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  • 1 University of Szeged Faculty of Medicine Department of Public Health Dóm tér 10 H-6720 Szeged Hungary
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Arsenic affects large populations and attacks, among others, the nervous system. Waterborne or occupational exposure causes electrophysiological alterations and motor disturbances in humans, and analogous effects were found in animals. Certain phytochemicals may be protective against As-caused damages. In the present study it was investigated whether the flavonoid rutin, applied via the drinking water (2 g/L), ameliorates the effects of arsenic given by gavage (10 mg/kg b.w., in form of NaAsO2) on open field motility, evoked cortical and peripheral electrophysiological activity, and body weight gain in adult male Wistar rats. Body weight gain was significantly reduced from the 4th week of the 6 weeks arsenic treatment and this effect was largely abolished by rutin in the combination treatment group. Rats treated by arsenic alone showed decreased open field motility; latency of the cortical evoked potentials increased and peripheral nerve conduction velocity decreased. These functional alterations were also counteracted by co-administration of rutin, and both the antioxidant and the chelating activity of rutin might have contributed to the ameliorative effect. These results are apparently novel and support the potential role of natural agents in preserving human health in a contaminated environment.

  • Afanasev, I. B., Dorozhko, A. I., Brodskii, A. V., Kostyuk, V. A., Potapovitch, A. I. (1989) Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol. 38, 1763–1769.

    Potapovitch A. I. , 'Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation ' (1989 ) 38 Biochem. Pharmacol. : 1763 -1769.

    • Search Google Scholar
  • Armstrong, C. W., Stroube, R. B., Rubio, T., Siudyla, E. A., Miller, G. B. Jr. (1984) Outbreak of fatal arsenic poisoning caused by contaminated drinking water. Arch. Environ. Health 39, 276–279.

    Miller G. B. , 'Outbreak of fatal arsenic poisoning caused by contaminated drinking water ' (1984 ) 39 Arch. Environ. Health : 276 -279.

    • Search Google Scholar
  • Balakumar, P., Kaur, J. (2009) Arsenic exposure and cardiovascular disorders: An overview. Cardiovasc. Toxicol. 9, 169–176.

    Kaur J. , 'Arsenic exposure and cardiovascular disorders: An overview ' (2009 ) 9 Cardiovasc. Toxicol. : 169 -176.

    • Search Google Scholar
  • Börzsönyi, M., Bereczky, A., Rudnai, P., Csanády, M., Horváth, A. (1992) Epidemiological studies on human subjects exposed to arsenic in drinking water in Southeast Hungary (Letter). Arch. Toxicol. 66, 77–78.

    Horváth A. , 'Epidemiological studies on human subjects exposed to arsenic in drinking water in Southeast Hungary (Letter) ' (1992 ) 66 Arch. Toxicol. : 77 -78.

    • Search Google Scholar
  • Chattopadhyay, S., Bhaumik, S., Purkayastha, M., Basu, S., Chaudhuri, A. N., Das Gupta, S. (2002) Apoptosis and necrosis in developing brain cells due to arsenic toxicity and protection with antioxidants. Toxicol. Lett. 136, 65–76.

    Gupta S. , 'Apoptosis and necrosis in developing brain cells due to arsenic toxicity and protection with antioxidants ' (2002 ) 136 Toxicol. Lett. : 65 -76.

    • Search Google Scholar
  • Coyle, J. T., Puttfarcken, P. (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689–695.

    Puttfarcken P. , 'Oxidative stress, glutamate and neurodegenerative disorders ' (1993 ) 262 Science : 689 -695.

    • Search Google Scholar
  • Duker, A. A., Carranza, E. J. M., Hale, M. (2005) Arsenic geochemistry and health. Environ. Int. 31, 631–641.

    Hale M. , 'Arsenic geochemistry and health ' (2005 ) 31 Environ. Int. : 631 -641.

  • Fincher, R. M., Koerker, R. M. (1987) Long-term survival in acute arsenic encephalopathy. Follow-up using newer measures of electrophysiologic parameters. Am. J. Med. 82, 549–552.

    Koerker R. M. , 'Long-term survival in acute arsenic encephalopathy. Follow-up using newer measures of electrophysiologic parameters ' (1987 ) 82 Am. J. Med. : 549 -552.

    • Search Google Scholar
  • Formica, J. V., Regelson, W. (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 33, 1061–1080.

    Regelson W. , 'Review of the biology of quercetin and related bioflavonoids ' (1995 ) 33 Food Chem. Toxicol. : 1061 -1080.

    • Search Google Scholar
  • García-Chávez, E., Segura, B., Merchant, H., Jiménez, I., Del Razo, L. M. (2007) Functional and morphological effects of repeated sodium arsenite exposure on rat peripheral sensory nerves. J. Neurol. Sci. 258, 104–110.

    Razo L. M. , 'Functional and morphological effects of repeated sodium arsenite exposure on rat peripheral sensory nerves ' (2007 ) 258 J. Neurol. Sci. : 104 -110.

    • Search Google Scholar
  • Gomes Rodrigues, A. M., dos Santos Marcilio, F., Frazao Muzitano, M., Giraldi-Guimaraes, A. (2013) Therapeutic potential of treatment with the flavonoid rutin after cortical focal ischemia in rats. Brain Res. 1503, 53–61.

    Giraldi-Guimaraes A. , 'Therapeutic potential of treatment with the flavonoid rutin after cortical focal ischemia in rats ' (2013 ) 1503 Brain Res. : 53 -61.

    • Search Google Scholar
  • Guerra-Araiza, C., Alvarez-Mejia, A. L., Sanchez-Torres, S., Farfan-Garcia, E., Mondragon-Lozano, R., Pinto-Almazan, R., Salgado-Ceballos, H. (2013) Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases. Free Rad. Res. 47, 451–462.

    Salgado-Ceballos H. , 'Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases ' (2013 ) 47 Free Rad. Res. : 451 -462.

    • Search Google Scholar
  • Halatek, T., Sinczuk-Walczak, H., Rabieh, S., Wasowicz, W. (2009) Association between occupational exposure to arsenic and neurological, respiratory and renal effects. Toxicol. Appl. Pharmacol. 239, 193–199.

    Wasowicz W. , 'Association between occupational exposure to arsenic and neurological, respiratory and renal effects ' (2009 ) 239 Toxicol. Appl. Pharmacol. : 193 -199.

    • Search Google Scholar
  • Hughes, M. F. (2002) Arsenic toxicity and potential mechanisms of action. Toxicol. Lett. 133, 1–16.

    Hughes M. F. , 'Arsenic toxicity and potential mechanisms of action ' (2002 ) 133 Toxicol. Lett. : 1 -16.

    • Search Google Scholar
  • Javed, H., Khan, M. M., Ahmad, A., Vaibhav, K., Ahmad, M. E., Khan, A., Ashafaq, M., Islam, F., Siddiqui, M. S., Safhi, M. M., Islam, F. (2012) Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience 210, 340–352.

    Islam F. , 'Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type ' (2012 ) 210 Neuroscience : 340 -352.

    • Search Google Scholar
  • Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C. J., Valko, M. (2011) Arsenic: toxicity, oxidative stress and human disease. J. Appl. Toxicol. 31, 95–107.

    Valko M. , 'Arsenic: toxicity, oxidative stress and human disease ' (2011 ) 31 J. Appl. Toxicol. : 95 -107.

    • Search Google Scholar
  • Kandel, E. R., Schwartz, J. H. (1985) Principles of Neural Science. Elsevier, New York.

    Schwartz J. H. , '', in Principles of Neural Science , (1985 ) -.

  • Kim, K. H., Lee, K. W, Kim, D. Y., Park, H. H., Kwon, I. B., Lee, H. J. (2005) Optimal recovery of high-purity rutin crystals from the whole plant of Fagopyrum esculentum Moench (buckwheat) by extraction, fractionation, and recrystallization. Biores. Technol. 96, 1709–1712.

    Lee H. J. , 'Optimal recovery of high-purity rutin crystals from the whole plant of Fagopyrum esculentum Moench (buckwheat) by extraction, fractionation, and recrystallization ' (2005 ) 96 Biores. Technol. : 1709 -1712.

    • Search Google Scholar
  • Le Quesne, P. M., McLeod, J. G. (1977) Peripheral neuropathy following a single exposure to arsenic. Clinical course in four patients with electrophysiological and histological studies. J. Neurol. Sci. 32, 437–451.

