View More View Less
  • 1 The University of South Florida College of Medicine St. Joseph Hospital’s Cancer Institute Affiliated with the H. L. Moffitt Comprehensive Cancer Center; Departments of Medical Microbiology/Immunology and Molecular Medicine Tampa FL USA
  • 2 St. Joseph’s Hospital Cancer Institute 3001 W. Dr Martin Luther King Jr Blvd. Tampa FL 33607-6307 USA
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $784.00

In leukemic mice, the native host’s explicit and well-defined immune reactions to the leukemia virus (a strong exogenous antigen) and to leukemia cells (pretending in their native hosts to be protected “self” elements) are extinguished and replaced in GvHD (graft-versus-host disease) by those of the immunocompetent donor cells. In many cases, the GvHD-inducer donors display genetically encoded resistance to the leukemia virus. In human patients only antileukemia and anti-tumor cell immune reactions are mobilized; thus, patients are deprived of immune reactions to a strong exogenous antigen (the elusive human leukemia-sarcoma retroviruses). The innate and adaptive immune systems of mice have to sustain the immunosuppressive effects of leukemia-inducing retroviruses. Human patients due to the lack of leukemiainducing retroviral pathogens (if they exist, they have not as yet been discovered), escape such immunological downgrading. After studying leukemogenic retroviruses in murine and feline (and other mammalian) hosts, it is very difficult to dismiss retroviral etiology for human leukemias and sarcomas. Since no characterized and thus recognized leukemogenic-sarcomagenic retroviral agents are being isolated from the vast majority of human leukemias-sarcomas, the treatment for these conditions in mice and in human patients vastly differ. It is immunological and biological modalities (alpha interferons; vaccines; adoptive lymphocyte therapy) that dominate the treatment of murine leukemias, whereas combination chemotherapy remains the main remission-inducing agent in human leukemias-lymphomas and sarcomas (as humanized monoclonal antibodies and immunotoxins move in). Yet, in this apparently different backgrounds in Mus and Homo, GvHD, as a treatment modality, appears to work well in both hosts, by replacing the hosts’ anti-leukemia and anti-tumor immune faculties with those of the donor. The clinical application of GvHD in the treatment of human leukemias-lymphomas and malignant solid tumors remains a force worthy of pursuit, refinement and strengthening. Graft engineering and modifications of the inner immunological environment of the recipient host by the activation or administration of tumor memory T cells, selected Treg cells and natural killer (NKT) cell classes and cytokines, and the improved pharmacotherapy of GvHD without reducing its antitumor efficacy, will raise the value of GvHD to the higher ranks of the effective antitumor immunotherapeutical measures. Clinical interventions of HCT/HSCT (hematopoietic cell/stem cell transplants) are now applicable to an extended spectrum of malignant diseases in human patients, being available to elderly patients, who receive non-myeloablative conditioning, are re-enforced by post-transplant donor lymphocyte (NK cell and immune T cell) infusions and post-transplant vaccinations, and the donor cells may derive from engineered grafts, or from cord blood with reduced GvHD, but increased GvL/GvT-inducing capabilities (graft-versus leukemia/tumor). Post-transplant T cell transfusions are possible only if selected leukemia antigen-specific T cell clones are available. In verbatim quotation: “Ultimately, advances in separation of GvT from GvHD will further enhance the potential of allogeneic HCT as a curative treatment for hematological malignancies” (Rezvani, A.R. and Storb, R.F., Journal of Autoimmunity 30:172–179, 2008 (see in the text)). It may be added: for cure, a combination of the GvL/T effects with new targeted therapeutic modalities, as elaborated on in this article, will be necessary.

  • Ferrara, J. L. M., Cooke, K. R., Teshima, K.: The pathophysiology of graft-vs.-host disease. In Ferrara, J. L., Cooke, K. R., Deeg, H. J. (authors/editors): Graft-vs-Host Disease, 3rd edition. Marcel Dekker, New York, NY, 2005, pp. 1–34.

    Teshima K. , '', in Graft-vs-Host Disease , (2005 ) -.

  • Gadi, V. K., Nash, A. R.: Hematopoietic stem cell transplantation. In Greer, J. P., Foerster, J., Rodgers, G. M., Paraskevas, F., Glader, B., Arbe, D. A., Means, Jr. R. T. (eds): Wintrobe’s Clinical Hematology, 12th edition. Wolters Kluwer Lippincott Williams & Wilkins, Philadelphia, PA, 2009, pp. 722–748.

    Nash A. R. , '', in Wintrobe’s Clinical Hematology , (2009 ) -.

  • Reddy, P., Ferrara, J. L. M.: Graft-versus-host disease and graft-versus-leukemia effect. In Hoffman, R., Benz, Jr. E. J., Shattil, S. J., Furle, B., Cohen, H. J., Silberstein, L. E., McGlave, P. (eds): Hematology Basic Principles and Practice, 4th edition. Philadelphia, PA, Elsevier Churchill Livingstone, 2005, pp. 1783–1800.

    Ferrara J. L. M. , '', in Hematology Basic Principles and Practice , (2005 ) -.

  • Shullenberger, C. C., Sinkovics, J. G.: Lymphocytic cytotoxins in wasting syndrome. N. England. J. Med. 283, 1348–1349 (1970).

    Sinkovics J. G. , 'Lymphocytic cytotoxins in wasting syndrome ' (1970 ) 283 N. England. J. Med. : 1348 -1349.

    • Search Google Scholar
  • Sinkovics, J. G., Trujillo, J. M., Pienta, R. J., Ahearn, M. J.: Leukemogenesis stemming from autoimmune disease. In Genetic Concepts and Neoplasia. The University of Texas M. D. Anderson Hospital (ed). Williams & Wilkins, Baltimore, MD, 1970, pp. 138–190.

    Ahearn M. J. , '', in Genetic Concepts and Neoplasia , (1970 ) -.

  • Sinkovics, J. G., Horvath, J. C.: Human natural killer cells: A comprehensive review. Int. J. Oncol. 27, 5–47 (2005). Erratum. Int. J. Oncol. 27, 33 (2005).

    Horvath J. C. , 'Human natural killer cells: A comprehensive review ' (2005 ) 27 Int. J. Oncol. : 5 -47.

    • Search Google Scholar
  • Murphy, J. B.: The effect of adult chicken organ grafts on the chick embryo. J. Exp. Med. 24, 1–10 (1916).

    Murphy J. B. , 'The effect of adult chicken organ grafts on the chick embryo ' (1916 ) 24 J. Exp. Med. : 1 -10.

    • Search Google Scholar
  • Rous, P., Murphy, J. B.: The histological signs of resistance to a transmissible sarcoma of the fowl. J. Exp. Med. 15, 270–286 (1912).

    Murphy J. B. , 'The histological signs of resistance to a transmissible sarcoma of the fowl ' (1912 ) 15 J. Exp. Med. : 270 -286.

    • Search Google Scholar
  • Rous, P.: An experimental comparison of transplanted tumor and a transplanted normal tissue capable of growth. J. Exp. Med. 12, 344–366 (1910).

    Rous P. , 'An experimental comparison of transplanted tumor and a transplanted normal tissue capable of growth ' (1910 ) 12 J. Exp. Med. : 344 -366.

    • Search Google Scholar
  • Rous, P.: A sarcoma of the fowl transmissible by an agent separable from the tumor cells. J. Exp. Med. 13, 397–411 (1911).

    Rous P. , 'A sarcoma of the fowl transmissible by an agent separable from the tumor cells ' (1911 ) 13 J. Exp. Med. : 397 -411.

    • Search Google Scholar
  • Cock, A. G., Simonsen, M.: Immunological attack on newborn chickens by injected adult cells. Immunology 2, 103–110 (1958).

    Simonsen M. , 'Immunological attack on newborn chickens by injected adult cells ' (1958 ) 2 Immunology : 103 -110.

    • Search Google Scholar
  • Burnet, M., Burnet, D.: Graft versus host reactions on the chorioallantoic membrane of the chick embryo. Nature 188, 376–379 (1960).

    Burnet D. , 'Graft versus host reactions on the chorioallantoic membrane of the chick embryo ' (1960 ) 188 Nature : 376 -379.

    • Search Google Scholar
  • Billingham, R., Brent, T., Medawar, P.: Actively acquired tolerance. Phil. Trans. B 239, 357–414 (1956).

    Medawar P. , 'Actively acquired tolerance ' (1956 ) 239 Phil. Trans. B : 357 -414.

  • Billingham, R. E.: The biology of graft-versus-host reactions. Harvey Lec. 62, 21–78 (1966).

    Billingham R. E. , 'The biology of graft-versus-host reactions ' (1966 ) 62 Harvey Lec. : 21 -78.

    • Search Google Scholar
  • Hašek, M., Chutná, J.: Complexity of the state of immunological tolerance. Immunol. Rev. 46, 3–26 (1979).

    Chutná J. , 'Complexity of the state of immunological tolerance ' (1979 ) 46 Immunol. Rev. : 3 -26.

    • Search Google Scholar
  • Jánossy, T., Erdõs, E., Végh, P.: Induction of neonatal transplantation tolerance in mice: The role of H-2 complex and cell dose. Ann. Immunol. Hung. 24, 255–266 (1984).

    Végh P. , 'Induction of neonatal transplantation tolerance in mice: The role of H-2 complex and cell dose ' (1984 ) 24 Ann. Immunol. Hung. : 255 -266.

    • Search Google Scholar
  • Barnes, D., Loutit, J.: Treatment of murine leukemia with x-rays and homologous bone marrow. Br. J. Haematol. 3, 241–252 (1957).

    Loutit J. , 'Treatment of murine leukemia with x-rays and homologous bone marrow ' (1957 ) 3 Br. J. Haematol. : 241 -252.

    • Search Google Scholar
  • Mathé, G., Amiel, J. L., Schwarzenberg, L., Cattan, A., Schneider, M.: Adoptive immunotherapy of acute leukemia: Experimental and clinical results. Cancer Res. 25, 1525–1531 (1965).

    Schneider M. , 'Adoptive immunotherapy of acute leukemia: Experimental and clinical results ' (1965 ) 25 Cancer Res. : 1525 -1531.

    • Search Google Scholar
  • Boranić, M.: Transient graft-versus-host reaction in the treatment of leukemia in mice. J. Natl. Cancer Inst. 41, 421–437 (1968).

    Boranić M. , 'Transient graft-versus-host reaction in the treatment of leukemia in mice ' (1968 ) 41 J. Natl. Cancer Inst. : 421 -437.

    • Search Google Scholar
  • Bortin, M. M., Rimm, A. A., Salzstein, E. C.: Graft versus leukemia: Quantification of adoptive immunotherapy in murine leukemia. Science 179, 811–813 (1973a).

    Salzstein E. C. , 'Graft versus leukemia: Quantification of adoptive immunotherapy in murine leukemia ' (1973 ) 179 Science : 811 -813.

    • Search Google Scholar
  • Bortin, M. M., Rimm, A. A., Salzstein, E. C., Rodey, G. E.: Apparent independent antihost and antileukemic activity of transplanted immunocompetent cells. Transplantation 16, 162–188 (1973b).

    Rodey G. E. , 'Apparent independent antihost and antileukemic activity of transplanted immunocompetent cells ' (1973 ) 16 Transplantation : 162 -188.

    • Search Google Scholar
  • Bortin, M. M., Rimm, A. A., Rodey, G. E., Giller, R. H., Salzstein, E. C.: Prolonged survival in long-passage AKR leukemia using chemotherapy, radiotherapy and adoptive immunotherapy. Cancer Res. 34, 1851–1856 (1974).

    Salzstein E. C. , 'Prolonged survival in long-passage AKR leukemia using chemotherapy, radiotherapy and adoptive immunotherapy ' (1974 ) 34 Cancer Res : 1851 -1856.

    • Search Google Scholar
  • Bortin, M. M., Truitt, R. L., Rose, W. C., Rimm, A. A., Salzstein, E. C.: Adoptive immunotherapy of spontaneous leukemia-lymphoma in AKR mice. Adv. Exp. Med. Biol. 73PtB, 331–339 (1976).

    Salzstein E. C. , 'Adoptive immunotherapy of spontaneous leukemia-lymphoma in AKR mice ' (1976 ) 73PtB Adv. Exp. Med. Biol. : 331 -339.

    • Search Google Scholar
  • Salzstein, E. C., Glasspiegel, J. S., Rimm, A. A., Giller, R. H., Bortin, M. M.: Graft versus leukemia for “cell cure” of long-passage AKR leukemia after chemoradiotherapy. Cancer Res. 32, 1658–1662 (1971).

    Bortin M. M. , 'Graft versus leukemia for “cell cure” of long-passage AKR leukemia after chemoradiotherapy ' (1971 ) 32 Cancer Res : 1658 -1662.

    • Search Google Scholar
  • Rose, W. C., Bortin, M. M., Salzstein, E. C.: Prolonged survival of AKR mice following allogeneic bone marrow transplantation. Experientia 30, 1085–1086 (1974).

    Salzstein E. C. , 'Prolonged survival of AKR mice following allogeneic bone marrow transplantation ' (1974 ) 30 Experientia : 1085 -1086.

    • Search Google Scholar
  • Truitt, R. L., Rimm, A. A., Salzstein, E. C., Rose, W. C., Bortin, M. M.: Graft-versus-leukemia for AKRspontaneous leukemia-lymphoma. Transplant. Proc. 8, 569–574 (1976).

    Bortin M. M. , 'Graft-versus-leukemia for AKRspontaneous leukemia-lymphoma ' (1976 ) 8 Transplant. Proc. : 569 -574.

    • Search Google Scholar
  • Putman, D. L., Kind, P. D., Goldin, A., Kende, M.: Adoptive immunochemotherapy of a transplantable AKR leukemia (K36). Int. J. Cancer 21, 230–233 (1978).

    Kende M. , 'Adoptive immunochemotherapy of a transplantable AKR leukemia (K36) ' (1978 ) 21 Int. J. Cancer : 230 -233.

    • Search Google Scholar
  • Mathé, G., Amiel, J. L., Bernard, J.: Traitement de souris AkR à l’âge de six mois par irradiation totale suivie de transfusion de cellules hématopoïétiques allogéniques. Incidences respectives de la leucémie et du syndrome secondaire. Bull. Cancer 47, 331–340 (1960).

    Bernard J. , 'Traitement de souris AkR à l’âge de six mois par irradiation totale suivie de transfusion de cellules hématopoïétiques allogéniques. Incidences respectives de la leucémie et du syndrome secondaire ' (1960 ) 47 Bull. Cancer : 331 -340.

    • Search Google Scholar
  • Mathé, G., Amiel, J. L., Friend, C.: Essai de traitement de la leucémie de Charlotte Friend par la greffe de cellules hématopoïétiques de donneurs isogéniques vaccinées contre le virus. Bull. Cancer 49, 416–420 (1962).

    Friend C. , 'Essai de traitement de la leucémie de Charlotte Friend par la greffe de cellules hématopoïétiques de donneurs isogéniques vaccinées contre le virus ' (1962 ) 49 Bull. Cancer : 416 -420.

    • Search Google Scholar
  • Korngold, R., Marini, J. C., de Baca, M. E., Murphy, G. F., Giles-Komar, J.: Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus leukemia responses. Biol. Blood Marrow Transplant. 9, 292–303 (2003).

    Giles-Komar J. , 'Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus leukemia responses ' (2003 ) 9 Biol. Blood Marrow Transplant. : 292 -303.

    • Search Google Scholar
  • Sinkovics, J.: Observations on various runting syndromes in mice. Arch. Ges. Virusforsch. 12, 143–147 (1962a).

    Sinkovics J. , 'Observations on various runting syndromes in mice ' (1962 ) 12 Arch. Ges. Virusforsch. : 143 -147.

    • Search Google Scholar
  • Sinkovics, J. G.: Abnormal immune and other complicating phenomena associated with a viral mouse leukemia. J. Inf. Dis. 110, 282–296 (1962b).

    Sinkovics J. G. , 'Abnormal immune and other complicating phenomena associated with a viral mouse leukemia ' (1962 ) 110 J. Inf. Dis. : 282 -296.

    • Search Google Scholar
  • Sinkovics, J. G.: Lymphoid cells of homologous immune activity in a mouse leukemia. In Conceptual Advances in Immunology and Oncology. The University of Texas M. D. Anderson Hospital (ed). Hoeber Medical Division, Harper and Rowe Publishers. New York, NY, 1963, pp. 165–182.

    Sinkovics J. G. , '', in Conceptual Advances in Immunology and Oncology , (1963 ) -.

  • Sinkovics, J. G., Howe, C. D.: Approaches to the pathogenesis of runt (homologous) disease. Texas Rep. Biol. Med. 22, 591–608 (1964a).

    Howe C. D. , 'Approaches to the pathogenesis of runt (homologous) disease ' (1964 ) 22 Texas Rep. Biol. Med. : 591 -608.

    • Search Google Scholar
  • Sinkovics, J. G., Shullenberger, C. C.: Effect of hematopoietic chimerism on the course of Rauscher viral mouse leukemia. Proc. Am. Assoc. Cancer Res. 54th Ann. Meeting, Toronto, Canada, 4/1, 62 #246 (1963).

    Shullenberger C. C. , 'Effect of hematopoietic chimerism on the course of Rauscher viral mouse leukemia ' (1963 ) 4/1 Proc. Am. Assoc. Cancer Res. 54th Ann. Meeting, Toronto, Canada : 62 -.

    • Search Google Scholar
  • Sinkovics, J. G., Howe, C. D., Shullenberger, C. C.: Interferon production, antibody response and homograft rejection-type defense mechanism in viral mouse leukemia. Proc. Am. Assoc. Cancer Res. 55th Ann. Meeting, Chicago, IL, 5/1, 59 #231 (1964b).

    Shullenberger C. C. , 'Interferon production, antibody response and homograft rejection-type defense mechanism in viral mouse leukemia ' (1964 ) 5/1 Proc. Am. Assoc. Cancer Res. 55th Ann. Meeting, Chicago, IL : 59 -.

    • Search Google Scholar
  • Sinkovics, J. G., Shullenberger, C. C., Howe, C. D.: Prolongation and prevention of Rauscher virus mouse leukemia by spleen cells of naturally resistant or actively immunized mice. Offic. Publ. Am. Fed. Clin. Res. Natl. Meeting Atlantic City, NJ, 13, 1:36 (1965b).

    Howe C. D. , 'Prolongation and prevention of Rauscher virus mouse leukemia by spleen cells of naturally resistant or actively immunized mice ' (1965 ) 13 Offic. Publ. Am. Fed. Clin. Res. Natl. Meeting Atlantic City, NJ : 1:36 -.

    • Search Google Scholar
  • Sinkovics, J. G., Shullenberger, C. C., Howe, C. D., Bertin, B. A.: Treatment of leukemic mice with irradiation and adoptive immunization. Proc. Am. Assoc. Cancer Res. 57th Ann. Meeting, Denver; Colorado, 7, 65 #257 (1966a).

    Bertin B. A. , 'Treatment of leukemic mice with irradiation and adoptive immunization ' (1966 ) 7 Proc. Am. Assoc. Cancer Res. 57th Ann. Meeting, Denver; Colorado : 65 -.

    • Search Google Scholar
  • Sinkovics, J. G., Shullenberger, C. C., Howe, C. D.: Immunological functions of homologous spleen cells in viral mouse leukemia. Texas Rep. Biol. Med. 23, 94–109 (1965c).

    Howe C. D. , 'Immunological functions of homologous spleen cells in viral mouse leukemia ' (1965 ) 23 Texas Rep. Biol. Med. : 94 -109.

    • Search Google Scholar
  • Sinkovics, J. G., Shullenberger, C. C., Howe, C. D., Bertin, B. A.: Mouse leukemia, a dichotomy of virus neutralizing and cytotoxic antibodies. Arch. Ges. Virusforsch. 19, 75–80 (1966b).

    Bertin B. A. , 'Mouse leukemia, a dichotomy of virus neutralizing and cytotoxic antibodies ' (1966 ) 19 Arch. Ges. Virusforsch. : 75 -80.

    • Search Google Scholar
  • Sinkovics, J. G.: The causative viruses of murine leukemia and their identification through immune responses of the host. In Carcinogenesis: A Broad Critique. The University of Texas M. D. Hospital (ed). Williams & Wilkins, Baltimore, MD, 1967, pp. 157–174.

    Sinkovics J. G. , '', in Carcinogenesis: A Broad Critique , (1967 ) -.

  • Sinkovics, J. G., Bertin, B. A., Howe, C. D.: Some properties of the photodynamically inactivated Rauscher mouse leukemia virus. Cancer Res. 25, 624–627 (1965a).

    Howe C. D. , 'Some properties of the photodynamically inactivated Rauscher mouse leukemia virus ' (1965 ) 25 Cancer Res. : 624 -627.

    • Search Google Scholar
  • Sinkovics, J. G.: Immunology of tumors in experimental animals. In Harris, J. E., Sinkovics, J. G. (authors): The Immunology of Malignant Disease, 2nd edition. C. V. Mosby, Saint Louis, Missouri, 1976a, pp. 93–282.

    Sinkovics J. G. , '', in The Immunology of Malignant Disease , (1976 ) -.

  • Sinkovics, J. G.: Discussion paper: Modalities of immunotherapy for virally induced murine neoplasms. Ann. N. Y. Acad. Sci. 276, 557–564 (1976b).

    Sinkovics J. G. , 'Discussion paper: Modalities of immunotherapy for virally induced murine neoplasms ' (1976 ) 276 Ann. N. Y. Acad. Sci. : 557 -564.

    • Search Google Scholar
  • Sinkovics, J. G., Pienta, R. J., Fiorentino, M., Bertin, B. A.: Neutralization of sublines of a mouse leukemia virus with murine antibody as measured by the spleen focus assay. Cancer Res. 27, 88–95 (1967).

    Bertin B. A. , 'Neutralization of sublines of a mouse leukemia virus with murine antibody as measured by the spleen focus assay ' (1967 ) 27 Cancer Res. : 88 -95.

    • Search Google Scholar
  • Sinkovics, J. G., Ahearn, M. J., Shirato, E., Shullenberger, C. C.: Viral leukemogenesis in immunologically and hematologically altered mice. J. Reticuloendothel. Soc. 8, 474–492 (1970a).

    Shullenberger C. C. , 'Viral leukemogenesis in immunologically and hematologically altered mice ' (1970 ) 8 J. Reticuloendothel. Soc. : 474 -492.

    • Search Google Scholar
  • Sinkovics, J. G.: The graft-versus-leukemia (GvL) reaction: Its early history, value in human bone marrow transplantation and recent developments concerning its mechanism and induction. In Dicke, K. A., Keating, A. (eds): Autologous Marrow and Blood Transplantion, 1994. The Cancer Treatment Research and Educational Institute Arlington, TX, 1995. pp. 305–318.

    Sinkovics J. G. , '', in Autologous Marrow and Blood Transplantion, 1994 , (1995 ) -.

  • Sinkovics, J. G., Hirano, M., Szakacs, A., Shullenberger, C. C., Howe, C. D.: Growth of lymphoreticular malignant cells in the pre-conditioned murine host. In: The Proliferation and Spread of Neoplastic Cells. The University of Texas M. D. Anderson Hospital (ed.). Williams & Wilkins, Baltimore MD, 1968, pp. 615–639.

    Howe C. D. , '', in The Proliferation and Spread of Neoplastic Cells , (1968 ) -.

  • Sinkovics, J. G., Ahearn, M. J., Thornell, E. W., Shullenberger, C. C.: Effects of hematopoietic and immunological alterations in newborn mice on leukemogenesis and tumor growth. Proc. Am. Assoc. Cancer Res. 61st Ann. Meeting, Philadelphia, PA, 11: 73 #288 (1970b).

    Shullenberger C. C. , 'Effects of hematopoietic and immunological alterations in newborn mice on leukemogenesis and tumor growth ' (1970 ) 11 Proc. Am. Assoc. Cancer Res. 61st Ann. Meeting, Philadelphia, PA : 73 -.

    • Search Google Scholar
  • Hirano, M., Sinkovics, J. G., Shullenberger, C. C., Howe, C. D.: Murine lymphoma: Augmented growth in mice with pertussis vaccine-induced lymphocytosis. Science 158, 1061–1064 (1967).

    Howe C. D. , 'Murine lymphoma: Augmented growth in mice with pertussis vaccine-induced lymphocytosis ' (1967 ) 158 Science : 1061 -1064.

    • Search Google Scholar
  • Sinkovics, J. G., Groves, G. F., Howe, C. D.: Actions of interferon in tissue cultures harboring mouse leukemia virus. Experientia 4, 927–928 (1968a).

    Howe C. D. , 'Actions of interferon in tissue cultures harboring mouse leukemia virus ' (1968 ) 4 Experientia : 927 -928.

    • Search Google Scholar
  • Sinkovics, J. G., Szakacs, A., Butler, J. J., Hirano, M., Shullenberger, C. C., Howe, C. D.: Pathological conditions (leukemias and sarcomas, leukemoid reactions, runt disease and immunization without disease) associated with the inoculation of a long term tissue culture line of a murine leukemia virus. In Clifford, P., Linsell, C. A., Timms, G. L. (eds): Cancer in Africa. East African Med. J. and East African Publishing House, Nairobi, Kenya, 1968b, pp. 143–153.

    Howe C. D. , '', in Cancer in Africa , (1968 ) -.

  • Sinkovics, J. G., Pienta, R. J., Trujillo, J. M., Ahearn, M. J.: Leukemogenesis in mice immunologically altered at birth and immunocompetence of leukemic lymphoblasts. In Immunity and Tolerance in Oncogenesis. Division of Cancer Research, University of Perugia, for the IV. Perugia Quadrennial International Conference on Cancer (ed). Perugia, Italy, 1969, pp. 975–987.

    Ahearn M. J. , '', in Immunity and Tolerance in Oncogenesis , (1969 ) -.

  • Sinkovics, J. G.: Cytolytic Immune Lymphocytes in the Armamentarium of the Human Host. Schenk Buchverlag, Passau & Dialog Campus, Budapest, 2008a, pp. 391.

    Sinkovics J. G. , '', in Cytolytic Immune Lymphocytes in the Armamentarium of the Human Host , (2008 ) -.

    • Search Google Scholar
  • Sinkovics, J. G.: Cytolytic immune lymphocytes in the armamentarium of the human host. Acta Microbiol. Immunol. Hung. 5, 371–382 (2008b). Erratum. Acta Microbiol. Immunol. Hung. 56, 197 (2009).

    Sinkovics J. G. , 'Cytolytic immune lymphocytes in the armamentarium of the human host ' (2008 ) 5 Acta Microbiol. Immunol. Hung. : 371 -382.

    • Search Google Scholar
  • Sinkovics, J. G., Harris, J. E.: Immunology and immunotherapy of human tumors. In Harris, J. E., Sinkovics, J. G. (authors) The Immunology of Malignant Disease, 2nd ed. C. V. Mosby, Saint Louis, Missouri, 1976, pp. 410–578.

    Sinkovics J. G. , '', in The Immunology of Malignant Disease , (1976 ) -.

  • Jones, S. C., Murphy, G. F., Korngold, R.: Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4+25+ T cells to allow an effective graft-versus-leukemia response. Biol. Blood Marrow Transplant. 9, 243–256 (2003).

    Korngold R. , 'Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4+25+ T cells to allow an effective graft-versus-leukemia response ' (2003 ) 9 Biol. Blood Marrow Transplant. : 243 -256.

    • Search Google Scholar
  • Jones, S. C., Friedman, T. M., Murphy, G. F., Korngold, R.: Specific donor Vβ-associated responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens. Biol. Blood Marrow Transplant. 10, 91–100 (2004).

    Korngold R. , 'Specific donor Vβ-associated responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens ' (2004 ) 10 Biol. Blood Marrow Transplant. : 91 -100.

    • Search Google Scholar
  • Asjö, A., Klein, E., Fenyõ, E. M., Klein, G.: The role of humoral immunity and the contribution of the F1 anti-parental effect in the rejection of a Moloney leukemia virus-induced lymphoma graft. Cancer Immunol. Immmunother. 15, 92–95 (1983).

    Klein G. , 'The role of humoral immunity and the contribution of the F1 anti-parental effect in the rejection of a Moloney leukemia virus-induced lymphoma graft ' (1983 ) 15 Cancer Immunol. Immmunother. : 92 -95.

    • Search Google Scholar
  • Dalianis, T., Ahrlund-Richter, L., Merino, F., Klein, E., Klein, G.: Reduced humoral and cellular cytotoxic sensitivity in histocompatibility variants of the YAC (Moloney) lymphoma. Immunogenetics 12, 371–380 (1981).

    Klein G. , 'Reduced humoral and cellular cytotoxic sensitivity in histocompatibility variants of the YAC (Moloney) lymphoma ' (1981 ) 12 Immunogenetics : 371 -380.

    • Search Google Scholar
  • Slettenmark, B., Klein, E.: Cytotoxic and neutralization tests with serum and lymph node cells of isologous mice with induced resistance against Gross lymphomas. Cancer Res. 22, 947–954 (1962).

    Klein E. , 'Cytotoxic and neutralization tests with serum and lymph node cells of isologous mice with induced resistance against Gross lymphomas ' (1962 ) 22 Cancer Res : 947 -954.

    • Search Google Scholar
  • Friend, C.: Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J. Exp. Med. 105, 307–318 (1957).

    Friend C. , 'Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia ' (1957 ) 105 J. Exp. Med. : 307 -318.

    • Search Google Scholar
  • Friend, C.: Immunological relationship of a filterable agent causing leukemia in adult mice. I. The neutralization of infectivity by specific antiserum. J. Exp. Med. 119, 120–128 (1959).

    Friend C. , 'Immunological relationship of a filterable agent causing leukemia in adult mice. I. The neutralization of infectivity by specific antiserum ' (1959 ) 119 J. Exp. Med. : 120 -128.

    • Search Google Scholar
  • Wahren, B.: Cytotoxic assays and other immunologic studies induced by Friend virus. J. Natl. Cancer Inst. 31, 111–123 (1963).

    Wahren B. , 'Cytotoxic assays and other immunologic studies induced by Friend virus ' (1963 ) 31 J. Natl. Cancer Inst. : 111 -123.

    • Search Google Scholar
  • Old, L., Boyse, E. A., Lilly, F.: Formation of cytotoxic antibody against leukemias induced by Friend virus. Cancer Res. 23, 1063–1068 (1963).

    Lilly F. , 'Formation of cytotoxic antibody against leukemias induced by Friend virus ' (1963 ) 23 Cancer Res. : 1063 -1068.

    • Search Google Scholar
  • Fink, M. A., Rauscher, F. J.: Immune reactions to a murine leukemia virus. Induction of immunity to infection with virus in the natural host. J. Natl. Cancer Inst. 32, 1075–1086 (1964).

    Rauscher F. J. , 'Immune reactions to a murine leukemia virus. Induction of immunity to infection with virus in the natural host ' (1964 ) 32 J. Natl. Cancer Inst. : 1075 -1086.

    • Search Google Scholar
  • Voisin, V., Legault, P., Ospina, D. P., Ben-David, Y., Rassart, E.: Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus. BMC Med. Genomics 3, 1–35 (2010).

    Rassart E. , 'Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus ' (2010 ) 3 BMC Med. Genomics : 1 -35.

    • Search Google Scholar
  • Ancheva, M.: The immunosuppressive effect of the Graffi leukemia virus. Vopr. Virusol. 16, 661–665 (1971).

    Ancheva M. , 'The immunosuppressive effect of the Graffi leukemia virus ' (1971 ) 16 Vopr. Virusol. : 661 -665.

    • Search Google Scholar
  • Pasternak, G.: Antigens induced by the mouse leukemia viruses. Adv. Cancer Res. 12, 1–99 (1969).

    Pasternak G. , 'Antigens induced by the mouse leukemia viruses ' (1969 ) 12 Adv. Cancer Res. : 1 -99.

    • Search Google Scholar
  • Pasternak, G., Graffi, A.: Immunological studies on virus and cell interaction with a mouse leukemia virus. Zentralbl. Veterinärmed. B 15, 65–72 (1968).

    Graffi A. , 'Immunological studies on virus and cell interaction with a mouse leukemia virus ' (1968 ) 15 Zentralbl. Veterinärmed. B : 65 -72.

    • Search Google Scholar
  • Sinkovics, J. G., Pienta, R. J., Ahearn, M. J., Trujillo, J. M., Mikulik, F. M.: Activities of immune lymphoid cells against leukemia virus-carrier murine neoplastic cells. Bibl. Haematol. 36, 618–623 (1970c).

    Mikulik F. M. , 'Activities of immune lymphoid cells against leukemia virus-carrier murine neoplastic cells ' (1970 ) 36 Bibl. Haematol. : 618 -623.

    • Search Google Scholar
  • Vandeputte, M., De Lafonteyne, J., Billiau, A., De Somer, P.: Influence and production of interferon in Rauscher virus infected mice. Arch. Ges. Virusforsch. 20, 235–245 (1967).

    Somer P. , 'Influence and production of interferon in Rauscher virus infected mice ' (1967 ) 20 Arch. Ges. Virusforsch. : 235 -245.

    • Search Google Scholar
  • Glasgow, L. A., Friedman, S. B.: Interferon and host resistance to Rauscher virus-induced leukemia. J. Virol. 3, 99–105 (1969).

    Friedman S. B. , 'Interferon and host resistance to Rauscher virus-induced leukemia ' (1969 ) 3 J. Virol. : 99 -105.

    • Search Google Scholar
  • Hekman, R. A., Trapman, J.: The effect of murine interferon-alpha/beta on an established Rauscher murine leukemia virus-induced erythroleukemia in BALB/c mice. Int. J. Cancer 35, 515–520 (1985).

    Trapman J. , 'The effect of murine interferon-alpha/beta on an established Rauscher murine leukemia virus-induced erythroleukemia in BALB/c mice ' (1985 ) 35 Int. J. Cancer : 515 -520.

    • Search Google Scholar
  • Gresser, I., Maury, C., Belardelli, F., Maunoury, M. T., Machover, D.: Effectiveness of mouse interferon alpha/beta compared to single-agent chemotherapy in increasing survival time of mice after intravenous inoculation of Friend erythroleukemia cells. J. Natl. Cancer Inst. 80, 126–131 (1988).

    Machover D. , 'Effectiveness of mouse interferon alpha/beta compared to single-agent chemotherapy in increasing survival time of mice after intravenous inoculation of Friend erythroleukemia cells ' (1988 ) 80 J. Natl. Cancer Inst. : 126 -131.

    • Search Google Scholar
  • Gerlach, N., Gibbert, K., Alter, C., Nair, S., Zelinskyy, G., James, C. M., Dittmer, U.: Anti-retroviral effects of type I IFN subtypes in vivo. Eur. J. Immunol. 39, 136–146 (2009).

    Dittmer U. , 'Anti-retroviral effects of type I IFN subtypes in vivo ' (2009 ) 39 Eur. J. Immunol. : 136 -146.

    • Search Google Scholar
  • Bekesi, J. G., Roboz, J. P., Zimmerman, E., Holland, J. F.: Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon. Cancer Res. 36, 631–639 (1976).

    Holland J. F. , 'Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon ' (1976 ) 36 Cancer Res. : 631 -639.

    • Search Google Scholar
  • Rossi, G. B., Marchegiani, M., Matarese, G. P., Gresser, I.: Inhibitory effect of interferon on multiplication of Friend leukemia cells in vivo. J. Natl. Cancer Inst. 54, 993–996 (1975).

    Gresser I. , 'Inhibitory effect of interferon on multiplication of Friend leukemia cells in vivo ' (1975 ) 54 J. Natl. Cancer Inst. : 993 -996.

    • Search Google Scholar
  • Belardelli, F., Gresser, I., Maury, C., Duvillard, P., Prade, M., Maunoury, M. T.: Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously. Int. J. Cancer 31, 649–653 (1983).

    Maunoury M. T. , 'Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously ' (1983 ) 31 Int. J. Cancer : 649 -653.

    • Search Google Scholar
  • Gresser, I., Kaido, T., Maury, C., Woodrow, D., Moss, J., Belardelli, F.: Interaction of IFN alpha/beta with host cells essential to the early inhibition of Friend erythroleukemia visceral metastases in mice. Int. J. Cancer 57, 604–611 (1994).

    Belardelli F. , 'Interaction of IFN alpha/beta with host cells essential to the early inhibition of Friend erythroleukemia visceral metastases in mice ' (1994 ) 57 Int. J. Cancer : 604 -611.

    • Search Google Scholar
  • Gresser, I., Maury, C., Kaido, T., Bandu, M. T., Tovey, M. G., Maunoury, M. T., Fantuzzi, L., Gessani, S., Greco, G., Belardelli, F.: The essential role of endogenous IFN alpha/beta in the anti-metastatic action of sensitized T lymphocytes in mice injected with Friend erythroleukemia cells. Int. J. Cancer 63, 726–731 (1995).

    Belardelli F. , 'The essential role of endogenous IFN alpha/beta in the anti-metastatic action of sensitized T lymphocytes in mice injected with Friend erythroleukemia cells ' (1995 ) 63 Int. J. Cancer : 726 -731.

    • Search Google Scholar
  • Gresser, I., Maury, C., Carnaud, C., De Maeyer, E., Maunoury, M. T., Belardelli, F.: Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend erythroleukemia cells. VII. Role of the immune system in the inhibition of visceral metastases. Int. J. Cancer 46, 468–474 (1990).

    Belardelli F. , 'Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend erythroleukemia cells. VII. Role of the immune system in the inhibition of visceral metastases ' (1990 ) 46 Int. J. Cancer : 468 -474.

    • Search Google Scholar
  • Chany, C.: My tortuous journey to a life in interferon research. J. Interferon Cytokine Res. 27, 897–899 (2007).

    Chany C. , 'My tortuous journey to a life in interferon research ' (2007 ) 27 J. Interferon Cytokine Res. : 897 -899.

    • Search Google Scholar
  • Gresser, I.: Interferons an unfolding tale. J. Interferon Cytokine Res. 27, 447–452 (2007).

    Gresser I. , 'Interferons an unfolding tale ' (2007 ) 27 J. Interferon Cytokine Res. : 447 -452.

    • Search Google Scholar
  • Sarma, P. S., Shiu, G., Baron, S., Huebner, R. J.: Inhibitory effect of interferon on murine sarcoma and leukaemia virus infection in vitro. Nature 223, 845–846 (1969).

    Huebner R. J. , 'Inhibitory effect of interferon on murine sarcoma and leukaemia virus infection in vitro ' (1969 ) 223 Nature : 845 -846.

    • Search Google Scholar
  • Périés, J., Canivet, M., Olivié, M., Sallé, M., Boiron, M.: Decrease of sensitivity to interferon in cells infected by murine leukemia-sarcoma viruses. J. Natl. Cancer Inst. 51, 455–463 (1973).

    Boiron M. , 'Decrease of sensitivity to interferon in cells infected by murine leukemia-sarcoma viruses ' (1973 ) 51 J. Natl. Cancer Inst. : 455 -463.

    • Search Google Scholar
  • Chany-Fournier, F., Chany, C., Lafay, F.: Mechanism of polykaryocyte induction by vesicular stomatitis virus in rat XC cells. J. Gen. Virol. 34, 305–314 (1977).

    Lafay F. , 'Mechanism of polykaryocyte induction by vesicular stomatitis virus in rat XC cells ' (1977 ) 34 J. Gen. Virol. : 305 -314.

    • Search Google Scholar
  • Sinkovics, J. G., Horvath, J. C.: Natural and genetically engineered viral agents for oncolysis and gene therapy of human cancers. Arch. Immunol. Ther. Exp. 56,Suppl, 1, 3s–59s (2008).

    Horvath J. C. , 'Natural and genetically engineered viral agents for oncolysis and gene therapy of human cancers ' (2008 ) 56 Arch. Immunol. Ther. Exp. : 3s -59s.

    • Search Google Scholar
  • Marques, R., Antunes, I., Eksmond, U., Stoye, J., Hasenkrug, K., Kassiotis, G. B.: Lymphocyte activation by coinfection prevents immune control of Friend virus infection. J. Immunol. 181, 3432–3440 (2008).

    Kassiotis G. B. , 'Lymphocyte activation by coinfection prevents immune control of Friend virus infection ' (2008 ) 181 J. Immunol. : 3432 -3440.

    • Search Google Scholar
  • Wheelock, E. F.: Inhibitory effects of Sendai virus on Friend virus leukemia in mice. J. Natl. Cancer Inst. 38, 771–778 (1967).

    Wheelock E. F. , 'Inhibitory effects of Sendai virus on Friend virus leukemia in mice ' (1967 ) 38 J. Natl. Cancer Inst. : 771 -778.

    • Search Google Scholar
  • Pike, R,, Filbym A,, Ploquin, M. J., Eksmond, U., Marques, R., Antunes, I., Hasenkrug, K., Kassiotis, G.: Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J. Virol. 83, 11211–11222 (2009).

    Kassiotis G. , 'Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection ' (2009 ) 83 J. Virol. : 11211 -11222.

    • Search Google Scholar
  • Pogodina, V. V., Malenko, G. V., Levina, L. S., Karmyshev, Vla., Farutina, L. M.: Mechanisms of the stimulating action of the Rauscher leukemia virus on togavirus reproduction in the bodies of BALB/c strain mice. Vopr. Virusol. 4, 449–454 (1980).

    Farutina L. M. , 'Mechanisms of the stimulating action of the Rauscher leukemia virus on togavirus reproduction in the bodies of BALB/c strain mice ' (1980 ) 4 Vopr. Virusol. : 449 -454.

    • Search Google Scholar
  • Pogodina, V. V., Senyuta, N. B., Karmysheva, V. V., Korolev, M. B., Satalkina, M. I., Kiseleva, L., Merekalova, Z. I., Mazurenko, N. P.: Study on the mechanism of interference between Friend leukemia and Sindbis viruses in tissue culture. Neoplasma 23, 61–70 (1976).

    Mazurenko N. P. , 'Study on the mechanism of interference between Friend leukemia and Sindbis viruses in tissue culture ' (1976 ) 23 Neoplasma : 61 -70.

    • Search Google Scholar
  • Zinkernagel, R. M., Hengartner, H.: Regulation of the immune response by antigen. Science 293, 251–253 (2001).

    Hengartner H. , 'Regulation of the immune response by antigen ' (2001 ) 293 Science : 251 -253.

    • Search Google Scholar
  • Antunes, I., Tolaini, M., Kissenpfennig, A., Iwashiro, M., Kuribayashi, K., Malissen, B., Hasenkrug, K., Kassiotis, G.: Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity 29, 782–794 (2008).

    Kassiotis G. , 'Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology ' (2008 ) 29 Immunity : 782 -794.

    • Search Google Scholar
  • Weislow, O. S., Wheelock, E. F.: Suppression of established Friend virus leukemia by statolon: Potentiation of statolon’s leukemosuppressive activity by chlorite-oxidized oxyamylose. Infect. Immun. 1, 129–136 (1975).

    Wheelock E. F. , 'Suppression of established Friend virus leukemia by statolon: Potentiation of statolon’s leukemosuppressive activity by chlorite-oxidized oxyamylose ' (1975 ) 1 Infect. Immun. : 129 -136.

    • Search Google Scholar
  • Tóth, F. D., Váczi, L., Berencsi, C.: Interferon and antibody production in inbred mice infected with the Rauscher virus. Acta Micriobiol. Acad. Sci. Hung. 18, 23–27 (1971a).

    Berencsi C. , 'Interferon and antibody production in inbred mice infected with the Rauscher virus ' (1971 ) 18 Acta Micriobiol. Acad. Sci. Hung. : 23 -27.

    • Search Google Scholar
  • Tóth, F. D., Váczi, L., Berencsi, C.: Effect of interferon treatment on the tumour-specific antibody response of BALB-c mice infected with Rauscher virus. Acta Microbiol. Acad. Sci. Hung. 18, 109–112 (1971b).

    Berencsi C. , 'Effect of interferon treatment on the tumour-specific antibody response of BALB-c mice infected with Rauscher virus ' (1971 ) 18 Acta Microbiol. Acad. Sci. Hung. : 109 -112.

    • Search Google Scholar
  • Heremans, H., Billiau, A., Colombatti, A., Hilgers, J., de Somer, P.: Interferon treatment of NZB mice: Accelerated progression of autoimmune disease. Infect. Immun. 21, 925–930 (1978).

    Somer P. , 'Interferon treatment of NZB mice: Accelerated progression of autoimmune disease ' (1978 ) 21 Infect. Immun. : 925 -930.

    • Search Google Scholar
  • Gross, L.: The Rauscher virus: A mixture of the Friend virus and the mouse leukemia virus (Gross)? Acta Haematol. 35, 200–213 (1966).

    Gross L. , 'The Rauscher virus: A mixture of the Friend virus and the mouse leukemia virus (Gross)? ' (1966 ) 35 Acta Haematol. : 200 -213.

    • Search Google Scholar
  • Sinkovics, J. G.: The earliest concept of the “hybridoma principle” recognized in 1967–1968. Front Rad. Ther. Oncol. 24, 18–31 (1990).

    Sinkovics J. G. , 'The earliest concept of the “hybridoma principle” recognized in 1967–1968 ' (1990 ) 24 Front Rad. Ther. Oncol. : 18 -31.

    • Search Google Scholar
  • Sinkovics, J. G.: A notable phenomenon recapitulated. Fusion product of a murine lymphoma cell and a leukemia virus-neutralizing antibody-producer host plasma cell formed spontaneously and secreting the specific antibody continuously. Acta Microbiol. Immunol. Hung. 52, 1–40 (2005).

    Sinkovics J. G. , 'A notable phenomenon recapitulated. Fusion product of a murine lymphoma cell and a leukemia virus-neutralizing antibody-producer host plasma cell formed spontaneously and secreting the specific antibody continuously ' (2005 ) 52 Acta Microbiol. Immunol. Hung. : 1 -40.

    • Search Google Scholar
  • Bock, O., Hussein, K., Neusch, M., Schlué, J., Wiese, B., Kreipe, H.: Transcription factor Fli-1 expression by bone marrow cells in chronic myeloproliferative disorders is independent of an underlying JAK2 (V617F) mutation. Eur. J. Haematol. 77, 463–470 (2006).

    Kreipe H. , 'Transcription factor Fli-1 expression by bone marrow cells in chronic myeloproliferative disorders is independent of an underlying JAK2 (V617F) mutation ' (2006 ) 77 Eur. J. Haematol. : 463 -470.

    • Search Google Scholar
  • Sinkovics, J. G.: Adult human sarcomas. I. Basic science. Exp. Rev. Anticancer Ther. 7, 31–56 (2007).

    Sinkovics J. G. , 'Adult human sarcomas. I. Basic science ' (2007 ) 7 Exp. Rev. Anticancer Ther. : 31 -56.

    • Search Google Scholar
  • Sinkovics, J. G.: Adult human sarcomas. II. Medical oncology. Exp. Rev. Anticancer Ther. 7, 183–210 (2007).

    Sinkovics J. G. , 'Adult human sarcomas. II. Medical oncology ' (2007 ) 7 Exp. Rev. Anticancer Ther. : 183 -210.

    • Search Google Scholar
  • Kaygusuz, G., Kuzu, I.: Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors. Turk. J. Gastroenterol. 20, 83–86 (2009).

    Kuzu I. , 'Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors ' (2009 ) 20 Turk. J. Gastroenterol. : 83 -86.

    • Search Google Scholar
  • Strestik, B. D., Olbrich, A. R. M., Hasenkrug, K. J., Dittmer, U.: The role of IL-5, IL-6 and IL-10 in primary and vaccine-primed immune responses to infection with Friend retrovirus (Murine leukaemia virus). J. Gen. Virol. 82, 1349–1354 (2001).

    Dittmer U. , 'The role of IL-5, IL-6 and IL-10 in primary and vaccine-primed immune responses to infection with Friend retrovirus (Murine leukaemia virus) ' (2001 ) 82 J. Gen. Virol. : 1349 -1354.

    • Search Google Scholar
  • Dietz, M., Fouchey, S. P., Longley, C., Rich, M. A., Furmanski, P.: Spontaneous regression of Friend virus-induced erythroleukemia. I. The role of the helper mouse leukemia virus component. J. Exp. Med. 145, 594–606 (1977).

    Furmanski P. , 'Spontaneous regression of Friend virus-induced erythroleukemia. I. The role of the helper mouse leukemia virus component ' (1977 ) 145 J. Exp. Med. : 594 -606.

    • Search Google Scholar
  • Friend, C.: The regulation of differentiation in murine virus-induced erythroleukemia cells. Cell Differ. 11, 202–212 (1980).

    Friend C. , 'The regulation of differentiation in murine virus-induced erythroleukemia cells ' (1980 ) 11 Cell Differ : 202 -212.

    • Search Google Scholar
  • Sinkovics, J. G.: Antitumor activity of L-asparaginase and rifampicin. Lancet 2, 48–49 (1941).

    Sinkovics J. G. , 'Antitumor activity of L-asparaginase and rifampicin ' (1941 ) 2 Lancet : 48 -49.

    • Search Google Scholar
  • Borden, E. C., Carter, W. A., Sensenbrenner, L. L., Owens, A. H., Lichtenstein, J., Gray, G. D., Neil, G. L., Nichol, P. R., Li, L. H.: Inhibition by streptovaricins of Rauscher virus splenomegaly. Int. J. Cancer 14, 817–825 (1974).

    Li L. H. , 'Inhibition by streptovaricins of Rauscher virus splenomegaly ' (1974 ) 14 Int. J. Cancer : 817 -825.

    • Search Google Scholar
  • Sassa, S., Wolpe, S., Cerami, A.: Inhibition of erythroid differentiation of mouse erythroleukemia cells by a macrophage product(s). Blood Cells 13, 161–169 (1987).

    Cerami A. , 'Inhibition of erythroid differentiation of mouse erythroleukemia cells by a macrophage product(s) ' (1987 ) 13 Blood Cells : 161 -169.

    • Search Google Scholar
  • Affabris, E., Federico, M., Romeo, C., Coccia, E. M., Rossi, G. B.: Opposite effects of murine interferons on erythroid differentiation of Friend cells. Virology 5, 185–193 (1988).

    Rossi G. B. , 'Opposite effects of murine interferons on erythroid differentiation of Friend cells ' (1988 ) 5 Virology : 185 -193.

    • Search Google Scholar
  • Sala, A., Gresser, I., Chassoux, D., Maury, C., Santodonato, L., Eid, P., Maunoury, M., Barca, S., Cianfrigila, M., Belardelli, F.: Inhibition of Friend leukemia cell visceral metastases by a new monoclonal antibody and role of the immune system of the host in its action. Cancer Res. 52, 2880–2889 (1992).

    Belardelli F. , 'Inhibition of Friend leukemia cell visceral metastases by a new monoclonal antibody and role of the immune system of the host in its action ' (1992 ) 52 Cancer Res : 2880 -2889.

    • Search Google Scholar
  • Dittmer, U., Peterson, K. E., Messer, R., Stromnes, I. M., Race, B., Hasenkrug, K. J.: Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection. J. Virol. 75, 654–760 (2001).

    Hasenkrug K. J. , 'Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection ' (2001 ) 75 J. Virol. : 654 -760.

    • Search Google Scholar
  • Nair, S. R., Zelinskyy, G., Schimmer, S., Gerlach, N., Kassiotis, G., Dittmer, U.: Mechanisms of control of acute Friend virus infection by CD4+ helper T cells and their functional impairment by regulatory T cells. J. Gen. Virol. 91, 440–451 (2009).

    Dittmer U. , 'Mechanisms of control of acute Friend virus infection by CD4+ helper T cells and their functional impairment by regulatory T cells ' (2009 ) 91 J. Gen. Virol. : 440 -451.

    • Search Google Scholar
  • Cervi, D., Shaked, Y., Haeri, M., Usenko, T., Lee, C. R., Haigh, J, J., Nagy, A., Kerbel, R. S., Yefenof, E., Ben-David, Y.: Enhanced natural killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia. Blood 109, 2139–2146 (2007).

    Ben-David Y. , 'Enhanced natural killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia ' (2007 ) 109 Blood : 2139 -2146.

    • Search Google Scholar
  • Iwanami, N., Niwa, A., Yasutomi, Y., Tabata, N., Miyazawa, M.: Role of natural killer cells in resistance against Friend retrovirus-induced leukemia. J. Virol. 75, 3152–3163 (2001).

    Miyazawa M. , 'Role of natural killer cells in resistance against Friend retrovirus-induced leukemia ' (2001 ) 75 J. Virol. : 3152 -3163.

    • Search Google Scholar
  • Siegert, W., Fenyõ, E. M., Klein, G.: Separation of the Moloney leukemia virus-determined cell surface antigen (MCSA) from known virion proteins associated with the cell membrane. Int. J. Cancer 20, 75–82 (1977).

    Klein G. , 'Separation of the Moloney leukemia virus-determined cell surface antigen (MCSA) from known virion proteins associated with the cell membrane ' (1977 ) 20 Int. J. Cancer : 75 -82.

    • Search Google Scholar
  • Kiessling, R. W., Welsh, R. M., Jr.: Killing of normal cells by activated mouse natural killer cells: Evidence for two patterns of genetic regulation of lysis. Int. J. Cancer 25, 611–615 (1980).

    Welsh R. M. , 'Killing of normal cells by activated mouse natural killer cells: Evidence for two patterns of genetic regulation of lysis ' (1980 ) 25 Int. J. Cancer : 611 -615.

    • Search Google Scholar
  • Dahl, C. A.: Natural cytotoxicity in the mouse embryo: Characterization of yolk sac-associated natural cytotoxic cells and their activity. Eur. J. Immunol. 13, 747–755 (1983).

    Dahl C. A. , 'Natural cytotoxicity in the mouse embryo: Characterization of yolk sac-associated natural cytotoxic cells and their activity ' (1983 ) 13 Eur. J. Immunol. : 747 -755.

    • Search Google Scholar
  • Lindvall, M., Eriksson, H., Hedlund, G., Sjögren, H. O.: Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma. Scand. J. Immunol. 46, 476–487 (1997).

    Sjögren H. O. , 'Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma ' (1997 ) 46 Scand. J. Immunol. : 476 -487.

    • Search Google Scholar
  • Prigozhina, T. B., Elkin, G., Khitrin, S., Slavin, S.: Prevention of acute graft-vs-host disease by a single low-dose cyclophosphamide injection following allogeneic bone marrow transplantation. Exp. Hematol. 36, 1750–1759 (2008).

    Slavin S. , 'Prevention of acute graft-vs-host disease by a single low-dose cyclophosphamide injection following allogeneic bone marrow transplantation ' (2008 ) 36 Exp. Hematol. : 1750 -1759.

    • Search Google Scholar
  • Yu, P., Cao, S., Xin, N., An, X. M., Qi, J., Ren, X. B.: Application of low dose of fludarabine and cyclophosphamide combined with donor NK cells as a non-myeloablative conditioning regimen for the haploidentical hematopoietic stem cell transplantation in mice. Zhongguo Shi Yan XueYe Xue Za Zhi 15, 1013–1018 (2007). (PubMed Abstract).

    Ren X. B. , 'Application of low dose of fludarabine and cyclophosphamide combined with donor NK cells as a non-myeloablative conditioning regimen for the haploidentical hematopoietic stem cell transplantation in mice ' (2007 ) 15 Zhongguo Shi Yan XueYe Xue Za Zhi : 1013 -1018.

    • Search Google Scholar
  • Wang, C. Y., Tan, H., Guo, K. Y.: The action of donor-derived NK cell in leukemic mice MHC haplotype-mismatched bone marrow transplantation. Zhonghua Xue Ye Xue Za Zhi 30, 107–110 (2009) (PubMed Abstract).

    Guo K. Y. , 'The action of donor-derived NK cell in leukemic mice MHC haplotype-mismatched bone marrow transplantation ' (2009 ) 30 Zhonghua Xue Ye Xue Za Zhi : 107 -110.

    • Search Google Scholar
  • Ghosh, A., Koestner, W., Hapke, M., Schlaphoff, V., Länger, F., Baumann, R., Koenecke, C., Comberg, M., Welte, K., Blazar, B. R., Sauer, M. G.: Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras. Blood 113, 4440–4448 (2009).

    Sauer M. G. , 'Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras ' (2009 ) 113 Blood : 4440 -4448.

    • Search Google Scholar
  • He, K. M., Ma, Y., Wang, S., Min, W. P., Zhong, R., Jevnikar, A., Zhang, Z. X.: Donor double-negative Treg promote allogeneic mixed chimerism and tolerance. Eur. J. Immunol. 37, 3455–3466 (2007).

    Zhang Z. X. , 'Donor double-negative Treg promote allogeneic mixed chimerism and tolerance ' (2007 ) 37 Eur. J. Immunol. : 3455 -3466.

    • Search Google Scholar
  • Verbinnen, B., Billiau, A. D., Vermeiren, J., Galicia, G., Bullens, D. M., Boon, L., Cadot, P., Hens, G., Dewolf-Peeters, C., Van Gool, S. W., Ceuppens, J. L.: Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade. J. Immunol. 181, 1034–1042 (2008).

    Ceuppens J. L. , 'Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade ' (2008 ) 181 J. Immunol. : 1034 -1042.

    • Search Google Scholar
  • Fevery, S., Billiau, A. D., Sprangers, B., Rutgeerts, O., Lenaerts, C., Goebels, J., Landuyt, W., Kasran, A., Boon, L., Sagaert, X., De Wolf-Peeters, C., Waer, M., Vanderberghe, P.: CTLA4-blockade in murine bone marrow chimeras induces a host-derived anti-leukemia effect without graft-versus-host disease. Leukemia 21, 1451–1459 (2007).

    Vanderberghe P. , 'CTLA4-blockade in murine bone marrow chimeras induces a host-derived anti-leukemia effect without graft-versus-host disease ' (2007 ) 21 Leukemia : 1451 -1459.

    • Search Google Scholar
  • Whitaker-Menezes, D., Jones, S. C., Friedman, T. M., Korngold, R., Murphy, G. F.: An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression. Biol. Blood Marrow Transplant. 9, 559–570 (2003).

