Using NMR spectroscopy benzene derivatives were detected in mycelia of Fusarium graminearum, a pathogen of wheat and maize. In previous studies F. graminearum was found to cause cancer to humans and benzene derivatives were detected in breath of cancer sufferers. Surprisingly, no study found benzene derivatives to be the cancerous agents in F. graminearum. In this study we detected benzene derivatives in F. graminearum and propose to study their role as cancer agents.
ACD/Structure Elucidator, version 12.01. Advanced Chemistry Development, Inc., Toronto, ON, Canada. www.acdlabs.com, 2014.
Bucci, T., Hansen, D. K., Laborde, J. B. (1996) Leucoencephalomacia and hemorrhage in the brain of rabbits gavaged with mycotoxin fumonisin B1. Nat. Toxins 4, 51–52.
Desjardins, A. E., Hohn, T. M. (1997) Mycotoxins in plant pathogenesis. Mol. Plant Microbe In. 10, 147–152.
Desjardins, A. E., Hohn, T. M., McCormick, S. P. (1993) Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol. Mol. Biol. Rev. 57, 595–604.
Goswami, R. S., Kistler, H. C. (2004) Heading for disaster: Fusarium graminearum on cereal crops. Mol. Plant Pathol. 5, 515–525.
Fandohan, P., Hell, K., Marasas, W. F. O., Winfgield, M. J. (2003) Infection of maize by Fusarium species and contamination with fumonisin in Africa. Afr. J. Biotechnol. 2, 570–579.
Marasas, W. F. O., Kellerman, T. S., Gelderblom, W. C. A., Coetzer, J. A. W., Thiel, P. G., Van Der Lugt, J. J. (1988) Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55, 197–203.
NMRShiftDB Servers (2014) NMRShiftDB, Ref type: online source. Available from: http://nmrshiftdb.nmr.uni-koeln.de/
Peraica, M., Radic, B., Lucic, A., Pavlovic, M. (1999) Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77, 754–766.
Phillip, M., Gleeson, K., Hughes, J. M. B., Greenberg, J., Cataneo, R. N., Baker, L., McVay, W. P. (1999) Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353, 1930–1933.