Authors:
,
, and
Wedad Refaiea Al-Otaibi
Wedad Refaiea Al-Otaibi
King Saud University, P.O. Box 22452, Riyadh-11495, Saudi Arabia
Search for other papers by Wedad Refaiea Al-Otaibi in
Current site
Google Scholar
PubMed
Search for other papers by Wedad Refaiea Al-Otaibi in
Current site
Google Scholar
PubMed
Promy Virk
Promy Virk
King Saud University, P.O. Box 22452, Riyadh-11495, Saudi Arabia
Search for other papers by Promy Virk in
Current site
Google Scholar
PubMed
Search for other papers by Promy Virk in
Current site
Google Scholar
PubMed
Mai Elobeid
Mai Elobeid
King Saud University, P.O. Box 22452, Riyadh-11495, Saudi Arabia
Search for other papers by Mai Elobeid in
Current site
Google Scholar
PubMed
Search for other papers by Mai Elobeid in
Current site
Google Scholar
PubMed
The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Adaramoye, O. A., Osaimoje, D. O., Akinsanya, A. M., Nneji, C. M., Fafunso, M. A., Ademowo, O. G. (2008) Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats. Basic Clin. Pharmacol. Toxicol. 102, 412–418.
-
2.
Ahamed, M., Siddiqui, M. K. J. (2007) Low level lead exposure and oxidative stress: current opinions. Clin. Chim. Acta 383, 57–64.
-
3.
Allouche, L., Hamadouche, M., Touabti, A., Khennouf, S. (2011) Effect of long-term exposure to low or moderate lead concentrations on growth, lipid profile and liver function in albino rats. Adv. Biol.Res. 5, 339–347.
-
4.
Bahde, R., Palmes, D., Minin, E., Stratmann, U., Diller, R., Haier, J., Spiegel, H. U. (2007) Bromelain ameliorates hepatic microcirculation after warm ischemia. J. Surg. Res. 139, 88–96.
-
5.
Baum, C. R. (1999) Treatment of mercury intoxication. Curr. Opin. Pediatr. 11, 265–268.
-
6.
Beyer, W. N., Gaston, G., Brazzle, R., O’Connell, A. F., Audet, D. J. (2007) Deer exposed to exceptionally high concentrations of lead near the Continental Mine in Idaho, SA. Environ. Toxicol. Chem. 26, 1040–1046.
-
7.
Chobotova, K., Vernallis, A. B., Majid, F. A. A. (2010) Bromelain’s activity and potential as an anticancer agent: current evidence and perspectives. Cancer Lett. 290, 148–156.
-
8.
Cobbett, C., Goldsbrough, P. (2002) Phytochelatins and metallothionein: roles in heavy metal detoxification and homeostasis. Annu. Rev. Plant Physiol. 53, 159–182.
-
9.
Cornelius, C. E. (1979) Biochemical evaluation of hepatic function in dogs. JAAHA 15, 259–269.
-
10.
Dash, D. K., Yeligar, V. C., Nayak, S. S., Ghosh, T., Rajalingam, R., Sengupta, P., Maiti, B. C., Maity, T. K. (2007) Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn.) R. Br. on paracetamol-induced hepatotoxicity in rats. Trop. J. Pharm. Res. 6, 755–765.
-
11.
Gregory, S., Kelly, N. D. (1996) Bromelain: A literature review and discussion of its therapeutic applications. Alt. Med. Rev. 4, 243–257.
-
12.
Gürer, H., Özgünes, H., Saygin, E., Ercal, N. (2001) Antioxidant effect of taurine against lead-induced oxidative stress. Arch. Environ. Contam. Toxicol. 41, 397–402.
-
13.
Humphreys, D. J. (1991) Effects of exposure to excessive quantities of lead on animals. Brit. Vet. J. 147, 18–30.
-
14.
Koivula, M. J., Eeva, T. (2010) Metal-related oxidative stress in birds. Environ. Pollut. 158, 2359–2370.
-
15.
Lakshmi, B. V. S., Sudhakar, M., Aparna, M. (2013) Protective potential of Black grapes against lead induced oxidative stress in rats. Environ. Toxicol. Pharmacol. 35, 361–368.
-
16.
Mohammad, I. K., Mahdi, A. A., Raviraja, A., Najmul, I., Iqbal, A., Thuppil, V. (2008) Oxidative stress in painters exposed to low lead levels. Arh. Hig. Rada Toksikol. 59, 161–169.
-
17.
Newairy, A. S. A., Abdou, H. M. (2009) Protective role of flax lignans against lead acetate induced oxidative damage and hyperlipidemia in rats. Food Chem. Toxicol. 47, 813–818.
-
18.
Pavan, R., Jain, S., Kumar, A. (2012) Properties and therapeutic application of bromelain: a review. Biotechnol. Res. Int. 2012, 976203, doi: 10.1155/2012/976203.
-
19.
Piste, P. (2013) CYSTEINE-Master Antioxidant. Int. J. Pharmaceut. Chem. Bio. Sci. 3, 143–149.
-
20.
Reglero, M. M., Taggart, M. A., Castellanos, P., Mateo, R. (2009) Reduced sperm quality in relation to oxidative stress in red deer from a lead mining area. Environ. Pollut. 157, 2209–2215.
-
21.
Sharma, A., Sharma, V., Kansal, L. (2009) Therapeutic effects of Allium sativum on lead-induced biochemical changes in soft tissues of Swiss albino mice. Pharmacogn. Mag. 5, 364–371.
-
22.
Taussig, S. J., Batkin, S. (1988) Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J. Ethnopharmacol. 22, 191–203.
-
23.
Wells, B. G., Dipiro, J. T., Schwinghammer, T. L., Cecily, V., Dipiro, C. V. (2009) Pharmacotherapy Handbook. Seventh Edition. McGraw-Hill, New York.
-
24.
Xia, D., Yu, X., Liao, S., Shao, Q., Mou, H., Ma, W. (2010) Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. J. Ethnopharmacol. 130, 414–420.
Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- Chemical Abstracts
- Current Contents: Agriculture
- Biology and Environmental Sciences
- Elsevier BIOBASE
- Global Health
- Index Medicus
- Index Veterinarius
- Medline
- Referativnyi Zhurnal
- Science Citation Index
- Science Citation Index Expanded (SciSearch)
- SCOPUS
- The ISI Alerting Services
- Zoological Abstracts
| Acta Biologica Hungarica | |
|---|---|
| Language | English |
| Size | |
| Year of Foundation |
1950 |
| Publication Programme |
changed title |
| Volumes per Year |
|
| Issues per Year |
|
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 0236-5383 (Print) |
| ISSN | 1588-256X (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Nov 2024 | 47 | 0 | 0 |
| Dec 2024 | 26 | 0 | 0 |
| Jan 2025 | 53 | 0 | 0 |
| Feb 2025 | 29 | 0 | 0 |
| Mar 2025 | 47 | 1 | 2 |
| Apr 2025 | 23 | 0 | 0 |
| May 2025 | 0 | 0 | 0 |
Author:
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory