Authors:
Dóra Rédei University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

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Norbert Kúsz University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

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Máté Szabó University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

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Gyula Pinke Faculty of Agricultural and Food Sciences, University of West Hungary, Vár u. 2, H-9200 Mosonmagyaróvár, Hungary

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István Zupkó University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

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Judit Hohmann University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

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The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.

  • 1.

    Barina, Z., Shevera, M., Sirbu, C., Pinke, G. (2013) Current distribution and spreading of Euphorbia davidii (E. dentata agg.) in Europe. Cent. Eur. J. Biol. 8, 8795.

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  • 2.

    Jassbi, A. R. (2006) Chemistry and biological activity of secondary metabolites in Euphorbia from Iran. Phytochemistry 67, 19771984.

  • 3.

    Lage, H., Duarte, N., Coburger, C., Hilgeroth, A., Ferreira, M. J. U. (2010) Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells. Phytomedicine 17, 441448.

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    Markham, K. R., Ternai, B., Stanley, R., Geiger, H., Mabry, T. J. (1978) Carbon-13 NMR studies of flavonoids—III: Naturally occurring flavonoid glycosides and their acylated derivatives. Tetrahedron 34, 13891397.

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    Markham, K. R., Geiger, H. (1994) 1H nuclear magnetic resonance spectroscopy of flavonoids and their glycosydes in hexadeuterodimethylsulfoxide. In: Harborne, J. B. (ed.) The Flavonoids. Chapman & Hall, London, pp. 441497.

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  • 6.

    Mok, S. Y., Lee, S. (2013) Identification of flavonoids and flavonoid rhamnosides from Rhododendron mucronulatum for. albiflorum and their inhibitory activities against aldose reductase. Food Chem. 136, 969974.

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  • 7.

    Molnár, J., Ocsovszki, I., Puskás, L., Ghane, T., Hohmann, J., Zupkó, I. (2013) Investigation of the antiproliferative action of the quinoline alkaloids kokusaginine and skimmianine on human cell lines. Curr. Signal Transduct. Ther. 8, 148155.

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  • 8.

    Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 5563.

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  • 9.

    Schultes, R. E. (1987) Members of the Euphorbiaceae in primitive and advanced societies. Bot. J. Linn. Soc. 94, 7995.

  • 10.

    Strack, D., Heilmann, J., Mömken, M., Wray, V. (1988) Cell wall-conjugated phenolics from Coniferae leaves. Phytochemistry 27, 35173521.

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  • 11.

    Vasas, A., Rédei, D., Csupor, D., Molnár, J., Hohmann, J. (2012) Diterpenes from European Euphorbia species serving as prototypes for natural-product-based drug discovery. Eur. J. Org. Chem. 2012, 51155130.

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  • 12.

    Yang, Y., Riina, R., Morawetz, J. J., Haevermans, T., Aubriot, X., Berry, P. E. (2012) Molecular phylogenetics and classification of Euphorbia subgenus Chamaesyce (Euphorbiaceae). Taxon 61, 764789.

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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
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H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)