    Murphy G. F. , 'An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression ' (2003 ) 9 Biol. Blood Marrow Transplant. : 559 -570.

    • Search Google Scholar
  • Zhan, Q., Signoretti, S., Whitaker-Menezes, D., Friedman, T. M., Korngold, R., Murphy, G. F.: Cytokeratin 15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive anti-apoptotic phenotype. J. Invest. Dermatol. 127, 106–115 (2007).

    Murphy G. F. , 'Cytokeratin 15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive anti-apoptotic phenotype ' (2007 ) 127 J. Invest. Dermatol. : 106 -115.

    • Search Google Scholar
  • Korngold, R.: Biology of graft-vs.-host disease. Am. J. Pediatr. Hematol. Oncol.15, 18–27 (1993).

    Korngold R. , 'Biology of graft-vs.-host disease ' (1993 ) 15 Am. J. Pediatr. Hematol. Oncol. : 18 -27.

    • Search Google Scholar
  • Patterson, A. E., Korngold, R.: Infusion of select leukemia-reactive TCR Vbeta+ T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 7, 187–196 (2001).

    Korngold R. , 'Infusion of select leukemia-reactive TCR Vbeta+ T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation ' (2001 ) 7 Biol. Blood Marrow Transplant. : 187 -196.

    • Search Google Scholar
  • Scheffold, C., Scheffold, Y. C., Cao, T. M., Gworek, J., Shizuru, J. A.: Cytokines and cytotoxic pathways in engraftment resistance to purified hematopoietic stem cells. Biol. Blood Marrow Transplant. 11, 1–12 (2005).

    Shizuru J. A. , 'Cytokines and cytotoxic pathways in engraftment resistance to purified hematopoietic stem cells ' (2005 ) 11 Biol. Blood Marrow Transplant. : 1 -12.

    • Search Google Scholar
  • Podack, E. R.: Cytolytic Lymphocytes and Complement: Effectors of the Immune System. Volume II, CRC Press, Boca Raton, FL, 1988, pp. 235.

    Podack E. R. , '', in Cytolytic Lymphocytes and Complement: Effectors of the Immune System. Volume II , (1988 ) -.

    • Search Google Scholar
  • Sinkovics, J. G.: Malignant lymphoma arising from natural killer cells: Report of the first case in 1970 and newer developments of the FasL → FasR system. Acta Microbiol. Immunol. Hung. 44, 295–307 (1997). Erratum. The Fas receptor is CD95.

    Sinkovics J. G. , 'Malignant lymphoma arising from natural killer cells: Report of the first case in 1970 and newer developments of the FasL → FasR system ' (1997 ) 44 Acta Microbiol. Immunol. Hung. : 295 -307.

    • Search Google Scholar
  • Sinkovics, J. G., Horvath, J. C.: Virological and immunological connotations of apoptotic and anti-apoptotic forces in neoplasia. Int. J. Oncology 19, 473–488 (2001). Erratum. Int. J. Oncol. 27, 33 (2005).

    Horvath J. C. , 'Virological and immunological connotations of apoptotic and anti-apoptotic forces in neoplasia ' (2001 ) 19 Int. J. Oncology : 473 -488.

    • Search Google Scholar
  • Sitkovsky, M. V., Henkart, P. A.: Cytotoxic Lymphocytes: Basic Mechanisms and Medical Applications. Lippincott Williams & Wilkins, Philadelphia, PA, 2000.

    Henkart P. A. , '', in Cytotoxic Lymphocytes: Basic Mechanisms and Medical Applications , (2000 ) -.

    • Search Google Scholar
  • Castor, M. G., Rezende, B., Resende, C. B., Alessandri, A. L., Fagundes, C. T., Sousa, L. P., Arantes, R. M., Souza, D. G., Silva, T. A., Proudfoot, A. E., Teixera, M. M., Pinho, V.: The CCL3/macrophage inflammatory protein-1 (alpha)-binding protein evasin-1 protects from graft-versus-host disease but not modify graft-versus leukemia in mice. J. Immunol. 184, 2646–2654 (2010).

    Pinho V. , 'The CCL3/macrophage inflammatory protein-1 (alpha)-binding protein evasin-1 protects from graft-versus-host disease but not modify graft-versus leukemia in mice ' (2010 ) 184 J. Immunol. : 2646 -2654.

    • Search Google Scholar
  • Palmer, L. A., Sale, G. E., Balogun, J. I., Li, D., Jones, D., Molldrem, J. J., Storb, R. F., Ma, Q.: Chemokine receptor CCR5 mediates allo-immune responses in graft-vs-host diaease. Biol. Blood Marrow Transplant. 16, 311–319 (2009).

    Ma Q. , 'Chemokine receptor CCR5 mediates allo-immune responses in graft-vs-host diaease ' (2009 ) 16 Biol. Blood Marrow Transplant. : 311 -319.

    • Search Google Scholar
  • Iwasaki, A., Medzhitov, R.: Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5, 987–995 (2004).

    Medzhitov R. , 'Toll-like receptor control of the adaptive immune responses ' (2004 ) 5 Nat. Immunol. : 987 -995.

    • Search Google Scholar
  • Jones, J. M., Wilson, R., Bealmear, P. M.: Mortality and gross pathology of secondary disease in germ-free mouse radiation chimeras. Radiat. Res. 45, 577–588 (1971).

    Bealmear P. M. , 'Mortality and gross pathology of secondary disease in germ-free mouse radiation chimeras ' (1971 ) 45 Radiat. Res. : 577 -588.

    • Search Google Scholar
  • Berger, C., Riddell, S. R.: Principles of immune cell therapy. In Lichtman, M. A., Kipps, T. J., Kaushansky, K., Beutler, E., Seligson, U., Prchal, J. T. (eds): Williams Hematology 7th edition. McGraw-Hill, New York, NY, 2006, pp. 323–332.

    Riddell S. R. , '', in Williams Hematology , (2006 ) -.

  • Böiers, C., Buza-Vidas, N., Jensen, C. T., Pronk, C. J., Kharazi, S., Wittmann, L., Sitnicka, E., Hultquist, A., Jacobsen, S. E.: Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development. Blood 115, 5061–5068 (2010).

    Jacobsen S. E. , 'Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development ' (2010 ) 115 Blood : 5061 -5068.

    • Search Google Scholar
  • Guimond, M., Freud, A. G., Mao, H. C., Yu, J., Blaser, B. W., Leong, J. W., Vandeusen, F. B., Dorrance, A., Zhang, J., Mackall, C. L., Caliguri, M. A.: In vivo role of Flt3 ligand and dendritic cells in NK homeostasis. J. Immunol. 184, 2769–2775 (2010).

    Caliguri M. A. , 'In vivo role of Flt3 ligand and dendritic cells in NK homeostasis ' (2010 ) 184 J. Immunol. : 2769 -2775.

    • Search Google Scholar
  • Liu, Y. J.: A unified theory of central tolerance in the thymus. Trends Immunol. 27, 215–221 (2006).

    Liu Y. J. , 'A unified theory of central tolerance in the thymus ' (2006 ) 27 Trends Immunol. : 215 -221.

    • Search Google Scholar
  • Watanabe, N., Wang, Y. H., Le, H. K., Ito, T., Wang, Y. H., Cao, W., Liu, Y. H.: Hassall’s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436, 1181–1185 (2005).

    Liu Y. H. , 'Hassall’s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus ' (2005 ) 436 Nature : 1181 -1185.

    • Search Google Scholar
  • Miller, J. S., Curtsinger, J., Berthold, M., Malvey, K., Bliss, R. L., Le, C. T., Fautsch, S. K., Dudek, A. Z., Blazar, B. R., Panoskaltsis-Mortari, A.: Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation. Clin. Immunol. 117, 144–151 (2005).

    Panoskaltsis-Mortari A. , 'Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation ' (2005 ) 117 Clin. Immunol. : 144 -151.

    • Search Google Scholar
  • Bao, X. J., Hou, L. H., Sun, A. N., Qiu, Q. C., Yuan, X. N., Chen, M. H., Chen, Z. X., He, J.: The impact of KIR2DS4 alleles and the expression of KIR in the development of acute GVHD after unrelated allogeneic hematopoietic SCT. Bone Marrow Transplant. 45, 1435–1441 (2010).

    He J. , 'The impact of KIR2DS4 alleles and the expression of KIR in the development of acute GVHD after unrelated allogeneic hematopoietic SCT ' (2010 ) 45 Bone Marrow Transplant : 1435 -1441.

    • Search Google Scholar
  • Hsu, K. C., Dupont, B.: Natural killer cell receptors: Regulating innate immune responses to hematologic malignancy. Semin. Hematol. 42, 91–103 (2005).

    Dupont B. , 'Natural killer cell receptors: Regulating innate immune responses to hematologic malignancy ' (2005 ) 42 Semin. Hematol. : 91 -103.

    • Search Google Scholar
  • Norman, P. J., Parham, P.: Complex interactions: The immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors. Semin. Hematol. 42, 65–75 (2005).

    Parham P. , 'Complex interactions: The immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors ' (2005 ) 42 Semin. Hematol. : 65 -75.

    • Search Google Scholar
  • Venstrom, J. M., Gooley, T. A., Spellman, S., Pring, J., Maikki, M., Dupont, B., Petersdorf, E., Hsu, K. C.: Donor activating KIR3DS1 is associated with decreased acute GvHD in unrelated allogeneic stem cell transplantation. Blood 115, 3162–3165 (2010).

    Hsu K. C. , 'Donor activating KIR3DS1 is associated with decreased acute GvHD in unrelated allogeneic stem cell transplantation ' (2010 ) 115 Blood : 3162 -3165.

    • Search Google Scholar
  • Schroder, K., Zhou, R., Tschopp, J.: The NLRP3 inflammasome: a sensor for metabolic danger? Science 327, 296–300 (2010).

    Tschopp J. , 'The NLRP3 inflammasome: a sensor for metabolic danger? ' (2010 ) 327 Science : 296 -300.

    • Search Google Scholar
  • Eisenbarth, S. C., Flavell, R. A.: Innate instruction of adaptive immunity revisited: The inflammasome. EMBO Mol. Med. 1, 92–98 (2009).

    Flavell R. A. , 'Innate instruction of adaptive immunity revisited: The inflammasome ' (2009 ) 1 EMBO Mol. Med. : 92 -98.

    • Search Google Scholar
  • Aymeric, L., Apetoh, L., Ghiringhelli, F., Tesniere, A., Martins, I., Kroemer, G., Smyth, M. J., Zitvogel, L.: Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res. 70, 855–858 (2010).

    Zitvogel L. , 'Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity ' (2010 ) 70 Cancer Res. : 855 -858.

    • Search Google Scholar
  • Latz, E.: The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22, 28–33 (2010).

    Latz E. , 'The inflammasomes: mechanisms of activation and function ' (2010 ) 22 Curr. Opin. Immunol. : 28 -33.

    • Search Google Scholar
  • Weber, A., Wasiliew, P., Kracht, M.: Interleukin-1beta (IL-1beta) processing pathway. Sci. Signal 3, cm1 (2010).

  • Penack, O., Holler, E., van den Brink, M. R.: Graft-versus-host disease regulation by microbe-associated molecules and innate immune receptors. Blood 115, 1865–1872 (2009).

    Brink M. R. , 'Graft-versus-host disease regulation by microbe-associated molecules and innate immune receptors ' (2009 ) 115 Blood : 1865 -1872.

    • Search Google Scholar
  • McDermott, D. H., Conway, S. E., Wang, T., Ricklefs, S. M., Agovi, M. A., Tran, H. T., Milford, E., Spellman, S., Abdi, R.: Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation. Blood 115, 2311–2318 (2010).

    Abdi R. , 'Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation ' (2010 ) 115 Blood : 2311 -2318.

    • Search Google Scholar
  • Szendrõi, T., Hajdu, Z., Mikó, I., Bagyó, J., Bokk, A., Barnák, G., Furka, I.: Autologous spleen transplantation. Orvosi Hetilap (Budapest) 134, 125–128 (1993).

    Furka I. , 'Autologous spleen transplantation ' (1993 ) 134 Orvosi Hetilap (Budapest) : 125 -128.

    • Search Google Scholar
  • Baker, C. C., Gaines, H. O., Niven-Fairchild, A. T.: The effect of tuftsin and splenectomy on mortality after intraabdominal sepsis. J. Surg. Res. 36, 499–502 (1984).

    Niven-Fairchild A. T. , 'The effect of tuftsin and splenectomy on mortality after intraabdominal sepsis ' (1984 ) 36 J. Surg. Res. : 499 -502.

    • Search Google Scholar
  • Mücke, D.: Tuftsin. Allerg. Immunol. 30, 127–138 (1964).

    Mücke D. , '' (1964 ) 30 Tuftsin. Allerg. Immunol. : 127 -138.

  • Chu, D. Z., Nishioka, K., el-Hagin, T., Hopfer, R. L., Romsdahl, M. M.: Effects of tuftsin on postsplenectomy sepsis. Surgery 97, 701–706 (1985).

    Romsdahl M. M. , 'Effects of tuftsin on postsplenectomy sepsis ' (1985 ) 97 Surgery : 701 -706.

    • Search Google Scholar
  • Spirer, Z., Zakuth, V., Tzehoval, E., Dagan, S., Fridkin, M., Golander, A., Melamed, I.: Tuftsin stimulates IL-1 production by human mononuclear cells, human spleen cells and mouse spleen cells in vitro. J. Clin. Lab. Immunol. 28, 27–31 (1989).

    Melamed I. , 'Tuftsin stimulates IL-1 production by human mononuclear cells, human spleen cells and mouse spleen cells in vitro ' (1989 ) 28 J. Clin. Lab. Immunol. : 27 -31.

    • Search Google Scholar
  • Cormia, F. E., Campos, L. T., Sinkovics, J. G.: Infections after splenectomy. Clin. Res. 21, 61 (1973).

    Sinkovics J. G. , 'Infections after splenectomy ' (1973 ) 21 Clin. Res. : 61 -.

  • Peczesny, S., Krijanovski, O. I., Braun, T. M., Choi, S. W., Clouthier, S. G., Kuick, R., Misek, D. E., Cooke, K. R., Kitko, C. L., Weyand, A., Bickley, D., Jones, D., Whitfield, J., Reddy, P., Levine, J. E., Hanash, S. M., Ferrara, J. L.: A biomarker panel for acute graft-versus-host disease. Blood 113, 271–272 (2009).

    Ferrara J. L. , 'A biomarker panel for acute graft-versus-host disease ' (2009 ) 113 Blood : 271 -272.

    • Search Google Scholar
  • Hori, T., Naishiro, Y., Sohma, H., Suzuki, N., Hatakeyama, N., Yamamoto, M., Sonoda, T., Mizue, Y., Imai, K., Tsutsumi, H., Kokai, Y.: CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood 111, 4403–4412 (2008).

    Kokai Y. , 'CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease ' (2008 ) 111 Blood : 4403 -4412.

    • Search Google Scholar
  • Goyal, R. K., Lin, Y., Schultz, K. R., Ferrell, R. E., Hee, Y., Fairfull, L., Livote, E., Yanik, G., Atlas, M.: Tumor necrosis factor-alpha gene polymorphisms are associated with severity of acute GVHD following matched unrelated donor BMT in children: A pediatric blood and marrow transplant consortium study. Biol. Blood Marrow Transplant. 16, 927–936 (2010).

    Atlas M. , 'Tumor necrosis factor-alpha gene polymorphisms are associated with severity of acute GVHD following matched unrelated donor BMT in children: A pediatric blood and marrow transplant consortium study ' (2010 ) 16 Biol. Blood Marrow Transplant. : 927 -936.

    • Search Google Scholar
  • Wong, F. L., Francisco, L., Togawa, K., Bosworth, A., Gonzales, M., Hanby, C., Sabado, M., Grant, M., Forman, J., Bhatia, S.: Long-term recovery after hematopoietic cell transplantation: Predictors of quality of life concerns. Blood 115, 2508–2519 (2010).

    Bhatia S. , 'Long-term recovery after hematopoietic cell transplantation: Predictors of quality of life concerns ' (2010 ) 115 Blood : 2508 -2519.

    • Search Google Scholar
  • Brown, R. A., Adkins, D., Khoury, H., Vij, R., Goodnough, L. T., Shenoy, S., DiPersio, J. F.: Long-term follow-up of high-risk allogeneic peripheral-blood stem-cell transplant recipients: Graft-versus-host disease and transplant-related mortality. J. Clin. Oncol. 17, 806–812 (1999).

    DiPersio J. F. , 'Long-term follow-up of high-risk allogeneic peripheral-blood stem-cell transplant recipients: Graft-versus-host disease and transplant-related mortality ' (1999 ) 17 J. Clin. Oncol. : 806 -812.

    • Search Google Scholar
  • Khouri, I. F., Keating, M., Köbling, M., Przepiorka, D., Anderlini, P., O’Brien, S., Giralt, S., Ippoliti, C., von Wolff, B., Gajewski, J., Donato, M., Claxton, D., Ueno, N., Andersson, B., Gee, A., Champlin, R.: Transplant-Lite: Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J. Clin. Oncol. 16, 2817–2824 (1998).

    Champlin R. , 'Transplant-Lite: Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies ' (1998 ) 16 J. Clin. Oncol. : 2817 -2824.

    • Search Google Scholar
  • Bollard, C. M., Gee, A. P.: Graft engineering to enhance engraftment, reduce graft-versus-host-disease, and provide a graft-versus-tumor effect. In Hoffman, R., Benz, E. J., Shatti, Jr. S. J., Furi, B., Cohen, H. J., Silberstein, L. E., McGlave, P. (eds): Hematology Basic Principles and Practice. Elsevier Churchill Livingstone, Philadelphia, PA, 2005, pp. 1783–1828.

    Gee A. P. , '', in Hematology Basic Principles and Practice , (2005 ) -.

  • Sullivan, M. D., Storb, R., Buckner, D., Fefer, A., Fisher, L., Weiden, P. L., Witherspoon, R. P., Appelbaum, F. R., Banaji, M., Hansen, J., Martis, P., Sanders, J. E., Singer, J. Thomas, E. D.: Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms. N. Engl. J. Med. 320, 828–834 (1989).

    Thomas E. D. , 'Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms ' (1989 ) 320 N. Engl. J. Med. : 828 -834.

    • Search Google Scholar
  • Passweg, J. R., Tiberghien, P., Cahn, J. Y., Vowels, M. R., Camitta, R. M., Gale, R. P., Herzig, R. H., Hoelzer, D., Horowitz, M. M., Ifrah, N., Klein, J. P., Marks, D. I., Ramsay, N. K., Rowlings, P. A., Weisdorf, D. J., Zhang, M. J., Barrett, A. J.: Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Transplant. 21, 153–158 (1998).

    Barrett A. J. , 'Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia ' (1998 ) 21 Bone Marrow Transplant. : 153 -158.

    • Search Google Scholar
  • Nishikawa, S., Terakura, S., Yasuda, T., Imahashi, N., Saio, H., Iida, H., Kamiya, Y., Niimi, K., Morishita, Y., Kohno, A., Yokozawa, T., Ohashi, H., Sawa, M., Kodera, Y., Miyamura, K.: Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia. Int. J. Hematol. 91, 419–425 (2010).

    Miyamura K. , 'Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia ' (2010 ) 91 Int. J. Hematol. : 419 -425.

