Acta Microbiologica et Immunologica Hungarica
Volume/Issue:
Volume 53: Issue 1
Prevalence and Avidity of Human Herpesvirus-6 Specific IgG Antibodies in Pregnant Women in Hungary
Authors: Ibolya Stiller 1 , Rozália Pusztai 2 , Erzsébet Sombor 3 , L. Orosz 4 , A. Pál 5 , and B. Taródi 6
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  • 1 Medical Microbiology and Immunobiology, University of Szeged Szeged, Hungary
  • 2 Medical Microbiology and Immunobiology, University of Szeged Szeged, Hungary
  • 3 Medical Microbiology and Immunobiology, University of Szeged Szeged, Hungary
  • 4 Medical Microbiology and Immunobiology, University of Szeged Szeged, Hungary
  • 5 Obstetrics and Gynecology, University of Szeged Szeged, Hungary
  • 6 Medical Microbiology and Immunobiology, University of Szeged Szeged, Hungary
DOI:
https://doi.org/10.1556/amicr.53.2006.1.2
Page Count:
25–34
Publication Date:
01 Mar 2006
Online Publication Date:
06 Jun 2006
Article Category:
Research Article
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The prevalence, the level and the avidity of human herpesvirus-6 (HHV-6) specific IgG were examined in pregnant women and age-matched female blood donors. The study group consisted of 180 women (age 14-45); 60 women with normal pregnancy, 60 pregnant women with fetuses suspected of having any viral infection and 60 healthy blood donors with no history of pregnancy. Plasma or serum samples were tested for HHV-6 IgG antibodies by an immunofluorescence assay. Ninety-eight percent of blood donors and 97% of 120 pregnant women had IgG antibodies to HHV-6. The rate of seropositivity in women  with normal pregnancies  and women with fetuses suspected to have viral infection was the same. Pregnant women (n=120) had significantly lower antibody titer than blood donors. No significant differences were found in the same respect between the two groups of pregnant women. Low avidity of IgG antibodies to HHV-6 was detected in 5% of pregnant women.

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Cover Acta Microbiologica et Immunologica Hungarica
Acta Microbiologica et Immunologica Hungarica A Quarterly of the Hungarian Academy of Sciences
Print ISSN:
1217-8950
Online ISSN:
1588-2640
Keywords:
seroprevalence; pregnancy; human herpespesvirus-6; IgG antibody; avidity

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