath, G., Kiss, P., Laszlo, E., Farkas, J., Furjes, G., Nemeth, J., Reglodi, D. (2010) Changes in pituitary adenylate cyclase activating polypeptide following renal ischemia–reperfusion in rats. Transplant. Proc. 42, 2283–2286.

    Reglodi D. , 'Changes in pituitary adenylate cyclase activating polypeptide following renal ischemia–reperfusion in rats ' (2010 ) 42 Transplant. Proc. : 2283 -2286 .

    • Search Google Scholar

  • Szakaly, P., Laszlo, E., Kovacs, K., Racz, B., Horvath, G., Ferencz, A., Lubics, A., Kiss, P., Tamas, A., Brubel, R., Opper, B., Baba, A., Hashimoto, H., Farkas, J., Matkovits, A., Magyarlaki, T., Helyes, Zs., Reglodi, D. (2011) Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury. Neuropeptides 45, 113–121.

    Reglodi D. , 'Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury ' (2011 ) 45 Neuropeptides : 113 -121 .

    • Search Google Scholar

  • Tamas, A., Reglodi, D., Farkas, O., Kovesdi, E., Pal, J., Povlishock, J. T., Schwarcz, A., Czeiter, E., Szanto, Z., Doczi, T., Buki, A., Bukovics, P. (2012) Effect of PACAP in central and peripheral nerve injuries. Int. J. Mol. Sci. 13, 8430–8448.

    Bukovics P. , 'Effect of PACAP in central and peripheral nerve injuries ' (2012 ) 13 Int. J. Mol. Sci. : 8430 -8448 .

    • Search Google Scholar

  • Uchida, D., Arimura, A., Somogyvari-Vigh, A., Shioda, S., Banks, W. A. (1996) Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide. Brain Res. 736, 280–286.

    Banks W. A. , 'Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide ' (1996 ) 736 Brain Res. : 280 -286 .

    • Search Google Scholar

  • Vannay, A., Fekete, A., Langer, R., Toth, T., Sziksz, E., Vasarhelyi, B., Szabo, A. J., Losonczy, G., Adori, C., Gal, A., Tulassay, T., Szabo, A. (2009) Dehydroepiandrosterone pretreatment alters the ischemia/reperfusion-induced VEGF, IL-1, and IL-6 gene expression in acute renal failure. Kidney Blood Press. Res. 32, 175–184.

    Szabo A. , 'Dehydroepiandrosterone pretreatment alters the ischemia/reperfusion-induced VEGF, IL-1, and IL-6 gene expression in acute renal failure ' (2009 ) 32 Kidney Blood Press. Res. : 175 -184 .

    • Search Google Scholar

  • Vaudry, D., Falluel-Morel, A., Bourgault, S., Basille, M., Burel, D., Wurtz, O., Fournier, A., Chow, B. K., Hashimoto, H., Galas, L., Vaudry, H. (2009) Pituitary adenylate cyclase activating polypeptide and its receptors: 20 years after the discovery. Pharmacol. Rev. 61, 283–357.

    Vaudry H. , 'Pituitary adenylate cyclase activating polypeptide and its receptors: 20 years after the discovery ' (2009 ) 61 Pharmacol. Rev. : 283 -357 .

    • Search Google Scholar

  • Wei, Y., Mojsov, S. (1996) Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology. J. Neuroendocrinol. 8, 811–817.

    Mojsov S. , 'Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology ' (1996 ) 8 J. Neuroendocrinol. : 811 -817 .

    • Search Google Scholar

  • Zhou, X., Rodriguez, W. I., Casillas, R. A., Ma, V., Tam, J., Hu, Z., Lelievre, V., Chao, A., Waschek, J. A. (1999) Axotomy-induced changes in pituitary adenylate cyclase activating polypeptide (PACAP ) and PACAP receptor gene expression in the adult rat facial motor nucleus. J. Neurosci. Res. 57, 953–961.

    Waschek J. A. , 'Axotomy-induced changes in pituitary adenylate cyclase activating polypeptide (PACAP ) and PACAP receptor gene expression in the adult rat facial motor nucleus ' (1999 ) 57 J. Neurosci. Res. : 953 -961 .

    • Search Google Scholar
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Acta Biologica Hungarica
Print ISSN:
0236-5383
Online ISSN:
1588-256X

Senior editors

Editor(s)-in-Chief: Elekes, Károly

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation		 1950
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2024 26 0 0
Jan 2025 40 0 0
Feb 2025 45 0 0
Mar 2025 73 0 0
Apr 2025 22 0 0
May 2025 25 0 0
Jun 2025 0 0 0