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  • 1 University of Szeged Institute of Clinical Microbiology Szeged Hungary
  • 2 University of Szeged Institute of Anaesthesiology and Intensive Care Szeged Hungary
  • 3 University of Szeged Department of Infectious Diseases, First Clinic of Internal Medicine Szeged Hungary
  • 4 University of Szeged Department of Infectious Disease, First Department of Internal Medicine Kálvária sgt. 57 H-6725 Szeged Hungary
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The incidence of Candida species causing bloodstream infections in the University Hospital of Szeged, Hungary, between 1996 and 2009, and the susceptibilities of these isolates to antifungal agents were evaluated.Automated blood culture systems (Vital, bioMérieux, Marcy-l’Etoile, France; and BACTEC 9120, Becton-Dickinson Diagnostic Systems, Sparks, USA) were used. The in vitro susceptibilities of the yeast isolates to antifungal agents were determined by the Etest method (AB Biodisk, Solna, Sweden).Bloodstream infections were caused by yeast strains in 231 cases during this period, and 226 Candida strains were cultured from 216 candidaemia patients. Bloodstream infections caused by multiple Candida spp. were diagnosed almost every year. Of the 216 patients, 67 were children; and 55 infants needed intensive care. In 2005, C. glabrata caused an increase in the incidence of invasive fungal infections in the Neonatal Intensive Care Unit. The PFGE analysis of 12 isolates distinguished 4 different karyotypes. The incidence of bloodstream infections caused by fungi did not change during the 14-year study period. The most frequent species cultured from blood samples were C. albicans and C. glabrata. The incidence of resistant isolates remained constant. The local trends of fungaemia must be monitored and compared with global reports.

  • Arendrup, M. C., Fuursted, K., Gahrn-Hansen, B., Jensen, I. M., Knudsen, J. D., Lundgren, B., Schønheyder, H. C., Tvede, M.: Seminational surveillance of fungemia in Denmark: Notably high rates of fungemia and numbers of isolates with reduced azole susceptibility. J. Clin. Microbiol. 43, 4434–4440 (2005).

    Tvede M. , 'Seminational surveillance of fungemia in Denmark: Notably high rates of fungemia and numbers of isolates with reduced azole susceptibility ' (2005 ) 43 J. Clin. Microbiol. : 4434 -4440.

    • Search Google Scholar
  • Messer, S. A., Jones, R. N., Fritsche, T. R.: International surveillance of Candida spp. and Aspergillus spp.: report from the SENTRY Antimicrobial Surveillance Program (2003). J. Clin. Microbiol. 44, 1782–1787 (2006).

  • Swinne, D., Watelle, M., Suetens, C., Mertens, K., Fonteyne, P.-A., Nolard, N.: A one-year survey of candidaemia in Belgium in 2002. Epidemiol. Infect. 132, 1175–1180 (2004).

    Nolard N. , 'A one-year survey of candidaemia in Belgium in 2002 ' (2004 ) 132 Epidemiol. Infect. : 1175 -1180.

    • Search Google Scholar
  • Tortorano, A. M., Pennan, J., Bernhardt, H., Klingspor, L., Kibbler, C. C., Faure, O., Biraghi, E., Canton, E., Zimmermann, K., Seaton, S., Grillot, R., the ECMM Working Group on Candidaemia: Epidemiology of candidaemia in Europe: Results of 28-month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study. Eur. J. Clin. Microbiol. Infect. Dis. 23, 317–322 (2004).

    Grillot R. , 'Epidemiology of candidaemia in Europe: Results of 28-month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study ' (2004 ) 23 Eur. J. Clin. Microbiol. Infect. Dis. : 317 -322.

    • Search Google Scholar
  • Bedini, A., Venturelli, C., Mussini, C., Guaraldi, G., Codeluppi, M., Borghi, V., Rumpianesi, F., Barchiesi, F., Esposito, R.: Epidemiology of candidaemia and antifungal susceptibility patterns in an Italian tertiary-care hospital. Clin. Microbiol. Infect. 12, 75–80 (2006).

    Esposito R. , 'Epidemiology of candidaemia and antifungal susceptibility patterns in an Italian tertiary-care hospital ' (2006 ) 12 Clin. Microbiol. Infect. : 75 -80.

    • Search Google Scholar
  • González, G. M., Elizondo, M., Ayala, J.: Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: Results of a 3-year (2004 to 2007) surveillance study. J. Clin. Microbiol. 46, 2902–2905 (2008).

    Ayala J. , 'Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: Results of a 3-year (2004 to 2007) surveillance study ' (2008 ) 46 J. Clin. Microbiol. : 2902 -2905.

