Acta Microbiologica et Immunologica Hungarica
Volume/Issue:
Volume 52: Issue 3-4
Comparative Study of Potential Virulence Factors in Human Pathogenic and Saprophytic Trichoderma longibrachiatum Strains
Authors: Zsuzsanna Antal 1 , L. Kredics 2 , J. Pakarinen 3 , Ilona Dóczi 4 , Maria Andersson 5 , Mirja Salkinoja-Salonen 6 , L. Manczinger 7 , A. Szekeres 8 , L. Hatvani 9 , C. Vágvölgyi 10 , and Elisabeth Nagy 11
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  • 1 Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 2 Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 3 Department of Applied Chemistry and Microbiology, University of Helsinki P.O. Box 56, FIN-00014 Helsinki, Finland
  • 4 Department of Clinical Microbiology, University of Szeged Somogyi Béla tér 1, H-6725 Szeged, Hungary
  • 5 Department of Applied Chemistry and Microbiology, University of Helsinki P.O. Box 56, FIN-00014 Helsinki, Finland
  • 6 Department of Applied Chemistry and Microbiology, University of Helsinki P.O. Box 56, FIN-00014 Helsinki, Finland
  • 7 Department of Microbiology, University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 8 Department of Microbiology, University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 9 Department of Microbiology, University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 10 Department of Microbiology, University of Szeged P.O. Box 533, H-6701 Szeged, Hungary
  • 11 Microbiological Research Group, Hungarian Academy of Sciences and University of Szeged, and, Department of Clinical Microbiology, University of Szeged P.O. Box 533, H-6701 Szeged, Hungary; and, Somogyi Béla tér 1, H-6725 Szeged, Hungary
DOI:
https://doi.org/10.1556/amicr.52.2005.3-4.6
Page Count:
341–350
Publication Date:
01 Oct 2005
Online Publication Date:
26 Oct 2005
Article Category:
Research Article
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Potential virulence factors of 9 saprophytic and 12 clinical Trichoderma longibrachiatum strains were examined in the present study, in order to compare their capacity to cause infection in humans. All of the strains were able to grow at temperatures up to 40 °C and at pH values ranging from 2.0 to 9.0. Carbon and nitrogen source utilization experiments revealed that all of the strains were able to utilize a series of basic amino acids both as sole carbon and nitrogen sources. The MIC values of the tested antifungal drugs were found to be 0.016-8 µg/ml for amphotericin B, 64-256 µg/ml for fluconazole, 0.5-32 µg/ml for itraconazole and 0.008-1 µg/ml for ketoconazole in the case of the examinedis olates. Metabolites of the strains inhibited the growth of different bacteria, furthermore, compounds produced by three clinical isolates reduced the motility of boar spermatozoa, indicating their toxicity to mammalian cells as well. On the whole, there were no significant differences in the examined features between strains derived from clinical or soil samples. The question, however, whether all environmental Trichoderma longibrachiatum strains have the capacity to cause infections or not, remains still unanswered.

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Cover Acta Microbiologica et Immunologica Hungarica
Acta Microbiologica et Immunologica Hungarica A Quarterly of the Hungarian Academy of Sciences
Print ISSN:
1217-8950
Online ISSN:
1588-2640
Keywords:
temperature; temperature

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