Acta Microbiologica et Immunologica Hungarica
Volume/Issue:
Volume 52: Issue 3-4
Localization of Human T-cell Lymphotropic Virus-1 gag Proviral Sequences in Dermato-immunological Disorders with Eosinophilia
Authors: K. Nagy 1 , Márta Marschalkó 2 , B. Kemény 3 , and A. Horváth 4
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  • 1 Institute of Medical Microbiology, Semmelweis University Nagyvárad tér 4, H-1089 Budapest, Hungary
  • 2 Department of Dermatology and Venerology, Semmelweis University Mária u. 41, H-1085 Budapest, Hungary
  • 3 National Institute of Dermato-Venerology Mária u. 41, H-1085 Budapest, Hungary
  • 4 National Institute of Dermato-Venerology Mária u. 41, H-1085 Budapest, Hungary
DOI:
https://doi.org/10.1556/amicr.52.2005.3-4.10
Page Count:
385–396
Publication Date:
01 Oct 2005
Online Publication Date:
26 Oct 2005
Article Category:
Research Article
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The mechanisms leading to the development of eosinophilia were investigated in 65 patients with immunodermatological disorders, including the role of eosinophilotactic cytokines and the possible involvement of human T-cell leukemia virus, HTLV. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. Increased level of GM-CSF was detected in 33% of disorders studied. Elevated level of IL-5 and eotaxin was detected in 27% and 30%, respectively, of patients with bullous diseases. Elevated level of GM-CSF and eotaxin was found in 33% and 46%, respectively, of patients with inflammatory diseases. Neither of the four cytokines, however proved to be responsible alone or together for the induction of eosinophilia. The possible indirect role of human retroviruses through induction of eosinophilic chemotactic cytokines is hypothesized.

  • Kaufman, L. D., Gleich, G. J.: The expanding clinical spectrum of multisystem disease associated with eosinophilia. Arch Dermatol 133, 225-227 (1997).

    'The expanding clinical spectrum of multisystem disease associated with eosinophilia. ' () 133 Arch Dermatol : 225 -227.

    • Search Google Scholar

  • Marschalkó, M.: Diagnostics of cutan lymphomas. Orv Hetil 142(52), 2903-2906 (2001).

    'Diagnostics of cutan lymphomas. ' () 142 Orv Hetil : 2903 -2906.

  • Steffen, C.: Eosinophilic pustular folliculitis (Ofuji's disease) with response to dapsone therapy. Arch Dermatol 121, 921-923 (1995).

    'Eosinophilic pustular folliculitis (Ofuji's disease) with response to dapsone therapy. ' () 121 Arch Dermatol : 921 -923.

    • Search Google Scholar

  • Basarab, T., Russell Jones, R.: Ofuji's disease with unusual histological features. Exp Clin Dermatol 21(1), 67-71 (1996).

    'Ofuji's disease with unusual histological features. ' () 21 Exp Clin Dermatol : 67 -71.

  • Koike, T., Enokihara, H., Arimura, H., Ninomiya, H., Yamashiro, K., Tsuruoka, N., Tsujimoto, M., Aoyagi, M., Watanabe, K., Nakamura, Y., Saitou, K., Furusawa, S., Shishido, H.: Serum concentrations of IL-5, GM-CSF, and IL-3 and the production by lymphocytes in various eosinophilia. Am J Haemat 50, 98-102 (1995).

    'Serum concentrations of IL-5, GM-CSF, and IL-3 and the production by lymphocytes in various eosinophilia. ' () 50 Am J Haemat : 98 -102.

    • Search Google Scholar

  • Ponath, P. D., Qin, S., Ringler, D. J., Clark-Lewis, I., Wang, J., Kassam, N., Smith, H., Shi, X., Gonzalo, J. A., Newman, W., Gutierrez-Ramos, J-C., Mackay, C. R.: Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 97(3), 604-612 (1996).

    'Cloning of the human eosinophil chemoattractant, eotaxin: expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. ' () 97 J Clin Invest : 604 -612.

    • Search Google Scholar

  • Griffith-Johnson, D. A., Collins, P. D., Rossi, A. G., Jose, P. J., Williams, T. J.: The chemokine eotaxin activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Comm 197(3) (1993).

    'The chemokine eotaxin activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. ' () 197 Biochem Biophys Res Comm .

    • Search Google Scholar

  • Helander, S. D., Peters, M. S., Kuo, T. T., Su, P. P.: Kimura's disease and angiolymphoid hyperplasia with eosinophilia: new observations from immunohistochemical studies of lymphocyte markers, endothelial antigens, and granulocyte proteins. J Cutan Pathol 22(4), 319-326 (1995).

    'Kimura's disease and angiolymphoid hyperplasia with eosinophilia: new observations from immunohistochemical studies of lymphocyte markers, endothelial antigens, and granulocyte proteins. ' () 22 J Cutan Pathol : 319 -326.

    • Search Google Scholar

  • Lim, We, Tan, N. G., Tan, K. P.: Radiological features in a patient with Kimura's disease. Singapore Med J 38(3), 125-128 (1997).

    'Radiological features in a patient with Kimura's disease. ' () 38 Singapore Med J : 125 -128.

    • Search Google Scholar

  • Fermand, J. P., Mitjavila, M. T., Couedic, J. P., Tsapis, A., Berger, R., Modigliani, R. Seligmann, M., Brouet, J. C., Vainchenker, W.: Role of granulocyte-macrophage colony-stimulating-factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma. Brit J Haemat 83, 359-364 (1993).

    'Role of granulocyte-macrophage colony-stimulating-factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma. ' () 83 Brit J Haemat : 359 -364.

