Acta Microbiologica et Immunologica Hungarica
Volume/Issue:
Volume 51: Issue 3
The Antimotility Action of a Trifluoromethyl Ketone on Some Gram-negative Bacteria
Authors: Gabriella Spengler 1 , Annamária Molnár 2 , G. Klausz 3 , Yvette Mándi 4 , M. Kawase 5 , N. Motohashi 6 , and J. Molnár 7
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  • 1 Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary
  • 2 Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary
  • 3 Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary
  • 4 Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary
  • 5 Faculty of Pharmaceutical Sciences, Josai University Sakado, Saitama, Japan
  • 6 Meiji Pharmaceutical University Kiyose, Tokyo, Japan
  • 7 Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged Dóm tér 10, H-6720 Szeged, Hungary
DOI:
https://doi.org/10.1556/amicr.51.2004.3.12
Page Count:
351–358
Publication Date:
01 Nov 2004
Online Publication Date:
19 Jul 2005
Article Category:
Research Article
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The inhibition of bacterial motility was studied by a trifluoro methyl ketone derivative on two Escherichia coli strains (wild strain having a proton pump system and the proton pump-deficient mutant strain) and two Helicobacter pylori strains (clarithromycin susceptible and clarithromycin resistant). Evidence is presented of the inhibitory action of 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone (TF18) on the proton motive forces of the two bacterial strains by affecting the action of biological motor and proton efflux in the membranes. The swimming, the forward motion was more sensitive than the vibration or tumbling to the inhibition. We suppose that the inhibiton of bacterial motility is related to the virulence of bacteria: consequently the pathogenicity can be reduced in the presence of TF18.

  • Young, G. M., Schmiel, D. H., Miller, V. L.: A new pathway for the secretion of virulence factors by bacteria: the flagellar export apparatus functions as a protein-secretion system. Proc Natl Acad Sci USA 96, 6456-6461 (1999).

    'A new pathway for the secretion of virulence factors by bacteria: the flagellar export apparatus functions as a protein-secretion system. ' () 96 Proc Natl Acad Sci USA : 6456 -6461.

    • Search Google Scholar

  • Minamino, T., Imae, Y., Oosawa, F., Kobayashi, Y., Oosawa, K.: Effect of intracellular pH on rotational speed of bacterial flagellar motors. J Bacteriol 185, 1190-1194 (2003).

    'Effect of intracellular pH on rotational speed of bacterial flagellar motors. ' () 185 J Bacteriol : 1190 -1194.

    • Search Google Scholar

  • Molnár, J., Ren, J., Kristiansen, J. E., Nakamura, M. J.: Effects of some tricyclic psychopharmacons and structurally related compounds on motility of Proteus vulgaris. Antonie van Leeuwenhoek 62, 315-320 (1992).

    'Effects of some tricyclic psychopharmacons and structurally related compounds on motility of Proteus vulgaris. ' () 62 Antonie van Leeuwenhoek : 315 -320.

    • Search Google Scholar

  • Alföldi, L., Raskó, I., Kerekes, E.: L-serine deaminase of E. coli. J Bacteriol 96, 1512-1518 (1968).

    'L-serine deaminase of E. coli. ' () 96 J Bacteriol : 1512 -1518.

  • Eliopoulos, G. M., Moellering, R. C.: Antimicrobial combinations. In: Victor, L. (ed.): Antibiotics in Laboratory Medicine. 3rd edition, Baltimore, Maryland, USA, 434-441 (1991).

  • Okusu, H., Ma, D., Nikaido, H.: AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol 178, 306-308 (1996).

    'AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. ' () 178 J Bacteriol : 306 -308.

    • Search Google Scholar

  • Bren, A., Eisenbach, M.: How signals are heard during bacterial chemotaxis: protein-protein interactions in sensory signal propagation. J Bacteriol 182, 6865-6873 (2000).

    'How signals are heard during bacterial chemotaxis: protein-protein interactions in sensory signal propagation. ' () 182 J Bacteriol : 6865 -6873.

    • Search Google Scholar

  • Berg, H. C.: Constraints on models for the flagellar motors. Philos Trans R Soc Lond B 335, 491-502 (2000).

    'Constraints on models for the flagellar motors. ' () 335 Philos Trans R Soc Lond B : 491 -502.

    • Search Google Scholar

  • Oosawa, F., Hayashi, S.: Coupling between flagellar motor rotation and proton flux in bacteria. J Phys Soc Jpn 52, 4019-4028 (1983).

    'Coupling between flagellar motor rotation and proton flux in bacteria. ' () 52 J Phys Soc Jpn : 4019 -4028.

    • Search Google Scholar

  • Molnár, J., Haszon, I., Bodrogi, T., Martonyi, E., Turi, S.: Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis. Int J Urol Nephrol 22, 405-411 (1990).

    'Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis. ' () 22 Int J Urol Nephrol : 405 -411.

    • Search Google Scholar

  • Glagoley, A. N., Skulachev, V. P.: The proton pump is a molecular engine of motile bacteria. Nature 272, 280-282 (1978).

    'The proton pump is a molecular engine of motile bacteria. ' () 272 Nature : 280 -282.

  • Gerhard, M., Rad, R., Prinz, C., Naumann, M.: Pathogenesis of Helicobacter pylori infection. Helicobacter 7, 17-23 (2002).

    'Pathogenesis of Helicobacter pylori infection. ' () 7 Helicobacter : 17 -23.

  • Parkinson, J. S.: Bacterial chemotaxis: a new player in response regulator dephosphorylation. J Bacteriol 185, 1492-1494 (2003).

    'Bacterial chemotaxis: a new player in response regulator dephosphorylation. ' () 185 J Bacteriol : 1492 -1494.

    • Search Google Scholar

  • Kawase, M., Sakagami, H., Kusama, K., Motohashi, N., Saito, S.: α-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. Bioorganic & Medicinal Chemistry Letters 9, 3113-3118 (1999).

    'α-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines. ' () 9 Bioorganic & Medicinal Chemistry Letters : 3113 -3118.

    • Search Google Scholar

  • Kawase, M., Motohashi, N., Sakagami, H., Kanamoto, T., Nakashima, H., Ferenczy, L., Wolfard, K., Miskolci, C., Molnár, J.: Antimicrobial activity of trifluoromethyl ketones and their synergism with promethazine. Int J Antimicrob Agents 18, 161-165 (2001).

    'Antimicrobial activity of trifluoromethyl ketones and their synergism with promethazine. ' () 18 Int J Antimicrob Agents : 161 -165.

    • Search Google Scholar

  • Kawase, M. et al.: In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones. Bioorg Med Chem Lett 9, 193-194 (1999).

    'In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones. ' () 9 Bioorg Med Chem Lett : 193 -194.

    • Search Google Scholar
Cover Acta Microbiologica et Immunologica Hungarica
Acta Microbiologica et Immunologica Hungarica A Quarterly of the Hungarian Academy of Sciences
Print ISSN:
1217-8950
Online ISSN:
1588-2640
Keywords:
motility; motility; trifluoromethyl ketone; proton pump inhibitor

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