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  • 1 First Department of Medicine, Medical Faculty, University of Pécs Ifjúság út 13, H-7624 Pécs, Hungary
  • 2 Division of Virology, “Johan Béla” National Center for Epidemiology Gyáli út 2-6, H-1097 Budapest, Hungary
  • 3 Division of Virology, “Johan Béla” National Center for Epidemiology Gyáli út 2-6, H-1097 Budapest, Hungary
  • 4 Division of Virology, “Johan Béla” National Center for Epidemiology Gyáli út 2-6, H-1097 Budapest, Hungary
  • 5 Blood Transfusion Centre Dischka u. 7, H-7621 Pécs, Hungary
  • 6 National Medical Center Szabolcs u. 35, H-1135 Budapest, Hungary
  • 7 Department of Clinical Chemistry, Medical Faculty University of Pécs, Ifjúság út 13, H-7624 Pécs, Hungary
  • 8 Department of Pathology, Baranya County Hospital Rákóczi u. 2, H-7621 Pécs, Hungary
  • 9 First Department of Medicine, Medical Faculty, University of Pécs Ifjúság út 13, H-7624 Pécs, Hungary
  • 10 First Department of Medicine, Medical Faculty, University of Pécs Ifjúság út 13, H-7624 Pécs, Hungary
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The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection.  Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

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