    • Search Google Scholar

  • Orachion, R., Dougherty, I., Katz, K., Street, N., Cruz, P.: HIV-related eosinophilic folliculitis is a Th2-dominant disease characterized by selective expression of eotaxin in dendritic cells and CCR-3 in T-cells. (Abstr. 964). J Invest Dermatol 110 (1998).

    'HIV-related eosinophilic folliculitis is a Th2-dominant disease characterized by selective expression of eotaxin in dendritic cells and CCR-3 in T-cells. (Abstr. 964). ' () 110 J Invest Dermatol .

    • Search Google Scholar

  • Nagy, K.: Molecular epidemiology of HTLV-like retroviral elements in Central-Europe. AIDS Res Hum Retrovir 17, (2001).

    'Molecular epidemiology of HTLV-like retroviral elements in Central-Europe. ' () 17 AIDS Res Hum Retrovir .

    • Search Google Scholar

  • Human IL-3 immunoassay, Quantikine, Cat. No. D3000, Manual.

  • Nagy, K., Clapham, P., Cheingsong-Popov, R., Weiss, R.: Human T-cell leukemia virus type I. Int J Cancer 32, 321-328 (1983).

    'Human T-cell leukemia virus type I. ' () 32 Int J Cancer : 321 -328.

  • Thomson, A.: The cytokine handbook. 2nd ed. Academic Press, London, pp. 127-140, 343-370.

    The cytokine handbook. , () 127 -140.

  • Marschalkó, M., Szigeti, Á., Hársing, J., Kelényi G., Karády, Á., Horváth, A.: CD30 positive cutan lymphoma. Orv Hetil, 2 June 1997.

    CD30 positive cutan lymphoma. , () 2.

  • Ingley, E., Young, I. G.: Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60. Blood 78(2), 339-344 (1991).

    'Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60. ' () 78 Blood : 339 -344.

    • Search Google Scholar

  • Limaye, A. P., Abrams, J. S., Silver, J. E., Ottesen, E. A., Nutman, T. B.: Regulation of parasite-induced eosinophilia: Selectively increased interleukin-5 production in helminth-infected patients. J Exp Med 172, 399-402 (1990).

    'Regulation of parasite-induced eosinophilia: Selectively increased interleukin-5 production in helminth-infected patients. ' () 172 J Exp Med : 399 -402.

    • Search Google Scholar

  • Li, G., Vowels, B. R., Benoit, B. M., Rook, A. H., Lessin, S. R.: Failure to detect HTLV-I proviral DNA in cell lines and tissues from patients with cutaneous T-cell lymphoma. J Insvest Dermatol 107, 308-313 (1996).

    'Failure to detect HTLV-I proviral DNA in cell lines and tissues from patients with cutaneous T-cell lymphoma. ' () 107 J Insvest Dermatol : 308 -313.

    • Search Google Scholar

  • Khan, M. Z., Sebenik, M., Zucker-Franklin, D.: Localization of HTLV-1 tax proviral sequence in skin biopsies of patients with mycosis fungoides by in situ PCR. J Invest Dermatol 106, 667-672 (1996).

    'Localization of HTLV-1 tax proviral sequence in skin biopsies of patients with mycosis fungoides by in situ PCR. ' () 106 J Invest Dermatol : 667 -672.

    • Search Google Scholar

  • Kiss, J., Tisza, T., D. Tóth, F. et al.: HTLV-1 related retroviral markers in Hungarian patients with mycosis fungoides. Acta Microbiol. Hung. 40(2), 123-130 (1993).

    'HTLV-1 related retroviral markers in Hungarian patients with mycosis fungoides. ' () 40 Acta Microbiol. Hung. : 123 -130.

    • Search Google Scholar

  • Takimoto, Y., Tanaka, H., Tanabe, O., Kuramoto, A., Sasaki, N., Nanba, K.: Anaplastic large-cell lymphoma (Ki-1 lymphoma) with expression of IL-5 mRNA and eosinophilic invasion. Acta Haematol 96, 245-248 (1996).

    'Anaplastic large-cell lymphoma (Ki-1 lymphoma) with expression of IL-5 mRNA and eosinophilic invasion. ' () 96 Acta Haematol : 245 -248.

    • Search Google Scholar

  • Kitaura, M., Nakajima, T., Imai, T., Harada, S., Combadiere, C., Tiffany, H. L., Murphy, P. M., Yoshie, O.: Molecular cloning of human eotaxin, an eosinophil selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 271(13), 7725-7730 (1996).

    'Molecular cloning of human eotaxin, an eosinophil selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. ' () 271 J Biol Chem : 7725 -7730.

    • Search Google Scholar

  • Nagy, K., Kemeny, B., Horvath, A.: HTLV-1 tax present in cutaneous T cell malignancies with eosinophilia, but not without it (Abstr). AIDS Res Hum Retrovir 21(5), 494 (2005).

    'HTLV-1 tax present in cutaneous T cell malignancies with eosinophilia, but not without it (Abstr). ' () 21 AIDS Res Hum Retrovir : 494.

    • Search Google Scholar

  • Foerster, J., Nolte, I., Junge, J., Bruinenberg, M., Schweiger, S., Spaar, K., van der Steege, G., Ehrelt, C., Mulder, M., Kalscheuer, V., Blumenthal-Barby, E., Winter, J., Seeman, P., Ständer, M., Sterry, W., Meerman, G.: Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis. J Invest Dermatol 124, 99-102 (2005).

    'Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis. ' () 124 J Invest Dermatol : 99 -102.

    • Search Google Scholar
Cover Acta Microbiologica et Immunologica Hungarica
Acta Microbiologica et Immunologica Hungarica A Quarterly of the Hungarian Academy of Sciences
Print ISSN:
1217-8950
Online ISSN:
1588-2640
Keywords:
eosinophilia; eosinophilia

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