    McLeod J. G. , 'Peripheral neuropathy following a single exposure to arsenic. Clinical course in four patients with electrophysiological and histological studies ' (1977 ) 32 J. Neurol. Sci. : 437 -451.

    • Search Google Scholar
  • Lindberg, A. L., Goessler, W., Gurzau, E., Koppova, K., Rudnai, P., Kumar, R., Fletcher, T., Leonardi, G., Slotova, K., Gheorghiuc, E., Vahter, M. (2006) Arsenic exposure in Hungary, Romania and Slovakia. J. Environ. Monit. 8, 203–208.

    Vahter M. , 'Arsenic exposure in Hungary, Romania and Slovakia ' (2006 ) 8 J. Environ. Monit. : 203 -208.

    • Search Google Scholar
  • Maggi, C. A., Meli, A. (1986): Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: General considerations. Experientia 42, 109–114.

    Meli A. , 'Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: General considerations ' (1986 ) 42 Experientia : 109 -114.

    • Search Google Scholar
  • Mishra, D., Flora, S. J. S. (2008) Quercetin administration during chelation therapy protects arsenicinduced oxidative stress in mice. Biol. Trace Elem. Res. 122, 137–147.

    Flora S. J. S. , 'Quercetin administration during chelation therapy protects arsenicinduced oxidative stress in mice ' (2008 ) 122 Biol. Trace Elem. Res. : 137 -147.

    • Search Google Scholar
  • Nordstrom, D. K. (2002) Public health. Worldwide occurrences of arsenic in ground water. Science 296, 2143–2145.

    Nordstrom D. K. , 'Public health. Worldwide occurrences of arsenic in ground water ' (2002 ) 296 Science : 2143 -2145.

    • Search Google Scholar
  • Omololu, P. A., Rocha, J. B. T., Kade, I. J. (2011) Attachment of rhamnosylglucoside on quercetin confers potent iron-chelating ability on its antioxidant properties. Exp. Toxicol. Pathol. 63, 249–255.

    Kade I. J. , 'Attachment of rhamnosylglucoside on quercetin confers potent iron-chelating ability on its antioxidant properties ' (2011 ) 63 Exp. Toxicol. Pathol. : 249 -255.

    • Search Google Scholar
  • Pandey, K. B., Rizvi, S. I. (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Med. Cell. Longevity 2, 270–278.

    Rizvi S. I. , 'Plant polyphenols as dietary antioxidants in human health and disease ' (2009 ) 2 Oxidative Med. Cell. Longevity : 270 -278.

    • Search Google Scholar
  • Papp, A., Pecze, L., Vezér, T. (2004) Dynamics of central and peripheral evoked electrical activity in the nervous system of rats exposed to xenobiotics. Centr. Eur. J. Occup. Envir. Med. 10, 52–59.

    Vezér T. , 'Dynamics of central and peripheral evoked electrical activity in the nervous system of rats exposed to xenobiotics ' (2004 ) 10 Centr. Eur. J. Occup. Envir. Med. : 52 -59.

    • Search Google Scholar
  • Park, S. E., Sapkota, K., Choi, J. H., Kim, M. K., Kim, Y. H., Kim, K. M., Kim, K. J., Oh, H. N., Kim, S. J., Kim, S. (2014) Rutin from Dendropanax morbifera Leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling. Neurochem. Res. 39, 707–718.

    Kim S. , 'Rutin from Dendropanax morbifera Leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling ' (2014 ) 39 Neurochem. Res. : 707 -718.

    • Search Google Scholar
  • Parvez, F., Wasserman, G. A., Factor-Litvak, P., Liu, X., Slavkovich, V., Siddique, A. B., Sultana, R., Sultana, R., Islam, T., Levy, D., Mey, J. L., van Geen, A., Khan, K., Kline, J., Ahsan, H., Graziano, J. H. (2011) Arsenic exposure and motor function among children in Bangladesh. Environ. Health Perspect. 119, 1665–1670.

    Graziano J. H. , 'Arsenic exposure and motor function among children in Bangladesh ' (2011 ) 119 Environ. Health Perspect. : 1665 -1670.

    • Search Google Scholar
  • Ratnaike, R. N. (2003) Acute and chronic arsenic toxicity. Postgrad. Med. J. 79, 391–396.

    Ratnaike R. N. , 'Acute and chronic arsenic toxicity ' (2003 ) 79 Postgrad. Med. J. : 391 -396.

