Authors:
Abdurrahman Kaya Department of Infectious Disease, Istanbul Training and Research Hospital, İstanbul, Turkey

Search for other papers by Abdurrahman Kaya in
Current site
Google Scholar
PubMed
Close
https://orcid.org/0000-0003-2100-3035
,
Sibel Yıldız Kaya Department of Infectious Disease, Sungurlu State Hospital, Çorum, Turkey

Search for other papers by Sibel Yıldız Kaya in
Current site
Google Scholar
PubMed
Close
,
Esra Zerdali Department of Infectious Disease, Haseki Training and Research Hospital, İstanbul, Turkey

Search for other papers by Esra Zerdali in
Current site
Google Scholar
PubMed
Close
,
Alper Koç Department of Internal Medicine, Division of Hematology, İstanbul Training and Research Hospital, İstanbul, Turkey

Search for other papers by Alper Koç in
Current site
Google Scholar
PubMed
Close
,
Bilge Çağlar Department of Infectious Disease, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Bilge Çağlar in
Current site
Google Scholar
PubMed
Close
,
Ümran Şümeyse Ertürk Elazığ Training and Research Hospital, Elazığ, Turkey

Search for other papers by Ümran Şümeyse Ertürk in
Current site
Google Scholar
PubMed
Close
,
Mesut Yılmaz Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Medipol University, İstanbul, Turkey

Search for other papers by Mesut Yılmaz in
Current site
Google Scholar
PubMed
Close
,
Gökhan Aygün Department of Medical Microbiolog, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Gökhan Aygün in
Current site
Google Scholar
PubMed
Close
,
Ilker Inanç Balkan Department of Infectious Disease, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Ilker Inanç Balkan in
Current site
Google Scholar
PubMed
Close
,
Bilgül Mete Department of Infectious Disease, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Bilgül Mete in
Current site
Google Scholar
PubMed
Close
,
Neşe Saltoglu Department of Infectious Disease, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Neşe Saltoglu in
Current site
Google Scholar
PubMed
Close
,
Ali Mert Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Medipol University, İstanbul, Turkey

Search for other papers by Ali Mert in
Current site
Google Scholar
PubMed
Close
, and
Ömer Fehmi Tabak Department of Infectious Disease, Medical School of Cerrahpasa, Istanbul University, İstanbul, Turkey

Search for other papers by Ömer Fehmi Tabak in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract

We investigated the cases with Aeromonas bacteremia in terms of clinical and microbiological characteristics, underlying disease and mortality rates. Patients with positive blood cultures were included in this research. Aeromonas bacteremia was diagnosed as at least one positive blood culture for Aeromonas species. The bacteremia was defined as community origin if the onset was in the community or within 72 hours of hospital admission. The others were considered as nosocomial. All bacteria were defined as Aeromonas with conventional method. Species identification was verified by VITEK system. Antibiotic susceptibility tests were analyzed with the disc diffusion, E-test method or VITEK system. Thirty-three patients were diagnosed with bacteremia due to Aeromonas spp. Hematologic and solid tumors were the leading underlying conditions, followed by cirrhosis. Two patients (6%) had community-acquired infections. Aeromonas hydrophila was the most common isolated bacterium. The crude mortality rate was 36%. 12 patients died and 6 deaths and 4 deaths were detected in patients with bacteremia caused by A. hydrophila and Aeromonas sobria respectively. All strains were resistant to ampicillin and more than 90% of the strains were susceptible to trimethoprim-sulfamethoxazole, fluoroquinolone, third generation cephalosporins, and carbapenems. Aeromonas sp. is not a frequent cause of bacteremia however, it may lead to high mortality rates, especially in the immunocompromised hosts and patients with liver cirrhosis. Nosocomial Aeromonas bacteremia is not uncommon in these populations. Broad-spectrum cephalosporins, piperacillin-tazobactam, fluoroquinolones, and carbapenems remain as effective antimicrobial agents for therapy of Aeromonas bacteremia.

  • 1.

    Edberg SC , Browne FA , Allen MJ . Issues for microbial regulation: Aeromonas as a model. Crit Rev Microbiol 2007; 33: 89100.

