View More View Less
  • 1 Tokushima Bunri University Laboratory of Pharmaceutical Education, Kagawa School of Pharmaceutical Sciences 1314-1 Shido, Sanuki Kagawa 769-2193 Japan
Restricted access

Neocortical pyramidal neurons are capable of intrinsic regenerative firing. A mathematical model introduced by Delord et al. [2] of these neurons based on the Hodgkin-Huxley formalism, varied the values of two parameters of the model, i.e. the maximal persistent sodium conductance (gNaP) and the leakage one (gl), and revealed the (gNaP, gl) parameter space supporting regenerative firing. The present study focused on another parameter of this model, i.e. the maximal fast sodium conductance (gNa), to investigate the (gNaP, gNa) parameter space involved in regenerative firing. When gNa was completely blocked, regenerative firing was suppressed. In addition, the gNa threshold necessary to induce regenerative firing was almost independent of the gNaP level. Finally, our results were compared with those of other types of neurons.

  • Butera, R. J., Rinzel, J., Smith, J. C. (1999) Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. J. Neurophysiol. 82, 382–397.

    Smith J. C. , 'Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons ' (1999 ) 82 J. Neurophysiol. : 382 -397.

    • Search Google Scholar
  • Delord, B., Klaassen, A. J., Burnod, Y., Costalat, R., Guigon, E. (1997) Bistable behavior in a neocortical neurone model. Neuroreport. 8, 1019–1023.

    Guigon E. , 'Bistable behavior in a neocortical neurone model ' (1997 ) 8 Neuroreport. : 1019 -1023.

    • Search Google Scholar
  • Del Negro, C. A., Koshiya, N., Butera, R. J., Smith, J. C. (2002) Persistent sodium current, membrane properties and bursting behavior of pre-Bötzinger complex inspiratory neurons in vitro. J. Neurophysiol. 88, 2242–2250.

    Smith J. C. , 'Persistent sodium current, membrane properties and bursting behavior of pre-Bötzinger complex inspiratory neurons in vitro ' (2002 ) 88 J. Neurophysiol. : 2242 -2250.

    • Search Google Scholar
  • Drion, G., Massotte, L., Sepulchre, R., Seutin, V. (2011) How modeling can reconcile apparently discrepant experimental results: The case of pacemaking in dopaminergic neurons. PLoS Comput. Biol. 7(5); e1002050.

    Seutin V. , 'How modeling can reconcile apparently discrepant experimental results: The case of pacemaking in dopaminergic neurons ' (2011 ) 7 PLoS Comput. Biol. : e1002050 -.

    • Search Google Scholar
  • Hodgkin, A. L., Huxley, A. F. (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117, 500–544.

    Huxley A. F. , 'A quantitative description of membrane current and its application to conduction and excitation in nerve ' (1952 ) 117 J. Physiol. : 500 -544.

    • Search Google Scholar
  • Shirahata, T. (2011) The effect of variations in sodium conductances on pacemaking in a dopaminergic retinal neuron model. Acta Biol. Hung. 62, 211–214.

    Shirahata T. , 'The effect of variations in sodium conductances on pacemaking in a dopaminergic retinal neuron model ' (2011 ) 62 Acta Biol. Hung. : 211 -214.

    • Search Google Scholar
  • Silva, L. R., Amitai, Y., Connors, B. W. (1991) Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science 251, 432–435.

    Connors B. W. , 'Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons ' (1991 ) 251 Science : 432 -435.

    • Search Google Scholar
  • Steffen, M. A., Seay, C. A., Amini, B., Cai, Y., Feigenspan, A., Baxter, D. A., Marshak, D. W. (2003) Spontaneous activity of dopaminergic retinal neurons. Biophys. J. 85, 2158–2169.

    Marshak D. W. , 'Spontaneous activity of dopaminergic retinal neurons ' (2003 ) 85 Biophys. J. : 2158 -2169.

    • Search Google Scholar

Editorial Board

      Csányi, Vilmos (Göd)
      Dudits, Dénes (Szeged)
      Falus, András (Budapest)
      Fischer, Ernő (Pécs)
      Gábriel, Róbert (Pécs)
      Gulya, Károly (Szeged)
      Gulyás, Balázs (Stockholm)
      Hajós, Ferenc (Budapest)
      Hámori, József (Budapest)
      Heszky, László (Gödöllő)
      Hideg, Éva (Szeged)
      E. Ito (Sanuki)
      Janda, Tibor (Martonvásár)
      Kavanaugh, Michael P. (Missoula)
      Kása, Péter (Szeged)
      Klein, Éva (Stockholm)
      Kovács, János (Budapest)
      Brigitte Mauch-Mani (Neuchâtel)
      Nässel, Dick R. (Stockholm)
      Nemcsók, János (Szeged)
      Péczely, Péter (Gödöllő)
      Roberts, D. F. (Newcastle-upon-Tyne)
      Sakharov, Dimitri A. (Moscow)
      Singh, Meharvan (Fort Worth)
      Sipiczky, Mátyás (Debrecen)
      Szeberényi, József (Pécs)
      Székely, György (Debrecen)
      Tari, Irma (Szeged)
      Vágvölgyi, Csaba (Szeged),
      L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)