    • Search Google Scholar
  • Martin, P. J., Counts, Jr, G. W., Appelbaum, F. R., Lee, S. J., Sanders, J. E., Deeg, H. J., Flowers, M. E. D., Syrjala, K. L., Hansen, J. A., Storb, R. F., Storer, B. E.: Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J. Clin. Oncol. 28, 1011–1016 (2010).

    Storer B. E. , 'Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation ' (2010 ) 28 J. Clin. Oncol. : 1011 -1016.

    • Search Google Scholar
  • Cornelius, E. A.: Development of tumors as a result of graft-versus-host reaction. Exp. Hematol. 1, 135–149 (1973).

    Cornelius E. A. , 'Development of tumors as a result of graft-versus-host reaction ' (1973 ) 1 Exp. Hematol. : 135 -149.

    • Search Google Scholar
  • Gmeinhart, B., Hinterberger, W., Greinix, H. T., Rabitsch, W., Kirnbauer, R., Reiter, E., Volc-Platzer, B.: Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD). Bone Marrow Transplant. 23, 1197–1199 (1999).

    Volc-Platzer B. , 'Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD) ' (1999 ) 23 Bone Marrow Transplant : 1197 -1199.

    • Search Google Scholar
  • Kruse, A. L., Grätz, K. W.: Oral carcinoma after hematopoietic stem cell transplantation: A new classification based on a literature review over 30 years. Head Neck Oncol. 1, 29 (2009).

    Grätz K. W. , 'Oral carcinoma after hematopoietic stem cell transplantation: A new classification based on a literature review over 30 years ' (2009 ) 1 Head Neck Oncol. : 29 -.

    • Search Google Scholar
  • Norton, J., Sloane, J. P.: A prospective study of cellular and immunologic changes in skin of allogeneic bone marrow recipients. Am. J. Pathol. 10, 597–602 (1994).

    Sloane J. P. , 'A prospective study of cellular and immunologic changes in skin of allogeneic bone marrow recipients ' (1994 ) 10 Am. J. Pathol. : 597 -602.

    • Search Google Scholar
  • Moss, S. F., Blaser, M. J.: Inflammation and the origin of cancer. Nat. Clin. Pract. Oncol. 2, 9–97 (2005).

    Blaser M. J. , 'Inflammation and the origin of cancer ' (2005 ) 2 Nat. Clin. Pract. Oncol. : 9 -97.

    • Search Google Scholar
  • Schottenfeld, D., Beebe-Dimmer, J.: Chronic inflammation: A common and important factor in the pathogenesis of neoplasia. CA Cancer J. Clin. 56, 69–83 (2006).

    Beebe-Dimmer J. , 'Chronic inflammation: A common and important factor in the pathogenesis of neoplasia ' (2006 ) 56 CA Cancer J. Clin. : 69 -83.

    • Search Google Scholar
  • Disis, M. L.: Immune regulation of cancer. J. Clin. Oncol. 28, 4531–4538 (2010).

    Disis M. L. , 'Immune regulation of cancer ' (2010 ) 28 J. Clin. Oncol. : 4531 -4538.

  • Rauch, D., Gross, S., Harding, J., Bokhari, S., Niewiesk, S., Lairmore, M., Piwnica-Worms, D., Ratner, L.: T-cell activation promotes tumorigenesis in inflammation-associated cancer. Retrovirology 6, 116–124 (2009).

    Ratner L. , 'T-cell activation promotes tumorigenesis in inflammation-associated cancer ' (2009 ) 6 Retrovirology : 116 -124.

    • Search Google Scholar
  • van Besien, K.: Allogeneic stem cell transplantation in follicular lymphoma: Recent progress and controversy. Hematology Am. Soc. Hematol. Educ. Program, 2009, pp. 610–618.

  • Ramirez-Montagut, T., Chow, A., Kochman, A. A., Smith, O. M., Suh, D., Sindhi, H, Li, S., Borsotti, C., Grubin, J., Patel, N., Terrwey, T. H., Kim, T. D., Heller, G., Murphy, G. F., Liu, C., Alpdogan, O., van den Brink, M. R.: IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. J. Immunol. 179, 1669–1680 (2007).

    Brink M. R. , 'IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease ' (2007 ) 179 J. Immunol. : 1669 -1680.

    • Search Google Scholar
  • Childs, W., Clave, E., Tisdale, J., Plante, M., Hensel, N., Barrett, J.: Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral blood progenitor cell transplant: Evidence for a graft-versus-tumor effect. J. Clin. Oncol. 17, 2044–2049 (1999).

    Barrett J. , 'Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral blood progenitor cell transplant: Evidence for a graft-versus-tumor effect ' (1999 ) 17 J. Clin. Oncol. : 2044 -2049.

    • Search Google Scholar
  • Ueno, N. T., Childs, R. W.: What’s past is prologue: Lessons learned and the need for further development of allogeneic hematopoietic stem cell transplantation for renal cell carcinoma. Biol. Blood Marrow Transplant. 13, 31–33 (2007).

    Childs R. W. , 'What’s past is prologue: Lessons learned and the need for further development of allogeneic hematopoietic stem cell transplantation for renal cell carcinoma ' (2007 ) 13 Biol. Blood Marrow Transplant. : 31 -33.

    • Search Google Scholar
  • Peres, E., Abidi, M. H., Mellon-Reppen, S., Klein, J., Braun, T., Abelia, E., Dansey, R.: Reduced intensity transplantation for metastatic renal cell cancer with 2-year follow-up. J. Immunother. 30, 562–566 (2007).

    Dansey R. , 'Reduced intensity transplantation for metastatic renal cell cancer with 2-year follow-up ' (2007 ) 30 J. Immunother. : 562 -566.

    • Search Google Scholar
  • Drachenberg, D., Childs, R. W.: Allogeneic hematopoietic stem cell transplantation for cytokine refractory renal cell carcinoma. Cancer Treat. Res. 116, 213–226 (2003).

    Childs R. W. , 'Allogeneic hematopoietic stem cell transplantation for cytokine refractory renal cell carcinoma ' (2003 ) 116 Cancer Treat. Res. : 213 -226.

    • Search Google Scholar
  • Bay, J. O., Cabrespine-Faugeras, A., Tabrizi, R., Blaise, D., Viens, P., Bornhauser, M., Slavin, S., Rosti, G., Peccatori, J., Demiere, T., Bregni, M.: Allogeneic hematopoietic stem cell transplantation in ovarian cancer - the EBMT experience. Int. J. Cancer 127, 1446–1452 (2010).

    Bregni M. , 'Allogeneic hematopoietic stem cell transplantation in ovarian cancer - the EBMT experience ' (2010 ) 127 Int. J. Cancer : 1446 -1452.

    • Search Google Scholar
  • Takahashi, Y., Harashima, N., Kajigaya, S., Vokoyama, H., Cherkasova, E., McCoy, J. P., Hanada, K., Mens, O., Kurlander, R., Tawab, A., Srinivasan, R., Lundquist, A., Malinzak, E., Geller, N., Lerman, M. I., Childs, R. W.: Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. J. Clin. Invest. 118, 1099–1109 (2008).

    Childs R. W. , 'Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells ' (2008 ) 118 J. Clin. Invest. : 1099 -1109.

    • Search Google Scholar
  • Bhosle, S., Suppiah, S., Molinaro, R., Liang, Y., Arnold, R., Diehl, W., Makarova, N., Blackwell, J., Petros, J., Liotta, D., Hunter, E., Ly, H.: Evaluation of cellular determinants required for the in vitro XMRV entry of human prostate cancer and non-cancerous cells. J. Virol. 84, 6288–6296 (2010).

    Ly H. , 'Evaluation of cellular determinants required for the in vitro XMRV entry of human prostate cancer and non-cancerous cells ' (2010 ) 84 J. Virol. : 6288 -6296.

    • Search Google Scholar
  • Stiele, K., Schulz, C., Lavanya, M., Aepfelbacher, M., Stocking, C., Fischer, N.: Host range and cellular tropism of the human exogenous gammaretrovirus XMRV. Virology 399, 223–230 (2010).

    Fischer N. , 'Host range and cellular tropism of the human exogenous gammaretrovirus XMRV ' (2010 ) 399 Virology : 223 -230.

    • Search Google Scholar
  • Torikai, H., Akatsuka, Y., Yatabe, Y., Morishima, Y., Kodera, Y., Kuzushima, K., Takahashi, T.: Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: Application for allogeneic transplantation. Int. J. Hematol. 87, 467–473 (2008).

    Takahashi T. , 'Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: Application for allogeneic transplantation ' (2008 ) 87 Int. J. Hematol. : 467 -473.

    • Search Google Scholar
  • Hambach, L., Vermeij, M., Buser, A., Aghai, Z., van der Kwast, T., Goulmy, E.: Targeting a single mismatched minor histocompatibility antigen with tumor-restricted expression eradicates human solid tumors. Blood 112, 1844–1852 (2008).

    Goulmy E. , 'Targeting a single mismatched minor histocompatibility antigen with tumor-restricted expression eradicates human solid tumors ' (2008 ) 112 Blood : 1844 -1852.

    • Search Google Scholar
  • Aglietta, M., Barkholdt, L., Schianca, F. C., Caravelli, D., Omazic, B., Minotto, C., Leone, F., Hentschke, P., Bertoldero, G., Capaldi, A., Ciccone, G., Niederwieser, D., Ringdén, O., Demirer, T.: Reduced-intensity allogeneic hematopoietic stem cell transplantation in metastatic colorectal cancer as a novel adoptive cell therapy. Biol. Blood Marrow Transplant. 15, 326–335 (2009).

    Demirer T. , 'Reduced-intensity allogeneic hematopoietic stem cell transplantation in metastatic colorectal cancer as a novel adoptive cell therapy ' (2009 ) 15 Biol. Blood Marrow Transplant. : 326 -335.

    • Search Google Scholar
  • Ringdén, O., Karlsson, H., Olsson, R., Omazic, B., Uhlin, M.: The allogeneic graft-versus cancer effect. Br. J. Haematol. 147, 614–633 (2009).

    Uhlin M. , 'The allogeneic graft-versus cancer effect ' (2009 ) 147 Br. J. Haematol. : 614 -633.

    • Search Google Scholar
  • Koreth, J., Aldridge, J., Kim, H. T., Alyea, E. P. 3rd, Cutler, C., Armand, P., Ritz, J., Antin, J. H., Soiffer, R. J., Ho, V. T.: Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: Hematologic malignancy outcomes are not impaired in advanced age. Biol. Blood Marrow Transplant. 16, 792–800 (2010).

    Ho V. T. , 'Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: Hematologic malignancy outcomes are not impaired in advanced age ' (2010 ) 16 Biol. Blood Marrow Transplant. : 792 -800.

    • Search Google Scholar
  • Fontaine, P., Roy-Proulx, G., Knafo, L., Baron, C., Roy, D-C., Perreault, C.: Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease. Nat. Med. 7, 789–794 (2001).

    Perreault C. , 'Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease ' (2001 ) 7 Nat. Med. : 789 -794.

    • Search Google Scholar
  • Klein, G., Klein, E.: Conversion of solid neoplasms into ascites tumors. Ann. N. Y. Acad. Sci. 63, 640–661 (1956).

    Klein E. , 'Conversion of solid neoplasms into ascites tumors ' (1956 ) 63 Ann. N. Y. Acad. Sci. : 640 -661.

    • Search Google Scholar
  • Michálek, J., Collins, R. H., Durrani, H. P., Václaková, P., Ruff, L. E., Douek, S. C., Vitetta, E. S.: Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4+ T cells by virtue of their receptor β loci sequence. Proc. Natl. Acad. Sci. USA 100, 1180–1184 (2003).

    Vitetta E. S. , 'Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4+ T cells by virtue of their receptor β loci sequence ' (2003 ) 100 Proc. Natl. Acad. Sci. USA : 1180 -1184.

    • Search Google Scholar
  • Montagna, D., Daudt, L., Locatelli, F., Montini, E., Turin, I., Lisini, D., Giorgiani, G., Bernardo, M. E., Maccario, R.: Single-cell cloning of human donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction. Cancer Res. 66, 7310–7316 (2006).

    Maccario R. , 'Single-cell cloning of human donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction ' (2006 ) 66 Cancer Res. : 7310 -7316.

    • Search Google Scholar
  • Watson, D., Hu, M., Zhang, G. Y., Wang, Y. M., Alexander, S. I.: Tolerance induction by removal of alloreactive T cells: In-vivo and pruning strategies. Cur. Opin. Organ Transplant. 14, 357–363 (2009).

    Alexander S. I. , 'Tolerance induction by removal of alloreactive T cells: In-vivo and pruning strategies ' (2009 ) 14 Cur. Opin. Organ Transplant. : 357 -363.

    • Search Google Scholar
  • Li, N., Chen, Y., He, W., Yi, T., Zhao, D., Zhang, C., Lin, C. L., Todorov, I., Kandeel, F., Forman, S., Zeng, D.: AntiCD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI. Blood 113, 953–962 (2009).

    Zeng D. , 'AntiCD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI ' (2009 ) 113 Blood : 953 -962.

    • Search Google Scholar
  • Samarasinghe, S., Mancao, C., Pule, M., Nawroly, N., Karlsson, H., Brewin, J., Openshaw, P., Gaspar, H. B., Veys, P., Amrolia, P. J.: Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for clinically applicable allodepletion strategy. Blood 115, 396–407 (2010).

    Amrolia P. J. , 'Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for clinically applicable allodepletion strategy ' (2010 ) 115 Blood : 396 -407.

    • Search Google Scholar
  • Devine, S. M., Soiffer, R. J., Pasquini, M. C., Carter, S., Hari, P. N., DeVore, S., Stein, A., Lazarus, H. M., Linker, C., Stadtmauer, E. A., Keever-Taylor, C. A., O’Reilly, R. J.: HLA-identical sibling-matched, CD34+ selected, T cell depleted peripheral blood stem cells following myeloablative conditioning for first or second remission acute myeloid leukemia (AML): Results of blood and marrow transplant clinical trial network BMT CTN protocol 0303. Blood 114, 273 #655 (2009).

    O’Reilly R. J. , 'HLA-identical sibling-matched, CD34+ selected, T cell depleted peripheral blood stem cells following myeloablative conditioning for first or second remission acute myeloid leukemia (AML): Results of blood and marrow transplant clinical trial network BMT CTN protocol 0303 ' (2009 ) 114 Blood : 273 -.

    • Search Google Scholar
  • Tanaka, M., Suda, T., Haze, K., Nakamura, N., Soto, K., Kimura, F., Motoyoshi, K., Mizuki, H., Tagawa, S., Ohga, S., Hatake, K., Drummond, A. H., Nagata, J.: Fas ligand in human serum. Nat. Med. 2, 317–322 (1996).

    Nagata J. , 'Fas ligand in human serum ' (1996 ) 2 Nat. Med. : 317 -322.

  • Hartwig, U. F., Nonn, M., Khan, S., Link, I., Huber, C., Herr, W.: Depletion of alloreactive donor T lymphocytes by CD95-mediated activation-induced cell death retains antileukemic, antiviral, and immunoregulatory T cell immunity. Biol. Blood Marrow Transplant. 14, 99–109 (2008).

    Herr W. , 'Depletion of alloreactive donor T lymphocytes by CD95-mediated activation-induced cell death retains antileukemic, antiviral, and immunoregulatory T cell immunity ' (2008 ) 14 Biol. Blood Marrow Transplant. : 99 -109.

    • Search Google Scholar
  • Georgantas, R. W. 3rd, Bohana-Kastan, O., Civin, C. I.: Ex vivo soluble fas ligand treatment of donor cells to selectively reduce murine acute graft versus host disease. Transplantation 82, 471–478 (2006).

    Civin C. I. , 'Ex vivo soluble fas ligand treatment of donor cells to selectively reduce murine acute graft versus host disease ' (2006 ) 82 Transplantation : 471 -478.

    • Search Google Scholar
  • Bohana-Kastan, O., Morisot, S., Hildreth, R., Brayton, C., Levitsky, H. I., Civin, C. I.: Elective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand. J. Immunol. 183, 696–705 (2009).

    Civin C. I. , 'Elective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand ' (2009 ) 183 J. Immunol. : 696 -705.

    • Search Google Scholar
  • Shono, Y., Ueha, S., Wang, Y., Abe, J., Krachi, M., Matsuno, Y., Sugiyama, T., Nagasawa, T., Imamura, M., Matsushima, K.: Bone marrow graft-versus-host disease: Early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation. Blood 115, 5401–5411 (2010).

    Matsushima K. , 'Bone marrow graft-versus-host disease: Early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation ' (2010 ) 115 Blood : 5401 -5411.

    • Search Google Scholar
  • Remberger, M., Jaksch, M., Uzunei, M., Mattsson, J.: Serum levels of cytokines correlate to donor chimerism and acute graft-vs-host disease after hematopoietic stem cell transplantation. Eur. J. Haematol. 70, 384–391 (2003).

    Mattsson J. , 'Serum levels of cytokines correlate to donor chimerism and acute graft-vs-host disease after hematopoietic stem cell transplantation ' (2003 ) 70 Eur. J. Haematol. : 384 -391.

    • Search Google Scholar
  • Talmadge, J.: Hematopoietic stem cell graft manipulation as a mechanism of immunotherapy. Int. Immunopharmacol. 3, 1121–1143 (2003).

    Talmadge J. , 'Hematopoietic stem cell graft manipulation as a mechanism of immunotherapy ' (2003 ) 3 Int. Immunopharmacol. : 1121 -1143.

    • Search Google Scholar
  • Leffel, M. S., Vogelsang, G. B., Lucas, D. P., Delaney, N. L., Zachary, A. A.: Association between TGF-beta expression and severe GvHD in allogeneic bone marrow transplantation. Transplant Proc. 33, 485–486 (2001).

    Zachary A. A. , 'Association between TGF-beta expression and severe GvHD in allogeneic bone marrow transplantation ' (2001 ) 33 Transplant Proc. : 485 -486.

    • Search Google Scholar
  • Billiau, D., Sefrioui, H., Overbergh, L., Rutgeers, O., Goebels, J., Matthieu, C., Waer, M.: Transforming growth factor-beta inhibits lymphokine activated killer cytotoxicity of bone marrow cells: Implications for the graft-versus-leukemia effect in irradiation allogeneic bone marrow chimeras. Transplantation 71, 292–296 (2001).

    Waer M. , 'Transforming growth factor-beta inhibits lymphokine activated killer cytotoxicity of bone marrow cells: Implications for the graft-versus-leukemia effect in irradiation allogeneic bone marrow chimeras ' (2001 ) 71 Transplantation : 292 -296.

    • Search Google Scholar
  • Su, H., Ye, D. Q., Wang, B. L., Fang, X. H., Chen, J., Wang, Q., Li, W. X., Zhang, N.: Transforming growth factor-beta-induced CD4+CD25+ regulatory T cells in vitro reverse and prevent a murine lupus-like syndrome of chronic graft-versus-host disease. Br. J. Dermatol. 158, 1197–1209 (2008).

    Zhang N. , 'Transforming growth factor-beta-induced CD4+CD25+ regulatory T cells in vitro reverse and prevent a murine lupus-like syndrome of chronic graft-versus-host disease ' (2008 ) 158 Br. J. Dermatol. : 1197 -1209.

    • Search Google Scholar
  • Zhang, Q., Helfand, B. T., Jang, T. L., Zhu, L. J., Chen, L., Yang, X. J., Kozlowski, J., Smith, N., Kundu, S. D., Yang, G., Rajui, A. A., Javonovic, B., Pons, M., Lindholm, P., Guo, Y., Catalona, W. I., Lee, C.: Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy. Clin. Cancer Res. 15, 3557–3567 (2009).

