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  • 1 Microbiology Division, School of Biological Sciences, University of Nottingham Please ask the editor of the journal.
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Protein secretion is a vital process in fungi. For many, the secretion of hydrolytic enzymes provides a crucial step in their nutrition in nature. However, in recent years the list of different types of secreted proteins that have been discovered has extended significantly. These have been shown to have a diversity of functions including toxic molecule transport and control of desiccation. The majority of secreted proteins are glycosylated and our understanding of this aspect of fungal biochemistry has also extended in recent years. This review addresses the process of protein secretion from the cytological, biochemical and genetical standpoints. Advances in technology in many areas of scientific approach have enabled a better and understanding of this important process in fungi.

  • Rexach, M., Denfert, C., Wuestehube, L., Schekman, R.: Genes and proteins required for vesicular transport from the endoplasmic-reticulum. Ant van Leeu Int J Gen Mol Microbiol 61, 87-92 (1992).

    'Genes and proteins required for vesicular transport from the endoplasmic-reticulum. ' () 61 Ant van Leeu Int J Gen Mol Microbiol : 87 -92.

    • Search Google Scholar
  • Seitsma, J. H., Wosten, H. A. B., Wessels, J. G. H.: Cell wall growth and protein secretion in fungi. Canadian Journal of Botany 73, S388-S395 (1995).

    'Cell wall growth and protein secretion in fungi. ' () 73 Canadian Journal of Botany : S388 -S395.

    • Search Google Scholar
  • Vainstein, M. H., Peberdy, J. F.: Location of invertase in Aspergillus nidulans: release during hyphal wall digestion and secretion by protoplasts. Mycol Res 95, 1270-1274 (1991).

    'Location of invertase in Aspergillus nidulans: release during hyphal wall digestion and secretion by protoplasts. ' () 95 Mycol Res : 1270 -1274.

    • Search Google Scholar
  • Chen, J-S.: Biochemical and genetic aspects of invertase secretion in Aspergillus nidulans. Ph. D. Thesis, University of Nottingham. 1995.

  • Nevalainen, H., Lavygina, L., Neethkling, D., Packer, N.: The biochemical nature of the cell envelope of a high cellulase secreting mutant differs from that of the Trichoderma reesei. J Biotech 42, 53-59 (1995).

    'The biochemical nature of the cell envelope of a high cellulase secreting mutant differs from that of the Trichoderma reesei. ' () 42 J Biotech : 53 -59.

    • Search Google Scholar
  • Reichard, U.: The role of secretory and structure-associated proteinases of Aspergillus fumigatus in the pathogenesis of invasive aspergillosis. Mycoses 41, 78-82 (1998).

    'The role of secretory and structure-associated proteinases of Aspergillus fumigatus in the pathogenesis of invasive aspergillosis. ' () 41 Mycoses : 78 -82.

    • Search Google Scholar
  • Sejalon Delmas, N., Mateos, F. V., Bottin, A., Rickauer, M., Dargent, R., Esquerre Tugaye, M. T.: Purification, elicitor activity and cell wall localisation of a glycoprotein from Phytophthera parasitica var. nicotianae, a fungal pathogen of tobacco. Phytopathology 87, 899-909 (1997).

    'Purification, elicitor activity and cell wall localisation of a glycoprotein from Phytophthera parasitica var. nicotianae a fungal pathogen of tobacco. ' () 87 Phytopathology : 899 -909.

    • Search Google Scholar
  • Perfect, S. E., O'Connell, R. J., Green, E. F., Doering Saad, C., Green, J. R.: Expression cloning of a fungal proline-rich glycoprotein specific to biotrophic interface formed in the Colletotrichum-bean infection. Plant J 15, 273-279 (1998).

    'Expression cloning of a fungal proline-rich glycoprotein specific to biotrophic interface formed in the Colletotrichum-bean infection. ' () 15 Plant J : 273 -279.

