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  • 1 University of Szeged, Szeged, Hungary
  • | 2 King Saud University, Riyadh, Kingdom of Saudi Arabia
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The genetic background of mitochondrial DNA polymorphism in Candida albicans was studied by physical and functional mapping of four haplotypes identified recently in a hospital-population. The restriction patterns revealed considerable differences; however, the size of the mitochondrial DNA did not vary significantly. Sequence data demonstrated that size differences arose by short deletions, while restriction fragment length polymorphisms are caused by nucleotide substitutions in single sites. Gene rearrangement could not be detected; nevertheless, the coincidence of nucleotide substitution pattern in the inverted repeat region suggested the occurrence of homologue recombination.

  • 1.

    Anderson, J. B., Wickens, C., Khan, M., Cowen, L. E., Federspiel, N., Jones, T., Kohn, L. M. (2001) Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans. J. Bacteriol. 183, 865872.

    • Search Google Scholar
    • Export Citation
  • 2.

    Calderone, R. A., Fonzi, W. A. (2001) Virulence factors of Candida albicans. TIM 9, 327335.

  • 3.

    Cannon, R. D., Lamping, E., Holmes, A. E., Niimi, K., Tanabe, K., Niimi, M., Monk, B. C. (2007) Candida albicans drug resistance – another way to cope with stress. Microbiology 153, 32113217.

    • Search Google Scholar
    • Export Citation
  • 4.

    Farkas, Z., Kocsubé, S., Tóth, M., Vágvölgyi, C., Kucsera, J., Varga, J., Pfeiffer, I. (2008) Genetic variability of Candida albicans isolates in a university hospital in Hungary. Mycoses 52, 318325.

    • Search Google Scholar
    • Export Citation
  • 5.

    Gerhold, J. M., Aun, A., Sedman, T., Joers, P., Sedman, J. (2010) Strand invasion structures in the inverted repeat of Candida albicans mitochondrial DNA reveal a role for homologous recombination in replication. Molecular Cell, 39, 851861.

    • Search Google Scholar
    • Export Citation
  • 6.

    Hamari, Zs. , Pfeiffer, I., Ferenczy, L., Kevei, F. (1999) Interpretation of variability of mitochondrial genomes in the species Aspergillus carbonarious. Antonie van Leeuwenhoek, 75, 225231.

    • Search Google Scholar
    • Export Citation
  • 7.

    Jacobsen, M. D., Rattray, A. M. J., Gow, N. A. R., Odds, F., Shaw, D. J. (2008) Mitochondrial haplotypes and recombination in Candida albicans. Med. Mycol. 46, 647654.

    • Search Google Scholar
    • Export Citation
  • 8.

    Láday, M., Pfeiffer, I., Kucsera, J., Kevei, F., Gácser, A., Szécsi, A., Hamari, Zs. (2001) One-day ready-to-use fungal mitochondrial DNA preparation. BioTechniques 30, 12321233.

    • Search Google Scholar
    • Export Citation
  • 9.

    Miyakawa, Y., Mabuchi, T. (1994) Characterization of a species-specific DNA fragment originating from the Candida albicans mitochondrial genome. J. Med. Vet. Mycol. 32, 7175.

    • Search Google Scholar
    • Export Citation
  • 10.

    Miyakawa, Y., Ozawa, T. (2009) A new type of DNA polymorphism identi?ed in the species-specific DNA region originating from the Candida albicans mitochondrial genome. Curr. Microbiol. 58, 438442.

    • Search Google Scholar
    • Export Citation
  • 11.

    Morgan, J. (2005) Global trends in candidemia: review of reports from 1995–2005. Curr. Infect. Dis. Rep. 7, 429439.

  • 12.

    Pfaller, M. A., Diekema, D. J. (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 20, 133163.

    • Search Google Scholar
    • Export Citation
  • 13.

    Pfaller, M. A., Pappas, P. G., Wingard, J. R. (2006) Invasive fungal pathogens: Current epidemiological trends. Clin. Infect. Dis. 43 (Suppl. 1), S3S14.

    • Search Google Scholar
    • Export Citation
  • 14.

    Shaw, J. A., Troutman, W. B., Lasker, B. A., Mason, M. M., Riggsby, W. S. (1989) Characterization of the inverted duplication in the mitochondrial DNA of Candida albicans. J. Bacteriol. 171, 63536356.

    • Search Google Scholar
    • Export Citation
  • 15.

    Sobel, J. D. (2006) The emergence of non-albicans Candida species as causes of invasive candidiasis and candidemia. Curr. Infect. Dis. Rep. 8, 427433.

    • Search Google Scholar
    • Export Citation
  • 16.

    Wenzel, R. P. (1995) Nosocomial candidiasis: Risk factors and attributable mortality. Clin. Infect. Dis. 20, 15311534.

  • 17.

    Wills, J. W., Troutman, W. B., Riggsby, W. S. (1985) Circular mitochondrial genome of Candida albicans contains a large inverted duplication. J. Bacteriol. 164, 713.

    • Search Google Scholar
    • Export Citation

Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

Acta Biologica Hungarica
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H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)