    Lee C. , 'Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy ' (2009 ) 15 Clin. Cancer Res. : 3557 -3567.

    • Search Google Scholar
  • Gajewski, T. F., Meng, Y., Harlin, H.: Immune suppression in the tumor microenvironment. J. Immunother. 29, 233–240 (2006).

    Harlin H. , 'Immune suppression in the tumor microenvironment ' (2006 ) 29 J. Immunother. : 233 -240.

    • Search Google Scholar
  • Huang, X., Lee, C.: From TGF-beta to cancer therapy. Curr. Drug Targets 4, 243–250 (2003).

    Lee C. , 'From TGF-beta to cancer therapy ' (2003 ) 4 Curr. Drug Targets : 243 -250.

  • Sullivan, D. E., Ferris, M., Nguyen, H., Abboud, E., Brody, A. R.: TNF-alpha induces TGF-beta(1) expression in lung fibroblasts at the transcriptional level via AP-1 activation. J. Cell Mol. Med. 13, 1866–1876 (2009).

    Brody A. R. , 'TNF-alpha induces TGF-beta(1) expression in lung fibroblasts at the transcriptional level via AP-1 activation ' (2009 ) 13 J. Cell Mol. Med. : 1866 -1876.

    • Search Google Scholar
  • Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., Hirao, A.: TGF-beta-FOXO signaling maintains leukaemia-initiating cells in chronic myeloid leukemia. Nature 463, 676–680 (2010).

    Hirao A. , 'TGF-beta-FOXO signaling maintains leukaemia-initiating cells in chronic myeloid leukemia ' (2010 ) 463 Nature : 676 -680.

    • Search Google Scholar
  • Atanackovic, D., Cao, Y., Luetkens, T., Panse, J., Faltz, C., Arfsten, J., Bartels, K., Wolschke, C., Elermann, T., Zander, A. R., Fehse, B., Bokemeyer, C., Kroger, N.: CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation. Haematologica 93, 423–430 (2008).

    Kroger N. , 'CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation ' (2008 ) 93 Haematologica : 423 -430.

    • Search Google Scholar
  • Lee, S. J., Klein, J., Haagenson, M., Baxter-Lowe, L. A., Confer, D. L., Eapen, M., Fernandez-Vina, M., Flomenberg, N., Horowitz, M., Hurley, C. K., Noreen, H., Oudshoorn, M., Petersdorf, E., Setterholm, M., Spellman, S., Weisdorf, D., Williams, T. M., Anasetti, C.: High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110, 4576–4583 (2007).

    Anasetti C. , 'High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation ' (2007 ) 110 Blood : 4576 -4583.

    • Search Google Scholar
  • Perkins, J., Field, T., Kim, J., Kharfan-Dabaja, M. A., Fernandez, H., Ayala, E., Perez, L., Xu, M., Alsina, M., Ochoa, L., Sullivan, D., Janssen, W., Anasetti, C.: A phase II trial comparing tacrolimus and mycophenolate mofetil to tacrolimus and methotrexate for acute graft-versus-host disease prophylaxis. Biol. Blood Marrow Transplant. 16, 937–947 (2010).

    Anasetti C. , 'A phase II trial comparing tacrolimus and mycophenolate mofetil to tacrolimus and methotrexate for acute graft-versus-host disease prophylaxis ' (2010 ) 16 Biol. Blood Marrow Transplant. : 937 -947.

    • Search Google Scholar
  • Boatsman, E. E., Fu, C. H., Song, S. X., Moore, T. B.: Graft-versus-leukemia effect on infant lymphoblastic leukemia relapsed after sibling hematopoietic stem cell transplantation. J. Pediatr. Hematol. Oncol. 32, e57–60 (2010).

    Moore T. B. , 'Graft-versus-leukemia effect on infant lymphoblastic leukemia relapsed after sibling hematopoietic stem cell transplantation ' (2010 ) 32 J. Pediatr. Hematol. Oncol. : e57 -60.

    • Search Google Scholar
  • Berger, C., Flowers, M. E., Warren, E. H., Riddell, S. R.: Analysis of transgene-specific immune responses that limit in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood 107, 2294–2302 (2006).

    Riddell S. R. , 'Analysis of transgene-specific immune responses that limit in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation ' (2006 ) 107 Blood : 2294 -2302.

    • Search Google Scholar
  • Gendelman, M., Yassai, M., Tivol, E., Krueger, A., Gorski, J., Drobyski, W. R.: Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitution. Biol. Blood Marrow Transplant. 9, 742–752 (2003).

    Drobyski W. R. , 'Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitution ' (2003 ) 9 Biol. Blood Marrow Transplant. : 742 -752.

    • Search Google Scholar
  • Lupo-Stanghellini, M. T., Provasi, E., Bondanza, A., Ciceri, F., Bordignon, C., Bonini, C.: Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation. Hum. Gene Ther. 21, 241–250 (2010).

    Bonini C. , 'Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation ' (2010 ) 21 Hum. Gene Ther. : 241 -250.

    • Search Google Scholar
  • Rezvani, A. R., Storb, R. F: Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation. J. Autoimmun. 30, 172–179 (2008).

    Storb R. F. , 'Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation ' (2008 ) 30 J. Autoimmun. : 172 -179.

    • Search Google Scholar
  • Filatenkov, A., Müller, A. M., Tseng, W. W., Dejbakhsh-Jones, S., Winer, D., Luong, R., Shizuru, J. A., Engleman, E. G., Strober, S.: Ineffective vaccination against solid tumors can be enhanced by hematopoietic cell transplantation. J. Immunol. 183, 7196–7203 (2009).

    Strober S. , 'Ineffective vaccination against solid tumors can be enhanced by hematopoietic cell transplantation ' (2009 ) 183 J. Immunol. : 7196 -7203.

    • Search Google Scholar
  • Chen, X., Zeng, Y., Li, G., Larmonier, N., Graner, M. W., Katsanis, E.: Peritransplantation vaccination with chaperon-rich cell lysate induces leukemia immunity. Biol. Blood Marrow Transplant. 2, 275–283 (2006).

    Katsanis E. , 'Peritransplantation vaccination with chaperon-rich cell lysate induces leukemia immunity ' (2006 ) 2 Biol. Blood Marrow Transplant. : 275 -283.

    • Search Google Scholar
  • Ho, V. T., Vannerman, M., Kim, H., Sasada, T., Kang, Y. J., Pasek, M., Cutler, C., Koreth, J., Alyea, E., Sarantopoulos, S., Antin, J. H., Ritz, J., Canning, C., Kutok, J., Mihm, M. C., Dranoff, G., Soiffer, R.: Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation. Proc. Natl. Acad. Sci. USA 106, 5825–5830 (2009).

    Soiffer R. , 'Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation ' (2009 ) 106 Proc. Natl. Acad. Sci. USA : 5825 -5830.

    • Search Google Scholar
  • Sangiolo, D., Mesiano, G., Carnevale-Schianca, F., Placibello, W., Aglietta, M., Cignetti, A.: Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin. Biol. Ther. 9, 831–840 (2009).

    Cignetti A. , 'Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation ' (2009 ) 9 Expert Opin. Biol. Ther. : 831 -840.

    • Search Google Scholar
  • Moretta, A., Pende, D., Locatelli, F., Moretta, L.: Activating and inhibitor killer immunoglobulin-like receptors (KIR) in haploidentical haemopoietic stem cell transplantation to cure high-risk leukaemias. Clin. Exp. Immunol. 157, 325–331 (2009).

    Moretta L. , 'Activating and inhibitor killer immunoglobulin-like receptors (KIR) in haploidentical haemopoietic stem cell transplantation to cure high-risk leukaemias ' (2009 ) 157 Clin. Exp. Immunol. : 325 -331.

    • Search Google Scholar
  • Passweg, J. R., Koehl, U., Uharek, L., Meyer-Monard, S., Tichelli, A.: Naturalkiller-cell-based treatment in hematopoietic stem-cell transplantation. Best Pract. Res. Clin. Haematol. 19, 811–824 (2006).

    Tichelli A. , 'Naturalkiller-cell-based treatment in hematopoietic stem-cell transplantation ' (2006 ) 19 Best Pract. Res. Clin. Haematol. : 811 -824.

    • Search Google Scholar
  • Savani, B. N., Rezvani, K., Mielke, S., Montero, A., Kurlander, R., Carter, C. S., Leitman, S., Read, E. J., Childs, R., Barrett, A. J.: Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood 107, 1688–1695 (2006).

    Barrett A. J. , 'Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia ' (2006 ) 107 Blood : 1688 -1695.

    • Search Google Scholar
  • Sconocchia, G., Lau, M., Provenzano, M., Rezvani, K., Wongsena, W., Fujiwara, H., Hensel, N., Melenhorst, J., Li, J., Ferrone, S., Barrett, A. J.: The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions. Blood 106, 3666–3672 (2005).

    Barrett A. J. , 'The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions ' (2005 ) 106 Blood : 3666 -3672.

    • Search Google Scholar
  • Yong, A. S., Keyvanfar, K., Hensel, N., Eniafe, R., Savani, B. N., Berg, M., Lundquist, A. S., Adams, S., Sloand, E. M., Goldman, J. M., Childs, R., Barrett, A. J.: Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib. Blood 113, 875–882 (2009).

    Barrett A. J. , 'Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib ' (2009 ) 113 Blood : 875 -882.

    • Search Google Scholar
  • Terme, M., Borg, C., Guilhot, F., Masurier, C., Flament, C., Wagner, E. F., Caillat-Zucman, S., Bernheim, A., Turhan, A. G., Caignard, A., Zitvogel, L.: BCR/ABL promotes dendritic cell-mediated natural killer cell activation. Cancer Res. 65, 6409–6417 (2005).

    Zitvogel L. , 'BCR/ABL promotes dendritic cell-mediated natural killer cell activation ' (2005 ) 65 Cancer Res : 6409 -6417.

    • Search Google Scholar
  • Young, F. M., Campbell, A., Emo, K. L., Jansson, J., Wang, P. Y., Jordan, C. T., Mullen, C. A.: High-risk acute lymphoblastic leukemia cells with bcr-abl and INK4A/ARF mutations retain susceptibility to alloreactive T cells. Biol. Blood Marrow Transplant. 14, 622–630 (2008).

    Mullen C. A. , 'High-risk acute lymphoblastic leukemia cells with bcr-abl and INK4A/ARF mutations retain susceptibility to alloreactive T cells ' (2008 ) 14 Biol. Blood Marrow Transplant. : 622 -630.

    • Search Google Scholar
  • Ruggeri, L., Mancusi. A., Capanni, M., Aloisi, T., Carotti, A., Aversa, F., Martelli, M. F., Velardi, A.: Selecting haploidentical transplant donors for deploying optimal NK cell allotherapy. Blood 114, 211 #511 (2009).

    Velardi A. , 'Selecting haploidentical transplant donors for deploying optimal NK cell allotherapy ' (2009 ) 114 Blood : 211 -.

    • Search Google Scholar
  • Miller, J. S., Soignier, Y., Panoskaltsis-Mortari, A., McNearney, S. A., Yun, G. H., Fautsch, S. K., Mc Kenna, D., Le, C., Defor, T. E., Burns, L. J., Orchard, P. J., Blazar, B. R., Wagner, J. E., Slingaard, A., Weisdorf, D. J., Okazaki, I. J., McGave, P. B.: Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105, 3051–3057 (2005).

    McGave P. B. , 'Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer ' (2005 ) 105 Blood : 3051 -3057.

    • Search Google Scholar
  • Rubnitz, J. E., Inaba, H., Ribeiro, R. C., Pounds, S., Rooney, B., Bell, T., Pui, C-H., Leung, W.: NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J. Clin. Oncol. 28, 955–959 (2010).

    Leung W. , 'NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia ' (2010 ) 28 J. Clin. Oncol. : 955 -959.

    • Search Google Scholar
  • Verneris, M. R., Grupp, S. A.: Natural killer cell consolidation for acute myelogenous leukemia: A cell therapy ready for prime time? J. Clin. Oncol. 28, 909–910 (2010).

    Grupp S. A. , 'Natural killer cell consolidation for acute myelogenous leukemia: A cell therapy ready for prime time? ' (2010 ) 28 J. Clin. Oncol. : 909 -910.

    • Search Google Scholar
  • Rathman, S., Glatzel, S., Schönberg, K., Uhrberg, M., Follo, M., Schulz-Houtari, C., Kaymer, M., Veelken, H., Finke, J., Fisch, P.: Expansion of NKG2A-LIR1-natural killer cells in HLA-matched, killer cell immunoglobulin-like receptors/HLA-ligand mismatched patients following hematopoietic cell transplantation. Biol. Blood Marrow Transplant. 16, 469–481 (2010).

    Fisch P. , 'Expansion of NKG2A-LIR1-natural killer cells in HLA-matched, killer cell immunoglobulin-like receptors/HLA-ligand mismatched patients following hematopoietic cell transplantation ' (2010 ) 16 Biol. Blood Marrow Transplant. : 469 -481.

    • Search Google Scholar
  • Decot, V., Voillard, L., Latger-Cannard, V., Aissi-Rothé, L., Perrier, P., Stoltz, J. F., Bensoussan, D.: Natural killer cell amplification for adoptive leukemia relapse immunotherapy: Comparison of three cytokines, IL-2, IL-15, or IL-7 and impact on NKG2D, KIR2DL1, and KIR2DL2 expression. Exp. Hematol. 38, 351–362 (2010).

    Bensoussan D. , 'Natural killer cell amplification for adoptive leukemia relapse immunotherapy: Comparison of three cytokines, IL-2, IL-15, or IL-7 and impact on NKG2D, KIR2DL1, and KIR2DL2 expression ' (2010 ) 38 Exp. Hematol. : 351 -362.

    • Search Google Scholar
  • Teshima, T., Hill, G. R., Pan, L., Brinson, Y., van den Brink, M. R., Cooke, K. R., Ferrara, J. L.: IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. J. Clin. Invest. 104, 317–325 (1999).

    Ferrara J. L. , 'IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation ' (1999 ) 104 J. Clin. Invest. : 317 -325.

    • Search Google Scholar
  • Chen, G., Wu, D., Wang, Y., Cen, J., Feng, Y., Sun, A., Tang, X., Chan, H., Zhu, Z.: Expanded donor natural killer cell and IL-2, IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation. Eur. J. Haematol. 81, 226–235 (2008).

    Zhu Z. , 'Expanded donor natural killer cell and IL-2, IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation ' (2008 ) 81 Eur. J. Haematol. : 226 -235.

    • Search Google Scholar
  • Bucher, C., Koch, L., Vogtenhuber, C., Goren, E., Munger, M., Panoskaltsis-Mortari, A., Sivakumar, P., Blazar, B. R.: IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 14, 5375–5384 (2009).

    Blazar B. R. , 'IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation ' (2009 ) 14 Blood : 5375 -5384.

    • Search Google Scholar
  • Petersen, S. L.: Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunological aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. Dan. Med. Bull. 54, 112–139 (2007).

    Petersen S. L. , 'Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunological aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning ' (2007 ) 54 Dan. Med. Bull. : 112 -139.

    • Search Google Scholar
  • Das, F. R., Komorowski, R., Hessner, M. J., Subramanian, N., Huettner, C. S., Cua, D., Drobynski, W. R.: Blockade of interleukin 23 signaling results in targeted protection of the colon and allows for separation of graft versus host and graft versus leukemia responses. Blood 115, 5249–5258 (2010).

    Drobynski W. R. , 'Blockade of interleukin 23 signaling results in targeted protection of the colon and allows for separation of graft versus host and graft versus leukemia responses ' (2010 ) 115 Blood : 5249 -5258.

    • Search Google Scholar
  • He, S., Cao, Q., Qiu, Y., Mi, J., Zhang, J. Z., Jin, N. M., Ge, H., Emerson, S. G., Zhang, Y., Zhang, Y.: A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3-neutralizing antibody. J. Immunol. 181, 7581–7592 (2008).

    Zhang Y. , 'A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3-neutralizing antibody ' (2008 ) 181 J. Immunol. : 7581 -7592.

    • Search Google Scholar
  • Sinkovics, J. G., Smith, J. P.: Septicemia with Bacteroides in patients with malignant disease. Cancer 25, 663–671 (1970).

    Smith J. P. , 'Septicemia with Bacteroides in patients with malignant disease ' (1970 ) 25 Cancer : 663 -671.

    • Search Google Scholar
  • Sinkovics, J. G., Smith, J. P.: Salmonellosis complicating malignant disease. Cancer 24, 631–636 (1969).

    Smith J. P. , 'Salmonellosis complicating malignant disease ' (1969 ) 24 Cancer : 631 -636.

  • Sinkovics, J. G.: Clinical recognition and treatment of endotoxinemia. In Friedman, H., Szentivanyi, A. (eds): The Immunobiology and Immunopharmacology of Endotoxins. Plenum Press, New York, NY, 1986, pp. 269–279.

    Sinkovics J. G. , '', in The Immunobiology and Immunopharmacology of Endotoxins , (1986 ) -.

  • Sinkovics, J. G.: Infectious complications. In Sinkovics, J. G. (author): Medical Oncology an Advanced Course, 2nd ed. Marcel Dekker, New York, NY, 1986, pp. 1557–1739.

    Sinkovics J. G. , '', in Medical Oncology an Advanced Course , (1986 ) -.

  • Beelen, D. W., Elmaagacli, A., Muller, K. D., Hirche, H., Schaefer, U. W.: Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results of long-term follow-up of an open-label prospectively randomized trial. Blood 93, 3267–3275 (1999).

    Schaefer U. W. , 'Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results of long-term follow-up of an open-label prospectively randomized trial ' (1999 ) 93 Blood : 3267 -3275.

    • Search Google Scholar
  • Sullivan, K. M., Dykewicz, C. A., Longworth, D. L., Boeckh, M., Baden, L. R., Rubin, L. R., Sepkowitz, K. A.: Preventing opportunistic infections after hematopoietic stem cell transplantation: the Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Society for Blood and Marrow Transplantation Practice Guidelines and beyond. Hematology Am. Soc. Hematol. Educ. Program, 392–421 (2001).

  • Le Blanc, K., Ringdén, O.: Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 11, 321–334 (2005).

    Ringdén O. , 'Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation ' (2005 ) 11 Biol. Blood Marrow Transplant. : 321 -334.

    • Search Google Scholar
  • Wang, L., Zhao, R. C.: Mesenchymal stem cells targeting the GVHD. Sci. China C. Life. Sci. 52, 603–609 (2009).

    Zhao R. C. , 'Mesenchymal stem cells targeting the GVHD ' (2009 ) 52 Sci. China C. Life. Sci. : 603 -609.

    • Search Google Scholar
  • Horwitz, E. M., Dominici, M.: How do mesenchymal stromal cells exert their therapeutic benefit? Cytotherapy 10, 771–774 (2008).

    Dominici M. , 'How do mesenchymal stromal cells exert their therapeutic benefit? ' (2008 ) 10 Cytotherapy : 771 -774.

    • Search Google Scholar
  • Grisendi, G., Bussolari, R., Cafarelli, L., Petak, I., Rasini, V., Veronesi, E., De Santos, G., Spano, C., Tagliazzucchi, M., Bart-Juhasz, H., Scarabelli, L., Bambi, F., Frassoldati, A., Rosi, G., Casali, C., Morandi, U., Horwitz, E. M., Paolucci, P., Conte, P., Dominici, M.: Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res. 70, 3718–3729 (2010).