    • Search Google Scholar
  • Tagu, D., Martin, F.: Molecular analysis of cell wall proteins expressed during the early steps of ectomycorrhiza development. New Phytol 133, 73-85 (1996).

    'Molecular analysis of cell wall proteins expressed during the early steps of ectomycorrhiza development. ' () 133 New Phytol : 73 -85.

    • Search Google Scholar
  • Wessels, J. G. H., DeVries, O. M. H., Asgeirsdottir, S. A., Schuren, F. H. J.: Hydrophobin genes involved in formation of aerial hyphae and fruit bodies in Schizophyllum. Plant Cell 3, 793-799 (1991).

    'Hydrophobin genes involved in formation of aerial hyphae and fruit bodies in Schizophyllum. ' () 3 Plant Cell : 793 -799.

    • Search Google Scholar
  • Kershaw, M. J., Talbot, N. J.: Hydrophobins and repellents: proteins with fundamental roles in fungal morphogenesis. Fun Genet Biol 23, 18-33 (1998).

    'Hydrophobins and repellents: proteins with fundamental roles in fungal morphogenesis. ' () 23 Fun Genet Biol : 18 -33.

    • Search Google Scholar
  • Wosten, H. A. B., Schuren, F. H. J., Wessels, J. G. H.: Interfacial self-assembly of a hydrophobin into an amphipathic protein membrane mediates fungal attachment to hydrophobic surfaces. EMBO Journal 13, 5848-5854 (1994).

    'Interfacial self-assembly of a hydrophobin into an amphipathic protein membrane mediates fungal attachment to hydrophobic surfaces. ' () 13 EMBO Journal : 5848 -5854.

    • Search Google Scholar
  • Talbot, N. J., Kershaw, M. J., Wakley, G. E., de Vries, O. M. H., Wessels, J. G. H., Hamer, J. E.: MPG1 encodes a fungal hydrophobin involved in surface interactions during infection-related development of Magnaporthe grisea. Plant Cell 8, 985-989 (1996).

    'MPG1 encodes a fungal hydrophobin involved in surface interactions during infection-related development of Magnaporthe grisea. ' () 8 Plant Cell : 985 -989.

    • Search Google Scholar
  • Wessels, J. G. H., Asglerdottir, S. A., Birkenhkamp, K. U., deVries, O. M. H., Lugones, L. G., Scheer, J. M. J., Schuren, F. H. J., Schuurs, T. A., van Weeter, M. A., Wosten, H. B.: Genetic regulation of emergent growth in Schizophyllum commune. Canadian Journal of Botany 73, S273-S281 (1995).

    'Genetic regulation of emergent growth in Schizophyllum commune. ' () 73 Canadian Journal of Botany : S273 -S281.

    • Search Google Scholar
  • DeGroot, P. W. J., Schaap, P. J., Sonnenberg, A. S. M., Visser, J.: The Agaricus bisporus hypA gene encodes a hydrophobin and specifically accumulates in peel tissue of mushroom caps during fruit body development. J Mol Biol 257, 1008-1018 (1996).

    'The Agaricus bisporus hypA gene encodes a hydrophobin and specifically accumulates in peel tissue of mushroom caps during fruit body development. ' () 257 J Mol Biol : 1008 -1018.

    • Search Google Scholar
  • Lugones, L. G., Bosscher, J. S., Scholtmeyer, K., de Vries, O. M. H., Wessels, J. G. H.: An abundant hydrophobin (ABH1) forms hydrophobic rodlet layers in Agaricus bisporus fruiting bodies. Microbiology-UK 142, 1321-1329 (1996).

    'An abundant hydrophobin (ABH1) forms hydrophobic rodlet layers in Agaricus bisporus fruiting bodies. ' () 142 Microbiology-UK : 1321 -1329.

    • Search Google Scholar
  • Lugones, L. G., Wosten, H. A. B., Wessels, J. G. H.: A hydrophobin (ABH3) specifically secreted by vegetatively growing hyphae of Agaricus bisporus (common white button mushroom). Microbiology-UK 144, 2345-2353 (1998).