    • Search Google Scholar
  • Rodríguez, V. M., Jiménez-Capdeville, M. L., Giordano, M. (2003) The effects of arsenic exposure on the nervous system. Toxicol. Lett. 145, 1–18.

    Giordano M. , 'The effects of arsenic exposure on the nervous system ' (2003 ) 145 Toxicol. Lett. : 1 -18.

    • Search Google Scholar
  • Sárközi, K., Krisch, J., Papp, A. (2013) Effect of green tea on arsenic toxicity in rats. In: Galbács, G. (ed.) Proceedings of the 19 th International Symposium on Analytical and Environmental Problems, Szeged, pp. 261–264.

    Papp A. , '', in Proceedings of the 19thInternational Symposium on Analytical and Environmental Problems , (2013 ) -.

    • Search Google Scholar
  • Sárközi, K., Nagy, V., Papp, A., Tombácz, E., Szabó, A. (2013) The effect of three natural antioxidants on the general and nervous system toxicity of manganese nanoparticles in rats. Centr. Eur. J. Occup. Environ. Med. 19, 31–42.

    Szabó A. , 'The effect of three natural antioxidants on the general and nervous system toxicity of manganese nanoparticles in rats ' (2013 ) 19 Centr. Eur. J. Occup. Environ. Med. : 31 -42.

    • Search Google Scholar
  • Schulz, H., Nagymajtényi, L., Institóris, L., Papp, A., Siroki, O. (2002) A study on behavioral, neurotoxicological, and immunotoxicological effects of subchronic arsenic treatment in rats. J. Toxicol. Environ. Health. 65, 1181–1193.

    Siroki O. , 'A study on behavioral, neurotoxicological, and immunotoxicological effects of subchronic arsenic treatment in rats ' (2002 ) 65 J. Toxicol. Environ. Health. : 1181 -1193.

    • Search Google Scholar
  • Stavric, B. (1994) Role of chemopreventers in human diet. Clin. Biochem. 27, 319–332.

    Stavric B. , 'Role of chemopreventers in human diet ' (1994 ) 27 Clin. Biochem. : 319 -332.

  • Szabó, A., Lengyel, Z., Lukács, A., Papp, A. (2006) Studies on the neurotoxicity of arsenic in rats in different exposure timing schemes. Trace Elem. Electrol. 23, 193–196.

    Papp A. , 'Studies on the neurotoxicity of arsenic in rats in different exposure timing schemes ' (2006 ) 23 Trace Elem. Electrol. : 193 -196.

    • Search Google Scholar
  • Vahidnia, A., van der Voet, G. B., de Wolff, F. A. (2007) Arsenic neurotoxicity — A review. Hum. Exp. Toxicol. 26, 823–832.

    Wolff F. A. , 'Arsenic neurotoxicity — A review ' (2007 ) 26 Hum. Exp. Toxicol. : 823 -832.

  • Vezér, T., Kurunczi, A., Náray, M., Papp, A., Nagymajtényi, L. (2007) Behavioral effects of subchronic inorganic manganese exposure in rats. Am. J. Ind. Med. 50, 841–852.

    Nagymajtényi L. , 'Behavioral effects of subchronic inorganic manganese exposure in rats ' (2007 ) 50 Am. J. Ind. Med. : 841 -852.

    • Search Google Scholar
  • Yadav, R. S., Sankhwar, M. L., Shukla, R. K., Chandra, R., Pant, A. B., Islam, F., Khanna, V. K. (2009) Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicol. Appl. Pharmacol. 240, 367–376.

    Khanna V. K. , 'Attenuation of arsenic neurotoxicity by curcumin in rats ' (2009 ) 240 Toxicol. Appl. Pharmacol. : 367 -376.

    • Search Google Scholar
  • Zafrilla, P., Morillas, J. M., Rubio-Perez, J. M., Villar, E. C. (2009) Ingredients for functional drinks in neurodegenerative diseases: a review. Natural Products Comm. 4, 1–22.

    Villar E. C. , 'Ingredients for functional drinks in neurodegenerative diseases: a review ' (2009 ) 4 Natural Products Comm. : 1 -22.

    • Search Google Scholar
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      Csányi, Vilmos (Göd)
      Dudits, Dénes (Szeged)
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