    • Search Google Scholar
  • Yapar, N., Uysal, U., Yucesoy, M., Cakir, N., Yuce, A.: Nosocomial bloodstream infections associated with Candida species in a Turkish University Hospital. Mycoses 49, 134–138 (2006).

    Yuce A. , 'Nosocomial bloodstream infections associated with Candida species in a Turkish University Hospital ' (2006 ) 49 Mycoses : 134 -138.

    • Search Google Scholar
  • Pfaller, M. A., Diekema, D. J., Ostrosky-Zeichner, L., Rex, J. H., Alexander, B. D., Andes, D., Brown, S. D., Chaturvedi, V., Ghannoum, M. A., Knapp, C. C. D. J., Sheehan, D. J., Walsh, T. J.: Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin and micafungin: analysis and proposal for interpretive MIC breakpoints. J. Clin. Microbiol. 46, 2620–2629 (2008).

    Walsh T. J. , 'Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin and micafungin: analysis and proposal for interpretive MIC breakpoints ' (2008 ) 46 J. Clin. Microbiol. : 2620 -2629.

    • Search Google Scholar
  • Sandven, P., Bevanger, L., Digranes, A., Haukland, H. H., Mannsaker, T., Gaustad, P.: Candidaemia in Norway (1991 to 2003): Results from nationwide study. J. Clin. Microbiol. 44, 1977–1981 (2006).

    Gaustad P. , 'Candidaemia in Norway (1991 to 2003): Results from nationwide study ' (2006 ) 44 J. Clin. Microbiol. : 1977 -1981.

    • Search Google Scholar
  • Pfaller, M. A., Diekema, D. J.: Twelve years of fluconazole in clinical practice: Global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida. Clin. Microbiol. Infect. 10Suppl. 1, 11–23 (2004).

    Diekema D. J. , 'Twelve years of fluconazole in clinical practice: Global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida ' (2004 ) 10 Clin. Microbiol. Infect. : 11 -23.

    • Search Google Scholar
  • Lee, J. S., Shin, J. H., Lee, K., Kim, M. N., Shin, B. M., Uh, Y., Lee, W. G., Lee, H. S., Chang, C. L., Kim, S. H., Shin, M. G., Suh, S. P., Ryang, D. W.: Species distribution and susceptibility to azole antifungals of Candida bloodstream isolates from eight university hospitals in Korea. Yonsei Med. J. 48, 779–786 (2007).

    Ryang D. W. , 'Species distribution and susceptibility to azole antifungals of Candida bloodstream isolates from eight university hospitals in Korea ' (2007 ) 48 Yonsei Med. J. : 779 -786.

    • Search Google Scholar
  • Tan, T. Y., Tan, A. L., Tee, N. W., Ng, L. S.: A retrospective analysis of antifungal susceptibilities of Candida bloodstream isolates from Singapore hospitals. Ann. Acad. Med. Singapore 37, 835–840 (2008).

    Ng L. S. , 'A retrospective analysis of antifungal susceptibilities of Candida bloodstream isolates from Singapore hospitals ' (2008 ) 37 Ann. Acad. Med. Singapore : 835 -840.

    • Search Google Scholar
  • National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard M27-A. Villanova, PA, NCCLS (1997).

    '', in Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard M27-A , (1997 ) -.

  • Odds, F. C., Bernaerts, R.: CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species. J. Clin. Microbiol. 32, 1923–1929 (1994).

    Bernaerts R. , 'CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species ' (1994 ) 32 J. Clin. Microbiol. : 1923 -1929.

    • Search Google Scholar
  • Larone, D. H.: Medically Important Fungi. A guide to identification. 2nd edition. Elsevier Science Publishing Co., Inc. Amsterdam, The Netherlands, 1987, pp. 173–185.

    Larone D. H. , '', in Medically Important Fungi. A guide to identification , (1987 ) -.

  • McGinnis, M. R., Pasarell, L.: Yeast identification using morphology. In: Isenberg, H. D. (ed.): Clinical Microbiology Procedures Handbook. Vol. 1. American Society for Microbiology, Washington, USA, 1992, p. 6.9.

    Pasarell L. , '', in Clinical Microbiology Procedures Handbook. Vol. 1 , (1992 ) -.

  • Etest technical guide No. 4: Antifungal susceptibility testing of yeasts. Solna, Sweden, AB Biodisk (1993).

  • Pfaller, M. A., Diekema, D. J., Rex, J. H., Espinel-Ingroff, A., Johnson, E. M., Andes, D., Chaturvedi, V., Ghannoum, M. A., Odds, F. C., Rinaldi, M. G., Sheehan, D. J., Troke, P., Walsch, T. J., Warnock, D. W.: Correlation of MIC with outcome for Candida species tested against voriconazole: Analysis and proposal for interpretive breakpoints. J. Clin. Microbiol. 44, 819–826 (2006).

