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  • 1 Institute of Medical Microbiology, Semmelweis University Nagyvárad tér 4, H-1089 Budapest, Hungary
  • 2 Department of Dermatology and Venerology, Semmelweis University Mária u. 41, H-1085 Budapest, Hungary
  • 3 National Institute of Dermato-Venerology Mária u. 41, H-1085 Budapest, Hungary
  • 4 National Institute of Dermato-Venerology Mária u. 41, H-1085 Budapest, Hungary
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The mechanisms leading to the development of eosinophilia were investigated in 65 patients with immunodermatological disorders, including the role of eosinophilotactic cytokines and the possible involvement of human T-cell leukemia virus, HTLV. HTLV-1 gag proviral sequences were revealed in two cases of lymphoproliferative disorders such as angiolymphoid hyperplasia with eosinophilia (ALHE) and CD4+ cutaneous lymphoma, respectively. Increased level of GM-CSF was detected in 33% of disorders studied. Elevated level of IL-5 and eotaxin was detected in 27% and 30%, respectively, of patients with bullous diseases. Elevated level of GM-CSF and eotaxin was found in 33% and 46%, respectively, of patients with inflammatory diseases. Neither of the four cytokines, however proved to be responsible alone or together for the induction of eosinophilia. The possible indirect role of human retroviruses through induction of eosinophilic chemotactic cytokines is hypothesized.

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