View More View Less
  • 1 Bagcilar Training and Research Hospital, Istanbul, Turkey
  • 2 Istanbul University, Istanbul, Turkey
  • 3 Haseki Research and Training Hospital, Istanbul, Turkey
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $784.00

Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0–12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the first, the seventh, the fourteenth and the 21st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classified as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no significant difference were present. Also, PCT and neopterin levels within the first 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period.

  • 1.

    Sheridan, R. L.:Sepsis in pediatric burn patients. Pediatr Crit Care Med 6, 112119 (2005). Doi: 10.1097/01.PCC.0000161577.27849.BE

  • 2.

    Balogh, D., Lammer, H., Kornberger, E., Stuffer, M., Schönitzer, D.:Neopterin plasma levels in burn patients. Burns 18, 185188 (1992). Doi: 10.1016/0305-4179(92)90068-6

    • Search Google Scholar
    • Export Citation
  • 3.

    Yao, Y. M., Yu, Y., Wang, Y. P., Tian, H. M., Sheng Z. Y.:Elevated serum neopterin level: its relation to endotoxaemia and sepsis in patients with major burns. Eur J Clin Invest 26, 224230 (1996). Doi: 10.1046/j.1365-2362.1996.128257.x

    • Search Google Scholar
    • Export Citation
  • 4.

    Fuchs, D., Weiss, G., Reibnegger, G., Wachter, H.:The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious and malignant diseases. Crit Rev Clin Lab 29, 307341 (1992). Doi: 10.3109/10408369209114604

    • Search Google Scholar
    • Export Citation
  • 5.

    Huber, C., Batchelor, J. R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J., Wachter, H.:Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon gamma J Exp Med 160, 310316 (1984). Doi: 10.1084/jem.160.1.310

    • Search Google Scholar
    • Export Citation
  • 6.

    Grabosch, A., Rokos, H.:Neopterin as parameter of cell-mediated immunity response in thermally injured patients. Burns 18, 113116 (1992). Doi: 10.1016/0305-4179(92)90006-G

    • Search Google Scholar
    • Export Citation
  • 7.

    Elshahat, A., Elshahat, E. M. F.:Neopterin as a prognostic marker in burned patients. Egypt J Plast Reconstr Surg 30, 1317 (2006). Full text available at http://www.medbc. com/meditline/review/egypt/vol_30/num_1/text/vol30n1p13.asp

    • Search Google Scholar
    • Export Citation
  • 8.

    Mann, E. A., Wood, G. L., Wade, C. E.:Use of procalcitonin for the detection of sepsis in the critically ill burn patient: a systematic review of the literature. Burns 37, 549558 (2011). Doi: 10.1016/j.burns.2010.04.013

    • Search Google Scholar
    • Export Citation
  • 9.

    Gilber, D. N.:Use of plasma procalcitonin levels as an adjunct to clinical microbiology. J Clin Microbiol 48, 23252329 (2010). Doi: 10.1128/JCM.00655-10

    • Search Google Scholar
    • Export Citation
  • 10.

    Ugarte, H., Silva, E., Mercan, D., De Mendonça , A., Vincent, J. L.:Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med 27, 498504 (1999). Doi: 10.1097/00003246-199903000-00024

    • Search Google Scholar
    • Export Citation
  • 11.

    Hausfater, P., Garric, S., Ayed, S. B., Rosenheim, M., Bernard, M., Riou, B.:Usefulness of procalcitonin as a marker of systemic infection in emergency department patients: a prospective study. Clin Infect Dis 34, 895901 (2002). Doi: 10.1086/339198

    • Search Google Scholar
    • Export Citation
  • 12.

    Harbarth, S., Holeckova, K., Froidevaux, C., Pittet, D., Ricou, B., Grau, G. E., Vadas, L., Pugin, L.:Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164, 396402 (2001). WOS: 000170651200012

    • Search Google Scholar
    • Export Citation
  • 13.

    Barati, M., Alinejad, F., Bahar, M. A., Tabrisi, M. S., Shamshiri, A. R., Bodouhi, N. O. L., Karimi, H.:Comparison of WBC, ESR, CRP and PCT serum levels in septic and nonseptic burn cases. Burns 34, 770774 (2008). Doi: 10.1016/j.burns.2008.01.014

    • Search Google Scholar
    • Export Citation
  • 14.

    Reinhart, K., Meisner, M., Brunkhorst, F. M.:Markers for sepsis diagnosis: What is useful? Crit Care Clin 22, 503519 (2006). Doi: 10.1016/j.ccc.2006.03.003

    • Search Google Scholar
    • Export Citation
  • 15.

