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  • 1 Second Department of Internal Medicine, Faculty of General Medicine, Semmelweis University PO Box 277, H-1444 Budapest, Hungary
  • 2 Institute for Small Animal Research 2100 Gödöllő, P.O. Box 417. Hungary
  • 3 National Center of Public Health, “Frederic Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene Budapest, Hungary
  • 4 National Center of Public Health, “Frederic Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene Budapest, Hungary
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The plasma level of endotoxin was determined in 116 healthy blood donors. After a routine physical and laboratory investigations the endotoxin level was determined with Limulus amebocyte lysate assay (LAL-test) by the chromogenic kinetic method of Bio-Whittaker Co. (USA). Its sensitivity was 0.005-50 EU/ml. The plasma level of endotoxin in most of the healthy donors was less than 1 EU/ml (in the range of 0.01-1.0 EU/ml), but always measurable. The average ±S.D. was 0.128±0.215 EU/ml. Because of the high standard deviation and high range of values, the data were distributed into two groups with the means of 0.05±0.022 EU/ml and 0.294±0.186 EU/ml. The difference between the groups was significant (p<0.001). In conclusion, endotoxin can be measured in plasma of healthy individuals.

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