    'A hydrophobin (ABH3) specifically secreted by vegetatively growing hyphae of Agaricus bisporus (common white button mushroom). ' () 144 Microbiology-UK : 2345 -2353.

    • Search Google Scholar
  • Nakari Setala, T., Aro, N., Kalkkinen, N., Alatalo, E., Penntilä, M.: Genetic and biochemical characterisation of the Trichoderma reesei hydrophobin HFB1. Eur J Biochem 235, 248-255 (1996).

    'Genetic and biochemical characterisation of the Trichoderma reesei hydrophobin HFB1. ' () 235 Eur J Biochem : 248 -255.

    • Search Google Scholar
  • Ngiam, C., Jeenes, D. J., Archer, D. B.: Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger. Curr Genet 31, 133-138 (1997).

    'Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger. ' () 31 Curr Genet : 133 -138.

    • Search Google Scholar
  • Torralba, S., Raudaskoski, M., Pedregosa, A. M.: Effects of methyl benzimidazole-2-yl carbamate on microtubule and actin cytoskeleton in Aspergillus nidulans. Protoplasma 202, 54-64 (1998).

    'Effects of methyl benzimidazole-2-yl carbamate on microtubule and actin cytoskeleton in Aspergillus nidulans. ' () 202 Protoplasma : 54 -64.

    • Search Google Scholar
  • Seiler, S., Nargang, F. E., Steinberg, G., Schliwa, M.: Kinesin is essential for cell morphogenesis and polarised secretion in Neurospora crassa. EMBO J 16, 3025-3034 (1997).

    'Kinesin is essential for cell morphogenesis and polarised secretion in Neurospora crassa. ' () 16 EMBO J : 3025 -3034.

    • Search Google Scholar
  • Munoz, G., Nakari Setala, T., Agosin, E., Penntilä, M.: Hydrophobin gene srhl, expressed during sporulation of the biocontrol agent Trichoderma harzianum. Curr Genet 32, 225-230 (1997).

    'Hydrophobin gene srhl, expressed during sporulation of the biocontrol agent Trichoderma harzianum. ' () 32 Curr Genet : 225 -230.

    • Search Google Scholar
  • Nakari Setala, T., Aro, N., Ilmen, M., Munoz, G., Kalkkinen, N., Penntilä, M.: Differential expression of the vegetative and spore-bound hydrophobins of Trichoderma reesei - cloning and characterisation of the hfb2 gene. Eur J Biochem 248, 415-423 (1997).

    'Differential expression of the vegetative and spore-bound hydrophobins of Trichoderma reesei - cloning and characterisation of the hfb2 gene. ' () 248 Eur J Biochem : 415 -423.

    • Search Google Scholar
  • Gooday, G. W.: The hyphal tip. In Smith, J. E. (ed.): Fungal Differentiation - a contemporary synthesis. Marcel Dekker Inc., New York. 1983. pp. 315-356.

    The hyphal tip. , () 315 -356.

  • Bourett, T. M., Howard, R. J.: Brefeldin A induced structural changes in the endomembrane system of a filamentous fungus, Magnaporthe grisea. Protoplasma 190, 151-163 (1996).

    'Brefeldin A induced structural changes in the endomembrane system of a filamentous fungus, Magnaporthe grisea. ' () 190 Protoplasma : 151 -163.

    • Search Google Scholar
  • Satait Jeunemaitre, B., Cole, L., Bourett, T., Howard, R., Hawes, C.: Brefeldin A effects in plant and fungal cells: something new about vesicle trafficking? J Microscopy Oxford 181, 162-177 (1996).

    'Brefeldin A effects in plant and fungal cells: something new about vesicle trafficking? ' () 181 J Microscopy Oxford : 162 -177.

    • Search Google Scholar
  • Hu, G. G., Rijkenberg, F. H. J.: Ultrastructural studies of the intracellular hyphae and haustorium of Puccinia recondita f. sp. tritici. J Phytopath 146, 39-50 (1998).

