Introduction
Natural products derived from medicinal plants provide beneficial cancer chemotherapeutic drugs. Bioactive constituents from plants are explored for their anticancer properties.
Methods
Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J) were isolated from Taxus wallichiana. Compounds were screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR 2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell lines.
Results
Tasumatrol B showed good cytotoxic activity conducted for the improvement of inhibiting potential of these compounds against the cancer drug target protein (EGFR tyrosine kinase enzyme). The docking study showed that all compounds have binding affinities and interaction profile with the receptor tyrosine kinase.
Discussion
The study suggests that these compounds could be used for the discovery of novel inhibitors against the target receptors for the treatment of cancer.
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Arfan, M., Amin, H., Khan, I., Shah, M. R., Shah, H., Khan, A. Z., Halimi, S. M. A., Khan, N., Kaleem, W. A., Qayum, M. (2012) Molecular simulations of bergenin as a new urease inhibitor. Med. Chem. Res. 21, 2454–2457.
-
Banerjee, S., Upadhyay, N., Kukreja, A. K., Ahuja, P. S., Kumar, S., Saha, G. C., Sharma, R. P., Chattopadhyay, S. K. (1996) Taxanes from in vitro cultures of the Himalayan yew Taxus wallichiana. Planta Med. 62, 329–331.
-
Barboni, L., Gariboldi, P., Torregiani, E., Appendino, G., Gabetta, B., Zini, G., Bombardelli, E. (1993) Taxanes from the needles of Taxus wallichiana. Phytochemistry 33, 145–150.
-
Bari, S. B., Adhikari, S., Surana, S. J. (2012) Tyrosine kinase receptor inhibitors: a new target for anticancer drug development. J. Pharma Sci. Tech. 1, 36–45.
-
Chang, M. W., Ayeni, C., Breuer, S., Torbett, B. E. (2010) Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina. PloS One 5, e11955.
-
Don, M.-J., Shen, C.-C., Syu, W. S., Ding, Y.-H., Sun, C. M. (2006) Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry 67, 497–503.
-
Gomes, C. A., da Cruz, T. G., Andrade, J. L., Milhazes, N., Borges, F., Marques, M. P. M. (2003) Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study. J. Med. Chem. 46, 5395–5401.
-
Gordaliza, M. (2007) Natural products as leads to anticancer drugs. Clinic. Transl. Oncol. 9, 767–776.
-
Hanwell, M. D., Curtis, E. E., Lonie, D. C., Vandermeersch, T., Zurek, E., Hutchison, G. R. (2012) Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J. Cheminform. 4, 17.
-
Jacob, R. B., Andersen, T., McDougal, O. M. (2012) Accessible high-throughput virtual screening molecular docking software for students and educators. PLoS Comput. Biol. 8, e1002499.
-
Khan, I., Nisar, M., Ahmad, M., Shah, H., Iqbal, Z., Saeed, M., Halimi, S. M. A., Kaleem, W. A., Qayum, M., Aman, A. (2011) Molecular simulations of Taxawallin I inside classical taxol binding site of β-tubulin. Fitoterapia 82, 276–281.
-
Kinghorn, A., Farnsworth, N., Soejarto, D., Cordell, G., Swanson, S., Pezzuto, J., Wani, M., Wall, M., Oberlies, N., Kroll, D. (2003) Novel strategies for the discovery of plant-derived anticancer agents. Pharm. Biol. 41, 53–67.
-
Kuete, V., Saeed, M. E. M., Kadioglu, O., Börtzler, J., Khalid, H., Greten, H. J., Efferth, T. (2015) Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells. Phytomedicine 22, 120–127.
-
Kumar, A., Kumar, S., Jain, S., Kumar, P., Goyal, R. (2013) Study of binding of pyridoacridine alkaloids on topoisomerase II using in silico tools. Med. Chem. Res. 22, 5431–5441.