  • 2.

    J Glenn Morris AH 2018. Available from: www.uptodate.com, https://www.uptodate.com/contents/aeromonas-infections/contributors [Accessed 31 Aug 2019].

  • 3.

    Janda JM , Abbott SL . Evolving concepts regarding the genus Aeromonas: an expanding panorama of species, disease presentations, and unanswered questions. Clin Infect Dis 1998; 27: 33244.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Janda JM . Recent advances in the study of the taxonomy, pathogenicity, and infectious syndromes associated with the genus Aeromonas. Clin Microbiol Rev 1991; 4: 397410.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    n.d. Available from: www.cdc.gov, https://www.cdc.gov/nhsn/pdfs/pscmanual/4psc_clabscurrent.pdf [Accessed 11 Oct 2020].

  • 6.

    French GL , Cheng AF , Duthie R , Cockram CS . Septicaemia in Hong Kong. J Antimicrob Chemother 1990; 25: 11525.

  • 7.

    Bahçe YG , Toyran A , Aksoy A . Direct identification and determination of antimicrobial susceptibility of Gram-negative bacilli using the PhoenixTM FX system in blood cultures flagging positive. Mikrobiyol Bul 2019; 53: 119-133.

    • Search Google Scholar
    • Export Citation
  • 8.

    Kitagawa H , Ohge H , Yu L , Kayama S , Hara T , Kashiyama S , Kajihara T , Hisatsune J , Sueda T , Sugai M . Aeromonas dhakensis is not a rare cause of Aeromonas bacteremia in Hiroshima, Japan. J Infect Chemother 2020; 26: 316-320.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Ko WC , Chuang YC . Aeromonas bacteremia: review of 59 episodes. Clin Infect Dis 1995; 20: 1298304.

  • 10.

    Ko WC , Lee HC , Chuang YC , Liu CC , Wu JJ . Clinical features and therapeutic implications of 104 episodes of monomicrobial Aeromonas bacteraemia. J Infect 2000; 40: 26773.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Lau SM , Peng MY , Chang FY . Outcomes of Aeromonas bacteremia in patients with different types of underlying disease. J Microbiol Immunol Infect 2000; 33: 2417.

    • Search Google Scholar
    • Export Citation
  • 12.

    Llopis F , Grau I , Tubau F , Cisnal M , Pallares R . Epidemiological and clinical characteristics of bacteraemia caused by Aeromonas spp. as compared compared with Escherichia coli and Pseudomonas aeruginosa. Scand J Infect Dis 2004; 36: 33541.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Tsai MS , Kuo CY , Wang MC , Wu HC , Chien CC , Liu JW . Clinical features and risk factors for mortality in Aeromonas bacteremic adults with hematologic malignancies. J Microbiol Immunol Infect 2006; 39: 1504.

    • Search Google Scholar
    • Export Citation
  • 14.

    Lakatos B , Szabó H , Csordás K , Tatai G , Nikolova R , Csomor J , Reményi P , Masszi T , Vályi-Nagy I , Sinkó J . Epidemiology of early infections after autologous hematopoietic stem cell transplantation. Analysis of data from 699 patients treated in a Hungarian centre. Orv Hetil 2020; 161: 103-109.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Wu CJ , Wu JJ , Yan JJ , Lee HC , Lee NY , Chang CM , et al. Clinical significance and distribution of putative virulence markers of 116 consecutive clinical Aeromonas isolates in southern Taiwan. J Infect 2007; 54: 1518.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Duthie R , Ling TW , Cheng AFB , French GL . Aeromonas septicaemia in Hong Kong species distribution and associated disease. J Infect 1995; 30: 2414.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Harris RL , Fainstein V , Elting L , Hopfer RL , Bodey GP . Bacteremia caused by Aeromonas species in hospitalized cancer patients. Rev Infect Dis 1985; 7: 31420.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Funada H , Matsuda T . Aeromonas bacteremia in patients with hematologic diseases. Intern Med 1997; 36: 1714.

  • 19.

