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  • 1 Kohat University of Science and Technology, Pakistan
  • 2 University of Swabi, Pakistan
  • 3 University of Peshawar, Pakistan
  • 4 University of Swabi, Pakistan
  • 5 Chinese Academy of Sciences, China
  • 6 University of Malakand, Pakistan
  • 7 University of Swabi, Pakistan
  • 8 Umm Al-Qura University, Saudi Arabia
  • 9 Erciyes University, Turkey
  • 10 Erciyes University, Turkey
  • 11 Selcuk University, Turkey
  • 12 Umm Al-Qura University, Saudi Arabia
  • 13 Zagazig University, Egypt
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Introduction

Natural products derived from medicinal plants provide beneficial cancer chemotherapeutic drugs. Bioactive constituents from plants are explored for their anticancer properties.

Methods

Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J) were isolated from Taxus wallichiana. Compounds were screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR 2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell lines.

Results

Tasumatrol B showed good cytotoxic activity conducted for the improvement of inhibiting potential of these compounds against the cancer drug target protein (EGFR tyrosine kinase enzyme). The docking study showed that all compounds have binding affinities and interaction profile with the receptor tyrosine kinase.

Discussion

The study suggests that these compounds could be used for the discovery of novel inhibitors against the target receptors for the treatment of cancer.

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