    Dominici M. , 'Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy ' (2010 ) 70 Cancer Res. : 3718 -3729.

    • Search Google Scholar
  • Guest, I., Ilic, Z., Ma, J., Grant, D., Glinsky, G., Sell, S.: Direct and indirect contribution of bone marrow-derived cells to cancer. Int. J. Cancer 126, 2308–2318 (2010).

    Sell S. , 'Direct and indirect contribution of bone marrow-derived cells to cancer ' (2010 ) 126 Int. J. Cancer : 2308 -2318.

    • Search Google Scholar
  • Baron, F., Lechanteur, C., Willems, E., Bruck, F., Baudoux, E., Seidel, L., Vanbellinghen, J. F., Hafraoul, K., Lejeune, M., Gothot, A., Fillet, G., Beguin, Y.: Co-transplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following non-myeloablative conditioning. Biol. Blood Marrow Transplant. 16, 838–847 (2010).

    Beguin Y. , 'Co-transplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following non-myeloablative conditioning ' (2010 ) 16 Biol. Blood Marrow Transplant. : 838 -847.

    • Search Google Scholar
  • Toubai, T., Paczesny, S., Shono, Y., Tanaka, J., Lowler, K. P., Malter, C. T., Kasai, M., Imamura, M.: Mesenchymal stem cells for treatment and prevention of graft-versus host disease after allogeneic hematopoietic cell transplantation. Curr. Stem. Cell Res. Ther. 4, 252–259 (2009).

    Imamura M. , 'Mesenchymal stem cells for treatment and prevention of graft-versus host disease after allogeneic hematopoietic cell transplantation ' (2009 ) 4 Curr. Stem. Cell Res. Ther. : 252 -259.

    • Search Google Scholar
  • Pidala, J., Anasetti, C.: Can antigen-specific regulatory T cells protect against graft vs. host disease and spare anti-malignancy alloresponse? Haematologica 95, 660–665 (2009).

    Anasetti C. , 'Can antigen-specific regulatory T cells protect against graft vs. host disease and spare anti-malignancy alloresponse? ' (2009 ) 95 Haematologica : 660 -665.

    • Search Google Scholar
  • Amarnath, S., Costanzo, C. M., Mariotti, J., Ullman, J. L., Telford, W. G., Kapoor, V., Riley, J. L., Levine, B. L., June, C. H., Fong, T., Warner, N. L., Fowler, D. H.: Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol. 8, e1000302 (2010).

    Fowler D. H. , 'Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1 ' (2010 ) 8 PLoS Biol : e1000302 -.

    • Search Google Scholar
  • Cao, J., Chen, C., Zeng, L., Li, L., Li, Z., Xu, K.: Engineered regulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation. Leuk. Res. 34, 1374–1382 (2009).

    Xu K. , 'Engineered regulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation ' (2009 ) 34 Leuk. Res. : 1374 -1382.

    • Search Google Scholar
  • Kitazawa, Y., Fujino, M., Li, X. X., Ichimaru, N., Okumi, M., Nonomura, N., Tsujimura, A., Isaka, Y., Kimura, H., Hünig, T., Takahara, S.: Superagonist CD28 antibody preferentially expanded Oxp3-expressing Treg cells and prevented graft-versus-host disease. Cell Transplant. 18, 627–637 (2009).

    Takahara S. , 'Superagonist CD28 antibody preferentially expanded Oxp3-expressing Treg cells and prevented graft-versus-host disease ' (2009 ) 18 Cell Transplant : 627 -637.

    • Search Google Scholar
  • Di Ianni, M., Falzetti, F., Carotti, A., Terenzi, A., Bonifacio, E., Reisner, Y., Velardi, A., Aversa, F., Martelli, M. F.: Adoptive immunotherapy with Tregs prevents GvHD and favours reconstitution after HLA haploidentical transplants for hematological malignancies. Blood 114, 4 #4 (2009).

    Martelli M. F. , 'Adoptive immunotherapy with Tregs prevents GvHD and favours reconstitution after HLA haploidentical transplants for hematological malignancies ' (2009 ) 114 Blood : 4 -.

    • Search Google Scholar
  • Matsuoka, K. I., Kim, H. T., McDonough, S., Bascug, G., Warshauer, B., Koreth, J., Cutler, C., Ho, V. T., Alyea, E. P., Antin, J. H., Soiffer, R. J., Ritz, J.: Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation. J. Clin. Invest. 120, 1479–1493 (2010).

    Ritz J. , 'Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation ' (2010 ) 120 J. Clin. Invest. : 1479 -1493.

    • Search Google Scholar
  • Mageneau, J. M., Qin, X., Tawara, I., Rogers, C. E., Kitko, C., Schlough, M., Bickley, D., Braun, T. M., Jang, P. S., Lowler, K. P., Jones, D. M., Choi, S. W., Reddy, P., Mineshi, S., Levine, J. E., Ferrara, J. L., Paczesny, S.: Frequency of CD4+ CD25hiFOXP3+ regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host disease. Biol. Blood Marrow Transplant. 16, 907–914 (2010).

    Paczesny S. , 'Frequency of CD4+ CD25hiFOXP3+ regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host disease ' (2010 ) 16 Biol. Blood Marrow Transplant. : 907 -914.

    • Search Google Scholar
  • Vela-Ojeda, J., Montiel-Cervantes, L., Granados-Lara, P., Reyes-Maldonado, E., Garcia-Latorre, E., Garcia-Chaves, J., Majluf-Cruz, A., Mayani, H., Borbolla-Escoboza, J. R., Esparza, M. G.: Role of CD4+CD25hiFoxp3+CD62L+ regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation. Stem Cell Dev. 19, 333–340 (2010).

    Esparza M. G. , 'Role of CD4+CD25hiFoxp3+CD62L+ regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation ' (2010 ) 19 Stem Cell Dev. : 333 -340.

    • Search Google Scholar
  • Pillai, A. B., George, T. I., Duff, S., Strober, S.: Host natural killer cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease. Blood 113, 4458–4467 (2009).

    Strober S. , 'Host natural killer cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease ' (2009 ) 113 Blood : 4458 -4467.

    • Search Google Scholar
  • Chen, X., Das, R., Komorowski, R., Beres, A., Hessner, M. J., Mihara, M., Drobyski, W. R.: Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood 114, 891–900 (2009).

    Drobyski W. R. , 'Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease ' (2009 ) 114 Blood : 891 -900.

    • Search Google Scholar
  • Zheng, J., Liu, Y., Lau, Y. L., Tu, W.: CD40-activated B cells are more potent than immature dendritic cell to induce and expand CD4+ regulatory T cells. Cell Mol. Immunol. 7, 44–50 (2010).

    Tu W. , 'CD40-activated B cells are more potent than immature dendritic cell to induce and expand CD4+ regulatory T cells ' (2010 ) 7 Cell Mol. Immunol. : 44 -50.

    • Search Google Scholar
  • Balkow, S., Krux, F., Loser, K., Becker, J. U., Grabbe, S., Dittmer, U.: Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors expansion of regulatory T cells. Blood 110, 3949–3958 (2007).

    Dittmer U. , 'Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors expansion of regulatory T cells ' (2007 ) 110 Blood : 3949 -3958.

    • Search Google Scholar
  • Zelinskyy, G., Dietze, K., Sparwasser, T., Dittmer, U.: Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog. 5(8), e1000406 1–6 (2009).

    Dittmer U. , 'Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus ' (2009 ) 5 PLoS Pathog : 1 -6.

    • Search Google Scholar
  • Zelinskyy, G., Dietze, K. K., Hüsecken, Y. P., Schimmer, S., Nair, S., Werner, T., Gibbert, K., Kershaw, O., Gruber, A. D., Sparwasser, T., Dittmer, U.: The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood 114, 3199–3297 (2009).

    Dittmer U. , 'The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response ' (2009 ) 114 Blood : 3199 -3297.

    • Search Google Scholar
  • Oh, U., Grant, C., Griffith, C., Fugo, K., Takenouchi, N., Jacobson, S.: Reduced Foxp3 protein expression is associated with inflammatory disease during human lymphotropic virus type 1 infection. J. Infect. Dis. 193, 1557–1566 (2009).

    Jacobson S. , 'Reduced Foxp3 protein expression is associated with inflammatory disease during human lymphotropic virus type 1 infection ' (2009 ) 193 J. Infect. Dis. : 1557 -1566.

    • Search Google Scholar
  • Saboury, A. H., Usuku, K., Hayashi, D., Izumo, S., Ohara, Y., Osame, M., Saito, M.: Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease. Blood 112, 2411–2420 (2008).

    Saito M. , 'Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease ' (2008 ) 112 Blood : 2411 -2420.

    • Search Google Scholar
  • Carod-Artal, F. J.: Immunopathogenesis and treatment of the myelopathy associated to the HTLV-1 virus. Rev. Neurol. 48, 147–155 (2009).

    Carod-Artal F. J. , 'Immunopathogenesis and treatment of the myelopathy associated to the HTLV-1 virus ' (2009 ) 48 Rev. Neurol. : 147 -155.

    • Search Google Scholar
  • Chen, Y., Liu, K., Xu, L., Chen, H., Liu, D., Zhang, X., Si, H., Han, W., Wang, Y., Zhao, T., Wang, J., Wang, J., Huang, X.: HLA-mismatched hematopoietic SCT without in vitro T-cell depletion for myelodysplastic syndrome. Bone Marrow Transplant. 45, 1333–1339 (2010).

    Huang X. , 'HLA-mismatched hematopoietic SCT without in vitro T-cell depletion for myelodysplastic syndrome ' (2010 ) 45 Bone Marrow Transplant : 1333 -1339.

    • Search Google Scholar
  • Nelson, R. P., Yu, M., Schwartz, J. E., Robertson, M. J., Hromas, R., Fausel, C. A., Vance, G. H., Dlouhy, S. R., Baute, J. A., Cox, E. A., Wood, L. L., Srivastava, S., Robertson, K. A., Haut, P. R., Farag, S. S., Abonour, R., Cornetta, K., Cripe, L. D.: Long-term disease-free survival after nonmyeloablative cyclophosphamide/fludarabine conditioning and related/unrelated allotransplantation for acute myeloid leukemia/myelodysplasia. Bone Marrow Transplant. 45, 1300–1308 (2010).

    Cripe L. D. , 'Long-term disease-free survival after nonmyeloablative cyclophosphamide/fludarabine conditioning and related/unrelated allotransplantation for acute myeloid leukemia/myelodysplasia ' (2010 ) 45 Bone Marrow Transplant. : 1300 -1308.

    • Search Google Scholar
  • Wang, J., Zhan, P., Ouyang, J., Chen, B., Zhou, R., Yang, Y.: Unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients: a meta analysis. Leuk. Res. 34, 1018–1022 (2009).

    Yang Y. , 'Unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients: a meta analysis ' (2009 ) 34 Leuk. Res. : 1018 -1022.

    • Search Google Scholar
  • Borroughs, L., Storb, R.: Low-intensity allogeneic hematopoietic stem cell transplantation for myeloid malignancies: Separating graft-versus-leukemia effect from graft-versus-host disease. Curr. Opin. Hematol. 12, 45–54 (2005).

    Storb R. , 'Low-intensity allogeneic hematopoietic stem cell transplantation for myeloid malignancies: Separating graft-versus-leukemia effect from graft-versus-host disease ' (2005 ) 12 Curr. Opin. Hematol. : 45 -54.

    • Search Google Scholar
  • Lim, Z. Y., Brand, R., Martino, R., van Biezen, A., Finke, J., Bacigalupo, A., Beelen, D., Devergie, A., Alessandrino, E., Willemze, R., Ruutu, T., Boogaerts, M., Falda, M., Jouet, J-P., Niederwieser, D., Kroger, N., Mufti, G. J., De Witte, T.: Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia. J. Clin. Oncol. 28, 405–411 (2010).

    Witte T. , 'Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemia ' (2010 ) 28 J. Clin. Oncol. : 405 -411.

    • Search Google Scholar
  • Meletis, J., Terpos, E.: Transplantation strategies for the management of patients with myelodysplastic syndromes. J. BUON (Balcan Union Oncology) 14, 551–564 (2009).

    Terpos E. , 'Transplantation strategies for the management of patients with myelodysplastic syndromes ' (2009 ) 14 J. BUON (Balcan Union Oncology) : 551 -564.

    • Search Google Scholar
  • Wagner, J. E. (ed.): Umbilical cord transplantation. Semin. Hematol. 47, 1–103 (2010).

  • Hütter, G., Schneider, T., Thiel, E.: Transplantation of selected or transgenic blood stem cells - a future treatment for HIV/AIDS? J. Int. AIDS Soc. 12, 1–10 (2009).

    Thiel E. , 'Transplantation of selected or transgenic blood stem cells - a future treatment for HIV/AIDS? ' (2009 ) 12 J. Int. AIDS Soc. : 1 -10.

    • Search Google Scholar
  • Carotenuto, P., Looij, D., Keldermans, L., de Wolf, F., Goudsmit, J.: Neutralizing antibodies are positively associated wth CD4+ T-cell counts and T-cell function in long-term AIDS-free infection. AIDS 122, 1591–1600 (1998).

    Goudsmit J. , 'Neutralizing antibodies are positively associated wth CD4+ T-cell counts and T-cell function in long-term AIDS-free infection ' (1998 ) 122 AIDS : 1591 -1600.

    • Search Google Scholar
  • Lorin, C., Mollet, L., Delebecque, F., Combredet, C., Hurtrel, B., Charmea, P., Brahic, M., Tangy, F.: A single injection of recombinant measles virus vaccine expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV. J. Virol. 78, 146–157 (2004).

    Tangy F. , 'A single injection of recombinant measles virus vaccine expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing antibodies and cellular immune responses to HIV ' (2004 ) 78 J. Virol. : 146 -157.

    • Search Google Scholar
  • Myers, L., Messer, R. J., Carmody, A. B., Hasenkrug, K. J.: Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loades. J. Immunol. 183, 1636–1643 (2009).

    Hasenkrug K. J. , 'Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loades ' (2009 ) 183 J. Immunol. : 1636 -1643.

    • Search Google Scholar
  • Sinkovics, J. G., Pienta, R. J., Trujillo, J. M., Ahearn, M. J.: An immunological explanation for the starry sky histological pattern of a malignant lymphoma. J. Inf. Dis. 120, 250–254 (1969).

    Ahearn M. J. , 'An immunological explanation for the starry sky histological pattern of a malignant lymphoma ' (1969 ) 120 J. Inf. Dis. : 250 -254.

    • Search Google Scholar
  • Sinkovics, J. G.: The first observation (in the late 1960s) of fused lymphoid cells continuously secreting a specific antibody. Bull. Molec. Med. 26, 61–80 (2005).

    Sinkovics J. G. , 'The first observation (in the late 1960s) of fused lymphoid cells continuously secreting a specific antibody ' (2005 ) 26 Bull. Molec. Med. : 61 -80.

    • Search Google Scholar
  • Mapara, M. Y., Kim, Y. M., Marx, J., Sykes, M.: Donor lymphocyte infusion-mediated graft-versus-leukemia effect in mixed chimeras established with a nonmyeloablative conditioning regimen: Extinction of graft-versus-leukemia effects after conversion to full donor chimerism. Transplantation 76, 297–306 (2003).

    Sykes M. , 'Donor lymphocyte infusion-mediated graft-versus-leukemia effect in mixed chimeras established with a nonmyeloablative conditioning regimen: Extinction of graft-versus-leukemia effects after conversion to full donor chimerism ' (2003 ) 76 Transplantation : 297 -306.

    • Search Google Scholar
  • Fernandez-Cruz, E., Woda, B. A., Feldman, J. D.: Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes. J. Exp. Med. 152, 823–841 (1980).

    Feldman J. D. , 'Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes ' (1980 ) 152 J. Exp. Med. : 823 -841.

    • Search Google Scholar
  • Luznik, L., Bolaños-Meade, J., Zahurak, M., Chen, A. R., Smith, B. D., Brodsky, R., Huff, C., Borrello, I., Matsui, W., Powell, J. D., Kasamen, Y., Goodman, S. N., Hess, A., Levitsky, H. I., Ambinder, R. F., Jones, R. J., Fuchs, E. J.: High-dose cyclophosphamide as single agent, short-course prophylaxis of graft-versus-host disease. Blood 115, 3224–3230 (2010).

    Fuchs E. J. , 'High-dose cyclophosphamide as single agent, short-course prophylaxis of graft-versus-host disease ' (2010 ) 115 Blood : 3224 -3230.

    • Search Google Scholar
  • Luznik, L., Fuchs, E. J.: High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation. Immunol. Res. 47, 65–77 (2010).

    Fuchs E. J. , 'High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation ' (2010 ) 47 Immunol. Res. : 65 -77.

    • Search Google Scholar
  • Toh, H. C., Sun, L., So, Y., Wu, Y., Phoon, Y. P., Chia, W. K., Wu, J., Wong, K. Y., Tan, P.: G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. Clin. Immunol. 132, 83–92 (2009).

    Tan P. , 'G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo ' (2009 ) 132 Clin. Immunol. : 83 -92.

    • Search Google Scholar
  • Xie, Y., Wu, M., Song, R., Ma, J., Shi, Y., Qin, W., Jin, Y.: A glucocorticoid amplifies IL-2-induced selective expansion of CD4+CD25+FOXP3+ regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation. Acta Biochim. Biophys. (Shanghai). 41, 781–791 (2009).

    Jin Y. , 'A glucocorticoid amplifies IL-2-induced selective expansion of CD4+CD25+FOXP3+ regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation ' (2009 ) 41 Acta Biochim. Biophys. (Shanghai) : 781 -791.

    • Search Google Scholar
  • Xia, G., Truitt, R. L., Johnson, B. D.: Graft-versus-leukemia and graft-versus-host reactions after donor lymphocyte infusions are initiated by host-type antigen-presenting cells and regulatory T cells in early and long-term chimeras. Biol. Blood Marrow Transplant. 12, 397–407 (2006).

    Johnson B. D. , 'Graft-versus-leukemia and graft-versus-host reactions after donor lymphocyte infusions are initiated by host-type antigen-presenting cells and regulatory T cells in early and long-term chimeras ' (2006 ) 12 Biol. Blood Marrow Transplant. : 397 -407.

    • Search Google Scholar
  • Symons, H. J., Levy, M. Y., Wang, J., Zhou, X., Zhou, G., Cohen, S. E., Luznik, L., Levitsky, H. I., Fuchs, E. J.: The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells. Biol. Blood Marrow Transplant. 14, 499–609 (2008).

    Fuchs E. J. , 'The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells ' (2008 ) 14 Biol. Blood Marrow Transplant. : 499 -609.

    • Search Google Scholar
  • Koonin, E. V., Wolf, Y. I.: Is evolution Darwinian or/and Lamarckian? Biol. Direct. 4,42, online pp. 1–31 (2009).

    Wolf Y. I. , 'Is evolution Darwinian or/and Lamarckian? ' (2009 ) 4 Biol. Direct. : 1 -31.

  • Santiago, M. L., Montyano, M., Bernitez, R., Messer, R. J., Yonemoto, W., Chesebro, B., Hasenkrug, K. J., Greene, W. C.: APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321, 1343–1346 (2008).

    Greene W. C. , 'APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection ' (2008 ) 321 Science : 1343 -1346.

    • Search Google Scholar
  • Dreguss, M. N., Lombard, L.S.: Experimental Studies in Equine Infectious Anemia. University of Pennsylvania Press, Philadelphia, PA, 1954.