    'Ultrastructural studies of the intracellular hyphae and haustorium of Puccinia recondita f. sp. tritici. ' () 146 J Phytopath : 39 -50.

    • Search Google Scholar
  • Lopez Franco, R., Bracker, C. E.: Diversity and dynamics of the Spitzenkorper in growing hyphal tips of higher fungi. Protoplasma 195, 90-111 (1996).

    'Diversity and dynamics of the Spitzenkorper in growing hyphal tips of higher fungi. ' () 195 Protoplasma : 90 -111.

    • Search Google Scholar
  • Wosten, H. A. B., Moukha, S. M., Sietsma, J. H., Wessels, J. G. H.: Localization of growth and secretion of proteins in Aspergillus niger. J Gen Microbiol 137, 2017-2023 (1991).

    'Localization of growth and secretion of proteins in Aspergillus niger. ' () 137 J Gen Microbiol : 2017 -2023.

    • Search Google Scholar
  • Jochova, J., Rupes, I., Peberdy, J. F.: Effect of the microtubule inhibitor benomyl on protein secretion in Aspergillus nidulans. Mycol Res 97, 23-27 (1993).

    'Effect of the microtubule inhibitor benomyl on protein secretion in Aspergillus nidulans. ' () 97 Mycol Res : 23 -27.

    • Search Google Scholar
  • Delucas, J. R., Monistrol, LF., Laborda, F.: Effect of antimicrotubular drugs on the secretion process of extracellular proteins in Aspergillus nidulans. Mycol Res 97, 961-966 (1993).

    'Effect of antimicrotubular drugs on the secretion process of extracellular proteins in Aspergillus nidulans. ' () 97 Mycol Res : 961 -966.

    • Search Google Scholar
  • Asgeirsdottir, S. A., Halsall, J. R., Casselton, L. A.: Expression of two closely linked hydrophobin gene of Coprinus cinereus is monokaryon specific and down-regulated by the oidl mutation. Fun Genet Biol 22, 54-63 (1997).

    'Expression of two closely linked hydrophobin gene of Coprinus cinereus is monokaryon specific and down-regulated by the oidl mutation. ' () 22 Fun Genet Biol : 54 -63.

    • Search Google Scholar
  • Dunn-Coleman, N. S., Bloebaum, P., Berka, R. M., Bodie, E., Robinson, N., Armstrong, G., Ward, M., Przetak, M., Carter, G. L., Lacost, R., Wilson, L. J., Kodama, K. H., Baliu, E. F., Bower, B., Lamsa, M., Heinsohn, H.: Commercial levels of chymosin production by Aspergillus. Bio-Technology 9, 976-981 (1991).

    'Commercial levels of chymosin production by Aspergillus. ' () 9 Bio-Technology : 976 -981.

    • Search Google Scholar
  • Vasquez, J., Smulian, A. G., Linkw, M. J., Cushion, M. T.: Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Inf Immun 64, 290-297 (1996).

    'Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. ' () 64 Inf Immun : 290 -297.

    • Search Google Scholar
  • Bidochka, M. J., Hajek, A. E.: Protoplast plasma membrane glycoproteins in two species of entomophthalean fungi. Mycol Res 100, 1094-1098 (1996).

    'Protoplast plasma membrane glycoproteins in two species of entomophthalean fungi. ' () 100 Mycol Res : 1094 -1098.

    • Search Google Scholar
  • Tobin, M. B., Peery, R. B., Skatrud, P. L.: Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus. Gene 200, 11-23 (1997).

    'Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus. ' () 200 Gene : 11 -23.

    • Search Google Scholar
  • Ward, P. P., Piddington, C. S., Cunningham, G. A., Zhou, X. D., Wyatt, R. D., Conneely, O. M.: A system for production of commercial quantities of human lactoferrin - a broad-spectrum natural antibiotic. Bio-Technology 13, 498-503 (1995).