    Wang JH , Wang CY , Chi CY , Ho MW , Ho CM , Lin PC . Clinical presentations, prognostic factors, and mortality in patients with Aeromonas sobria complex bacteremia in a teaching hospital: a 5-year experience. J Microbiol Immunol Infect 2009; 42: 5105.

    • Search Google Scholar
    • Export Citation
  • 20.

    Hofer E , Reis CMF dos , Theophilo GND , Cavalcanti VO , Lima NV de , Henriques M de FC de M . [Aeromonas associated with an acute diarrhea outbreak in São Bento do Una, Pernambuco]. Revista Da Sociedade Brasileira de Medicina Trop 2006; 239: 21720.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Janda JM , Abbott SL . The genus Aeromonas: taxonomy, pathogenicity, and infection. Clin Microbiol Rev 2010; 23: 3573.

  • 22.

    Janda JM , Guthertz LS , Kokka RP , Shimada T . Aeromonas species in septicemia: laboratory characteristics and clinical observations. Clin Infect Dis 1994; 19: 7783.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23.

    Moura Q , Fernandes MR , Cerdeira L , Santos ACM , de Souza TA , Ienne S , Pignatari ACC , Gales AC , Silva RM , Lincopan N . Draft genome sequence of a multidrug resistant Aeromonas hydrophila ST508 strain carrying rmtD and bla(CTX-M-131) isolated from a bloodstream infection. J Glob Antimicrob Resist 2017; 10: 289-290.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Sherlock CH , Burdge DR , Smith JA . Does Aeromonas hydrophila preferentially colonize the bowels of patients with hematologic malignancies? Diagn Microbiol Infect Dis 1987; 7: 638.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25.

    Nagata K , Takeshima Y , Tomii K , Imai Y . Fulminant fatal bacteremic pneumonia due to Aeromonas hydrophila in a non immunocompromised woman. Intern Med 2011; 50: 635.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26.

    Mukhopadhyay C , Bhargava A , Ayyagari A . Aeromonas hydrophila and aspiration pneumonia: a diverse presentation. Yonsei Med J 2003; 44: 108790.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27.

    Murphy OM , Gray J , Pedler SJ . Non-enteritic Aeromonas infections in hospitalized patients. J Hosp Infect 1995; 31: 5560.

  • 28.

    Kimura M , Araoka H , Yoneyama A . Aeromonas caviae is the most frequent pathogen amongst cases of Aeromonas bacteremia in Japan. Scand J Infect Dis 2013; 45: 3049.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 29.

    Patel KM , Svestka M , Sinkin J , Ruff P . Ciprofloxacin-resistant Aeromonas hydrophila infection following leech therapy: a case report and review of the literature. J Plast Reconstr Aesthet Surg 2013; 66: 20-2.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Collapse
  • Expand

Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

Editorial Office:
Akadémiai Kiadó Zrt.
Budafoki út 187-187, A/3, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Microbiologica et Immunologica Hungarica
Institute of Medical Microbiology
Semmelweis University
P.O. Box 370
H-1445 Budapest, Hungary
Phone: + 36 1 459 1500 ext. 56101
Fax: (36 1) 210 2959
E-mail: amih@med.semmelweis-univ.hu

 Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • CABELLS Journalytics
  • Chemical Abstracts
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • SCOPUS
  • Science Citation Index Expanded

2023  
Web of Science  
Journal Impact Factor 1.3
Rank by Impact Factor Q4 (Immunology)
Journal Citation Indicator 0.31
Scopus  
CiteScore 2.3
CiteScore rank Q3 (Infectious Diseases)
SNIP 0.389
Scimago  
SJR index 0.308
SJR Q rank Q3

Acta Microbiologica et Immunologica Hungarica
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article (only for OA publications)
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2025 Online subsscription: 772 EUR / 848 USD
Print + online subscription: 860 EUR / 944 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
Year of
Foundation
1954
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1217-8950 (Print)
ISSN 1588-2640 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 49 0 0
Sep 2024 50 0 0
Oct 2024 168 0 0
Nov 2024 92 0 0
Dec 2024 53 0 0
Jan 2025 132 0 0
Feb 2025 42 0 0