    Lombard L.S. , '', in Experimental Studies in Equine Infectious Anemia , (1954 ) -.

  • Hatziioannou, T., Perez-Caballero, D., Yang, A., Cowan, S., Bieniasz, P. D.: Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc. Natl. Acad. Sci. USA 101, 10774–10779 (2004).

    Bieniasz P. D. , 'Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha ' (2004 ) 101 Proc. Natl. Acad. Sci. USA : 10774 -10779.

    • Search Google Scholar
  • Kone, J., Arroyo, J., Savinelli, T., Lin, S., Boyd, K., Wu, Y., Nimmakayalu, M., Copeland, N. G., Jenkins, N. A., Qumsiyeh, M., Hu, P., Prescott, A., Wu, H., Yang, L., Roe, B., Perkins, A. A.: F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4. Leukemia 16, 1827–1834 (2002).

    Perkins A. A. , 'F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4 ' (2002 ) 16 Leukemia : 1827 -1834.

    • Search Google Scholar
  • Howard, J., Ung, Y., Adachi, D., Ben-David, Y.: p53-Independent tumor growth and in vitro cell survival for F-MuLV-induced erythroleukemia. Cell Growth Differ. 7, 1651–1660 (1996).

    Ben-David Y. , 'p53-Independent tumor growth and in vitro cell survival for F-MuLV-induced erythroleukemia ' (1996 ) 7 Cell Growth Differ : 1651 -1660.

    • Search Google Scholar
  • Howard, J. C., Li, Q., Chu, W., Zochodne, B., Kapoor, M., Ung, Y., Rosen, K., Ben-David, Y.: Bcl-2 expression in F-MuLV-induced erythroleukemias: A role for the anti-apoptotic action of Bcl-2 during tumor progression. Oncogene 20, 2291–2300 (2001).

    Ben-David Y. , 'Bcl-2 expression in F-MuLV-induced erythroleukemias: A role for the anti-apoptotic action of Bcl-2 during tumor progression ' (2001 ) 20 Oncogene : 2291 -2300.

    • Search Google Scholar
  • Drobyski, W. R., Komorowski, R., Logan, B., Gendelman, M.: Role of passive apoptotic pathway in graft-versus-host disease. J. Immunol. 169, 1626–1633 (2002).

    Gendelman M. , 'Role of passive apoptotic pathway in graft-versus-host disease ' (2002 ) 169 J. Immunol. : 1626 -1633.

    • Search Google Scholar
  • Yada, S., Takamura, N., Inagaki-Ohara, K., O’Leary, M. K., Wasem, T., Brunner, T., Green, D. R., Lin, T., Pinkoski, M. J.: The role of p53 and Fas in a model of acute murine graft-versus-host disease. J. Immunol. 174, 1291–1297 (2005).

    Pinkoski M. J. , 'The role of p53 and Fas in a model of acute murine graft-versus-host disease ' (2005 ) 174 J. Immunol. : 1291 -1297.

    • Search Google Scholar
  • Zucker-Franklin, D.: The role of human T cell lymphotropic virus type I tax in the development of cutaneous T cell lymphoma. Ann. N. Y. Acad. Sci. 941, 86–96 (2001).

    Zucker-Franklin D. , 'The role of human T cell lymphotropic virus type I tax in the development of cutaneous T cell lymphoma ' (2001 ) 941 Ann. N. Y. Acad. Sci. : 86 -96.

    • Search Google Scholar
  • Hakim, S. T., Alsayari, M., McLean, D. C., Saleem, S., Addank, K. C., Aggarwal, M., Mahalingam, K., Bagasra, O.: Large number of the human microRNAs target lentiviruses, retroviruses, and endogenous retroviruses. Biochem. Biophys. Res. Commun. 369, 357–362 (2008).

    Bagasra O. , 'Large number of the human microRNAs target lentiviruses, retroviruses, and endogenous retroviruses ' (2008 ) 369 Biochem. Biophys. Res. Commun. : 357 -362.

    • Search Google Scholar
  • Arbuckle, J. H., Medveczky, M. M., Luka, J., Hadley, S. H., Luegmayr, A., Ablashi, D., Lund, T. C., Tolar, J., De Meirleir, K., Montoya, J. G., Komaroff, A. L., Ambros, P. F., Medveczky, P. G.: The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc. Natl. Acad. Sci. USA 107, 5563–5568 (2010).

    Medveczky P. G. , 'The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro ' (2010 ) 107 Proc. Natl. Acad. Sci. USA : 5563 -5568.

    • Search Google Scholar
  • Dreyfus, D. H.: Paleo-immunology: Evidence consistent with insertion of a primordial herpes virus-like element in the origin of acquired immunity. PLoS ONE 4, e6778 (2009).

    Dreyfus D. H. , 'Paleo-immunology: Evidence consistent with insertion of a primordial herpes virus-like element in the origin of acquired immunity ' (2009 ) 4 PLoS ONE : e6778 -.

    • Search Google Scholar
  • Rulli, S. J. Jr., Mirro, J., Hill, S. A., Lloyd, P., Gorelick, R. J., Coffin, J. M., Derse, D., Rein, A.: Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses. J. Virol. 82, 6566–6575 (2008).

    Rein A. , 'Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses ' (2008 ) 82 J. Virol. : 6566 -6575.

    • Search Google Scholar
  • Breitenbuecher, F., Markova, B., Kasper, S., Carius, B., Stauder, T., Böhmer, F. D., Masson, K., Rönnstrand, L., Huber, C., Kindler, T., Fischer, T.: A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood 113, 4063–4073 (2009).

    Fischer T. , 'A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML ' (2009 ) 113 Blood : 4063 -4073.

    • Search Google Scholar
  • Kayser, S., Schlenk, R. F., Londono, M. C., Breitenbuecher, F., Wittke, K., Du, J., Groner, S., Späth, D., Krauter, J., Ganser, A., Döhner, H., Fischer, T., Döhner, K., German-Austrian AML Study Group (AMLSG): Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 114, 2386–2392 (2009).

    Döhner K. , 'Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome ' (2009 ) 114 Blood : 2386 -2392.

    • Search Google Scholar
  • Kasper, S., Breitenbuecher, F., Hoehn, Y., Heidel, F., Lipka, D. B., Markova, B., Huber, C., Kindler, T., Fischer, T.: The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Leuk. Res. 32, 1696–1708 (2008).

    Fischer T. , 'The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia ' (2008 ) 32 Leuk. Res. : 1696 -1708.

    • Search Google Scholar
  • Kojima, K., Konopleva, M., Tsao, T., Andreeff, M., Ishida, H., Shiotsu, Y., Jin, L, Tabe, Y., Nakakuma, H.: Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. Leukemia 24, 33–43 (2010).

    Nakakuma H. , 'Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis ' (2010 ) 24 Leukemia : 33 -43.

    • Search Google Scholar
  • Ravandi, F., Cortes, J. E., Jones, D., Faderl, S., Garcia-Manero, G., Konopleva, M. Y., Orien, S., Estrov, Z., Borthakur, G., Thomas, D., Pierce, S. R., Brandt, M., Byrd, A., Bekele, B. N., Ptratz, K., Luthra, R., Levis, M., Andreeff, M., Kantarjian, H. M.: Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J. Clin. Oncol. 28, 1856–1862 (2010).

    Kantarjian H. M. , 'Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia ' (2010 ) 28 J. Clin. Oncol. : 1856 -1862.

    • Search Google Scholar
  • Skobridis, K., Kinigopoulou, M., Theodorou, V., Giannousi, E., Russell, A., Chauhan, R., Sala, R., Brownlow, N., Kiriakidis, S., Domin, J., Tzakos, A. G., Dibb, N. J.: Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT and PDGF receptors. ChemMedChem 5, 130–139 (2010).

    Dibb N. J. , 'Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT and PDGF receptors ' (2010 ) 5 ChemMedChem : 130 -139.

    • Search Google Scholar
  • Mosca, J. D., Bednarik, D. P., Raj, N. B., Rosen, C. A., Sodroski, J. G., Haseltine, W. A., Hayward, G. S., Pitha, P. M.: Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to trans-acting factor encoded by herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 84, 7408–7412 (1987).

    Pitha P. M. , 'Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to trans-acting factor encoded by herpes simplex virus 1 ' (1987 ) 84 Proc. Natl. Acad. Sci. USA : 7408 -7412.

    • Search Google Scholar
  • Ostrove, J. M., Leonard, J., Weck, K. E., Rabson, A. B., Gendelman, H. E.: Activation of the human immunodeficiency virus by herpes simplex virus type 1. J. Virol. 61, 3726–3732 (1987).

    Gendelman H. E. , 'Activation of the human immunodeficiency virus by herpes simplex virus type 1 ' (1987 ) 61 J. Virol. : 3726 -3732.

    • Search Google Scholar
  • Perron, H., Suh, M., Lalande, B., Gratacap, B., Laurent, A., Stoebner, P., Seigneurin, J. M.: Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harbored by a leptomeningeal cell line from a patient with multiple sclerosis. J. Gen. Virol. 74, 65–72 (1993).

    Seigneurin J. M. , 'Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harbored by a leptomeningeal cell line from a patient with multiple sclerosis ' (1993 ) 74 J. Gen. Virol. : 65 -72.

    • Search Google Scholar
  • Csoma, E., Bácsi, A., Liu, X., Szabó, J., Ebbesen, P., Beck, Z., Kónya, J., Andirkó, I., Nagy, E., Tóth, F. D.: Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells. J. Med. Virol. 67, 67–87 (2002).

    Tóth F. D. , 'Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells ' (2002 ) 67 J. Med. Virol. : 67 -87.

    • Search Google Scholar
  • Tóth, F. D., Aboagye-Mathiesen, G., Szabó, J., Liu, X., Mosborg-Petersen, P., Kiss, J., Hager, H., Zdravkovic, M., Andirkó, I., Aranyosi, J.: Bidirectional enhancing activities between human T cell leukemia-lymphoma virus type I and human cytomegalovirus in human term syncytiotrophoblast cells cultured in vitro. AIDS Res. Hum. Retroviruses 11, 1495–1507 (1995).

    Aranyosi J. , 'Bidirectional enhancing activities between human T cell leukemia-lymphoma virus type I and human cytomegalovirus in human term syncytiotrophoblast cells cultured in vitro ' (1995 ) 11 AIDS Res. Hum. Retroviruses : 1495 -1507.

    • Search Google Scholar
  • Tóth, F. D., Aboagye-Mathiesen, G., Nemes, J., Liu, X., Andirkó, I., Hager, H., Zdravkovic, M., Szabó, J., Kiss, J., Aranyosi, J., Ebbesen, P.: Epstein-Barr virus permissively infects human syncytiotrophoblasts in vitro and induces replication of human T cell leukemia-lymphoma virus type I in dually infected cells. Virology 29, 400–414 (1997).

    Ebbesen P. , 'Epstein-Barr virus permissively infects human syncytiotrophoblasts in vitro and induces replication of human T cell leukemia-lymphoma virus type I in dually infected cells ' (1997 ) 29 Virology : 400 -414.

    • Search Google Scholar
  • Tinari, A., Superti, F., Ammendolia, M. G., Chiozzini, C., Hohenadl, C., Leone, P., Nappi, F., Nicoletti, M., Borsetti, A., Marchetti, M., Ensoli, B., Monini, P.: Primary effusion lymphoma cells undergoing human herpesvirus type 8 productive infection produce C-type retrovirus particles. Int. J. Immunopathol. Pharmacol. 21, 999–1006 (2008).

    Monini P. , 'Primary effusion lymphoma cells undergoing human herpesvirus type 8 productive infection produce C-type retrovirus particles ' (2008 ) 21 Int. J. Immunopathol. Pharmacol. : 999 -1006.

    • Search Google Scholar
  • Celum, C., Wald, C. C., Lingappa, J. R., Magaret, A. S., Wang, R. S., Mugo, N., Mujugira, A., Baeten, J. M., Mullins, J. I., Hughes, J. P., Bukusi, W. A., Cohen, C. R., Katabira, E., Ronald, A., Kiarie, J. et al. (Partners in Prevention HSV/HIV Transmission Study Team): Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N. Engl. J. Med. 362, 427–439 (2010)

    Kiarie J. , 'Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2 ' (2010 ) 362 N. Engl. J. Med. : 427 -439.

    • Search Google Scholar
  • Van de Perre, P., Segondy, M., Foulogne, V., Ouedraogo, A., Konate, I., Huraux, J. M., Mayaud, P., Nagot, N.: Herpes simplex virus and HIV-1: Deciphering viral synergy. Lancet Infect. Dis. 8, 490–497 (2008).

    Nagot N. , 'Herpes simplex virus and HIV-1: Deciphering viral synergy ' (2008 ) 8 Lancet Infect. Dis. : 490 -497.

    • Search Google Scholar
  • Baeten, J. M., Strick, L. B., Lucchetti, A., Whittington, W. L., Sanches, J., Coombs, R. W., Magaret, A., Wald, A., Corey, L., Celum, C.: Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial. J. Infect. Dis. 198, 1804–1808 (2008).

    Celum C. , 'Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial ' (2008 ) 198 J. Infect. Dis. : 1804 -1808.

    • Search Google Scholar
  • Vanpouille, G., Lisco, A., Derudas, M., Saba, E., Grivel, J. C., Brichacek, B., Scrimieri, F., Schols, D., McGuigan, C., Balzarini, J., Margolis, L.: A new class of dual-targeted antivirals: Monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2. J. Infect. Dis. 201, 635–643 (2010).

    Margolis L. , 'A new class of dual-targeted antivirals: Monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2 ' (2010 ) 201 J. Infect. Dis. : 635 -643.

    • Search Google Scholar
  • Sinkovics, J. G., Horvath, J. C.: Criminal collusion of herpes- and retro(lenti)viruses. Second International Conference of the M. Kaposi Research Foundation, Budapest, Hungary. Hungarian Venerological Archivum 4, 105–106 (2000).

    Horvath J. C. , 'Criminal collusion of herpes- and retro(lenti)viruses. Second International Conference of the M. Kaposi Research Foundation, Budapest, Hungary ' (2000 ) 4 Hungarian Venerological Archivum : 105 -106.

    • Search Google Scholar
  • Sinkovics, J. G., Horvath, C. J., Nagy, K.: The immunovirology of Kaposi’s sarcoma. The 22nd Annual Clinical Virology Symposium & Annual Meeting PanAmerican Society for Clinical Virology. Clearwater, FL. Abstracts, Session III, M2 (2006).

    Nagy K. , 'The immunovirology of Kaposi’s sarcoma ' (2006 ) III The 22nd Annual Clinical Virology Symposium & Annual Meeting PanAmerican Society for Clinical Virology. Clearwater, FL. Abstracts, Session : M2 -.

    • Search Google Scholar
  • Reddy, P., Cooke, K. R., Ferrara, J. L. M., Deeg, H. J.: Recent advances and future directions. In Ferrara, J. L. M., Cooke, K. B., Deeg, H. J. (eds): Graft-Vs-Host Disease. 3rd edition. Marcel Dekker, New York, NY, 2005. pp. 609–630.

    Deeg H. J. , '', in Graft-Vs-Host Disease , (2005 ) -.

  • Stone, R. M., Mayer, R. J.: Acute myeloid leukemia. In Abeloff, M. D., Armitage, J. O., Lichter, A. S., Niederhuber, J. E. (eds): Clinical Oncology. Churchill Livingstone, New York, 1995, pp. 1959–1976.

    Mayer R. J. , '', in Clinical Oncology , (1995 ) -.

  • Kolitz, J. E.: Acute myeloid leukemia and the myelodysplastic syndromes. In Chang, A. E., Ganz, P. A., Hayes, D. F., Kinsella, T. J., Pass, H. J., Schiller, H. J., Stone, J. H., Strecher, V. J. (eds): Oncology An Evidence-Based Approach. Springer Verlag, 2006, pp. 1155–1157.

  • Schlenk, R. F., Döhner, K., Mack, S., Stoppel, M., Király, F., Götze, K., Hartmann, F., Horst, H. A., Koller, E., Petzer, A., Grimminger, W., Kobbe, G., Glasmacher, A., Salwender, H., Kirchen, H., Haase, D., Kremers, A., Matzdorff, A., Benner, A., Döhner, H.: Perspective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high risk acute myeloid leukemia. German-Austrian trial AMLHD98A. J. Clin. Oncol. 28, 4642–4648 (2010).

    Döhner H. , 'Perspective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high risk acute myeloid leukemia. German-Austrian trial AMLHD98A ' (2010 ) 28 J. Clin. Oncol. : 4642 -4648.

    • Search Google Scholar
  • Koreth, J., Schlenk, R., Kopecky, K. J., Honda, S., Sierra, J., Djulbegovic, B. J., Wadleigh, M., DeAngelo, D. J., Stone, R. M., Sakamaki, H., Appelbaum, F. R., Döhner, H., Antin, J. H., Soiffer, R. J., Cutler, C.: Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: Systematic review and meta-analysis of prospective clinical trials. JAMA 301, 2340–2361 (2009).

    Cutler C. , 'Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: Systematic review and meta-analysis of prospective clinical trials ' (2009 ) 301 JAMA : 2340 -2361.

    • Search Google Scholar
  • Joseph, R. W., Couriel, D. R., Komanduri, K. V.: Chronic graft-versus-host disease after allogeneic stem cell transplantation: Challenges in prevention, science and supportive care. J. Support Oncol. 6, 361–372 (2008).

    Komanduri K. V. , 'Chronic graft-versus-host disease after allogeneic stem cell transplantation: Challenges in prevention, science and supportive care ' (2008 ) 6 J. Support Oncol. : 361 -372.

    • Search Google Scholar
  • Lim, J. H., Lee, M. H., Yi, H. G., Kim, J. H., Song, S. U.: Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: A report of two cases. Int. J. Hematol. Jun 1 (2010).

  • Prasad, V. K., Lucas, K. G., Kleiner, G. I., Talano, J. A., Jacobsohn, D., Broadwater, G., Monroy, R., Kurtzberg, J.: Efficacy and safety of ex-vivo cultured adult human mesenchymal stem cells (Prochymal TM) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate study. Biol. Blood Marrow Transplant. May 7 (2010).

  • Herrero, C., Pérez-Simón, J. A.: Immunomodulatory effect of mesenchymal stem cells. Braz. J. Med. Biol. Res. 43, 425–430 (2010).

    Pérez-Simón J. A. , 'Immunomodulatory effect of mesenchymal stem cells ' (2010 ) 43 Braz. J. Med. Biol. Res. : 425 -430.

    • Search Google Scholar
  • Hamadani, M., Blum, W., Phillips, G., Elder, P., Andritsos, L., Hofmeister, C., O’Donnell, L., Klisovic, R., Penza, S., Garzon, R., Krugh, D., Lin, T., Bechtel, T., Benson, D. M., Byrd, J. C., Marcucci, G., Devine, S. M.: Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies. Biol. Blood Marrow Transplant. 15, 1422–1430 (2009).

    Devine S. M. , 'Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies ' (2009 ) 15 Biol. Blood Marrow Transplant. : 1422 -1430.

    • Search Google Scholar
  • Davis, C. C., Marti, L. C., Sempowski, G. D., Jeyraj, D. A., Szabolcs, P.: Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: Acritical step toward adoptive immunotherapy after cord blood transplantation. Cancer Res. 70, 5249–5258 (2010).

    Szabolcs P. , 'Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: Acritical step toward adoptive immunotherapy after cord blood transplantation ' (2010 ) 70 Cancer Res : 5249 -5258.

    • Search Google Scholar