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  • 1 Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged P. O. Box 533, H-6701 Szeged, Hungary
  • 2 Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 3 Department of Clinical Microbiology, Faculty of Medicine, University of Szeged Somogyi Béla tér 1, H-6725 Szeged, Hungary
  • 4 Department of Microbiology, Faculty of Sciences, University of Szeged P. O. Box 533, H-6701 Szeged, Hungary
  • 5 Department of Microbiology, Faculty of Sciences, University of Szeged P. O. Box 533, H-6701 Szeged, Hungary
  • 6 I: Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged; II: Department of Clinical Microbiology, Faculty of Medicine, University of Szeged I: P. O. Box 533, H-6701 Szeged, Hungary; II: Somogyi Béla tér 1, H-6725 Szeged, Hungary
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Cefditoren is the active form of cefditoren pivoxil, a new, broad-spectrum oral cephalosporin with strong in vitro activity against penicillin-susceptible and resistant Streptococcus pneumoniae. In this study, the minimum inhibitory concentrations (MICs) of cefditoren were determined for a special selection of S. pneumoniae isolates known to be susceptible, moderately susceptible or fully resistant to penicillin; these isolates originated from the lower respiratory tract of adults with pneumonia or the upper respiratory tract of children with or without symptoms of infection. Some of this latter group of isolates exhibited extremely high MICs to penicillin (³32 mg/l), whereas the MICs of cefditoren did not exceed 2 mg/l. The MIC50 and MIC90 of cefditoren proved to be 0.25 and 1.0 mg/l, respectively, with a range of MICs £0.015-2.0 mg/l for all the tested S. pneumoniae isolates. Its good activity suggests that cefditoren is expected to be a potent drug in infections caused by penicillin-resistant and multidrug-resistant S. pneumoniae.

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