    'A system for production of commercial quantities of human lactoferrin - a broad-spectrum natural antibiotic. ' () 13 Bio-Technology : 498 -503.

    • Search Google Scholar
  • van Brunt, J.: Fungi: the perfect hosts. Biotechnology 4, 1057-1062 (1986).

    'Fungi: the perfect hosts. ' () 4 Biotechnology : 1057 -1062.

  • Davies, R. W.: Molecular biology of a high-level recombinant protein production system in Aspergillus. In Leong, S. A., Berka, R. M. (eds): Molecular Industrial Mycology. Marcel Dekker Inc, New York. 1991. pp. 45-82.

    Molecular biology of a high-level recombinant protein production system in Aspergillus. , () 45 -82.

    • Search Google Scholar
  • Jeenes, D. J., Pfaller, R., Archer, D. B.: Isolation and characterisation of a novel-stress inducible PDI-family gene from Aspergillus niger. Gene 193, 151-156 (1997).

    'Isolation and characterisation of a novel-stress inducible PDI-family gene from Aspergillus niger. ' () 193 Gene : 151 -156.

    • Search Google Scholar
  • Del Sorbo, G., Andrade, A. C., van Nistelrooy, J. G. M., van Kan, J. A. L., Balzi, E. E., De Waard, M. A.: Multidrug resistance in Aspergillus nidulans involves novel ATP-binding casette transporters. Mol Gen Genet 254, 417-426 (1997).

    'Multidrug resistance in Aspergillus nidulans involves novel ATP-binding casette transporters. ' () 254 Mol Gen Genet : 417 -426.

    • Search Google Scholar
  • Tomme, P., van Tilbeurgh, H., Petterson, G., van Damme, J., Vendekerchove, J., Knowles, J., Teeri, T., Claeyssens, M.: Studies of the cellulolytic system of Trichoderma reesei QM9414. Analysis of domain function in two cellobiohydrolases by limited proteolysis. Eur J Biochem 170, 575-581 (1988).

    'Studies of the cellulolytic system of Trichoderma reesei QM9414. Analysis of domain function in two cellobiohydrolases by limited proteolysis. ' () 170 Eur J Biochem : 575 -581.

    • Search Google Scholar
  • Pandey, A.: Glucoamylase research - an overview. Starch 47, 439-445 (1995).

    'Glucoamylase research - an overview. ' () 47 Starch : 439 -445.

  • Thompson, S. A., Golightly, E. J., Yaver, D. S.: Nucleotide sequence of the Aspergillus niger srpA gene. Gene 167, 337-338 (1995).

    'Nucleotide sequence of the Aspergillus niger srpA gene. ' () 167 Gene : 337 -338.

  • Wallis, G. L. F., Hemming, F. W., Peberdy, J. F.: Investigation of the glycosyltransferase enzymes involved in the initial stages of the N-linked protein glycosylation pathway in Aspergillus niger. Biochim Biophys Acta 1426, 91-98 (1999).

    'Investigation of the glycosyltransferase enzymes involved in the initial stages of the N-linked protein glycosylation pathway in Aspergillus niger. ' () 1426 Biochim Biophys Acta : 91 -98.

    • Search Google Scholar
  • Stedman, T. T., Buck, G. A.: Identification, characterisation and expression of the BiP endoplasmic reticulum resident chaperonins in Pneumocystis carinii. Infection and Immunity 64, 4463-4471 (1996).

    'Identification, characterisation and expression of the BiP endoplasmic reticulum resident chaperonins in Pneumocystis carinii. ' () 64 Infection and Immunity : 4463 -4471.

    • Search Google Scholar
  • Van Gemeren, I. A., Punt, P. J., Drint Kuyvenhoven, A., Broekhuijsen, M. P., vant Hoog, A., Beijersbergen, A., Verrips, C. T., van den Hondel, C. A. M. J. J.: The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins. Gene 198, 43-52 (1997).

    'The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins. ' () 198 Gene : 43 -52.

    • Search Google Scholar

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