-
Li, Q., Zhang, L., Ma, Z., Kong, X., Wang, F., Zhang, H., Wang, Y. (2011) Probing structural features and binding mode of 3-arylpyrimidin-2, 4-diones within housefly γ-aminobutyric acid (GABA) receptor. Inter. J. Mol. Sci. 12, 6293–6311.
-
Li, Z., Wan, H., Shi, Y., Ouyang, P. (2004) Personal experience with four kinds of chemical structure drawing software: review on ChemDraw, ChemWindow, ISIS/Draw, and ChemSketch. J. Chem. Info. Comp. Sci. 44, 1886–1890.
-
Liu, C., Schilling, J. K., Ravindra, R., Bane, S., Kingston, D. G. I. (2004) Syntheses and bioactivities of macrocyclic paclitaxel bis-lactones. Bioorg. Med. Chem. 12, 6147–6161.
-
Manley, P. W., Furet, P., Bold, G., Brüggen, J., Mestan, J., Meyer, T., Schnell, C. R., Wood, J., Haberey, M., Huth, A. (2002) Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J. Med. Chem. 45, 5687–5693.
-
Miller, R. W., Powell, R. G., Smith, C. R., Jr., Arnold, E., Clardy, J. (1981) Antileukemic alkaloids from Taxus wallichiana Zucc. J. Org. Chem. 46, 1469–1474.
-
Mukherjee, S., Ghosh, B., Jha, T. B., Jha, S. (2002) Variation in content of taxol and related taxanes in Eastern Himalayan populations of Taxus wallichiana. Planta Med. 68, 757–759.
-
Navia-Osorio, A., Garden, H., Cusidó, R. M., Palazón, J., Alfermann, A. W., Piñol, M. T. (2002) Taxol® and baccatin III production in suspension cultures of Taxus baccata and Taxus wallichiana in an airlift bioreactor. J. Plant Physiol. 159, 97–102.
-
Nisar, M., Khan, I., Simjee, S. U., Gilani, A. H., Perveen, H. (2008) Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc. J. Ethnopharmacol. 116, 490–494.
-
Nisar, M., Qayum, M., Adhikari, A., Khan, T., Kaleem, W. A., Ali, A., Choudhary, M. I. (2010) 4-Deacetylbaccatin III: a proposed biosynthetic precursor of paclitaxel from the bark of Taxus wallichiana. Nat. Prod. Commun. 5, 1727–1728.
-
Paarakh, P. M., Sreeram, S. C., Shruthi, S. D., Ganapathy, P. S. (2015) In vitro and in silico anticancer activity of ammonium glycyrrhizinate isolated from roots of Glycyrrhiza glabra Linn. Saudi J. Med. Pharm. Sci. 1, 4–8.
-
Phillipson, J. D. (2001) Phytochemistry and medicinal plants. Phytochemistry 56, 237–243.
-
Potterat, O., Hamburger, M. (2008) Drug discovery and development with plant-derived compounds. In: Petersen, F., Amstutz, R. (eds.) Natural Compounds as Drugs (Vol. I). Springer, Dordercht, The Netherlands.
-
Rathore, P., Roy, A., Karnatak, H. (2019) Modelling the vulnerability of Taxus wallichiana to climate change scenarios in South East Asia. Ecol. Indicators 102, 199–207.
-
Sturdikova, M., Fuska, J., Grossmann, E., Votický, Z. (1986) New compounds with cytotoxic and antitumor effects. Part 6: Monomeric indole alkaloids of Vinca minor L. and their effect on P388 cells. Die Pharmazie 41, 270–272.
-
Torres, P. H. M., Sodero, A. C. R., Jofily, P., Silva, F. P., Jr. (2019) Key topics in molecular docking for drug design. Int. J. Mol. Sci. 20, 4574.
-
Trott, O., Olson, A. J. (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comp. Chem. 31, 455–461.
-
Yellamma, K., Nagaraju, S., Peera, K., Praveen, K. (2013) To design novel lead molecules for the enzyme, AChE associated with Alzheimer’s disease. Int. J. Pharm. Sci. Rev. Res. 22, 296–302.
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