    Gabay, C., Kushner, I.:Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340, 448454 (1999). Doi: 10.1056/NEJM199902113400607

    • Search Google Scholar
    • Export Citation
  • 16.

    Pileri, D., Accardo-Palumbo, A., D’Amelio, L., D’Arpa, N., Arnone, G., Grisaffi, C., Amico, M., Brancato, R., Lombardo, C., Conte, F.:Serum levels of cortisol, immunoglobulin and C-reactive protein in burn patients. Ann Burns Fire Disasters 22, 35 (2009). PMCID: PMC3188205

    • Search Google Scholar
    • Export Citation
  • 17.

    von Heimburg, D., Stieghorst, W., Khorram-Sefat, R., Pallua, N.:Procalcitonin –a sepsis parameter in severe burns. Burns 24, 745750 (1998). Doi: 10.1016/S0305-4179(98)00109-0

    • Search Google Scholar
    • Export Citation
  • 18.

    Bargues, L., Chancerelle, Y., Catineau, J., Jault, P., Carsin, H.:Evaluation of serum procalcitonin concentration in the ICU following severe burn. Burns 33, 860864 (2007). Doi: 10.1016/j.burns.2006.10.401

    • Search Google Scholar
    • Export Citation
  • 19.

    Lavrentieva, A., Papadopoulou, S., Kioumis, J., Kaimakamis, E., Bitzani, M.:PCT as a diagnostic and prognostic tool in burn patients. Whether time course has role in monitoring sepsis treatment. Burns 38, 356363 (2012). Doi: 10.1016/j.burns.2011.08.021

    • Search Google Scholar
    • Export Citation
  • 20.

    Neely, A. N., Fowler, L. A., Kagan, R. J., Warden, G. D.:Procalcitonin in pediatric burn patients: an early indicator of sepsis? J Burn Care Rehabil 25, 7680 (2004). Doi: 10.1097/01.BCR.0000105095.94766.89

    • Search Google Scholar
    • Export Citation
  • 21.

    Pourakbari, B., Mamishi, S., Zafari, J., Khairkhah, H., Ashtiani, M. H., Abedini, M., Afsharpaiman, S., Rad, S. S.:Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection. Braz J Infect Dis 14, 252255 (2010). Doi: 10.1590/S1413-86702010000300009

    • Search Google Scholar
    • Export Citation
  • 22.

    Lavrentieva, A., Kontakiotis, T., Lazaridis, L., Tsotsolis, N., Koumis, J., Kyriazis, G., Bitzani, M.:Inflammatory markers in patients with severe burn injury. What is the best indicator of sepsis? Burns 33, 189194 (2007). Doi: 10.1016/j.burns.2006.07.001

    • Search Google Scholar
    • Export Citation
  • 23.

    Budkevich, L. I., Lecmanov, A. U., Kolokolchikova, E. G., Soshkina, V. V.:Comparing the morphological changes in burn wound tissues and the procalcitonin concentrations. Int J Biomed 3, 2326 (2013).

    • Search Google Scholar
    • Export Citation
  • 24.

    Carsin, H., Assicot, M., Feger, F., Roy, O., Pennacino, I., Le Bever, H., Ainaud, P., Bohuon, C.:Evaluation and significance of circulating procalcitonin levels compared with IL-6, TNF alpha and endotoxin levels early after thermal injury. Burns 23, 218224 (1997). Doi: 10.1016/S0305-4179(96)00124-6

    • Search Google Scholar
    • Export Citation
  • 25.

    Sachse, C., Machens, H. G., Felmerer, G., Berger, A., Henkel, E.:Procalcitonin as a marker for the early diagnosis of severe infections after thermal injury. J Burn Care Rehabil 20, 354360 (1999). Doi: 10.1097/00004630-199909000-00004

    • Search Google Scholar
    • Export Citation
  • 26.

    Lacour, A. G., Gervaix, A., Zamora, S. A., Vadas, L., Lombard, P. R., Dayer, J. M., Suter S.:Procalcitonin, IL-6, IL-8, IL-1 receptor antogonist and C-reactive protein as identifi-cators of serious bacterial infections in children with fewer without localizing signs. Eur J Pediatr 160, 95100 (2001). Doi: 10.1007/s004310000681

    • Search Google Scholar
    • Export Citation

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2020 3 0 0
Sep 2020 6 0 0
Oct 2020 8 0 0
Nov 2020 8 3 0
Dec 2020 2 0 0
Jan 2021 1 0 0
Feb 2021 0 0 0