    Warnock D. W. , 'Correlation of MIC with outcome for Candida species tested against voriconazole: Analysis and proposal for interpretive breakpoints ' (2006 ) 44 J. Clin. Microbiol. : 819 -826.

    • Search Google Scholar
  • Fodor, E., Dósa, E., Nagy, Á., Nagy, E., Ferenczy, L.: Karyotyping of Candida albicans and Candida glabrata isolates from recurrent vaginal infections by pulse-field gel electrophoresis. Acta Microbiol. Immunol. Hung. 49, 59–68 (2002).

    Ferenczy L. , 'Karyotyping of Candida albicans and Candida glabrata isolates from recurrent vaginal infections by pulse-field gel electrophoresis ' (2002 ) 49 Acta Microbiol. Immunol. Hung. : 59 -68.

    • Search Google Scholar
  • Lunel, F. V., Koeleman, J. G., Spanjaard, L., Vandenbroucke-Grauls, C., Schultz, C., Verbrugh, H. A., Vos, G., Troelstra, A., Mascini, E., Verweij, P. E., Voss, A.: Trends in fungaemia and antifungal susceptibility in the Netherlands. Neth. J. Medicine 64, 236–242 (2006).

    Voss A. , 'Trends in fungaemia and antifungal susceptibility in the Netherlands ' (2006 ) 64 Neth. J. Medicine : 236 -242.

    • Search Google Scholar
  • Almirante, B., Rodríguez, D., Park, B. J., Cuenca-Estrella, M., Planes, A. M., Almela, M., Mensa, J., Sanchez, F., Ayats, J., Gimenez, M., Saballs, P., Fridkin, S. K., Morgan, J., Rodriguez-Tudela, J. L., Warnock, D. W., Pahissa, A. and the Barcelona Candidemia Project Study Group. Epidemiology and predictors of mortality in cases of Candida bloodstream infection: Results from population-based surveillance, Barcelona, Spain, from 2002 to 2003. J. Clin. Microbiol. 43, 1829–1835 (2005).

    Pahissa A. , 'Epidemiology and predictors of mortality in cases of Candida bloodstream infection: Results from population-based surveillance, Barcelona, Spain, from 2002 to 2003 ' (2005 ) 43 J. Clin. Microbiol. : 1829 -1835.

    • Search Google Scholar
  • Boo, T. W., O’Reilly, B., O’Leary, J., Cryan, B.: Candidaemia in an Irish tertiary referral hospital: Epidemiology and prognostic factors. Mycoses 48, 251–259 (2005).

    Cryan B. , 'Candidaemia in an Irish tertiary referral hospital: Epidemiology and prognostic factors ' (2005 ) 48 Mycoses : 251 -259.

    • Search Google Scholar
  • Dóczi, I., Dósa, E., Hajdú, E., Nagy, E.: Aetilogy and antifungal susceptibility of yeast bloodstream infections in a Hungarian university hospital between 1996 and 2000. J. Med. Microbiol. 51, 677–681 (2002).

    Nagy E. , 'Aetilogy and antifungal susceptibility of yeast bloodstream infections in a Hungarian university hospital between 1996 and 2000 ' (2002 ) 51 J. Med. Microbiol. : 677 -681.

    • Search Google Scholar
  • Cisterna, R., Ezpeleta, G., Telleria, O., Guinea, J., Regueiro, G., Radríguez, J., Esperalba, J. and the Spanish Candidaemia Surveillance Group: A nationwide sentinel surveillance of bloodstream Candida spp. infection study in 40 tertiary-care hospitals in Spain. J. Clin. Microbiol. 48, 4200–4206 (2010).

    Esperalba J. , 'A nationwide sentinel surveillance of bloodstream Candida spp. infection study in 40 tertiary-care hospitals in Spain ' (2010 ) 48 J. Clin. Microbiol. : 4200 -4206.

    • Search Google Scholar
  • Odds, F. C., Hanson, M. F., Davidson, A. D, Jacobsen, M. D., Wright, P., Whyte, J. A., Gow, N. A., Jones, B. L.: One year prospective survey of Candida bloodstream infections in Scotland. J. Med. Microbiol. 56, 1066–1075 (2007).

    Jones B. L. , 'One year prospective survey of Candida bloodstream infections in Scotland ' (2007 ) 56 J. Med. Microbiol. : 1066 -1075.

    • Search Google Scholar

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